2021

    Cheng A, Jia W, Kawahata I, Fukunaga K. A novel fatty acid-binding protein 5 and 7 inhibitor ameliorates oligodendrocyte injury in multiple sclerosis mouse models. EBioMedicine 2021 Vol. 72 Pages 103582. 10.1016/j.ebiom.2021.103582
    Kawahata I. Impact of dopamine D2 receptors in hyperkinesia and hyperpathia. Nihon Yakurigaku Zasshi. 2021;156(5):313. doi: 10.1254/fpj.21057.
    Xu J, Kawahata I, Izumi H, Fukunaga K. T-Type Ca2+ Enhancer SAK3 Activates CaMKII and Proteasome Activities in Lewy Body Dementia Mice Model. Int J Mol Sci. 2021 Jun 8;22(12):6185. doi: 10.3390/ijms22126185.
    Kawahata I. The novel mechanism of α-synuclein propagation in synucleinopathy. Nihon Yakurigaku Zasshi. 2021;156(4):251. doi: 10.1254/fpj.21033.
    Guo Q, Kawahata I, Degawa T, Ikeda-Matsuo Y, Sun M, Han F, Fukunaga K. Fatty Acid-Binding Proteins Aggravate Cerebral Ischemia-Reperfusion Injury in Mice. Biomedicines. 2021 May 10;9(5):529. doi: 10.3390/biomedicines9050529.
    Cheng A, Jia W, Kawahata I, Fukunaga K. Impact of Fatty Acid-Binding Proteins in α-Synuclein-Induced Mitochondrial Injury in Synucleinopathy. Biomedicines. 2021 May 17;9(5):560. doi: 10.3390/biomedicines9050560.
    Cheng A, Wang YF, Shinoda Y, Kawahata I, Yamamoto T, Jia WB, Yamamoto H, Mizobata T, Kawata Y, Fukunaga K. Fatty acid-binding protein 7 triggers α-synuclein oligomerization in glial cells and oligodendrocytes associated with oxidative stress. Acta Pharmacol Sin. 2021 May 2. doi: 10.1038/s41401-021-00675-8.
    Fukui N, Yamamoto H, Miyabe M, Aoyama Y, Hongo K, Mizobata T, Kawahata I, Yabuki Y, Shinoda Y, Fukunaga K, Kawata Y. An α-synuclein decoy peptide prevents cytotoxic α-synuclein aggregation caused by fatty acid binding protein 3. J Biol Chem. 2021 Apr 13:100663. doi: 10.1016/j.jbc.2021.100663.
    Degawa T, Kawahata I, Izumi H, Shinoda Y, Fukunaga K. T-type Ca2+ channel enhancer SAK3 administration improves the BPSD-like behaviors in AppNL-G-F/NL-G-F knock-in mice. J Pharmacol Sci. 2021 May;146(1):1-9. doi: 10.1016/j.jphs.2021.02.006.
    Jia W, Kawahata I, Cheng A, Fukunaga K. The Role of CaMKII and ERK Signaling in Addiction. Int J Mol Sci. 2021 Mar 20;22(6):3189. doi: 10.3390/ijms22063189.
    Kamagata K, Chiba R, Kawahata I, Iwaki N, Kanbayashi S, Maeda K, Takahashi H, Hirano A, Fukunaga K, Ikeda K, Kameda T. Characterization of design grammar of peptides for regulating liquid droplets and aggregates of FUS. Sci Rep. 2021 Mar 23;11(1):6643. doi: 10.1038/s41598-021-86098-1.
    Matsuo K, Kawahata I, Melki R, Bousset L, Owada Y, Fukunaga K. Suppression of α-synuclein propagation after intrastriatal injection in FABP3 null mice. Brain Res. 2021 Jun 1;1760:147383. doi: 10.1016/j.brainres.2021.147383.
    Wang Y, Shinoda Y, Cheng A, Kawahata I, Fukunaga K. Epidermal Fatty Acid-Binding Protein 5 (FABP5) Involvement in Alpha-Synuclein-Induced Mitochondrial Injury under Oxidative Stress. Biomedicines. 2021 Jan 22;9(2):110. doi: 10.3390/biomedicines9020110.
    Yuan D, Cheng A, Kawahata I, Izumi H, Xu J, Fukunaga K. Single Administration of the T-Type Calcium Channel Enhancer SAK3 Reduces Oxidative Stress and Improves Cognition in Olfactory Bulbectomized Mice. Int J Mol Sci. 2021 Jan 13;22(2):741. doi: 10.3390/ijms22020741.
    Kawahata I, Sekimori T, Wang H, Wang Y, Sasaoka T, Bousset L, Melki R, Mizobata T, Kawata Y, Fukunaga K. Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons. Biomedicines. 2021 Jan 8;9(1):49. doi: 10.3390/biomedicines9010049.

2020

    Cheng A, Kawahata I, Fukunaga K. Fatty Acid Binding Protein 5 Mediates Cell Death by Psychosine Exposure through Mitochondrial Macropores Formation in Oligodendrocytes. Biomedicines. 2020 Dec 20;8(12):635. doi: 10.3390/biomedicines8120635.
    Jia W, Wilar G, Kawahata I, Cheng A, Fukunaga K. Impaired Acquisition of Nicotine-Induced Conditioned Place Preference in Fatty Acid-Binding Protein 3 Null Mice. Mol Neurobiol. 2021 May;58(5):2030-2045. doi: 10.1007/s12035-020-02228-2.
    Yabuki Y, Liu J, Kawahata I, Izumi H, Shinoda Y, Koga K, Ueno S, Shioda N, Fukunaga K. Anti-Epileptic Effects of FABP3 Ligand MF1 through the Benzodiazepine Recognition Site of the GABAA Receptor. Int J Mol Sci. 2020 Aug 1;21(15):5525. doi: 10.3390/ijms21155525.
    Izumi H, Kawahata I, Shinoda Y, Helmstetter FJ, Fukunaga K. SAK3 Administration Improves Spine Abnormalities and Cognitive Deficits in AppNL-G-F/NL-G-F Knock-in Mice by Increasing Proteasome Activity through CaMKII/Rpt6 Signaling. Int J Mol Sci. 2020 May 28;21(11):3833. doi: 10.3390/ijms21113833.
    Kawahata I, Fukunaga K. Degradation of Tyrosine Hydroxylase by the Ubiquitin-Proteasome System in the Pathogenesis of Parkinson's Disease and Dopa-Responsive Dystonia. Int J Mol Sci. 2020 May 27;21(11):3779. doi: 10.3390/ijms21113779.
    Yabuki Y, Matsuo K, Kawahata I, Fukui N, Mizobata T, Kawata Y, Owada Y, Shioda N, Fukunaga K. Fatty Acid Binding Protein 3 Enhances the Spreading and Toxicity of α-Synuclein in Mouse Brain. Int J Mol Sci. 2020 Mar 23;21(6):2230. doi: 10.3390/ijms21062230.
    Haga H, Yamada R, Izumi H, Shinoda Y, Kawahata I, Miyachi H, Fukunaga K. Novel fatty acid-binding protein 3 ligand inhibits dopaminergic neuronal death and improves motor and cognitive impairments in Parkinson's disease model mice. Pharmacol Biochem Behav. 2020 Apr;191:172891. doi: 10.1016/j.pbb.2020.172891. Epub 2020 Feb 29.
    Kawahata I, Bousset L, Melki R, Fukunaga K. Fatty Acid-Binding Protein 3 is Critical for α-Synuclein Uptake and MPP+-Induced Mitochondrial Dysfunction in Cultured Dopaminergic Neurons. Int J Mol Sci. 2019 Oct 28;20(21):5358. doi: 10.3390/ijms20215358.