2025.4.30 共同研究の研究成果「Sugawara T. et al, EFA6A, a guanine nucleotide exchange factor for Arf6, regulates developmental stage-dependent spine morphogenesis, synaptic plasticity, and long-term memory in the hippocampus. 」がMolecular Neurobiology誌に受理されました。詳しくは、Publicationをご覧ください。
2024.11.19 共同研究の研究成果「Inagaki R. et al, Aberrant extracellular dopamine clearance in the prefrontal cortex exhibit ADHD-like behavior in NCX3 heterozygous mice. 」がThe FEBS Journal誌に受理されました。詳しくは、Publicationをご覧ください。
2024.3.13 共同研究の研究成果「Inagaki R. et al, Preventive effect of propolis on cognitive decline in Alzheimer’s disease model mice. 」がNeurobiology of Aging誌に受理されました。詳しくは、Publicationをご覧ください。
2022.5.12 共同研究の研究成果「Moriguchi S. et al, Propolis promotes memantine-dependent rescue of cognitive deficits in APP-KI mice. 」がMolecular Neurobiology誌に受理されました。詳しくは、Publicationをご覧ください。
2021.10.27 共同研究の研究成果「Moriguchi S. et al, Memantine improves cognitive deficits via KATP channel inhibition in olfactory bulbectomized mice. 」がMolecular and Cellular Neuroscience誌に受理されました。詳しくは、Publicationをご覧ください。
2020.11.12 共同研究の研究成果「Nakagawasai O. et al, Scabronine G methyl ester improves memory-related behavior and enhances hippocampal cell proliferation and long-term potentiation via the BDNF-CREB pathway in olfactory bulbectomized mice」がFrontiers in Pharmacology誌に受理されました。詳しくは、Publicationをご覧ください。
2020.8.19 共同研究の研究成果「Moriguchi S. et al, Nicotine rescues depressive-like behaviors via α7-type nicotinic acetylcholine receptor activation in CaMKIV null mice」がMolecular Neurobiology誌に受理されました。詳しくは、Publicationをご覧ください。
2020.6.5 共同研究の研究成果「Moriguchi S. et al, Memantine improves depressive-like behaviors via Kir6.1 channel inhibition in olfactory bulbectomized mice」がNeuroscience誌に受理されました。詳しくは、Publicationをご覧ください。
2019.12.6 共同研究の研究成果「Inagaki R. et al, Kir6.1 heterozygous mice exhibit aberrant amygdala-dependent cued fear memory」がMolecular Neurobiology誌に受理されました。詳しくは、Publicationをご覧ください。
"Our aim is to educate the human resources who will take the lead on the development of medicine and clinical pharmacy as pharmaceutical experts."
・Drug Development of Alzheimer’s disease and mental disorders ・Demonstration of brain diabetes hypothesis of Alzheimer’s disease ・Exploration of pathologically relevant genes in neurodegenerative disorders based on failure of calcium signal ・Mechanism of brain inflammation focused on glia cells
Sugawara, T., Matsu-Ura, H., Inagaki, R., Kawamura, T., Tanaka, M., Hara, Y., Saito, K., Fukaya, M., Moriguchi, S., Sakagami, H EFA6A, a Guanine Nucleotide Exchange Factor for Arf6, Regulates Developmental Stage-Dependent Spine Morphogenesis, Synaptic Plasticity, and Long-Term Memory in the Hippocampus. Mol Neurobiol 62:11904-11919 (2025)
Inagaki, R., Kita, S., Niwa, N., Fukunaga, K., Iwamoto, T., Moriguchi, S Aberrant extracellular dopamine clearance in the prefrontal cortex exhibit ADHD-like behavior in NCX3 heterozygous mice. FEBS J 292: 426-444 (2025)
Inagaki, R., Yamakuni, T., Saito, T., Saido, T.C., Moriguchi, S Preventive effect of propolis on cognitive decline in Alzheimer’s disease model mice. Neurobiology of Aging 139: 20-29 (2024)
Moriguchi, S., Inagaki, R., Saito, T., Saido, T.C., Fukunaga, K. Propolis promotes memantine-dependent rescue of cognitive deficits in APP-KI mice. Mol Neurobiol. 59: 4630-4646 (2022)
Moriguchi, S., Inagaki, R., Fukunaga, K. Memantine improves cognitive deficits via KATP channel inhibition in olfactory bulbectomized mice. Mol. Cell. Neurosci. 117:103680 (2021)
Nakagawasai, O., Jia-Rong, L., Odaira, T., Takahashi, K., Nemoto, W., Moriguchi, S., Yabuki, Y., Kobayakawa, Y., Fukunaga, K., Nakada, M., Tan-No, K. Scabronine G methyl ester improves memory-related behavior and enhances hippocampal cell proliferation and long-term potentiation via the BDNF-CREB pathway in olfactory bulbectomized mice. Front Pharmacol. 11: 583291 (2020)
Moriguchi, S., Inagaki, R., Yi, L., Shibata, M., Fukunaga, K. Nicotine rescues depressive-like behaviors via α7-type nicotinic acetylcholine receptor activation in CaMKIV null mice. Mol Neurobiol. 57: 4929-4940 (2020)
Moriguchi, S., Inagaki, R., Shimojo, H., Sugimura, Y., Sakagami, H., Fukunaga, K. Memantine improves depressive-like behaviors via Kir6.1 channel inhibition in olfactory bulbectomized mice. Neuroscience. 442: 264-273 (2020)
Inagaki, R., Moriguchi, S., Fukunaga, K. Kir6.1 heterozygous mice exhibit aberrant amygdala-dependent cued fear memory. Mol Neurobiol 57: 1622-1635 (2020)
Moriguchi, S., Kita, S., Inagaki, R., Yabuki, Y., Sasaki, Y., Ishikawa, S., Sakagami, H., Iwamoto, T., Fukunaga, K. Aberrant amygdala-dependent cued fear memory in Na+/Ca2+ exchanger 1 heterozygous mice. Mol Neurobiol. 56: 4381-4394 (2019)
Moriguchi, S., Kita, S., Yabuki, Y., Inagaki, R., Izumi, H., Sasaki, Y., Tagashira, H., Horie, K., Takeda, J., Iwamoto, T., Fukunaga, K. Reduced CaM kinase II and CaM kinase IV activities underlie cognitive deficits in NCKX2 heterozygous mice. Mol Neurobiol. 55: 3889-3900 (2018)
Moriguchi, S., Ishizuka, T., Yabuki, Y., Shioda, N., Sasaki, Y., Tagashira, H., Yawo, H., Yeh, JZ., Sakagami, H., Narahashi, T., Fukunaga, K. Blockade of the KATP channel Kir6.2 by memantine represents a novel mechanism relevant to Alzheimer’s disease therapy. Mol Psychiatry. 128: 927-937 (2018)
Inagaki, R., Moriguchi, S., Fukunaga, K. Aberrant Amygdala-dependent Fear Memory in Corticosterone-treated Mice. Neuroscience. 388: 448-459 (2018)
Moriguchi, S., Kita, S., Fukaya, M., Osanai, M., Inagaki, R., Sasaki, Y., Izumi, H., Horie, K., Takeda, J., Saito, T., Sakagami, H., Saido, T.C., Iwamoto, T., Fukunaga, K. Reduced expression of Na+/Ca2+ exchanges is associated with cognitive deficits seen in Alzheimer’s disease model mice. Neuropharmacology. 131: 291-303 (2018)
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Associate Professor Shigeki Moriguchi (Ph.D.)
Mail Address： shigeki.moriguchi.a3(at)tohoku.ac.jp
Dr. Shigeki Moriguchi obtained the Ph.D. in 2001 from the Graduate School of Pharmaceutical Sciences, Kyushu University. Dr. Moriguchi has been studying as a postdoctoral fellow at Northwestern University Medical School in the United States since 2001 to 2004 (Prof. Toshio Narahashi’s Lab). Dr. Moriguchi was assigned as an assistant professor at the Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University at 2004 (Prof. Kohji Fukunaga’s Lab), then appointed as an associate professor (P.I.) of Research Center for Pharmaceutical development (RCPD), Graduate School of Pharmaceutical Sciences, Tohoku University at 2019. Dr. Moriguchi is focused on the mechanisms underlying Alzheimer’s disease, especially, cognition, and depression, aggression, and anxiety. Dr. Moriguchi also performs the drug development of Alzheimer’s disease target for brain diabetes hypothesis. This pursuit employs a combination of electrophysiological, biochemical, genetic and behavioral approaches.
Research Assistant Professor Ryo Inagaki (Ph.D.)
Mail Address: ryo.inagaki.a2(at)tohoku.ac.jp
D3 Narumi Endo
M2 Hayato Okino
M2 Wakana Matsumoto
M1 Keigo Ito
B4 Hinata Kawada
Technical Assistant Kanae Iwase
Alumni Nozomu Niwa (2025 Master's degree)
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i = 0;
while (!deck.isInOrder()) {
print 'Iteration ' + i;
deck.shuffle();
i++;
}
print 'It took ' + i + ' iterations to sort the deck.';
