先進脳創薬講座のサイトです

Department of CNS drug innovation, Tohoku Univeristy - Getting close to dementia

We have developed model mice for cerebral infarction, Alzheimer's disease, Parkinson's disease, Lewy body disease, depression, anxiety, epilepsy, mental retardation, and autism, and established a brain function evaluation system. In this CNS drug innovation course, we will provide a state-of-the-art brain function evaluation system, realize the development of seeds brain drug discovery owned by companies, and aim for a healthy brain longevity society.

Based on the results of our research so far, we have developed a diagnostic technology platform that can predict cerebral infarction, autism / mental retardation, Alzheimer's disease, Lewy body dementias, Parkinson's disease, and these diseases at an extremely early stage. Was successful. Along with basic research on new disease mechanisms and creation of new drug discovery targets, we will further develop these therapeutic agents and diagnostic technologies, aiming to commercialize and implement these research seeds toward the realization of a healthy brain and longevity society.

Therapeutics for DLB

BRI101, a treatment for Dementia with Lewy bodies (DLB), inhibits the intracellular aggregation of α-synuclein, the causative protein of Lewy body dementias.

Therapeutics for AD

BRI301, a therapuetics for Alzheimer's disease (AD), promotes the degradation of amyloid β protein, which is the causative protein of Alzheimer's disease.

Early diagnosis technology

Dementia diagnosis technology B-Refine can diagnose mild cognitive impairment and Alzheimer's dementia at an early stage by using our unique biomarkers.