Graduate School of Pharmaceutical Sciences, Tohoku University
東北大学大学院薬学研究科 医薬資源化学分野

発表論文

2019年

An automated microliter-scale high-throughput screening system (MSHTS) for real-time monitoring of protein aggregation using quantum-dot nanoprobes.

Sasaki, R.; Tainaka, R.; Ando, Y.; Hashi, Y.; Deepak, H. V.; Suga, Y.; Murai, Y.; Anetai, M.; Monde, K.; Ohta, K.; Ito, I.; Kikuchi, H.; Oshima, Y.; Endo, Y.; Nakao, H.; Sakono, M.; Uwai, K.; Tokuraku, K.

Sci. Rep. , 9, 2587 (2019)


Construction of a Meroterpenoid-like Compounds Library Based on Diversity-Enhanced Extracts.

Kikuchi, H.; Kawai, K.; Nakashiro, Y.; Yonezawa, T.; Kawaji, K.; Kodama, E. N.; Oshima, Y.

Chem.–Eur. J. , 25, 1106-1102 (2019)


Dictyostelium: An Important Source of Structural and Functional Diversity in Drug Discovery.

Kubohara, Y.; Kikuchi, H.

Cells, 8, 6 (2019)


Prenylated quinolinecarboxylic acid derivative prevents neuronal cell death through inhibition of MKK4.

Ogura, M.; Kikuchi, H.; Shakespear, N. B.; Suzuki, T.; Yamaki, J.; Homma, M. K.; Oshima, Y.; Homma, Y.

Biochem. Pharmacol., 162, 109-122 (2019)


2018年

Removal of the E-olefin Barrier of Humulene Leading to Unnatural Terpenoid-like Skeletons.

Nishimura, T.; Kawai, J.; Oshima, Y.; Kikuchi, H.

Org. Lett. , 20, 7317-7320 (2018)


Effect of brefelamide on proliferation of 1321N1 human astrocytoma cells induced by glial cell line-derived neurotrophic factor.

Honma, S.; Kouno, K.; Takasaka, S.; Mitazaki, S.; Abe, S.; Kikuchi, H.; Oshima, Y.; Yoshida, M.

Pharmazie , 73, 22-28 (2018)


Developments toward the Production of Diverse Natural-Product-Like Compounds: Diversity-Oriented Synthesis and Diversity-Enhanced Extracts.

Kikuchi, H.; Oshima, Y.

Heterocycles, 96, 1509-1527 (2018)


2017年

Isolation, Synthsis, and Biological Activity of Chlorinated Alkylresorcinols from Dictyostelium Cellular Slime Molds.

Kikuchi, H.; Ito, I.; Takahashi, K.; Ishigaki, H.; Iizumi, K.; Kubohara, Y.; Oshima, Y.

J. Nat. Prod. , 80, 2716-2722 (2017)


Biological activities of novel derivatives of differentiation-inducing factor 3 from Dictyostelium discoideum.

Takahashi, K.; Kikuchi, H.; Nguyen, V. H.; Oshima, Y.; Ishigaki, H.; Nakajima-Shimada, J.; Kubohara, Y.

Biol. Phram. Bull. , 40, 1941-1947 (2017)


Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.

Jain, V.; Yogavel, M.; Kikuchi, H.; Oshima, Y.; Hariguchi, N.; Matsumoto, M.; Goel, P.; Touquet, B.; Jumani, R. S.; Tacchini-Cottier, F.; Harlos, K.; Huston, C. D.; Hakimi, M.-A.; Sharma, A.

Structure , 25, 1495-1505 (2017)


Evidence that differentiation-inducing factor-1 controls chemotaxis and cell differentiation, at least in part, via mitochondria in Dictyostelium discoideum.

Kubohara, Y.; Kikuchi, H.; Nguyen, V. H.; Kuwayama, H.; Oshima, Y.

Biology Open , 6, 741-751 (2017)


Induction of Osteopontin by Dengue Virus-3 infection in THP-1 cells -Inhibition of the synthesis by Brefelamide and its derivative-

Pascapurnama, D. N.; Labayo, H. K. M.; Dapat, I.; Nagarajegowda, D. D.; Zhao, J.; Zhang, J.; Yamada, O.; Kikuchi, H.; Egawa, S.; Oshima, Y.; Chagan-Yasutan, H.; Hattori, T.

Front. Microbiol. , 8, 521 (2017)


1-Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation.

Tsuchida, K.; Tsujita, T.; Hayashi, M.; Ojima, A.; Keleku-Lukwete, N.; Katsuoka, F.; Otsuki, A.; Kikuchi, H.; Oshima, Y.; Suzuki, M.; Yamamoto, M.

Free Radical Biol. Med. , 103, 236-247 (2017)


Production of Novel Bispyrone Metabolites in the Cellular Slime Mold Dictyostelium giganteum Induced by Zinc(II) Ion.

Nguyen, V. H.; Kikuchi, H.; Sasaki, H.; Iizumi, K.; Kubohara, Y.; Oshima, Y.

Tetrahedron, 73, 583-588 (2017)


Alkaloids from aerial parts of Annona senegalensis against Streptococcus mutans.

Lall, N.; Kishore, N.; Bodiba, G.; More, E.; Tshikanlange, H.; Kikuchi, H.; Oshima, Y.

Nat. Prod. Res. , 16, 1944-1947 (2017)


多様性拡大抽出物が生み出す薬理活性指向型化合物ライブラリー

菊地晴久,大島吉輝

有機合成化学協会誌, 75, 349-359 (2017)


2016年

Monoterpene Indole Alkaloid-like Compounds Based on Diversity-enhanced Extracts of Iridoid-Containing Plants and Their Immune Checkpoint Inhibitory Activity.

Kikuchi, H.; Ichinohe, K.; Kida, S.; Murase, S.; Yamada, O.; Oshima, Y.

Org. Lett. , 18, 5948-5951 (2016)


Glutathione S-transferase 4 is a putative DIF-binding protein that regulates the size of fruiting bodies in Dictyostelium discoideum.

Kuwayama, H.; Kikuchi, H.; Oshima, Y.; Kubohara, Y.

Biochem. Biophys. Rep. , 8, 216-226 (2016)


Identification of brefelamide as a novel inhibitor of osteopontin that suppresses invasion of A549 lung cancer cells.

Zhang, J.; Yamada, O.; Kida, S.; Matsushita, Y.; Murase, S.; Hattori, T.; Kubohara, Y.; Kikuchi, H.; Oshima, Y.

Oncol. Rep. , 36, 2357-2364 (2016)


Development of Terpenoid Alkaloid-like Compound Library Based on a Humulene Skeleton.

Kikuchi, H.; Nishimura, T.; Kwon, E.; Kawai, J.; Oshima, Y.

Chem.–Eur. J. , 22, 15819-15825 (2016)


Oral administration of Dictyostelium differentiation-inducing factor-1 lowers blood glucose levels in streptozotocin-induced diabetic rats.

Kawaharada, R.; Nakamura, A.; Takahashi, K.; Kikuchi, H.; Oshima, Y.; Kubohara, Y.

Life Sci. , 155, 56-62 (2016)


1-Methyl-2-undecyl-4(1H)-quinolone, a derivative of quinolone alkaloid evocarpine, attenuates high phosphate-induced calcification of human aortic valve interstitial cells by inhibiting phosphate cotransporter PiT-1.

Seya, K.; Furukawa, K.; Chiyoya, M.; Yu, Z.; Kikuchi, H.; Daitoku, K.; Motomura, S.; Murakami, M.; Oshima Y.; Fukuda, I.

J. Pharmacol. Sci., 131, 51-57 (2016)


Design and Synthesis of Structure-Simplified Derivatives of Gonytolide for the Promotion of Innate Immune Responses.

Kikuchi, H.; Hoshikawa, T.; Kurata, S.; Katou, Y.; Oshima Y.

J. Nat. Prod., 79, 1259-1266 (2016)


Prenylated quinolinecarboxylic acid derivative suppresses immune response through inhibition of PAK2.

Ogura, M.; Kikuchi, H.; Suzuki, T.; Yamaki, J.; Homma, M. K.; Oshima, Y.; Homma, Y.

Biochem. Pharmacol. , 105, 55-65 (2016)


Agarol, an ergosterol derivative from Agaricus blazei, induces caspase-independent apoptosis in human cancer cells.

Shimizu, T.; Kawai, J.; Ouchi, K.; Kikuchi, H.; Oshima, Y.; Hidemi, R.

Int. J. Oncol., 48, 1670-1678 (2016)


2015年

Development of novel DIF-1 derivatives that selectively suppress innate immune responses.

Nguyen, V. H.; Kikuchi, H.; Kubohara, Y.; Takahashi, K.; Katou, Y.; Oshima, Y.

Bioorg. Med. Chem. , 23, 4311-4315 (2015)


Derivatives of Dictyostelium differentiation-inducing factors inhibit lysophosphatidic acid–stimulated migration of murine osteosarcoma LM8 cells.

Kubohara, Y.; Komachi, M.; Homma, Y.; Kikuchi, H., Oshima, Y.

Biochem. Biophys. Res. Commun. , 463, 800-805 (2015)


Structure of Prolyl-tRNA Synthetase-Halofuginone Complex Provides Basis for Development of Novel Drugs against Malaria and Toxoplasmosis.

Jain, V.; Yogavel, M; Oshima, Y.; Kikuchi, H.; Touquet, B.; Hakimi, M.-A.; Sharma, A.

Structure, 23, 819-829 (2015)


Weight loss by Ppc-1, a novel small molecule mitochondrial uncoupler derived from slime mold.

Suzuki, T.; Kikuchi, H.; Ogura, M.; Homma, M. K.; Oshima, Y.; Homma, Y.

PLOS ONE, 10, e0117078 (2015)


Isolation of a Cyclic Depsipetide, Aspergillicin F, and Synthesis of Aspergillicins with Innate Immune Modulating Activity.

Kikuchi, H.; Hoshikawa, T.; Fujimura, S.; Sakata, N.; Kurata, S.; Katou, Y.; Oshima, Y.

J. Nat. Prod., 78, 1949-1956 (2015)


Synthesis of prenylated quinolinecarboxylic acid derivatives and their anti-obesity activities.

Kikuchi, H.; Suzuki, T.; Ogura, M.; Homma, M. K.; Homma, Y.; Oshima, Y.

Bioorg. Med. Chem., 23, 66-72 (2015)


2014年

ZFC3H1, a zinc finger protein, modulates IL-8 transcription by binding with Celastramycin A, a potential immune suppressor.

Tomita, T.; Ieguchi, K.; Coin, F.; Kato, Y.; Kikuchi, H.; Oshima, Y.; Kurata, S.; Maru, Y.

PLOS ONE, 9, e108957 (2014)


Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase.

Jain, V.; Kikuchi, H.; Oshima, Y.; Sharma, A.; Yogavel, M.

J. Struct. Funct. Genomics, 15, 181-190 (2014)


Defects in the synthetic pathway prevent DIF-1 mediated stalk lineage specification cascade in the non-differentiating social amoeba Acytostelium subglobosum

Kurato Mohri, Takashi Hata, Haruhisa Kikuchi, Yoshiteru Oshima and Hideko Urushihara

Biology Open, 3, 553-560 (2014)


Properties of a non-bioactive fluorescent derivative of differentiation-inducing factor-3, an anti-tumor agent found in Dictyostelium discoideum

Yuzuru Kubohara, Haruhisa Kikuchi, Yusuke Matsuo, Yoshiteru Oshima and Yoshimi Homma

Biology Open, 3, 289-296 (2014)


Development of Diversity-Enhanced Extracts of Curcuma zedoaria and Their New Sesquiterpene-like Compounds

Haruhisa Kikuchi, Kazuyoshi Sakurai and Yoshiteru Oshima

Org. Lett., 16, 1916-1919 (2014)



Metarhizin A suppresses cell proliferation by inhibiting cytochrome c oxidase activity

Yasuhiro Katou, Naoya Endo, Toshiyuki Suzuki, Jiang Yu, Haruhisa Kikuchi, Yoshiteru Oshima and Yoshimi Homma

Life Sci., 103, 1-7 (2014)


Synthesis of febrifugine derivatives and development of an effective and safe tetrahydroquinazoline-type antimalarial

Haruhisa Kikuchi, Seiko Horoiwa, Ryota Kasahara, Norimitsu Hariguchi, Makoto Matsumoto and Yoshiteru Oshima

Eur. J. Med. Chem., 76, 10-19 (2014)



page top

2013年

The Dictyostelium prestalk inducer DIF-1 directs phosphorylation of a bZIP transcription factor

Yoko Yamada, Yuzuru Kubohara, Haruhisa Kikuchi, Yoshiteru Oshima, Hong-Yu Wang, Susan Ross and Jeffrey G. Williams

Int. J. Dev. Biol., 57, 375-381 (2013)


Mitochondria are the target organelle of differentiation-inducing factor-3, an anti-tumor agent isolated from Dictyostelium discoideum

Yuzuru Kubohara, Haruhisa Kikuchi, Yusuke Matsuo, Yoshiteru Oshima and Yoshimi Homma

PLoS One, 8, e72118 (2013)

Press release



Structures of spiroindicumides A and B, unprecedented carbon skeletal spirolactones, and determination of the absolute configuration by a vibrational circular dichroism exciton approach

Teigo Asai, Tohru Taniguchi, Takashi Yamamoto, Kenji Monde and Yoshiteru Oshima

Org. Lett., 15, 4320-4323 (2013)



Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, induces the production of anti-inflammatory cyclodepsipeptides from Beauveria felina

Yu-Ming Chung, Mohamed El-Shazly, Da-Wei Chuang, Tsong-Long Hwang, Teigo Asai, Yoshiteru Oshima, Mohamed L. Ashour, Yang-Chang Wu and Fang-Rong Chang

J. Nat. Prod., 76, 1260-1266 (2013)


Structurally diverse chaetophenol productions induced by chemically mediated epigenetic manipulation of fungal gene expression

Teigo Asai, Takashi Yamamoto, Naoki Shirata, Tohru Taniguchi, Kenji Monde, Isao Fujii, Katsuya Gomi, and Yoshiteru Oshima

Org. Lett., 15, 3346-3349 (2013)



Novel chlorinated dibenzofurans isolated from the cellular slime mold, Polysphondylium filamentosum, and their biological activities

Haruhisa Kikuchi, Yuzuru Kubohara, Van Hai Nguyen, Yasuhiro Katou, and Yoshiteru Oshima

Bioorg. Med. Chem., 21, 4628-4633 (2013)



Structures and absolute configurations of short-branched fatty acid dimers from an endophytic fungus of Aloe arborescens

Teigo Asai, Sae Otsuki, Tohru Taniguchi, Kenji Monde, Kouwa Yamashita, Hiroaki Sakurai, Tomoji Ozeki and Yoshiteru Oshima

Tetrahedron Lett., 54, 3402-3405 (2013)



An epigenetic modifier enhances the production of anti-diabetic and anti-inflammatory sesquiterpenoids from Aspergillus sydowii

Yu-Ming Chung, Chien-Kei Wei, Da-Wei Chuang, Mohamed El-Shazly, Chi-Ting Hsieh, Teigo Asai, Yoshiteru Oshima, Tusty-Jiuan Hsieh, Tsong-Long Hwang and Yang-Chang Wu

Bioorg. Med. Chem., 21, 3866-3872 (2013)


Benzophenones from an Endophytic Fungus, Graphiopsis chlorocephala, from Paeonia lactiflora Cultivated in the Presence of an NAD+-Dependent HDAC Inhibitor

Teigo Asai, Sae Otsuki, Hiroaki Sakurai, Kouwa Yamashita, Tomoji Ozeki and Yoshiteru Oshima

Org. Lett., 15, 2058-2061 (2013)



Structures and Biomimetic Synthesis of Polyketides of an Endophytic Penicillium sp. of Cataranthus roseus

Teigo Asai, Dan Luo, Kouwa Yamashita, and Yoshiteru Oshima

Org. Lett., 15, 1020-1023 (2013)



Ectopic Antenna Induction by Overexpression of CG17836/Xrp1 Encoding an AT-Hook DNA Binding Motif Protein in Drosophila

Noriko Tsurui-Nishimura, Thanh Quang Nguyen, Tomonori Katsuyama, Tatsurou Minami, Hirofumi Furuhashi, Yoshiteru Oshima, and Shoichiro Kurata

Biosci. Biotechnol. Biochem., 77, 339-344 (2013)


Derivatives of Dictyostelium discoideum Differentiation-inducing Factor-3 Suppress the Activities of Trypanosoma cruzi in vitro and in vivo

Junko Nakajima-Shimada, Toshimitsu Hatabu, Yukari Hosoi, Yoko Onizuka, Haruhisa Kikuchi, Yoshiteru Oshima and Yuzuru Kubohara

Biochem. Pharmacol., 85, 1603-1610 (2013)


Terresterol, a Polyoxygenated Lanostanoid, Isolated from Oomycete Saprolegnia terrestris, and Its Innate Immune Promoting Activity

Haruhisa Kikuchi, Yuichi Sato, Shoichiro Kurata Yasuhiro Katou and Yoshiteru Oshima

Tetrahedron, 69, 3536-3542 (2013)



糸 状菌二次代謝のエピジェネティック制御と天然物探索

浅井禎吾、大島吉輝

化 学と生物, 51, 13-21 (2013)


page top

2012年

Isolation, Synthesis and Biological Activity of Biphenyl and m-Terphenyl-type Compounds from Dictyostelium Cellular Slime Molds

Haruhisa Kikuchi, Yusuke Matsuo, Yasuhiro Katou, Yuzuru Kubohara, and Y. Oshima

Tetrahedron, 68, 8884-8889 (2012)



Stigmastane Derivatives from the Roots of Vernonia guineensis and Their Antimicrobial Activity

Arno R.N. Donfack, Ngeh J. Toyang, Hippolyte K. Wabo, Pierre Tane, Maurice D. Awouafack, Hasuhisa Kikuchi, Jean D.D. Tamokou, Jules R. Kuiate, and Yoshiteru. Oshima

Phytochemistry Lett., 5, 596-599 (2012)


Structural Diversity of New C13-Polyketides Produced by Chaetomium mollipilium Cultivated in the Presence of NAD+-Dependent Histone Deacetylase Inhibitor

Teigo Asai, Shuntaro Morita, Naoki Shirata, Tohru Taniguchi, Kenji Monde, Hiroaki Sakurai, Tomoji Ozeki, and Yoshiteru Oshima

Org. Lett., 14, 5456-5459 (2012)



Labdane-type Diterpenes and Flavones from Dodonaea viscose

Hippolyte K. Wabo, Philippe.Chabert, Pierre Tane, Olivier Note, Michel F. Tala, Jean Peluso, Christian Muller, Haruhisa Kikuchi, Yoshiteru Oshima, and Annelise Lobstein

Fitoterapia, 83, 859-863 (2012)


Apoptotic Effects of Satratoxin H Is Mediated Through DNA Double-stranded Break in PC12 Cells

Punnee Nusuetrong, Masaki Saito, Harushisa Kikuchi, Yoshiteru Oshima, Takahiro Moriya, and Norimichi Nakahata

J. Toxicol. Sci., 37, 803-812 (2012)


New Dimeric and Monomeric Chromanones, Gonytolides D-G, Isolated from the Fungus Gonytrichum sp.

Harushisa Kikuchi, Masato Isobe, Shoichiro Kurata, Yasuhiro Katou, and Yoshiteru Oshima

Tetrahedron, 68, 6218-6223 (2012)



Highly Oxidized Ergosterols and Isariotin Analogs, from an Entomopathogenic Fungus, Gibellula formosana, Cultivated in the Presence of Epigenetic Modifying Agents

Teigo Asai, Yu-Ming Chung, Hiroaki Sakurai, Tomoji Ozeki, Fang-Rong Chang, Yang-Chang Wu, Kouwa Yamashita, and Yoshiteru Oshima

Tetrahedron, 68, 5817-5823 (2012)



Aromatic Polyketide Production in Cordyceps indigotica, an Entomopathogenic Fungus, Induced by Exposure to a Histone Deacetylase Inhibitor

Teigo Asai, Takashi Yamamoto, Kouwa Yamashita, and Yoshiteru Oshima

Org. Lett., 14, 2006-2009 (2012)



Dihydrobenzofurans as Cannabinoid Receptor Ligands, from Cordyceps annullata, an Entomopathogenic Fungus, Cultivated in the Presence of HDAC Inhibitor

Teigo Asai, Luo Dan, Yutaro Obara, Tohru Taniguchi, Kenji Monde, Kouwa Yamashita, and Yoshiteru Oshima

Tetrahedron Lett., 53, 2239-2243 (2012)



Br-DIF-1 Accelerates Cardiomyocyte Differentiation from P19CL6 Embryonic Carcinoma Cells Induced by 1% Dimethyl Sulfoxide

K. Seya, K. Kanemaru, M. Matsuki, K. Hongo, K. Nakamura, M. Ishikawa, H. Kitahara, S. Motomura, H. Kikuchi, Y. Oshima, Y. Kubohara, and K. Furukawa

Brit. J. Pharmacol., 165, 870-879 (2012)


Tenuipyrone, a Novel Skeletal Polyketide from the Entomopathogenic Fungus, Isaria tenuipes, Cultivated in the Presence of Epigenetic Modifiers

Teigo Asai, Yu-Ming Chung, Hiroaki Sakurai, Tomoji Ozeki, Fang-Rong Chang, Kouwa Yamashita, and Yoshiteru Oshima

Org. Lett., 14, 513-515 (2012)



Aromatic Polyketide Glycosides from an Entomopathogenic Fungus, Cordyceps indigotica

Teigo Asai, Takashi Yamamoto, Yu-Ming Chung, Fang-Rong Chang, Yang-Chang Wu, Kouwa Yamashita, and Yoshiteru Oshima

Tetrahedron Lett., 53, 277-280 (2012)



Phenolic Compounds and Terpenoids from Hypericum lanceolatum

Hippolyte K. Wabo, Theodora K. Kowa, Antoine H.N. Lonfouo, Alembert T. Tchinda, Pierre Tane, Haruhisa Kikuchi, Michel Frederich, and Yoshiteru Oshima

Rec. Nat. Prod., 6, 94-100 (2012)
page top

2011年

Histone Deacetylase Inhibitor Induced the Production of Three Novel Prenylated Tryptophan Analogs in the Entomopathogenic Fungus, Torrubiella luteorostrata

T. Asai, T. Yamamoto, and Y. Oshima

Tetrahedron Lett., 52, 7042-7045 (2011)



Coupling of Two Diazotized 3-Aminothieno[3,4-c]coumarins with Aromatic Amines

Emmanuel S. Fondjo, Joseph Tsemeugne, Beibam L. Sondengam, Thomas Oppenlaender, Hippolyte K. Wabo, Pierre Tane, Joseph D. Connolly, Wim Dehaen, Taoufik Rohand, Haruhisa Kikuchi, and Yoshiteru OShima

J. Heterocyclic Chem., 48, 1295-1301 (2011)


Structures of the Dimeric and Monomeric Chromanones, Gonytolides A-C, Isolated from the Fungus Gonytrichum sp. and Their Promoting Activities of Innate Immune Responses

Haruhisa Kikuchi, Masato Isobe, Mizuki Sekiya, Yuko Abe, Tsuyoshi Hoshikawa, Kazunori Ueda, Shoichiro Kurata, Yasuhiro Katou, and Yoshiteru Oshima

Org. Lett., 13, 4624-4627 (2011)



A Phytoceramide Analog Stimulates the Production of Chemokines Through CREB Activation in Human Endothelial Cells

Mizuki Sekiya, Kazunori Ueda, Kaori Okazaki, Jun Tashima, Yasuhiro Katou, Haruhisa Kikuchi, Shoichiro Kurata, and Yoshiteru Oshima

Int. Immunopharmacol., 11, 1497-1503 (2011)


Autophagy Allows Second-signalled Autophagic Cell Death in Dictyostelium

Marie-Francoise Luciani, Corinne Giusti, Birthe Harms, Yoshiteru Oshima, Haruhisa Kikuchi, Yuzuru Kubohara, and Pierre Golstein

Autophagy, 7, 501-508 (2011)


Synthesis and Innate Immune Suppressive Effect of 1,2-Cyclopentanediol Derivatives

Haruhisa Kikuchi, Kaori Okazaki, Mizuki Sekiya, Yasuyuki Uryu, Kazunori Ueda, Shoichiro Kurata, Yasuhiro Katou, and Yoshiteru Oshima

Eur. J. Med. Chem., 46, 1263-1273 (2011)



Derivatives of Dictyostelium Differentiation-inducing Factors Promote Mitogen-activated IL-2 Production via AP-1 in Jurkat Cells

Katsunori Takahashi, Masami Murakami, Haruhisa Kikuchi, Yoshiteru Oshima, and Yuzuru Kubohara

Life Sci., 88, 480-485 (2011)
page top

2010年

KSRP/FUBP2 is a Binding Protein of GO-Y086, a Cytotoxic Curcumin Analogue

Hiroyuki Yamakoshi, Naoki Kanoh, Chieko Kudo, Atsuko Sato, Kazunori Ueda, Makoto Muroi, Shunsuke Kon, Masanobu Satake, Hisatsugu Ohori, Chikashi Ishioka, Yoshiteru Oshima, Hiroyuki Osada, Natsuko Chiba, Hiroyuki Shibata, and Yoshiharu Iwabuchi

ACS Medicinal Chemistry Letters, 1, 273-276 (2010)


Inhibitory Effect of Hericenone B from Hericium erinaceus on Collagen-induced Platelet Aggregation

Koichiro Mori, Haruhisa Kikuchi, Yutaro Obara, Masaya Iwashita, Yoshihito Azumi, Satomi Kinugasa, Satoshi Inatomi, Yoshiteru Oshima, and Norimichi Nakahata

Phytomedicine, 17, 1082-1085 (2010)


Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds

Haruhisa Kikuchi, Shinya Ishiko, Koji Nakamura, Yuzuru Kubohara, and Yoshiteru Oshima

Tetrahedron, 66, 6000-6007 (2010)



Preparation of an Antibody That Recognizes and Neutralizes Dictyostelium Differentiation-Inducing Factor-1

Yuzuru Kubohara, Haruhisa Kikuchi, Koji Nakamura, Yusuke Matsuo, and Yoshiteru Oshima

Biochem. Biophy. Res. Commun., 396, 364-369 (2010)


Cooperative Regulation of the Induction of the Novel Antibacterial Listericin by PGRP-LE and the JAK-STAT Pathway

Akira Goto, Tamaki Yano, Jun Terashima, Sshinzo Iwashita, Yoshiteru Oshima, and Shoichiro Kurata

J. Biol. Chem., 285, 15731-15738 (2010)


Xanthones and a Benzophenone from the Roots of Pentadesma butyracea and Their Antiproliferative Activity

Hippolyte K. Wabo, Haruhisa Kikuchi, Yasuhiro Katou, Pierre Tane, and Yoshiteru Oshima

Phytochemistry Letters, 3, 104-107 (2010)
page top

2009年

Revised Structure and Synthesis of Celastramycin A, a Potent Innate Immune Suppressor

H. Kikuchi, M. Sekiya, Y. Katou, K. Ueda, T. Kabeya, S. Kurata, and Y. Oshima

Org. Lett., 11, 1693-1695 (2009)


Peltophorum Africanum, a Traditional South African Medicinal Plant, Contains an Anti HIV-1 Constituent, Betulinic Acid

A. Theo, T. Masebe, Y. Suzuki, H. Kikuchi, S. Wada, C.L. Obi, P.O.Bessong, M. Usuzawa, Y. Oshima, and T. Hattori

Tohoku J. Exp. Med., 217, 93-99 (2009)


Autophagic or Necrotic Cell Death Triggered by Distinct Motifs of the Differentiation Factor DIF-1

M.F. Luciani, Y. Kubohara, H. Kikuchi, Y. Oshima, and P. Golstein

Cell Death Differ., 16, 564-570 (2009)


New Diterpene Pyrone-Type Compounds, Metarhizin A and B, Isolated from Entomopathogenic Fungus, Metarhizium flavoviride and Their Inhibitory Effects on Cellular Proliferation

H. Kikuchi, T. Hoshi, M. Kitayama, M. Sekiya, Y. Katou, K. Ueda, Y. Kubohara, H. Sato, M. Shimazu, S. Kurata, and Y. Oshima

Tetrahedron, 65, 469-477 (2009)


Opposite Effects of Two Resveratrol (trans-3,5,4'-Trihydroxystilbene) Tetramers, Vitisin A and Hopeaphenol, on Apoptosis of Myocytes Isolated from Adult Rat Heart

K. Seya, K. Kanemaru, C. Sugimoto, M. Suzuki, T. Takeo, S. Motomura, H. Kitahara, M. Niwa , Y. Oshima, and K. Furukawa

J. Pharmacol. Exp. Ther., 328, 90-98 (2009)
page top

2008年

Biological Activities of Novel Derivatives of DIF-1 Isolated from Dictyostelium

H. Kikuchi, S. Ishiko, Y. Oshima, N. Gokan, K. Hosaka, and Y. Kubohara

Biochem. Biophy. Res. Commun, 377,1012-1017 (2008)


Exploitation of the Derivatives of Dictyostelium Differentiation-Inducing Factor-1, Which Promote Glucose Consumption in Mammalian Cells

Y. Kubohara, H. Kikuchi, and Y. Oshima

Life Sci., 83,608-612 (2008)


Autophagic Control of Listeria through Intracellular Innate Immune Recognition in Drosophila

T. Yano, S. Mita, H. Ohmori, Y. Oshima, Y. Fujimoto, R. Ueda, H. Takada, W. E. Goldman, K. Fukase, N. Silverman, T. Yoshimori, and S. Kurata

Nature Immunol., 9, 908-916 (2008)


Satratoxin H Generates Reactive Oxygen Species and Lipid Peroxides in PC12 Cells

P. Nusuetrong, T. Pengsuparp, D. Meksuriyen, M. Tanitsu, H. Kikuchi, M. Mizugaki, K. Shimazu, Y. Oshima, N. Nakahata, and M. Yoshida

Biol. Pharm. Bull., 31, 1115-1120 (2008)


A Cyclopentanediol Analogue Selectively Suppresses the Conserved Innate Immunity Pathways, Drosophila IMD and TNF-a Pathways

M. Sekiya, K. Ueda, K. Okazaki, H. Kikuchi, S. Kurata, and Y. Oshima

Biochem. Pharmacol., 75, 2165-2174 (2008)
page top

2007年

Novel Biologically Active Compounds Isolated from Unexploited Organism, Cellular Slime Molds

H. Kikuchi

Yakugaku Zasshi, 127, 1431-1439 (2007)


MalariaCount: An Image Analysis-Based Program for the Accurate Determination of Parasitemia

S.W.S. Sio, W. Sun, S. Kumar, W.Z. Bin, S.S. Tan, S.H. Ong, H. Kikuchi, Y. Oshima, and K.S.W. Tan

J. Microbiol. Meth., 68, 11-18 (2007)


Dictyostelium Differentiation-Inducing Factor-1 Induces Glucose Transporter 1 Translocation and Promotes Glucose Uptake in Mammalian Cells

W. Omata, H. Shibata, M. Nagasawa, I. Kojima, H. Kikuchi, Y. Oshima, K. Hosaka, and Y. Kubohara

FEBS J., 274, 3392-3404 (2007)


Dihydrodictyopyrone A and C: New Members of Dictyopyrone Family Isolated from Dictyostelium Cellular Slime Molds

H. Kikuchi, K. Nakamura, Y. Kubohara, N. Gokan, K. Hosaka, Y. Maeda, and Y. Oshima

Tetrahedron Lett., 48, 5905-5909 (2007)


Synthesis of Dictyomedins Using Phosphazene Base Catalyzed Diaryl Ether Formation

M. Ebisawa , M. Ueno , Y. Oshima, and Y. Kondo

Tetrahedron Lett., 48, 8918-8921 (2007)


5,19-Cyclo-9b,10e-androstane-3,17-dione Promotes Neurotrophic Factor Biosynthesis in 1321N1 Human Astrocytoma Cells and Improves Passive Avoidance Learning Impairment

Y. Obara, A. Haganuma, S. Murakami, T. Chiba, K. Mori, O. Nakagawasai, T. Tadano, H. Kikuchi, Y. Oshima, and N. Nakahata

Brain Res., 1184, 57-64 (2007)
page top

2006年

The Drosophila Immune Response to Monomeric DAPtype Peptidoglycan Relies on Two PGRPs and a RHIMlike Domain

T. Kaneko, T. Yano, K. Aggarwal, J.-H. Lim, K. Ueda, Y. Oshima, C. Peach1, D. Erturk-Hasdemir, W. E. Goldman, B.-H. Oh, S. Kurata, and N. Silverman

Nature Immunol., 7, 715-723 (2006)


Exploration of a New Type of Antimalarial Compounds Based on Febrifugine

H. Kikuchi, K. Yamamoto, S. Horoiwa, N. Hariguchi, M. Matsumoto, and Y. Oshima

J. Med. Chem., 49, 4698-4706 (2006)


Structural Basis for Preferential Recognition of Diaminopimelic Acid-type Peptidoglycan by a Subset of Peptidoglycan Recognition Proteins

J.-H. Lim, M.-S. Kim, H.-E. Kim, T. Yano, Y. Oshima, K. Aggarwal, W. E. Goldman, N. Silverman, S. Kurata, and B.-H. Oh

J. Biol. Chem., 281, 8286-8295 (2006)


Isolation of Cholest-5-en-3-ol Fromate from the Red Alga Grateloupia turturu Yamada and Its Chemotaxonomic Significance

E. Plouguerne, H. Kikuchi, Y. Oshima, E. Deslandes, and V. Stiger-Pouvreau

Biochem. Syst. Ecol., 34, 714-717 (2006)


Establishment of ex vivo Systems to Identify Compounds Acting in Innate Immune Responses and to Determine Their Target Molecules Using Transgenic Drosophila

M. Sekiya, K. Ueda, T. Fujita, M. Kitayama, H. Kikuchi, Y. Oshima, and S. Kurata

Life Sci., 80, 113-119 (2006)


Anti-leukemic Activities of Dictyostelium Secondary Metabolites: A Novel Aromatic Metabolite, 4-Methyl-5-n-Pentylbenzene-1,3-Diol, Isolated from Dictyostelium mucoroides Suppresses Cell Growth in Human Leukemia K562 and HL-60 Cells

H. Kikuchi, Y. Oshima, A. Ichimura, N. Gokan, A. Hasegawa, K. Hosaka, and Y. Kubohara

Life Sci., 80, 160-165 (2006)
page top

2005年

Involvement of Reactive Oxygen Species and Stress -activated MAPKs in Satratoxin H-Induced Apotosis

P. Nusuetrong, M. Yoshida, H. Kikuchi, M. Tanitsu, M. Mizugaki, K. Shimazu, Y. Oshima, T. Pengsuparp, D. Meksuriyen, N. Nakahata
Eur. J. Pharmacol., 507, 239-246 (2005)


Adenosine as an Active Constituent of Auricularia auricula for the Inhibition of Rabbit Platelet Aggregation

A. Murata, N. Oka, S. Ohkubo, Y. Sato, M. Funamori, H. Kikuchi, M. Tanitsu, K. Koga, S. Sato, T. Tadano, Y. Oshima, and N. Nakahata
Pharmacometrics, 67 (3/4), 359-364 (2005)


Structural Requirements of Dictyostelium Differentiation-Inducing Factors for Their Stalk-Cell-Inducing Activity in Dictyostelium Cells and Anti-Proliferative Activity in K562 Human Leukemic Cells

N. Gokan, H. Kikuchi, K. Nakamura, Y. Oshima, K. Hosaka, and Y. Kubohara
Biochem. Pharmacol., 70, 676-685 (2005)


Dictyopyrones, Novel a-Pyronoids Isolated from Dictyostelium spp., Promote Stalk Cell Differentiation in Dictyostelium discoideum

A. Arai, K. Hosaka, H. Kikuchi, Y. Oshima, S. Tanaka, Y. Kubohara
Differentiation, 73, 377-384 (2005)


The Isolation and Synthesis of a Novel Aromatic Compound, Brefelamide, from Dictyostelium Cellular Slime Molds, and Its Inhibitory Effect on the Proliferation of Astrocytoma Cells

H. Kikuchi, Y. Saito, J. Sekiya, Y. Okano, M. Saito, N. Nakahata, Y. Kubohara, and Y. Oshima
J. Org. Chem., 70, 8854-8858 (2005)


Involvement of Winged Eye Encoding a Chromatin-Associated Bromo-Adjacent Homology Domain Protein in Disc Specification

T. Katsuyama, T. Sugawara, M. Tatsumi, Y. Oshima, W. J. Gehring, T. Aigaki, and S. Kurata
Proc. Natl. Acad. Sci. U.S.A., 102, 15918-15923 (2005)
page top

2004年

Novel Aromatics Bearing 4-O-Methylglucose Unit Isolated from the Oriental Crude Drug Bombyx Batryticatus

H. Kikuchi, N. Takahashi, and Y. Oshima
Tetrahedron Lett., 45, 367-370 (2004)


First Spirocyclic Trichothecanes, Spirotenuipesine A and B, Isolated from Entomopathogenic Fungus, Paecilomyces tenuipes

H. Kikuchi, Y. Miyagawa, Y. Sahashi, S. Inatomi, A. Haganuma, N. Nakahata, and Y. Oshima
J. Org. Chem., 69, 352-356 (2004)


Structural Requirements of Dictyopyrones Isolated from Dictyostelium spp. in the Regulation of Dictyostelium Development and in Anti-leukemic Activity

H. Kikuchi, K. Sasaki, J. Sekiya, Y. Maeda, A. Amagai, Y. Kubohara, and Y. Oshima
Bioorg. Med. Chem., 12, 3203-3214 (2004)


Novel Trichothecanes, Paecilomycines A, B, and C, Isolated from Entomopathogenic Fungus, Paecilomyces tenuipes

H. Kikuchi, Y. Miyagawa, Y. Sahashi, S. Inatomi, A. Haganuma, N. Nakahata, and Y. Oshima
Tetrahedron Lett., 45, 6225-6228 (2004)


Peptidoglycan Recognition Protein (PGRP)LE and PGRP-LC act synergistically in Drosophila immunity

A. Takehana, T. Yano, S. Mita, A. Kotani, Y. Oshima, and S. Kurata
EMBO J., 23, 4690-4700 (2004)


A Novel Carbon Skeletal Trichothecane, Tenuipesine A, Isolated from Entomopathogenic Fungus, Paecilomyces tenuipes

H. Kikuchi, Y. Miyagawa, K. Nakamura, Y. Sahashi, S. Inatomi, and Y. Oshima
Org. Lett., 6, 4531-4533 (2004)
page top

2003年

A Newly Established in Vitro Culture Using Transgenic Drosophila Reveals Functional Coupling between the Phospholipase A2-generated Fatty Acid Cascade and Lipopolysaccharide-dependent Activation of the immune deficiency (imd) Pathway in Insect Immunity

M. Yajima, M. Takada, N. Takahashi, H. Kikuchi, S. Natori, Y. Oshima, and S. Kurata
Biochem. J., 371, 205-210 (2003)


Endothelium-dependent Vasodilatory Effect of Vitisin C, a Novel Plant Oligostilbene from Vitis Plants (Vitaceae) in Rabbit Aorta

K. Seya, K. Furukawa, S. Taniguchi, G. Kodzuka, Y. Oshima, M. Niwa, and S. Motomura
Clin. Sci., 105, 73-79 (2003)


Multiple Activities of a Novel Substance, Dictyopyrone C Isolated from Dictyostelium discoideum, in Cellular Growth and Differentiation

Y. Maeda, H. Kikuchi, K. Sasaki, A. Amagai, J. Sekiya, Y. Takaya, and Y. Oshima
Protoplasma, 221, 185-192 (2003)


Metabolites of Febrifugine and Its Synthetic Analogue by Mouse Liver S9 and Their Antimalarial Activity against Plasmodium Malaria Parasite

S. Hirai, H. Kikuchi, H. Kim, K. Begum, Y. Wataya, H. Tasaka, Y. Miyazawa, K. Yamamoto, and Y. Oshima
J. Med. Chem., 46, 4351-4359 (2003)
page top

2002年

Guaiane- and Aristolane-Type Sesquiterpenoids of Nardostachys chinensis Roots

M. Tanitsu, Y. Takaya, M. Akasaka, M. Niwa, and Y. Oshima
Phytochemistry, 59, 845-849 (2002)


The Isolation and Synthesis of Two Novel N-Acetyl glucosamine Derivatives from Dictyostelium Cellular Slime Molds Which Exhibit Neurite Outgrowth Activity

H. Kikuchi J. Komiya, Y. Saito, J. Sekiya, S. Honma, N. Nakahata, and Y. Oshima
Tetrahedron Lett., 43, 1477-1480 (2002)


Potent Antimalarial Febrifugine Analogues against the Plasmodium Malaria Parasite

H. Kikuchi, H. Tasaka, S. Hirai, Y. Takaya, Y. Iwabuchi, H. Ooi, S. Hatakeyama, H. Kim, Y. Wataya, and Yoshiteru Oshima
J. Med. Chem., 45, 2563-2570 (2002)


Overexpression of a Pattern Recognition Receptor, Peptidoglycan Recognition Protein-LE, Activates Imd/Relish-Mediated Antibacterial Defense and the Prophenoloxidase Cascade in Drosophila larvae

A. Takehana, T. Katsuyama, T. Yano, Y. Oshima, H. Takada, T. Aigaki, and S. Kurata
Proc. Natl. Acad. Sci. U.S.A., 99, 13705-13710 (2002)
page top

2001年

Novel Aromatic Substances, Dictyomedin A and B, from Dictyostelium Cellular Slime Molds and Their Inhibitory Effects on Dictyostelium Development

Y. Takaya, H. Kikuchi, Y. Terui, J. Komiya, Y. Maeda, A. Ito, and Y. Oshima
Tetrahedron Lett., 42, 61-63 (2001)


Virol A, a Toxic trans-Polyacetylenic Alcohol of Cicuta virosa, Selectively Inhibits the GABA-Induced Cl(-) Current in Acutely Dissociated Rat Hippocampal CA1 Neurons

K. Uwai, K. Ohashi, Y. Takaya, Y. Oshima, K. Furukawa, K. Yamagata, T. Omura, and S. Okuyama
Brain Res., 889, 174-180 (2001)


Furanodictine A and B, Amino Sugar Analogues Produced by Cellular Slime Mold Dictyostelium discoideum, Showing Neuronal Differentiation Activity

H. Kikuchi, Y. Saito, J. Komiya, Y. Takaya, S. Honma, N. Nakahata, A. Ito, and Y. Oshima
J. Org. Chem., 66, 6982-6987 (2001)
page top

2000年

Novel Acyl a-Pyronoids, Dictyopyrone A, B, and C, from Dictyostelium Cellular Slime Molds

Y. Takaya, H. Kikuchi, Y. Terui, J. Komiya, K. Furukawa, K. Seya, S. Motomura, A. Ito, and Y. Oshima
J. Org. Chem., 65, 985-989 (2000)


Novel Guaiane Endoperoxides, Nardoguaianone A-D, from Nardostachys chinensis Roots and Their Antinociceptive and Antimalarial Activities

Y. Takaya, Y. Takeuji, M. Akasaka, O. Nakagawasai, T. Tadano, K. Kisara, H. Kim, Y. Wataya, M. Niwa, and Y. Oshima
Tetrahedron, 56, 7673-7678 (2000)


Novel Guaianoids, Nardoguaianone E-I, from Nardostachys chinensis Roots

Y. Takaya, M. Akasaka, Y. Takeuji, M. Tanitsu, M. Niwa, and Yoshiteru Oshima
Tetrahedron, 56, 7679-7683 (2000)


Exploring the Structural Basis of Neurotoxicity in C17-Polyacetylenes Isolated from Water Hemlock

K. Uwai, K. Ohashi, Y. Takaya, T. Ohta, T. Tadano, K. Kisara, K. Shibusawa, R. Sakakibara, and Y. Oshima
J. Med. Chem., 43, 4508-4515 (2000)
page top

1999年

New Oligostilbenes Having a Benzofuran from Vitis vinifera 'Kyohou'

J. Ito, Y. Takaya, Y. Oshima, and M. Niwa
Tetrahedron, 55, 2529-2544 (1999)


Stimulation of Neurotrophic Factor Secretion from 1321N1 Human Astrocytoma Cells by Novel Diterpenoids, Scabronines A and G

Y. Obara, N. Nakahata, T. Kita, Y. Takaya, H. Kobayashi, S. Hosoi, F. Kiuchi, T. Ohta, Y. Oshima, and Y. Ohizumi
Eur. J. Pharmacol., 370, 79-84 (1999)


New Type of Febrifugine Analogues, Bearing a Quinolizidine Moiety, Show Potent Antimalarial Activity against Plasmodium Malaria Parasite

Y. Takaya, H. Tasaka, T. Chiba, K. Uwai, M. Tanitsu, H. Kim, Y. Wataya, M. Miura, M. Takeshita, and Y. Oshima
J. Med. Chem., 42, 3163-3166 (1999)


Absolute Stereochemistry of Cicutoxin and Related Toxic Polyacetylenic Alcohols from Cicuta virosa

T. Ohta, Koji Uwai, Rikako Kikuchi, Shigeo Nozoe, Yoshiteru Oshima, Kenrou Sasaki and Fumihiko Yoshizaki
Tetrahedron, 55, 12087-12098 (1999)


Syntheses and Stereochemical Assignment of Toxic C17-Polyacetylenic Alcohols, Virols A, B, and C, Isolated from Water Hemlock (Cicuta virosa)

K. Uwai, Y. Oshima, T. Sugihara, and T. Ohta
Tetrahedron, 55, 9469-9480 (1999)


Febrifugine Fortifies Host Defence in Mice Against Plasmodium berghei NK65

K. Murata, F. Takano, S. Fushiya, and Y. Oshima
Biochem. Pharmacol., 58, 1593-1601 (1999)
page top

1998年

Novel Antimalarial Guaiane-type Sesquiterpenoids from Nardostachys chinensis Roots

Y. Takaya, K. Kurumada, Y. Takeuji, H. Kim, Y. Shibata, N. Ikemoto, Y. Wataya, and Y. Oshima
Tetrahedron Lett., 39, 1361-1364 (1998)


Lepiotins A and B, New Alkaloids from the Mushrooms, Macrolepiota neomastoidea and Chlorophyllum molybdites

T. Ohta, H. Inoue, G. Kusano, and Y. Oshima
Heterocycles, 47, 883-891 (1998)


Postischemic Changes of [3H]Nimodipine and [3H]Ryanodine Binding in the Gerbil Striatum and Hippocampus

T. Araki, H. Kato, K. Shuto, Y. Oshima, and Y. Itoyama
Eur. J. Neurol., 5, 195-201 (1998)


Absolute Configurations of Some Oligostilbenes from Vitis coignetiae and Vitis vinifera 'Kyohou'

J. Ito, K. Gobaru, T. Shimamura, M. Niwa, Y. Takaya, and Y. Oshima
Tetrahedron, 54, 6651-6660 (1998)


Studies on Constituent of "KAKO-BUSHI-MATSU”

M. Matsui, Y. Sato, H. Bando, M. Murayama, T. Osawa, T. Miura, and Y. Oshima
Natural Medicines, 52, 232-235 (1998)


Effect of NG-Nitro-L-Arginine Methyl Ester, a Nitric Oxide Synthase Inhibitor, on Neurotransmitter Receptor Systems in Aged Rats

T. Araki, Y. Oshima, H. Kato, K. Shuto, and Y. Itoyama
Eur. J. Neurol., 5, 601-608 (1998)


Scabronine A, a Novel Diterpenoid Having a Potent Inductive Activity of Nerve Growth Factor Synthesis, Isolated From the Mushroom Sarcodon scabrosus

T. Ohta, T. Kita, N. Kobayashi, Y. Obara, N. Nakahata, Y. Ohizumi, Y. Takaya, and Y. Oshima
Tetrahedron Lett., 39, 6229-6232 (1998)



Scabronines B, C, D, E and F, Novel Diterpenoids Showing Stimulating Activity of Nerve Growth Factor-Synthesis, from the Mushroom Sarcodon scabrosus

T. Kita, Y. Takaya, Y. Oshima, T. Ohta, K. Aizawa, T. Hirano, and T. Inakuma
Tetrahedron, 54, 11877-11886 (1998)


Pharmacological Properties of Pteleprenine, a Quinoline Alkaloid Extracted from Orixa japonica, on Guinea Pig Ileum and Canine Left Atrium

K. Seya, I. Miki, K. Murata, H. Junke, S. Motomura, T. Araki, Y. Itoyama, and Y. Oshima
J. Pharm. Pharmacol., 50, 803-807 (1998)


Enhancement of NO Production in Activated Macrophages in Vivo by an Anti-malarial Crude Drug, Dichroa febrifuga

K. Murata, F. Takano, S. Fushiya, and Y. Oshima
J. Nat. Prod., 61, 729-733 (1998)
page top

1997年

A New Hydroxystilbene Tetramer Named Isohopeaphenol from Vitis vinifera 'Kyohou'

J. Ito, M. Niwa, and Y. Oshima
Heterocycles, 45, 1809-1813 (1997)


Effect of NG-Nitro-L-Arginine on Age-Related Changes of Glutamate Receptor Systems and Immunophilin in Rats

T. Araki, Y. Oshima, H. Kato, K. Shuto, and Y. Itoyama
Meth. Find. Exp. Clin. Pharmacol., 19, 373-381 (1997)


Synthesis and Cataleptic Effects of Optically Active Dihydrohaloperidols and Dihydrobromoperidols

M. Takeshita, M. Miura, T. Hongo, T. Ohkubo, K. Sugawara, K. Kosaka, Y. Takeshita, T. Araki, and Y. Oshima
Chirality, 9, 443-445 (1997)


Specific CYP3A4 Inhibitors in Grapefruit Juice: Furocoumarin Dimers as Components of Drug Interaction

K. Fukuda, T. Ohta, Y. Oshima, N. Ohashi, M. Yoshikawa, and Y. Yamazoe
Pharmacogenetics, 7, 391-396 (1997)


Effects of L-DOPA and Bromocriptine on Haloperidol-induced Motor Deficits in Mice

T. Kobayashi, T. Araki, Y. Itoyama, M. Takeshita, T. Ohta, and Y. Oshima
Life Sci., 61, 2529-2538 (1997)


Vitisins D and E, Novel Oligostilbenes from Vitis coignetiae Stem Barks

K. Shinoda, Y. Takaya, T. Ohta, K. Hisamichi, M. Takeshita, M. Niwa, and Y. Oshima
Heterocycles, 46, 169-172 (1997)


page top