Cobalt-Catalyzed Intramolecular Olefin Hydroarylation Leading to Dihydropyrroloindoles and Tetrahydropyridoindoles

Abstract

Cobalt N‐heterocyclic carbene (NHC) catalysts promote intramolecular olefin hydroarylation of indoles bearing an N ‐homoallyl or bis(homoallyl) tether and a C3 aldimine directing group to afford dihydropyrroloindoles and tetrahydropyridoindoles under mild conditions. The course of the cyclization is dependent on the tether, but can be controlled by the NHC ligand.

Publication
Ding, Z.; Yoshikai, N. Angew. Chem. Int. Ed. 2013, 52, 8574-8578.