Cobalt-Catalyzed Alkenylation of Thiazoles with Alkynes via C–H Bond Functionalization

Abstract

A cobalt-Xantphos catalyst has been developed for the syn addition of (benzo)thiazoles to internal alkynes via C-H bond functionalization. The reaction affords C2-alkenylated (benzo)thiazoles with high regio- and stereoselectivities under mild conditions.

Publication
Ding, Z.; Yoshikai, N. Synthesis 2011, 2561-2566.