(38) Concise Total Synthesis of (+)-Pleiocarpamine and Convergent Total Syntheses of (+)-Voacalgine A and (+)-Bipleiophylline via an
Aerobic Oxidative Coupling
K. Okada, K. Ojima, H. Ueda, H. Tokuyama
J. Am. Chem. Soc., 145(30), 16337-16343 (2023) (DOI: 10.1021/jacs.3c05811).
(37) Synthetic Studies on Cimiciduphytine
K. Ojima, H. Ueda, H. Tokuyama
Bull. Chem. Soc. Jpn., 96,(5), 484-495 (2023) (DOI: 10.1246/bcsj.20230054).
(36) Iron-Catalyzed Biomimetic Dimerization of Tryptophan-Containing Peptides
H. Ueda, S. Sato, K. Noda, H. Hakamata, E. Kwon, N. Kobayashi, H. Tokuyama
Angew. Chem. Int. Ed., 62,(22), e202302404 (2023) (DOI: 10.1002/anie.202302404). Open Access
(35) Efficient and Scalable Asymmetric Total Synthesis of (−)-Emetine with Pharmaceutical Grade Quality; First Multigram Scale Synthesis
M.Yamada, K. Azuma, I. Takizawa, Y. Ejima, M. Yamano, K. Satoh, T. Doi, H. Ueda, H. Tokuyama
Org. Process Res. Dev., 27, 343-357 (2023) (DOI) (10.1021/acs.oprd.2c00355).
(34) Catalytic Enantioselective 5-endo-Bromocycloetherification of Unactivated Cyclic Alkenes
H. Xiong, K. Okada, K. Yoshida, H. Ueda, H. Tokuyama
Tetrahedron Lett., 101, 153906 (2022) (DOI: 10.1016/j.tetlet.2022.153906).
(33) Construction of Tetrahydroquinolines with Spirocyclic Structures at the 4-Position
Y. Wakahara, T. Noro, J. Sakata, H. Ueda, H. Tokuyama
Heterocycles, 105, 438-460 (2022) (DOI:10.3987/COM-22-S(R)16).
(32) Total synthesis of (±)-vinoxine: construction of the bridged pyrido[1,2-a]indole skeleton
via Tf2O-mediated Bischler–Napieralski reaction and stereoselective radical cyclization
K. Okada, H. Ueda, H. Tokuyama
Org. Biomol. Chem., 20,5943-5947 (2022) (DOI:10.1039/D2OB00274D).
(31) Synthesis of leuconoxine, leuconodine B, and rhazinilam by transformation of melodinine E via 6-hydro-21-dehydroxyleuconolam
A. Umehara, H. Ueda, H. Tokuyama
Tetrahedron, 79, 131809-131814 (2021) (DOI: 10.1016/j.tet.2020.131809).
(30) Synthesis of substituted anilines via a gold-catalyzed three-component reaction
H. Ueda, R. Yamamoto, M. Yamaguchi, H. Tokuyama
Org. Biomol. Chem., 19, 765-769 (2021) (DOI: 10.1039/D0OB02018D). selected as inside fort cover
(29) A Concise Enantioselective Total Synthesis of (–)-Deoxoapodine
K. Yoshida, K. Okada, H. Ueda, H. Tokuyama
Angew. Chem. Int. Ed., 59, 23089-23093 (2020) (DOI: 10.1002/anie.202010759).
(28) Nitrile Synthesis by Aerobic Oxidation of Primary Amines and in situ Generated Imines from Aldehydes and Ammonium Salt
with Grubbs Catalyst
T. Utsumi, K. Noda, D. Kawauchi, H. Ueda, H. Tokuyama
Adv. Synth. Catal., 362, 3583-3588 (2020) (DOI: 10.1002/adsc.202000663).
(27) Aerobic Dehydrogenation of N-Heterocycles with Grubbs Catalyst: Its Application to
Assisted-Tandem Catalysis to Construct N-Containing Fused Heteroarenes
D. Kawauchi, K. Noda, Y. Komatsu, K. Yoshida, H. Ueda, H. Tokuyama
Chem. Eur. J., 26, 15793-15798 (2020) (DOI:10.1002/chem.202001961). selected as Hot Paper and Frontispiece
(26) Identification of Emetine as a Therapeutic Agent for PulmonaryAarterial Hypertension -A Novel Eeffect of an Old Drug-
MAH Siddique, K. Satoh, R. Kurosawa, N. Kikuchi, M. Elias-Al-Mamun, J. Omura, T. Satoh, M. Nogi, S. Sunamura, S. Miyata,
H. Ueda, H. Tokuyama, H. Shimokawa
Arterioscler. Thromb. Vasc. Biol. (2019) (Doi: 10.1161/ATVBAHA.119.313309.).
(25) Construction of Indole Structure on Pyrroloindolines via AgNTf2-Mediated Amination/Cyclization Cascade:
Application to Total Synthesis of (+)-Pestalazine B
H. Hakamata, H. Ueda, H. Tokuyama
Org. Lett.,21, 4205-4209 (2019) (DOI:10.1021/acs.orglett.9b01399).
(24) Synthesis of Propargylic Ethers by Gold-Mediated Reaction of Terminal Alkynes with Acetals
D. Kawauchi, H. Ueda, H. Tokuyama
Chem. Pharm. Bull.,67, 872-876 (2019) (DOI: 10.1248/cpb.c19-00322). selected as highlighted paper and cover picture
(23) Double Functionalization of Styrenes by Cu-mediated Assisted Tandem Catalysis
M. Furuta, K. Sugiyama, M. Yamaguchi, H. Ueda, H. Tokuyama
Eur. J. Org. Chem., 15, 2056-2060 (2019) (DOI: 10.1002/ejoc.201900088).
(22) Novel Potent ABCB1 Modulator, Phenethylisoquinoline Alkaloid, Reverses Multidrug Resistance in Cancer Cell
N. Sugisawa, S. Ohnuma, H. Ueda, M. Murakami, K. Sugiyama, K. Ohsawa, K. Kano, H. Tokuyama, T. Doi,
J. Aoki, M. Ishida, K. Kudoh, T. Naitoh, S. V. Ambudkar, M. Unno
Mol. Pharmaceutics,15, 4021–4030 (2018) (DOI: 10.1021/acs.molpharmaceut.8b00457)
(21) Synthetic Studies Toward Isoschizogamine: Construction of Pentacyclic Core Structure
K. Sugimoto, H. Fujiwara, A. Takada, D.-G. Kim, H. Ueda, H. Tokuyama
Heterocycles, 97, 10280-1049 (2018) (DOI: 10.3987/COM-18-S(T)8).
(20) AgNTf2-Mediated Allylation with Allylsilanes at C3a-Position of Hexahydropyrroloindoles:
Application to Total Syntheses of Amauromine Alkaloids
H. Hakamata, S. Sato, H. Ueda, H. Tokuyama
Org. Lett., 19, 5308–5311 (2017) (DOI: 10.1021/acs.orglett.7b02602)
(19) AgNTf2-Mediated Arylation of Bromopyrroloindolines
S. Sato, A. Hirayama, T. Adachi, D. Kawauchi, H. Ueda, H. Tokuyama
Heterocycles, 94, 1940-1957 (2017) (DOI: 10.3987/COM-17-13777)
(18) Total Syntheses of (+)-T988 B and C via AgNTf2-Mediated Coupling of Bromopyrroloindoline with Indole
S. Sato, A. Hirayama, H. Ueda, H. Tokuyama
Asian J. Org. Chem., 6, 54-58 (2017) (DOI: 10.1002/1joc.201600474)
(17) Bioinspired Total Synthesis of the Dimeric Indole Alkaloid (+)-Haplophytine by Direct Coupling and Late-Stage Oxidative Rearrangement
H. Satoh, K. Ojima, H. Ueda, H. Tokuyama
Angew. Chem. Int. Ed., 55, 15157-15161 (2016) (DOI: 10.1002/anie.201609285)
(16) Condensation of Carboxylic Acids with Non-Nucleophilic N-Heterocycles and Anilides Using Boc2O
A. Umehara, H. Ueda, H. Tokuyama
J. Org. Chem., 81, 11444-11453 (2016) (DOI: 10.1021/acs.joc.6b02097)
(15) Convergent Synthesis of 2-Aryl-Substituted Quinolines by Gold-Catalyzed Cascade Reaction
H. Ueda, M. Yamaguchi, H. Tokuyama
Chem. Pharm. Bull., 64, 824-829 (2016) (DOI: 10.1248/cpb.c16-00193)
(14) Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase
J. Morita, K. Kano, K. Kato, H. Takita, H. Sakagami, Y. Yamamoto, E. Mihara, H. Ueda, T. Sato, H. Tokuyama, H. Arai,
H. Asou, J. Takagi, R. Ishitani, H. Nishimasu, O. Nureki, J. Aoki
Scientific Reports, 6, 20995 (2016) (DOI: 10.1038/srep20995)
(13) Total syntheses of codonopsinine and 4-epi-codonopsinine via gold-mediated tandem catalyzed pyrrole synthesis
M. Yamaguchi, D. Itagaki, H. Ueda, H. Tokuyama
J. Antibiot.,69, 253-258 (2016) (DOI: 10.1038/ja.2016.13)
(12) Synthesis of Substituted Quinolizidines via a Gold-Catalyzed Double Cyclization Cascade
S. Nonaka, K. Sugimoto, H. Ueda, H. Tokuyama
Adv. Synth. Catal., 358, 380-385 (2016) (DOI: 10.1002/adsc.201500907)
(11) Total Synthesis of (–)-Isoschizogamine
A. Takada, H. Fujiwara, K. Sugimoto, H. Ueda, H. Tokuyama
Chem. Eur. J., 21, 16400-16403 (2015) (DOI: 10.1002/chem.201503606)
(10) Synthetic studies on lycopodine: construction of hexahydrojulolidine core by intramolecular Mannich reaction
T. Sato, H. Ueda, H. Tokuyama
Tetrahedron Lett., 25, 2503-2507 (2014) (DOI: 10.1016/j.tetlet.2014.10.150)
(9) Auto tandem Catalysis: Synthesis of Pyrroles by Gold-Catalyzed Cascade Reaction
H. Ueda, M. Yamaguchi, H. Kameya, K. Sugimoto, H. Tokuyama
Org. Lett., 16, 4948-4951 (2014) (DOI: 10.1021/ol5024695)
(8) Acetic Acid-Promoted Metal-Free Aerobic Carbon-Carbon Bond Forming Reactions at α-Position of Tertiary Amines
H. Ueda, K. Yoshida, H. Tokuyama
Org. Lett., 16, 4194-4197 (2014) (DOI: 10.1021/ol5018883)
(7) Total Syntheses of Leuconoxine, Leuconodine B, and Melodinine E by Oxidative Cyclic Aminal Formation
and Diastereoselective Ring-Closing Metathesis
A. Umehara, H. Ueda, H. Tokuyama
Org. Lett., 16, 2526-2529 (2014) (DOI: 10.1021/ol500903e)
(6) Synthetic Studies on Isoschizogamine: Construction of [3.3.1] Bicyclic Aminal Core by Using Oxidative Skeletal Rearrangement
H. Ueda, A. Takada, H. Tokuyama
Tetrahedron Lett., 54, 7115-7118 (2013) (DOI: 10.1016/j.tetlet.2013.10.083)
(5) Protecting-Group-Free Total Synthesis of (–)-Rhazinilam and (–)-Rhazinicine using a Gold-Catalyzed Cascade Cyclization
K. Sugimoto, K. Toyoshima, S. Nonaka, K. Kotaki, H. Ueda, H. Tokuyama
Angew. Chem. Int. Ed., 52, 7168-7171 (2013) (DOI: 10.1002/anie.201303067)
(4) Synthetic Studies on Strictamine: Unexpected Oxidation of Tertiary Amine in Ru-Catalyzed Ring-Closing Olefin Metathesis
Y. Komatsu, K. Yoshida, H. Ueda, H. Tokuyama
Tetrahedron Lett., 54, 377-380 (2013) (DOI: 10.1016/j.tetlet.2012.10.129)
(3) Divergent Total Synthesis of (–)-Aspidophytine and its Congeners via Fischer Indole Synthesis
H. Satoh, H. Ueda, H. Tokuyama
Tetrahedron, 69, 89-95 (2013) (DOI: 10.1016/j.tet.2012.10.060)
(2) Total Synthesis of (+)-Haplophytine
H. Ueda, H. Satoh, K. Matsumoto, K. Sugimoto, T. Fukuyama, H. Tokuyama
Angew. Chem. Int. Ed., 48, 7600-7603 (2009) (DOI: 10.1002/anie.200902192)
(1) Palladium-Catalyzed Coupling Reaction of Propargylic Oxiranes with Arylboronic Acids in Aqueous Media
M. Yoshida, H. Ueda, M. Ihara
Tetrahedron Lett., 46, 6705-6708 (2005) (DOI: 10.1016/j.tetlet.2005.07.134)
(4) 制御の難しいアミンの酸化をあえて有機合成に利用する
植田浩史、徳山英利
化学と教育、65, 190-191 (2017).
(3) 化学合成が老化現象を解明する！？グルコセパンの効率的全合成
H.Ueda
Chemistry (Kagaku), 71, 61-62 (2016)
(2) ユズリハが産み出す高度縮環アルカロイド：ダフマニジンEの全合成
H.Ueda
Farumashia, 48, 434 (2012)
(1) 現在の有機合成化学をもってしても合成困難な天然物とは？
二量体型アルカロイド(+)-Haplophytineの全合成
徳山英利，植田浩史，福山透
化学と生物，48，450-453 (2010)