訪問記録

・2022年12月05日　シャリフ・ヒダーヤットゥラ国立イスラム大学ジャカルタ健康科学部から Zilhadia健康化学部長、Yuli Amran健康化学副学部長、Fajar Ariyanti公衆衛生プログラムコーディネータが表敬訪問されました。（詳細）
・2022年09月03日　第 3 回 BINDS 合成勉強会において、施設見学を行いました。（詳細）
・2022年07月01日　大野総長、青木理事・副学長が訪問されました。（詳細）

シンポジウム・ポスター

第２回　医薬品開発研究センターセミナー (2022年6月3日)（ポスター）
第１回　医薬品開発研究センターセミナー (2022年5月12日)（ポスター）
医薬品開発研究センター講演会(2020年1月16日）（ポスター）

第５回　理研・星薬科大学ー東北大学大学院薬学研究科シンポジウム (2022年12月16日)（ポスター）
第４回　理研・星薬科大学ー東北大学大学院薬学研究科シンポジウム (2021年12月24日)（ポスター）
第３回　理研・星薬科大学ー東北大学大学院薬学研究科シンポジウム (2020年12月24日)（ポスター）

第９回　医薬品開発研究センターシンポジウム　「低分子でタンパク質を繰る」(2024年3月15日）（ポスター）
第８回　医薬品開発研究センターシンポジウム　「挑戦的アプローチから創薬へ」(2023年8月7日）（ポスター）
第７回　医薬品開発研究センターシンポジウム　「変性・損傷とその防御」　（2023年3月7日）（ポスター）
第６回　医薬品開発研究センターシンポジウム　「先導する解析力」　（2022年8月2日）（ポスター）
第５回　医薬品開発研究センターシンポジウム　「創薬への革新的アプローチ」　（2022年2月22日）（ポスター）
第４回　医薬品開発研究センターシンポジウム　「脳と創薬」（2021年8月6日）（ポスター）
第３回　医薬品開発研究センターシンポジウム　「免疫と創薬」（2020年12月10日）（ポスター）
第２回　医薬品開発研究センターシンポジウム　「酸化ストレスと創薬」(2020年7月28日）（ポスター）
第１回　医薬品開発研究センターシンポジウム　(2019年11月15日）（ポスター）

2023

Original Articles

  1. The Mycobacterium tuberculosis mycothiol S-transferase is divalent metal-dependent for mycothiol binding and transfer
    Yahani P. Jayasinghe, Michael T. Banco, Jared J. Lindenberger, Lorenza Favrot, Zuzana Palčeková, Mary Jackson, Shino Manabe, Donald R. Ronning, RSC Med. Chem. in press. doi.org/10.1039/D2MD00401A
  2. Tumor targeting of 211At-labeled antibody under sodium ascorbate protection against radiolysis
    Hiroki Takashima, Kazunobu Ohnuki, Shino Manabe, Yoshikatsu Koga, Ryo Tsumura, Takahiro Anzai, Yang Wang, Xiaojie Yin, Nozomi Sato, Yudai Shigekawa, Akihiro Nambu, Sachiko Usuda, Hiromitsu Haba, Hirofumi Fujii, Masahiro Yasunaga, Mol. Pharm. 20(2), 1156–1167 (2023). doi.10.1021/acs.molpharmaceut.2c00869
  3. LiHMDS-mediated deprotonative coupling of toluenes with ketone
    Masanori Shigeno, Akihisa Kajima, Eito Toyama, Toshinobu Korenaga, Hiroyuki Yamakoshi, Kanako Nozawa-Kumada, Yoshinori Kondo, Chem. Eur. J. e202203549 (2023) doi.org/10.1002/chem.202203549

Reviews

  1. Function of protein C-mannosylation in physiology and pathology
    Kazuchika Nishitsuji, Midori Ikezaki, Shino Manabe, Yoshito Ihara Trends Glycosci. Glycotechnol. 35, E23–E27 (2023); 35, J23–J27 (2023). doi.org/10.4052/tigg.2218.1e

Proceedings

  1. Prevention of radionuclide-induced antibody denaturation maintains active targeting and maximizes antitumor efficacy in 211At-radioimmunotherapy, Hiroki Takashima, Kazunobu Ohnuki, Shino Manabe, Yoshikatsu Koga, Ryo Tsumura, Takashiro, Anzai, Yang Wang, Xiaojie Yin, Nozomi Sato, Yudai Shigekawa, Akihiro Nambu, S. Usuda, Hiromitsu Haba, Hirofumi Fujii, Masahiro Yasunaga, RIKEN Accel. Prog. Rep. in press.

2022

Original Articles

  1. Stereoselective synthesis of the DE ring portion of kadcoccilactone A by a radical addition/cyclization approach, Kimihiro Noguchi, Sayuri Saito, Hiroyuki Yamakoshi, Seiichi Nakamura, Eur. J. Org. Chem. e202201201 (2022) doi.org/10.1002/ejoc.202201201
  2. Protection from contamination by 211At, an enigmatic but promising alpha emitter Kazunobu Ohnuki, Mitsuyoshi Yoshimoto, Hiromitsu Haba, Shino Manabe, Hiroki Takashima, Masahiro Yasunaga, Hirofumi Fujii, EJNMMI Physics, 9, 39 (2022). doi.org/10.1186/s40658‐022‐00469‐9
  3. Structure-activity relationship and mechanistic study on gugglesterone derivatives; discovery of new anti-pancreatic cancer candidate
    Kohyama, A.; Kim, M. J.; Yokoyama, R.; Sun, S.; Omar, A. M.; Phan, N. D.; Meselhy, M. R.; Tsuge, K.; Awale, S.; Matsuya, Y. Bioorg. Med. Chem. 54(15), 116563 (2022). doi.org/10.1016/j.bmc.2021.116563
  4. Direct C-H carboxylation forming polyfunctionalized aromatic carboxylic acids by combined Bronsted bases
    Masanori Shigeno, Kazuya Hanasaka, Itsuki Tohara, Koki Izumi, Hiroyuki Yamakoshi, Eunsang Kwon, Kanako Nozawa- Kumada, Yoshinori Kondo
    Org. Lett. 24(3), 809-814 (2022) DOI:10.1021/acs.orglett.1c03866
  5. Thrombospondin type 1 repeat-derived C-mannosylated peptide attenuates synaptogenesis of cortical neurons induced by primary astrocytes via TGF-β
    Kazuchika Nishitsuji, Midori Ikezaki, Shino Manabe, Kenji Uchimura, Yukishige Ito, Yoshito Ihara
    Glycoconj. J. 39(5), 701-710. DOI:10.1007/s10719-021-10030-y
  6. C-Mannosylated tryptophan-containing peptide binds 1 to actinin-4 and suppresses E2 cadherin-dependent cell-cell interactions in lung epithelial-like A549 cells
    Midori Ikezaki, Kazuchika Nishitsuji, Ko Matsumura, Shino Manabe, Yukinao Shibukawa, Yoshinao Wada, Yukishige Ito, Yoshito Ihara
    Biochimie, 192, 136-146 (2022) DOI:10.1016/j.biochi.2021.10.007

Reviews

  1. Sodium ascorbate protects 211At-labeled antibodies from reactive oxygen species damage
    Shino Manabe, Hiroki Takashima, Yoshikatsu Koga, Kazunobu Onuki, Ryo Tsumura, Takahiro Anzai, Nozomu Iwata, Masahiro Yasunaga, Yang Wang, Takuya Yokokita, Yukiko Komori, Daiki Mori, Hiromitsu Haba, Hirofumi Fujii, Yasuhiro Matsumura, RIKEN Accel. Prog. Rep. 55, S25 (2022).

Proceedings

  1. Sodium ascorbate protects 211At-labeled antibodies from reactive oxygen species damage Shino Manabe, Hiroki Takashima, Yoshikatsu Koga, Kazunobu Onuki, Ryo Tsumura, Takahiro Anzai, Nozomu Iwata, Masahiro Yasunaga, Yang Wang, Takuya Yokokita, Yukiko Komori, Daiki Mori, Hiromitsu Haba, Hirofumi Fujii, Yasuhiro Matsumura, RIKEN Accel. Prog. Rep. 55, S25 (2022).

2021

Regular papers

  1. Stabilization of an 211At-labelled antibody with sodium ascorbate
    Shino Manabe, Hiroki Takashima, Kazunobu Ohnuki, Yoshikatsu Koga, Ryo Tsumura, Nozomi Iwata, Yang Wang, Takuya Yokokita, Yukiko Komori, Sachiko Usuda, Daiki Mori, Hiromitsu Haba, Hirofumi Fujii, Masahiro Yasunaga, Yasuhiro Matsumura
    ACS Omega, in press. DOI:10.1021/acsomega.1c00684
  2. Antitumor effect of an 211At-labeled anti-tissue factor antibody protected by sodium ascorbate in gastric cancer xenograft models
    Hiroki Takashima, Yoshikatsu Koga, Shino Manabe, Kazunobu Onuki, Ryo Tsumura, Takahiro Anzai, Nozomi Iwata, Yan Wang, Takuya Yokokita, Yukiko Komori, Daiki Mori, Hiromitsu Haba, Hirofumi Fujii, Yasuhiro Matsumura, Masahiro Yasunaga,
    Cancer Sci. 112(5), 1975–1986 (2021) DOI:10.1111/cas.14857
  3. Quantification of serum C-mannosyl tryptophan by novel assay to evaluate renal function and vascular complications in patients with type 2 diabetes
    Shuhei Morita, Yoko Inai, Shiho Minakata, Shohei Kishimoto, Shino Manabe, Naoyuki Iwahashi, Kazuhiko Ino, Yukishige Ito, Takashi Akamizu, Yoshito Ihara
    Sci. Rep. 11, 1946 (2021) DOI:10.1038/s41598-021-81479-y
  4. Antitumor effect of humanized anti-tissue factor antibody-drug conjugate in peritoneal disseminated pancreatic cancer model
    Ryo Tsumura, Takahiro Anzai, Shino Manabe, Hiroki Takashima, Yoshikatsu Koga, Masashiro Yasunaga, Yasuhiro Matsumura
    Oncol. Rep. 45(1), 329-336 (2021) DOI:10.3892/or.2020.7850
  5. Stereoselective 1,4-Addition of Primary Alcohols to γ-Alkoxy-α,β-unsaturated Esters
    Saki Inatomi, Yuta Takayanagi, Kento Watanabe, Akinori Toita, Hiroyuki Yamakoshi, Seiichi Nakamura
    Synthesis 53(01), 161–174 (2021) DOI:10.1055/s-0040-1707274

Reviews

  1. Antibody glycoengineering and homogeneous antibody-drug conjugate preparation
    Shino Manabe, Yoshiki Yamaguchi
    Chem. Rec. 21 (11) 3005-3014 (2021)
    DOI:10.1002/tcr.202100054
  2. Recent development of stereoselective glycosylation reactions
    Shino Manabe
    Heterocycles, 102(2) 177-201 (2021) DOI:10.3987/REV-20-933
  3. Protein C-mannosylation and C-mannosyl tryptophan in chemical biology and medicine
    Shiho Minakata, Shino Manabe, Yoko Inai, Midori Ikezaki, Kazuchika Nishitsuji, Yukishige Ito, Yoshito Ihara
    Molecules, 26, 5258 (2021) DOI:10.3390/molecules26175258

Proceedings

  1. Development of radioimmunotherapy with astatine-211-counjugated antibodies Hiroki Takashima, Yoshikatsu Koga, K. Onuki, Shino Manabe, Ryo Tsumura T. Anzai, N. Iwata, Masahiro Yasunaga, W. Yang, T. Yokokita, Yukiko Komori, Daiki Mori, Hitomitsu Haba, Hirofumi Fujii, Yasuhiro Matsumura
    RIKEN Accel. Prog. Rep. in press.

Books

  1. C-Mannosyl tryptophan: from chemistry to biology
    Yoshito Ihara, Shino Manabe, Yoko Inai, Yukishige Ito, in “Comprehensive Glycoscience, IV Second Edition“ Johannis P. Karmerling, Gert. J. Boons, Yuan Chan Lee, Akemi Suzuki, Naoyuki Taniguchi, A. G. J. Voragen eds.
    Elsevier, in press.
  2. Spontaneous Raman and SERS microscopy for Raman tag imaging
    Hiroyuki Yamakoshi, Katsumasa Fujita
    “Stimulated Raman scattering microscopy techniques and applications”, 1st Edition
    Eds by J.-X. Cheng, W. Min, Y. Ozeki, D. Polli; Elsevier; pp 275-287 (2021)

2020年

Regular papers

  1. Monomeric C-mannosyl tryptophan is a degradation product of autophagy in cultured cells
    Shiho Minakata, Yoko Inai, Shino Manabe, Kazuchika Nishitsuji, Yukishige Ito, Yoshito Ihara
    Glycoconj. J. 37(5), 635-645 (2020) DOI:10.1007/s10719-020-09938-8
  2. C-Mannosyl tryptophan increases in the plasma of ovarian cancer
    Naoyuki Iwahashi, Yoko Inai, Shiho Minakata, Sho Sakurai, Shino Manabe, Yukishige Ito, Kazuhiko Ino, Yoshito Ihara
    Oncol. Lett. 19(1), 908-919 (2020) DOI:10.3892/ol.2019.11161
  3. Quantitative Drug Dynamics Visualized by Alkyne-Tagged Plasmonic-Enhanced Raman microscopy
    Kota Koike, Kazuki Bando, Jun Ando, Hiroyuki Yamakoshi, Naoki Terayama, Kosuke Dodo, Nicholas Isaac Smith, Mikiko Sodeoka, and Katsumasa Fujita,
    ACS Nano 14(11), 15032–15041 (2020) DOI:10.1021/acsnano.0c05010
  4. Kir6.1 heterozygous mice exhibit aberrant amygdala-dependent cued fear memory
    Ryo Inagaki†, Shigeki Moriguchi†, and Kohji Fukunaga, （†Contributd equally to this work）
    Mol Neurobiol 57, 1622-1635 (2020) DOI:10.1007/s12035-019-01840-1
  5. Memantine improves depressive-like behaviors via Kir6.1 channel inhibition in olfactory bulbectomized mice
    Shigeki Moriguchi, Ryo Inagaki, Hirotsugu Shimojo, Yoshihiko Sugimura, and Kohji Fukunaga
    Neuroscience 442, 264-273 (2020) DOI:10.1016/j.neuroscience.2020.06.002
  6. Nicotine rescues depressive-like behaviors via α7-type nicotinic acetylcholine receptor activation in CaMKIV null mice
    Shigeki Moriguchi, Ryo Inagaki, Lusha Yi, Mikako Shibata, Hiroyuki Sakagami, and Kohji Fukunaga
    Mol Neurobiol 57, 4929-4940 (2020) DOI:10.1007/s12035-020-02077-z
  7. Scabronine G methyl ester improves memory-related behavior and enhances hippocampal cell proliferation and long-term potentiation via the BDNF-CREB pathway in olfactory bulbectomized mice
    Osamu Nakagawasai, Lin Jia-Rong, Takayo Odaira, Kohei Takahashi, Wataru Nemoto, Shigeki Moriguchi, Yasushi Yabuki, Yu Kobayakawa, Kohji Fukunaga, Masahisa Nakada, and Koichi Tan-No
    Front Pharmacol 11, 583291 (2020) DOI:10.3389/fphar.2020.583291

Reviews

  1. Glycan-conjugated homogeneous antibody-drug conjugate synthesis
    Shino Manabe
    Translate. Regulat. Sci. 2(3), 84–89 (2020) DOI:10.33611/trs.2020_012

2019年

BOOK

  1. Recent Progress in Linker Technology for Antibody-drug Conjugates: Methods for Connection and Release
    Shino Manabe
    Cancer Drug Delivery Systems based on the Tumor Microenvironment. eds. by Yasuhiro Matsumura and David Tarin, Springer, pp. 93-123 (2019)
  2. Preclinical Studies of ADC Therapy for Solid Tumors
    Yoshikatsu Koga, Ryo Tsumura, Shino Manabe, Yasuhiro Matsumura
    Cancer Drug Delivery Systems based on the Tumor Microenvironment. eds. by Yasuhiro Matsumura and David Tarin Springer, pp. 125-154 (2019)
  3. CAST Therapy
    Masahiro Yasunaga, Shino Manabe, Yasuhiro Matsumura
    Cancer Drug Delivery Systems based on the Tumor Microenvironment. eds. by Yasuhiro Matsumura and David Tarin Springer, pp. 269-288 (2019)

REVIEWS

  1. Tips for DDS; Normal and Reverse phase DDS (J)
    Shino Manabe
    Drug Delivery Syst. 35, 147-149 (2020)
  2. Importance of Linker Design in ADC Development (J)
    Shino Manabe and Yoshiki Yamaguchi
    Medical Review, 17, 11-15 (2019)
  3. Antibody-drug conjugate preparation though Glycan Remodeling (J)
    Shino Manabe and Yoshiki Yamaguchi
    Fine Chemical, 48, 51-59 (2019)

REGULAR ARTICLES

  1. Aberrant amygdala-dependent cued fear memory in Na+/Ca2+  exchanger 1 heterozygous mice
    Shigeki Moriguchi, Satomi Kita, Ryo Inagaki, Yasushi Yabuki, Yuzuru Sasaki, Shun Ishikawa, Hiroyuki Sakagami, Takahiro Iwamoto and Kohji Fukunaga
    Mol. Neurobiol. 56, 4381-4394 (2019)
  2. Synthesis of Propargylic Ethers by Gold-Mediated Reaction of Terminal Alkynes with Acetals
    Miyu Furuta, Kyoko Sugiyama, Minami Yamaguchi, Hirofumi Ueda, Hidetoshi Tokuyama
    Chem. Pharm. Bull., 67, 872-876 (2019)
  3. Selenoprotein P; P for Plasma, Prognosis, Prophylaxis, and More
    Ryouhei Tsutsumi and Yoshiro Saito
    Biological and Pharmaceutical Bulletin, 43, 366-374(2020)
  4. Protease-activated receptor 2 exacerbates cisplatin-induced nephrotoxicity.
    Mari Watanabe, Yuji Oe, Emiko Sato, Akiyo Sekimoto, Hiroshi Sato, Sadayoshi Ito, and Nobuyuki
    Takahashi
    American Journal of Physiology Renal Physiology, 316(4), F654-F659, (2019)
  5. Nicotinamide alleviates kidney injury and pregnancy outcomes in lupus-prone MRL/lpr mice treated
    with lipopolysaccharide.
    Kenta Imaruoka, Yuji Oe, Tomofumi Fushima, Emiko Sato, Akiyo Sekimoto, Hiroshi Sato, Junichi
    Sugawara, Sadayoshi Ito, Nobuyuki Takahashi
    Biochemical and Biophysical Research Communications, 510(4), 587-593, (2019)
  6. Protease-activated receptor 2 protects against VEGF inhibitor-induced glomerular endothelial and
    podocyte injury.
    Yuji Oe, Tomofumi Fushima, Emiko Sato, Akiyo Sekimoto, Kiyomi Kisu, Hiroshi Sato, Junichi
    Sugawara, Sadayoshi Ito, Nobuyuki Takahashi
    Scientific Reports, 9, 2986, (2019)
  7. Tadalafil alleviates preeclampsia and fetal growth restriction in RUPP model of preeclampsia in mice.
    Akiyo Sekimoto, KayoTanaka , Yamato Hashizume, Emiko Sato, Tomoaki Ikeda, Nobuyuki Takahashi
    Biochemical and Biophysical Research Communications, 521(3), 769-774, (2020)
  8. Glomerular Injury Is Exacerbated in Lupus-Prone MRL/lpr Mice Treated with a Protease-Activated
    Receptor 2 Antagonist.
    Rina Itto, Yuji Oe, Kenta Imaruoka, Emiko Sato, Akiyo Sekimoto, Shu Yamakage, Satoshi Kumakura,
    Hiroshi Sato, Sadayoshi Ito, Nobuyuki Takahashi
    Tohoku Journal of Experimental Medicine, 249(2), 127-133, (2019)