{"id":2123,"date":"2017-08-03T21:19:42","date_gmt":"2017-08-03T12:19:42","guid":{"rendered":"http:\/\/www.pharm.tohoku.ac.jp\/~shigen\/asai_lab\/research-copy-copy\/"},"modified":"2026-02-13T16:16:40","modified_gmt":"2026-02-13T07:16:40","slug":"publication_page","status":"publish","type":"page","link":"http:\/\/www.pharm.tohoku.ac.jp\/~shigen\/asai_lab\/publication_page\/","title":{"rendered":"Publications"},"content":{"rendered":"[vc_row][vc_column][vc_raw_html]JTNDZm9udCUyMHNpemUlM0QlMjI0JTIyJTNFJTNDcCUyMGNsYXNzJTNEJTIyUEJfbGlua3MlMjIlM0UlM0NhJTIwaHJlZiUzRCUyMiUyM1JQJTIyJTNFUmVwcmVzZW50YXRpdmUlMjBwdWJsaWNhdGlvbnMlM0MlMkZhJTNFJTIwJTJGJTIwJTNDYSUyMGhyZWYlM0QlMjIlMjNQYiUyMiUzRVJlc2VhcmNoJTIwYXJ0aWNsZXMlM0MlMkZhJTNFJTIwJTJGJTIwJTNDYSUyMGhyZWYlM0QlMjIlMjNSdiUyMiUzRUJvb2tzJTIwJTI2JTIwUmV2aWV3cyUzQyUyRmElM0UlMjAlMkYlMjAlM0NhJTIwaHJlZiUzRCUyMiUyM1ByZXMlMjIlM0VQcmVzZW50YXRpb25zJTNDJTJGYSUzRSUzQyUyRnAlM0UlM0MlMkZmb250JTNF[\/vc_raw_html][vc_row_inner][vc_column_inner][vc_custom_heading text=”Representative publications” font_container=”tag:h3|text_align:left|color:%231e73be” use_theme_fonts=”yes” el_class=”PB_section_title” el_id=”RP”][vc_separator color=”custom”][\/vc_column_inner][\/vc_row_inner][vc_basic_grid post_type=”post” max_items=”6″ grid_id=”vc_gid:1770965072136-af2032976c5b3a1c991646a8bfc82b59-4″][\/vc_column][\/vc_row][vc_section css=”.vc_custom_1506052823421{margin-bottom: 15px !important;}”][vc_row][vc_column][vc_basic_grid post_type=”publications” max_items=”6″ item=”2369″ grid_id=”vc_gid:1770965072156-dc5295b8e2b680defeea5e27aad7ab46-8″][\/vc_column][\/vc_row][\/vc_section][vc_section][vc_row][vc_column][vc_custom_heading text=”Research articles” font_container=”tag:h3|text_align:left|color:%231e73be” use_theme_fonts=”yes” el_class=”PB_section_title” css=”.vc_custom_1508002075250{margin-top: 15px !important;margin-bottom: 0px !important;padding-bottom: 5px !important;}” el_id=”Pb”][vc_separator color=”custom” style=”shadow” css=”.vc_custom_1508125536701{margin-top: 5px !important;margin-bottom: 0px !important;padding-bottom: 20px !important;}” accent_color=”#0066bf”][vc_custom_heading text=”2026″ font_container=”tag:h3|font_size:18|text_align:left|color:%230066bf” use_theme_fonts=”yes” el_class=”PB_section_title” css=”.vc_custom_1770966907028{margin-top: 20px !important;margin-bottom: 0px !important;padding-bottom: 5px !important;}”][vc_column_text]4-Desmethyl 7-Prenyl Mollicellin Analogue Isolated from Chaetomium brasiliense.<\/strong>
\nMorita, S.,# Furumura, S.,# Morishita, Y., Ozaki, T., Fukano, H., Hoshino, H., Hirabayashi,A., Suzuki, M., Oshima, Y., Asai, T.,*
\n(Morita and Furumura are contributed equally.)
\n<\/em>Chem. Pharm. Bull.<\/em> 2026<\/strong>, 74<\/i>, 170-174.doi.org\/10.1248\/cpb.c25-00729<\/a>
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Genome mining-based discovery of an atypical fungal non-reducing polyketide synthase encoding dimeric alkylresorcinol biosynthesis.<\/strong>
\nHomma, Y.,# Hasegawa, T.,# Morishita, Y.,# Koremura, S., Sugawara, A., Ozaki, T., Asai, T.,*
\n(Homma, Hasegawa and Morishita are contributed equally.)
\n<\/em>J. Antibiot<\/em> 2026<\/strong>, doi.org\/10.1038\/s41429-025-00891-y.<\/a><\/p>\n

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Discovery of a fungal HR-PKS cluster encoding biosynthetic pathways for macrolides with two distinct ring sizes<\/strong>
\nLi, Y.,# Morishita, Y.,# Sugawara, A., Moussa, A. Y., Elissawy, A. M., Singab, A. N. B., Ozaki, T., Asai, T.*
\n(Li and Morishita are contributed equally.)
\n<\/em>Chem. Pharm. Bull.<\/em> 2026<\/strong>, 74,<\/i> 64-70. oi.org\/10.1248\/cpb.c25-00638<\/a><\/p>\n

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 <\/p>\n[\/vc_column_text][vc_custom_heading text=”2025″ font_container=”tag:h3|font_size:18|text_align:left|color:%230066bf” use_theme_fonts=”yes” el_class=”PB_section_title” css=”.vc_custom_1738056198141{margin-top: 20px !important;margin-bottom: 0px !important;padding-bottom: 5px !important;}”][vc_column_text]\nVinigrol Tricyclic Scaffold Biosynthesis Employs an Atypical Terpene Cyclase and a Multipotent Cyclization Cascade<\/strong>
\nTsukada, K., Sato, F., Matsuyama, T., Matsuda, R., Ozaki, T.,* Morishita, Y., Furumura, S., Homma, Y., Sekiya, H., Sugawara, A., Kubota, M., Mitsuhashi, T., Yasuno, Y., Shinada, T., Nagata, R., Kuzuyama, T., Taniguchi, T., Fujita, M., Uchiyama, M.,* Asai, T.*
\n(Tsukada, Sato and Matsuyama are contributed equally.)
\n<\/em>J. Am. Chem. Soc. <\/em> 2025<\/strong>, 147,<\/i> 45168-45177. doi\/10.1021\/jacs.5c14400<\/a><\/p>\n

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Genome Mining-Based Discovery of Pyrano[2,3-c]pyrrole Type Natural Products Possessing Alkyl Side Chain with Branched Methyl Groups<\/strong>
\nShi, Y., Ozaki, T.,* Morishita, Y., Taniguchi, T., Sato, H., Aoyama, Y., Sugawara, A., Numata, K Fuse, T., Matsuda, R., Hosotani, K., Fukano, H., Hoshino, Y., Hirabayashi, A., Suzuki, M., Yasuda, J., Yoshikawa, R., Hayashi, H., Kodama, N. E., Shimotai, Y., Hamamoto, H., Davis, A. R., Asai, T.*
\n<\/em>Org. Lett. <\/em>2025<\/strong>, 27,<\/i> 8580-8585. doi.org\/10.1021\/acs.orglett.5c02504<\/a><\/p>\n

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Ketosynthase Domain Catalyzes \u03b2-Lactonization in the Biosynthesis of the HMG-CoA Synthase Inhibitor Hymeglusin<\/strong>
\nHirokawa, M., Ozaki, T.,* Tsukada, K., Sugawara, A., Morishita, Y., Asai, T.*
\n<\/em>J. Am. Chem. Soc. <\/em>2025<\/strong>, 147,<\/i> 25136-25141. doi.org\/10.1021\/jacs.5c07060<\/a><\/p>\n

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Biosynthesis of Circumdatins Employs an Anthranilate Tailoring Pathway for NRPS Substrate Supplies<\/strong>
\nSato, Y., Morishita, Y., Homma, Y., Sugawara, A., Moussa, A. Y., Elissawy, A. M., Singab, A. N. B., Ozaki, T., Asai, T.*
\n(Sato and Morishita are contributed equally.)
\n<\/em>Org. Lett. <\/em>2025<\/strong>, 27,<\/i> 7170\u20137175. doi.org\/10.1021\/acs.orglett.5c02131<\/a><\/p>\n

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Discovery and Theoretical Studies of Nonenzymatic Polyketide Dimerizations of Chaetophenols<\/strong>
\nMatsui, H., Morishita, Y., Yamamoto, T., Ozaki, T., Sugawara, A., Masumoto, Y., Watanabe, M., Watanabe, A., Sato, H., Kanazawa, J., Taniguchi, T., Uchiyama, M.,* Asai, T.*
\n(Matsui and Morishita are contributed equally.)
\n<\/em>Org. Lett. <\/em>2025<\/strong>, 27,<\/i> 1095-1099. doi.org\/10.1021\/acs.orglett.4c04346<\/a><\/p>\n

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Overexpression of the RNA-binding protein NrdA affects global gene expression and secondary metabolism in Aspergillus species<\/strong>
\nKadooka, C., Izumitsu, K., Asai, T., Hiramatsu, K., Mori, K., Okutsu, K., Yoshizaki, Y., Takamine, K., Goto, M., Tamaki, H., Futagami, T.*
\n<\/em>mSphere.<\/em>2025<\/strong>, Feb 25;10(2):e0084924. doi: 10.1128\/msphere.00849-24<\/a><\/p>\n

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 [\/vc_column_text][vc_custom_heading text=”2024″ font_container=”tag:h3|font_size:18|text_align:left|color:%230066bf” use_theme_fonts=”yes” el_class=”PB_section_title” css=”.vc_custom_1704857199147{margin-top: 20px !important;margin-bottom: 0px !important;padding-bottom: 5px !important;}”][vc_column_text]Semi-synthesis of a DNA-Tagged Polyketide\u2212Peptide Hybrid Macrocycle Using a Biosynthetically Prepared Fungal Macrolide as a Synthetic Component Arthrinium sacchari<\/i><\/strong>
\nKoremura, S., Sugawara, A., Morishita, Y., Ozaki, T., Asai, T.* (Koremura, Sugawara and Morishita are contributed equally.)
\n<\/em>Org. Lett. <\/em>2024<\/strong>, 26,<\/i> 9151-9156. doi.org\/10.1021\/acs.orglett.4c03588<\/a><\/p>\n

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Genome mining of labdane-related diterpenoids: Discovery of the two-enzyme pathway leading to (\u2212)-sandaracopimaradiene in the fungus Arthrinium sacchari<\/i><\/strong>
\nSato, F., Sonohara, T., Fujiki, S., Sugawara, A., Morishita, Y., Ozaki, T.,* Asai, T.*
\n<\/em>Beilstein J. Org. Chem. <\/em>2024<\/strong>, 20, <\/i>714-720. doi.org\/10.3762\/bjoc.20.65<\/a><\/p>\n

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A new 3,6-dialkyl-\u03b1-pyrone produced by the heterologous expression of a PKS-NRPS hybrid enzyme derived from a Pestalotiopsis <\/i>endophyte<\/strong>
\nShi, Y., Ozaki, T., Sugawara, A., Morishita, Y., Tang, Y. P., Shivas, R. G., Davis, R. A., Asai, T.*
\nTetrahedron Lett.\u00a0 <\/em>2024<\/strong>, 134, <\/i>154865\u2013154867. doi.org\/10.1016\/j.tetlet.2023.154865<\/a><\/i><\/p>\n

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 [\/vc_column_text][vc_custom_heading text=”2023″ font_container=”tag:h3|font_size:18|text_align:left|color:%230066bf” use_theme_fonts=”yes” el_class=”PB_section_title” css=”.vc_custom_1676161067960{margin-top: 20px !important;margin-bottom: 0px !important;padding-bottom: 5px !important;}”][vc_column_text]Identification and Functional Characterization of Fungal Chalcone Synthase and Chalcone Isomerase<\/strong>
\nFurumura, S., Ozaki, T., Sugawara, A., Morishita, Y., Tsukada, K., Ikuta, T., Inoue, A., Asai, T.* (Furumura and Ozaki contributed equally.)
\n<\/em>J. Nat. Prod. <\/em>2023<\/strong>, 86, <\/em>398-405. doi.org\/10.1021\/acs.jnatprod.2c01027<\/a><\/p>\n

\"\"[\/vc_column_text][vc_custom_heading text=”2022″ font_container=”tag:h3|font_size:18|text_align:left|color:%230066bf” use_theme_fonts=”yes” el_class=”PB_section_title” css=”.vc_custom_1642740249704{margin-top: 20px !important;margin-bottom: 0px !important;padding-bottom: 5px !important;}”][vc_column_text]Discovery of a Cyclic Depsipeptide from Chaetomium mollipilium<\/em> by the Genome Mining Approach<\/strong>
\nHomma, Y., Sugawara, A., Morishita, Y., Tsukada, K., Ozaki, T., Asai, T.*
\n<\/em>Org. Lett. <\/em>2022<\/strong>, 24, <\/em>3504\u20133509. doi.org\/10.1021\/acs.orglett.2c01172<\/a><\/p>\n

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Synthetic Biology-Based Discovery of Diterpenoid Pyrones from the Genome of Eupenicillium shearii<\/em><\/span><\/strong>
\nMorishita, Y., Tsukada, K., Murakami. K., Irie, K., Asai, T.* (Morishita and Tsukada contributed equally.)
\n<\/em>J. Nat. Prod. <\/em>2022,<\/strong> 85, <\/em>384-390. doi.org\/10.1021\/acs.jnatprod.1c00973<\/a><\/p>\n

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 [\/vc_column_text][vc_custom_heading text=”2020″ font_container=”tag:h3|font_size:18|text_align:left|color:%230066bf” use_theme_fonts=”yes” el_class=”PB_section_title” css=”.vc_custom_1585361007351{margin-top: 20px !important;margin-bottom: 0px !important;padding-bottom: 5px !important;}”][vc_column_text]Genome Mining-Based Discovery of Fungal Macrolides Modified by Glycosylphosphatidylinositol (GPI)-Ethanolamine Phosphate Transferase Homologues<\/span><\/strong>
\nMorishita, Y., Aoki, Y., Ito, M., Hagiwara, D., Torimaru, K., Morita, D., Kuroda, T., Fukano, H., Hoshino, Y., Suzuki, M., Taniguchi, T., Mori, Keiji., Asai, T.*
\n<\/em>Org. Lett.\u00a0<\/em>2020<\/strong>,\u00a0<\/em> 22<\/em>, 5876-5879. \u00a0doi.org\/10.1021\/acs.orglett.0c01975<\/a><\/p>\n

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Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones<\/span><\/strong>
\nTsukada, K., Shinki, S., Kaneko, A., Murakami, K., Irie, K., Murai, M., Miyoshi, H., Dan, S., Kawaji, K., Hayashi, H., Kodama, E. N., Hori, A., Salim, E., Kuraishi, T., Hirata, N., Kanda, Y., Asai, T.<\/span>*
\n<\/em>Nature Commun.<\/em> 11<\/b>, Article\u00a0number:\u00a01830<\/span> (2020<\/span>), doi:\u00a010.1038\/s41467-020-15664-4.<\/a><\/p>\n

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Synthetic-biology-based discovery of fungal macrolide from Macrophomina phaseolina<\/em><\/span><\/strong>
\nMorishita, Y., Sonohara, T., Taniguchi, T., Adachi, K., Fujita, M., Asai, T.<\/span>*
\n<\/em>Org. Biomol. Chem.\u00a0<\/span><\/i>2020<\/b>, 18<\/i>, <\/span>doi: 10.1039\/D0OB00519C<\/a><\/p>\n

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Chemical Activation of Natural Product Biosynthesis in Filamentous Fungi<\/strong>
\nTeigo Asai
\n<\/em>Comprehensive Natural Products III: Chemistry and Biology, Vol. 7, Elsevier, 475-486 (2020).[\/vc_column_text][vc_custom_heading text=”2019″ font_container=”tag:h3|font_size:18|text_align:left|color:%230066bf” use_theme_fonts=”yes” el_class=”PB_section_title” css=”.vc_custom_1548289743625{margin-top: 20px !important;margin-bottom: 0px !important;padding-bottom: 5px !important;}”][vc_column_text]The Discovery of Fungal Polyene Macrolides via a Postgenomic Approach Reveals a Polyketide Macrocyclization by trans<\/em>-Acting Thioesterase in Fungi<\/strong>
\nYohei Morishita, Huiping Zhang, Tohru Taniguchi, Keiji Mori, Teigo Asai*
\n<\/em>Org. Lett.<\/em> 2019<\/strong>, 21, 4788\u22124792<\/a>.<\/p>\n

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Post-genomic approach based discovery of alkylresorcinols from a cricket-associated fungus, Penicillium soppi<\/em><\/strong>
\nAkiho Kaneko, Yohei Morishita, Kento Tsukada, Tohru Taniguchi, Teigo Asai*<\/sup>
\n<\/em>Org. Biomol. Chem.<\/em> 2019<\/strong>, 17,\u00a05239 – 5243.<\/a><\/p>\n

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Use of plant hormones to activate silent polyketide biosynthetic pathways in Arthrinium sacchari, a fungus isolated from a spider
\nY. Morishita, Y. Okazaki, Y. Y. Luo., J. Nunoki, T. Taniguchi, Y. Oshima, T Asai*
\n<\/em><\/a>Org. Biomol. Chem.<\/em> 2019<\/strong>, 17<\/em>, 780-784.<\/a>[\/vc_column_text][vc_custom_heading text=”2018″ font_container=”tag:h3|font_size:18|text_align:left|color:%230066bf” use_theme_fonts=”yes” el_class=”PB_section_title” css=”.vc_custom_1523854861330{margin-top: 20px !important;margin-bottom: 0px !important;padding-bottom: 5px !important;}”][vc_column_text]Pazopanib-induced crystal deposition in intestinal mucosa in a patient with retroperitoneal liposarcoma.
\nShigemitsu Horie, Hayato Nishida*, Toshihiko Sakurai, Osamu Ichiyanagi, Tomoyuki Kato, Makoto Yagi, Takanobu Kabasawa, Teigo Asai and Norihiko Tsuchiya.
\n<\/em><\/a>International Journal of Urology<\/em> 2018<\/strong>, doi: 10.1111\/iju.13567<\/em>.[\/vc_column_text][vc_custom_heading text=”2016″ font_container=”tag:h3|font_size:18|text_align:left|color:%230066bf” use_theme_fonts=”yes” el_class=”PB_section_title” css=”.vc_custom_1523854333846{margin-top: 20px !important;margin-bottom: 0px !important;padding-bottom: 5px !important;}”][vc_column_text]A lanthipeptide-like N-terminal leader region guides peptide epimerization by radical SAM epimerases – implications for RiPP evolution.
\nS. W. Fuchs, G. Lackner, B. I. Morinaka, Y. Morishita, T. Asai, S. Riniker, J. Piel*.
\nAngew. Chem. Int. Ed.<\/em> 2016<\/strong>, 55<\/em>, 12330-12333<\/a>.<\/p>\n

Epigenetic stimulation of polyketide production in Chaetomium cancroideum<\/em> by an NAD+<\/sup>-dependent HDAC inhibitor.
\nT. Asai*, S. Morita, T. Taniguchi, K. Monde, Y. Oshima*.
\nOrg. Biomol. Chem.<\/em> 2016<\/strong>, 14<\/em>, 646-651.<\/a>[\/vc_column_text][vc_custom_heading text=”2015″ font_container=”tag:h3|font_size:18|text_align:left|color:%230066bf” use_theme_fonts=”yes” el_class=”PB_section_title” css=”.vc_custom_1507955053839{margin-top: 15px !important;margin-bottom: 0px !important;padding-top: 20px !important;padding-bottom: 5px !important;}”][vc_column_text]Use of a biosynthetic intermediate to explore the chemical diversity of pseudo-natural fungal polyketides.
\nT. Asai*, K. Tsukada, S. Ise, N. Shirata, M. Hashimoto, I. Fujii, K. Gomi, K. Nakagawara, E. N. Kodama, Y, Oshima*.
\nNature Chem<\/em>. 2015<\/strong>, 7<\/em>, 737-743.<\/a><\/p>\n

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 [\/vc_column_text][vc_custom_heading text=”2013″ font_container=”tag:h3|font_size:18|text_align:left|color:%230066bf” use_theme_fonts=”yes” el_class=”PB_section_title” css=”.vc_custom_1507955214497{margin-top: 15px !important;margin-bottom: 0px !important;padding-top: 20px !important;padding-bottom: 5px !important;}”][vc_column_text]Structures of Spiroindicumides A and B, Unprecedented Carbon Skeletal Spirolactones, and Determination of the Absolute Configuration by Vibrational Circular Dichroism Exciton Approach.
\nT. Asai*, T. Taniguchi, T, Yamamoto, K. Monde, Y. Oshima*.
\nOrg. Lett.<\/em> 2013<\/strong>, 15<\/em>, 4320\u20134323.<\/a><\/p>\n

Suberoylanilide Hydroxamic Acid, a Histone Deacetylase Inhibitor, Induces the Production of Anti-inflammatory Cyclodepsipeptides from Beauveria felina<\/em>. Y. M. Chung, M. E. Shazly, D. W. Chuang, T. L. Hwang, T. Asai, Y. Oshima, M. L. Ashour, Y. C. Wu, F. R. Chang*.
\nJ<\/em>. Nat. Prod<\/em>. 2013<\/strong>, 76<\/em>, 1260\u20131266.<\/a><\/p>\n

Structurally Diverse Chaetophenol Productions Induced by Chemically Mediated Epigenetic Manipulation of Fungal Gene Expression.
\nT. Asai*, T. Yamamoto, N. Shirata, T. Taniguchi, K. Monde, I. Fujii, K. Gomi, Y. Oshima*.
\nOrg. Lett.<\/em> 2013<\/strong>, 15<\/em>, 3346-3349.<\/a><\/p>\n

An epigenetic modifier enhances the production of anti-diabetic and anti-inflammatory sesquiterpenoids from Aspergillus sydowii<\/em>.
\nY. M. Chung, C. K. Wei, D. W. Chuang, M. E. Shazly, C. T. Hsieh, T. Asai, Y. Oshima, T. J. Hsieh, T. L. Hwang, Y. C. Wu, F. R. Chang*.
\nBioorg. Med. Chem<\/em>. 2013<\/strong>, 21<\/em>, 3866-3872.<\/a><\/p>\n

Benzophenones from an Endophytic Fungus, Graphiopsis chlorocephala<\/em>, from Paeonia lactiflora<\/em> Cultivated in the Presence of an NAD+<\/sup>-Dependent HDAC Inhibitor.
\nT. Asai*, S. Otsuki, H. Sakurai, K. Yamashita, T. Ozeki, Y. Oshima*.
\nOrg<\/em>. Lett<\/em>. 2013<\/strong>, 15<\/em>, 2058-2061.<\/a><\/p>\n

Structures and absolute configurations of short-branched fatty acid dimers from an endophytic fungus of Aloe arborescens<\/em>.
\nT. Asai*, S. Otsuki, T. Taniguchi, K. Monde, K. Yamashita, H. Sakurai, T. Ozekid, Y. Oshima*.
\nTetrahedron<\/em> Lett<\/em>. 2013<\/strong>, 54, <\/em>3402-3405.<\/a><\/p>\n

Structures and Biomimetic Synthesis of Novel a-Pyrone Polyketides of an Endophytic Penicillium<\/em> sp. in Catharanthus roseus<\/em>.
\nT. Asai*, D. Luo, K. Yamashita, Y. Oshima*.
\nOrg<\/em>. Lett.<\/em> 2013<\/strong>, 15<\/em>, 1020-1023.<\/a>[\/vc_column_text][vc_custom_heading text=”2012″ font_container=”tag:h3|font_size:18|text_align:left|color:%230066bf” use_theme_fonts=”yes” el_class=”PB_section_title” css=”.vc_custom_1507956489864{margin-top: 15px !important;margin-bottom: 0px !important;padding-top: 20px !important;padding-bottom: 5px !important;}”][vc_column_text]Structural Diversity of New C13<\/sub>-Polyketides Produced by Chaetomium mollipilium<\/em> Cultivated in the Presence of a NAD+<\/sup>-Dependent Histone Deacetylase Inhibitor
\nT. Asai*, S. Morita, N. Shirata, T. Taniguchi, K. Monde, H. Sakurai, T. Ozeki, Y. Oshima*.
\nOrg<\/em>. Lett<\/em>. 2012<\/strong>, 14<\/em>, 5456-5459.<\/a><\/p>\n

Cyclic glycolipids from glandular trichome exudates of Cerastium glomeratum<\/em>.
\nT. Asai, Y. Nakamura, Y. Hirayama, K. Ohyama, Y. Fujimoto*.
\nPhytochemistry<\/em> 2012<\/strong>, 82<\/em>, 149-157.<\/a><\/p>\n

Highly oxidized ergosterols and isariotin analogs from an entomopathogenic fungus, Gibellula formosana<\/em>, cultivated in the presence of epigenetic modifying agents.
\nT. Asai*, Y. M. Chung, H. Sakurai, T. Ozeki, F. R. Chang, Y. C. Wu, K. Yamashita, Y. Oshima*.
\nTetrahedron<\/em> 2012<\/strong>, 68<\/em>, 5817-5823.<\/a><\/p>\n

Epi-a-bisabolol 6-deoxy-b-D-gulopyranoside from the glandular trichome exudate of Brillantaisia owariensis<\/em>.
\nT. Asai, Y. Hirayama, Y. Fujimoto*.
\nPhytochemistry Lett<\/em>. 2012<\/strong>, 5<\/em>, 376-378.<\/a><\/p>\n

Aromatic Polyketide Production in Cordyceps indigotica<\/em>, an Entomopathogenic Fungus, Induced by Exposure to a Histone Deacetylase Inhibitor.
\nT. Asai*, T. Yamamoto, Y. Oshima*.
\nOrg<\/em>. Lett<\/em>. 2012<\/strong>, 14<\/em>, 2006-2009.<\/a><\/p>\n

Dihydrobenzofurans as cannabinoid receptor ligands from Cordyceps annullata<\/em>, an entomopathogenic fungus cultivated in the presence of an HDAC inhibitor.
\nT. Asai*, D. Luo, Y. Obara, T. Taniguchi, K. Monde, K. Yamashita, Y. Oshima*.
\nTetrahedron Lett<\/em>. 2012<\/strong>, 53<\/em>, 2239-2243.<\/a><\/p>\n

Tenuipyrone, a Novel Skeletal Polyketide from the Entomopathogenic Fungus, Isaria tenuipes<\/em>, Cultivated in the Presence of Epigenetic Modifiers.
\nT. Asai*, Y. M. Chung, H. Sakurai, T. Ozeki, F. R.Chang, K. Yamashita, Y, Oshima*.
\nOrg. Lett<\/em>. 2012<\/strong>, 14<\/em>, 513-515.<\/a><\/p>\n

Aromatic polyketide glycosides from an entomopathogenic fungus, Cordyceps indigotica<\/em>.
\nT. Asai*, T. Yamamoto, Y. M. Chung, F. R. Chang, Y. C. Wu, K. Yamashita, Y. Oshima*.
\nTetrahedron Lett<\/em>. 2012<\/strong>, 53<\/em>, 277-280.<\/a>[\/vc_column_text][vc_custom_heading text=”2011″ font_container=”tag:h3|font_size:18|text_align:left|color:%230066bf” use_theme_fonts=”yes” el_class=”PB_section_title” css=”.vc_custom_1507957010458{margin-top: 15px !important;margin-bottom: 0px !important;padding-top: 20px !important;padding-bottom: 5px !important;}”][vc_column_text]Histone deacetylase inhibitor induced the production of three novel prenylated tryptophan analogs in the entomopathogenic fungus, Torrubiella luteorostrata<\/em>.
\nT. Asai*, T. Yamamoto, Y. Oshima*.
\nTetrahedron Lett<\/em>. 2011<\/strong>, 52<\/em>, 7042-7045.<\/a><\/p>\n

2-Acety-1-(3-glycosyloxyoctadecanoyl)glycerol and dammarane triterpenes in the exudates from secretary organs on the stipules and leaves of Cerasus yedoensis<\/em>,
\nT. Asai, Y. Fujimoto*.
\nPhytochemistry Lett<\/em>. 2011<\/strong>, 15<\/em>, 38-42.<\/a><\/p>\n

n<\/em>-Octyl a-L-rhamnopyranosyl-(1\u21922)-\u03b2-D-glucopyranoside derivatives from the glandular trichome exudate of Geranium carolinianum<\/em>,
\nT. Asai, T. Sakai, K. Ohyama, Y. Fujimoto*.
\nChem. Pharm. Bull<\/em>. 2011<\/strong>, 59<\/em>, 747-752.<\/a>[\/vc_column_text][vc_custom_heading text=”~2010″ font_container=”tag:h3|font_size:18|text_align:left|color:%230066bf” use_theme_fonts=”yes” el_class=”PB_section_title” css=”.vc_custom_1507957202864{margin-top: 15px !important;margin-bottom: 0px !important;padding-top: 20px !important;padding-bottom: 5px !important;}”][vc_column_text]Cyclic fatty acyl glycosides in the glandular trichome exudate of Silene gallica<\/em>.
\nT. Asai, Y. Fujimoto*.
\nPhytochemistry<\/em>, 2010<\/strong>, 71<\/em>, 1410-1417.<\/a><\/p>\n

Fatty acid derivatives and dammarane triterpenes from the glandular trichome exduates of Ibicella lutea<\/em> and Proboscidea louisiana<\/em>.
\nT. Asai, N. Hara, Y. Fujimoto*
\nPhytochemistry<\/em>, 2010<\/strong>, 71<\/em>, 877-894.<\/a><\/p>\n

Artabotryols A-E, new lanostane triterpenes from the seeds of Artabotrys odoratissimus
\n<\/em>C. Gupta, S. Prasad, M. Sahai, T. Asai, N. Hara, Y. Fujimoto.
\nHelv. Chim. Acta<\/em>, 2010<\/strong>, 93<\/em>, 1925-1932.<\/p>\n

Acylglycerols (=glycerides) from the glandular trichome exudate on the leaves of Paulownia tomentosa.<\/em>
\nT. Asai, N. Hara, S. Kobayashi, S. Kohshima, Y. Fujimoto*.
\n Helv. Chim. Acta<\/em>, 2009<\/strong>, 92<\/em>, 1473-1492.<\/a><\/p>\n

Geranylated flavanones from the secretion on the surface of the immature fruits of Paulownia tomentosa<\/em>.
\nT. Asai, N. Hara, S. Kobayashi, S. Kohshima, Y. Fujimoto*.
\nPhytochemistry. 2008<\/strong>, 69<\/em>, 1234-1241.<\/a><\/p>\n

Radermachol and naphthoquinone derivatives from Tecomella undulata<\/em>: complete 1<\/sup>H and 13<\/sup>C NMR assignments of radermachol with the aid of computational 13C shift prediction.
\nP. Singh, P. Khandelwal, N. Hara, T. Asai, Y. Fujimoto*.
\nInd. J. Chem. Sec B<\/em>, 2008<\/strong>, 47B<\/em>, 1865-1870.<\/p>\n

Anti-herbivore structures of Paulownia tomentosa<\/em>: morphology, distribution, chemical constituents, and changes during shoot and leaf development.
\nS. Kobayashi, T. Asai, Y. Fujimoto, S. Kohshima*.
\nAnn. Botany<\/em>, 2008<\/strong>, 101<\/em>, 1035-1047.<\/p>\n

Further studies on the constituents of the gorgonian octocoral Pseudopterogorgia elisabethae<\/em> collected in San Andres and Providencia islands, Colombian Caribbean: isolation of a putative biosynthetic intermediate leading to erogorgiaene.
\nC. Duque, M. Puyana, L. Castellanos, A. 5. Arias, H. Correa, O. Osorno, T. Asai, N. Hara, Y. Fujimoto*.
\nTetrahedron<\/em>, 2006,<\/strong> 62<\/em>, 4205-4213.<\/p>\n

Hyosmin, a new lignan from Hyocyamus niger L.
\nA. S. Begum, S. Verma, M. Sahai, T. Asai, N. Hara, Y Fujimoto*.
\nJ. Chem. Res<\/em>., 2006<\/strong>, 675-677.<\/p>\n

Apollineanin: a new flavanone from Tephrosia apollinea.
\n<\/em> A. Hisham, S. John, W. Shuaily, T. Asai, Y. Fujimoto.
\nNat. Prod. Res<\/em>., 2006<\/strong>, 20<\/em>, 1046-1052.<\/p>\n

A new kaempferol diglycoside from Datura suaveolens<\/em> Humb. & Bonpl. ex. Willd.
\nA. S. Begum, M. Sahai, Y. Fujimoto, T. Asai, K. Schneider, G. Nicholson, R. Suessmuth*.
\nNat. Prod. Res<\/em>., 20, 2006<\/strong>, 1231-1236.<\/p>\n

Hyosgerin, a new optically active coumarinolignan, from the seeds of Hyosymus niger.
\n<\/em> S. Begum, M. Sahai, R. Suessmuth, T. Asai, N. Hara, Y. Fujimoto*.
\nChem. Pharm. Bull<\/em>., 2006<\/strong>, 54<\/em>, 538-541.[\/vc_column_text][vc_row_inner][\/vc_row_inner][vc_column_inner][\/vc_column_inner][\/vc_column][\/vc_row][vc_row][\/vc_row][vc_column][\/vc_column][vc_column_text][\/vc_column_text][\/vc_section][vc_row][vc_column][vc_column_text][\/vc_column_text][\/vc_column][\/vc_row][vc_section][vc_row][vc_column][vc_separator css=”.vc_custom_1508126159814{margin-bottom: 15px !important;}”][vc_custom_heading text=”Books & Reviews” font_container=”tag:h3|text_align:left|color:%231e73be” use_theme_fonts=”yes” el_class=”PB_section_title” css=”.vc_custom_1649291573864{margin-top: 30px !important;margin-bottom: 0px !important;padding-bottom: 5px !important;}” el_id=”Rv”][vc_separator color=”custom” style=”shadow” css=”.vc_custom_1508125993742{margin-top: 5px !important;margin-bottom: 0px !important;padding-top: 10px !important;padding-bottom: 20px !important;}”][vc_column_text]\u2022\u5408\u6210\u751f\u7269\u5b66\u3092\u57fa\u76e4\u3068\u3059\u308b\u5929\u7136\u7269\u306e\u63a2\u7d22\u3068\u5275\u88fd\u7814\u7a76
\n\u6d45\u4e95\u798e\u543e\uff0e
\n\u79d1\u5b66\u3068\u5de5\u696d\u00a0 (Science and Industry) \u5dfb\uff1a 97\u00a0 \u53f7\uff1a 11\u00a0 \u30da\u30fc\u30b8\uff1a 340-345\u00a0 \u767a\u884c\u5e74\uff1a 2023\u5e7411\u670820\u65e5<\/a><\/p>\n

\u2022Synthetic Biology-Based Natural Product Discovery
\nTeigo Asai
\nNew Tide of Natural Product Chemistry Springer, 3-16 (2023)<\/a><\/p>\n

\u2022\u5408\u6210\u751f\u7269\u5b66\u3092\u57fa\u76e4\u3068\u3059\u308b\u5929\u7136\u7269\u306e\u63a2\u7d22\u7814\u7a76
\n\u6d45\u4e95\u798e\u543e\uff0e
\n\u5b9f\u9a13\u533b\u5b66 Vol. 41 No. 3 (2\u6708\u53f7) 2023 “\u3044\u307e\u77e5\u308a\u305f\u3044” \u9577\u9396DNA\u5408\u6210 \u2500\u30b1\u3099\u30ce\u30e0\u306f\u8aad\u3080\u6642\u4ee3\u304b\u3089\u66f8\u304f\u6642\u4ee3\u3078<\/a><\/p>\n

\u2022\u7cf8\u72b6\u83cc\u306e\u907a\u4f1d\u5b50\u60c5\u5831\u3092\u6d3b\u7528\u3059\u308b\u5929\u7136\u7269\u30b1\u30df\u30ab\u30eb\u30b9\u30da\u30fc\u30b9\u306e\u958b\u62d3
\n\u6d45\u4e95\u798e\u543e\uff0e
\n\u6708\u9593\u30d5\u30a1\u30a4\u30f3\u30b1\u30df\u30ab\u30eb \u7279\u96c6 \u30dd\u30b9\u30c8\u30b2\u30ce\u30e0\u6642\u4ee3\u306e\u5929\u7136\u7269\u5316\u5b66\u30fc\u30b2\u30ce\u30e0\u60c5\u5831\u306b\u57fa\u3065\u3044\u305f\u5929\u7136\u7269\u306e\u63a2\u7d22\u3068\u5408\u6210\u30fc Vol 50, No. 4 (2021)<\/a><\/p>\n

\u2022\u5fae\u751f\u7269\u306b\u300c\u5929\u7136\u306b\u306f\u306a\u3044\u5929\u7136\u7269\u300d\u3092\u3064\u304f\u3089\u305b\u308b
\n\u73fe\u4ee3\u5316\u5b66 FLASH 2020\u5e74 8\u6708\u53f7<\/a><\/p>\n

\u2022Chemical Activation of Natural Product Biosynthesis in Filamentous Fungi
\nTeigo Asai
\n<\/em>Comprehensive Natural Products III: Chemistry and Biology, Vol. 7, Elsevier, 475-486 (2020).<\/a><\/p>\n

\u2022\u5358\u96e2\u2022\u69cb\u9020\u6c7a\u5b9a\u306b\u7acb\u811a\u3059\u308b\u5929\u7136\u7269\u5316\u5b66\u7814\u7a76
\n\u6d45\u4e95\u798e\u543e\uff0e
\n\u6709\u6a5f\u5408\u6210\u5316\u5b66\u5354\u4f1a\u8a8c, \u5929\u7136\u7269\u5316\u5b66\u7279\u96c6\u53f7, 2018<\/strong>, 76 <\/em>406-409.<\/a><\/p>\n

\u2022\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u5236\u5fa1\u3092\u5229\u7528\u3059\u308b\u65b0\u898f\u533b\u85ac\u8cc7\u6e90\u306e\u958b\u62d3
\n\u6d45\u4e95\u798e\u543e\uff0c\u5927\u5cf6\u5409\u8f1d\uff0e
\n\u751f\u5316\u5b66 \u300c\u307f\u306b\u308c\u3073\u3085\u30fc\u300d, 2016<\/strong>, 88<\/em>, 643-648.<\/a><\/p>\n

\u2022\u5fae\u751f\u7269\u306e\u53ef\u80fd\u6027\u3092\u958b\u62d3\u3059\u308b\u2212\u591a\u69d8\u306a\u65b0\u5947\u5316\u5408\u7269\u5408\u6210\u306e\u305f\u3081\u306e\u65b0\u3057\u3044\u30a2\u30d7\u30ed\u30fc\u30c1\u2212
\n\u6d45\u4e95\u798e\u543e\uff0c\u5927\u5cf6\u5409\u8f1d\uff0e
\n\u73fe\u4ee3\u5316\u5b66 \u300c\u89e3\u8aac\u300d, 2016<\/strong>, 9<\/em>, 21-26.<\/a><\/p>\n

\u2022\u30b1\u30df\u30ab\u30eb\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30af\u30b9\u306b\u3088\u308b\u672a\u5229\u7528\u751f\u5408\u6210\u907a\u4f1d\u5b50\u306e\u6d3b\u7528\u3068\u591a\u69d8\u306a\u5929\u7136\u7269\u306e\u5275\u51fa.
\n\u6d45\u4e95\u798e\u543e\uff0c\u5927\u5cf6\u5409\u8f1d\uff0e
\n\u30d5\u30a1\u30eb\u30de\u30b7\u30a2\u300c\u6700\u524d\u7dda\u300d2014<\/strong>, 50<\/em>, 112\uff0d116.<\/a><\/p>\n

\u2022\u7cf8\u72b6\u83cc\u4e8c\u6b21\u4ee3\u8b1d\u306e\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a3\u30c3\u30af\u5236\u5fa1\u3068\u5929\u7136\u7269\u63a2\u7d22.
\n\u6d45\u4e95\u798e\u543e, \u5927\u5cf6\u5409\u8f1d.
\n\u5316\u5b66\u3068\u751f\u7269, 2013<\/strong>, 1<\/em>, 13-21.<\/a>[\/vc_column_text][vc_row_inner][vc_column_inner][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][\/vc_row][vc_column][\/vc_column][vc_column_text][\/vc_column_text][\/vc_section][vc_section][vc_row][vc_column][vc_custom_heading text=”Presentations” font_container=”tag:h3|text_align:left|color:%231e73be” use_theme_fonts=”yes” el_class=”PB_section_title” css=”.vc_custom_1508126210584{margin-top: 30px !important;margin-bottom: 0px !important;padding-bottom: 5px !important;}” el_id=”Pres”][vc_separator color=”custom” style=”shadow” css=”.vc_custom_1507959644324{margin-top: 5px !important;margin-bottom: 0px !important;padding-bottom: 0px !important;}”][vc_custom_heading text=”\u30fb2023\u5e74\u5ea6” font_container=”tag:h2|font_size:20|text_align:left|color:%230066bf” link=”url:http%3A%2F%2Fwww.pharm.tohoku.ac.jp%2F~shigen%2Fasai_lab%2Fwp-content%2Fuploads%2F2024%2F04%2F7a14bb3f13b520969f383ca8fcc1c15c-1.pdf”][vc_custom_heading text=”\u30fb2022\u5e74\u5ea6” font_container=”tag:h2|font_size:20|text_align:left|color:%230066bf” link=”url:http%3A%2F%2Fwww.pharm.tohoku.ac.jp%2F~shigen%2Fasai_lab%2Fwp-content%2Fuploads%2F2024%2F04%2F4d0f51f453bdac980bb9b0b4031e6c96.pdf”][vc_custom_heading text=”\u30fb2021\u5e74\u5ea6” font_container=”tag:h2|font_size:20|text_align:left|color:%230066bf” link=”url:http%3A%2F%2Fwww.pharm.tohoku.ac.jp%2F~shigen%2Fasai_lab%2Fwp-content%2Fuploads%2F2022%2F04%2F8ffb870f4a7757f085b21d5025bd2b3c.pdf”][vc_custom_heading text=”\u30fb2020\u5e74\u5ea6” font_container=”tag:h2|font_size:20|text_align:left|color:%230066bf” link=”url:http%3A%2F%2Fwww.pharm.tohoku.ac.jp%2F~shigen%2Fasai_lab%2Fwp-content%2Fuploads%2F2022%2F04%2F16677e3391d2ba12cb6c2bd3899a3961.pdf”][vc_custom_heading text=”\u30fb2019\u5e74\u5ea6” font_container=”tag:h2|font_size:20|text_align:left|color:%230066bf” link=”url:http%3A%2F%2Fwww.pharm.tohoku.ac.jp%2F~shigen%2Fasai_lab%2Fwp-content%2Fuploads%2F2022%2F04%2Fa201dff92ad4e7deb6b67f78aab86325.pdf”][vc_custom_heading text=”\u30fb2018\u5e74\u5ea6\u4ee5\u524d” font_container=”tag:h2|font_size:20|text_align:left|color:%230066bf” link=”url:http%3A%2F%2Fwww.pharm.tohoku.ac.jp%2F~shigen%2Fasai_lab%2Fwp-content%2Fuploads%2F2022%2F04%2Fa9e533b1718dc388f273da8d1a199479.pdf”][vc_custom_heading text=”\u30fb\u5929\u7136\u6709\u6a5f\u5316\u5408\u7269\u8a0e\u8ad6\u4f1a” font_container=”tag:h2|font_size:20|text_align:left|color:%230066bf” link=”url:http%3A%2F%2Fwww.pharm.tohoku.ac.jp%2F~shigen%2Fasai_lab%2Fwp-content%2Fuploads%2F2024%2F04%2F6ea32ef38f69f32fe2cbd5ca083fb43b.pdf”][vc_custom_heading text=”\u30fb\u56fd\u969b\u5b66\u4f1a” font_container=”tag:h2|font_size:20|text_align:left|color:%230066bf” link=”url:http%3A%2F%2Fwww.pharm.tohoku.ac.jp%2F~shigen%2Fasai_lab%2Fwp-content%2Fuploads%2F2024%2F04%2Fe64482fe63175233019eadf207042f91.pdf”][vc_custom_heading text=”” font_container=”tag:h2|font_size:16|text_align:left|color:%230066bf”][vc_row_inner][vc_column_inner][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row][\/vc_row][vc_column][\/vc_column][vc_column_text][\/vc_column_text][\/vc_section]\n","protected":false},"excerpt":{"rendered":"

[vc_row][vc_column][vc_raw_html]JTNDZm […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-2123","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/www.pharm.tohoku.ac.jp\/~shigen\/asai_lab\/wp-json\/wp\/v2\/pages\/2123","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.pharm.tohoku.ac.jp\/~shigen\/asai_lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.pharm.tohoku.ac.jp\/~shigen\/asai_lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.pharm.tohoku.ac.jp\/~shigen\/asai_lab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.pharm.tohoku.ac.jp\/~shigen\/asai_lab\/wp-json\/wp\/v2\/comments?post=2123"}],"version-history":[{"count":102,"href":"http:\/\/www.pharm.tohoku.ac.jp\/~shigen\/asai_lab\/wp-json\/wp\/v2\/pages\/2123\/revisions"}],"predecessor-version":[{"id":5709,"href":"http:\/\/www.pharm.tohoku.ac.jp\/~shigen\/asai_lab\/wp-json\/wp\/v2\/pages\/2123\/revisions\/5709"}],"wp:attachment":[{"href":"http:\/\/www.pharm.tohoku.ac.jp\/~shigen\/asai_lab\/wp-json\/wp\/v2\/media?parent=2123"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}