{"id":492,"date":"2020-12-03T13:52:12","date_gmt":"2020-12-03T04:52:12","guid":{"rendered":"http:\/\/www.pharm.tohoku.ac.jp\/research_center\/?page_id=492"},"modified":"2024-03-18T14:36:57","modified_gmt":"2024-03-18T05:36:57","slug":"achievement","status":"publish","type":"page","link":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/achievement\/","title":{"rendered":"\u696d\u7e3e"},"content":{"rendered":"\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

\u8a2a\u554f\u8a18\u9332<\/h2>

\u30fb2022\u5e7412\u670805\u65e5\u3000\u30b7\u30e3\u30ea\u30d5\u30fb\u30d2\u30c0\u30fc\u30e4\u30c3\u30c8\u30a5\u30e9\u56fd\u7acb\u30a4\u30b9\u30e9\u30e0\u5927\u5b66\u30b8\u30e3\u30ab\u30eb\u30bf\u5065\u5eb7\u79d1\u5b66\u90e8\u304b\u3089 Zilhadia\u5065\u5eb7\u5316\u5b66\u90e8\u9577\u3001Yuli Amran\u5065\u5eb7\u5316\u5b66\u526f\u5b66\u90e8\u9577\u3001Fajar Ariyanti\u516c\u8846\u885b\u751f\u30d7\u30ed\u30b0\u30e9\u30e0\u30b3\u30fc\u30c7\u30a3\u30cd\u30fc\u30bf\u304c\u8868\u656c\u8a2a\u554f\u3055\u308c\u307e\u3057\u305f\u3002\uff08\u8a73\u7d30<\/a>\uff09
\u30fb2022\u5e7409\u670803\u65e5\u3000\u7b2c 3 \u56de BINDS \u5408\u6210\u52c9\u5f37\u4f1a\u306b\u304a\u3044\u3066\u3001\u65bd\u8a2d\u898b\u5b66\u3092\u884c\u3044\u307e\u3057\u305f\u3002\uff08\u8a73\u7d30<\/a>\uff09
\u30fb2022\u5e7407\u670801\u65e5\u3000\u5927\u91ce\u7dcf\u9577\u3001\u9752\u6728\u7406\u4e8b\u30fb\u526f\u5b66\u9577\u304c\u8a2a\u554f\u3055\u308c\u307e\u3057\u305f\u3002\uff08\u8a73\u7d30<\/a>\uff09<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u30fb\u30dd\u30b9\u30bf\u30fc<\/h2>

\u7b2c\uff12\u56de\u3000\u533b\u85ac\u54c1\u958b\u767a\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u30bb\u30df\u30ca\u30fc (2022\u5e746\u67083\u65e5)\uff08\u30dd\u30b9\u30bf\u30fc<\/a>\uff09
\u7b2c\uff11\u56de\u3000\u533b\u85ac\u54c1\u958b\u767a\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u30bb\u30df\u30ca\u30fc (2022\u5e745\u670812\u65e5)\uff08\u30dd\u30b9\u30bf\u30fc<\/a>\uff09
\u533b\u85ac\u54c1\u958b\u767a\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u8b1b\u6f14\u4f1a(2020\u5e741\u670816\u65e5\uff09\uff08\u30dd\u30b9\u30bf\u30fc<\/a>\uff09<\/p>

\u7b2c\uff15\u56de\u3000\u7406\u7814\u30fb\u661f\u85ac\u79d1\u5927\u5b66\u30fc\u6771\u5317\u5927\u5b66\u5927\u5b66\u9662\u85ac\u5b66\u7814\u7a76\u79d1\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 (2022\u5e7412\u670816\u65e5)\uff08\u30dd\u30b9\u30bf\u30fc<\/a>\uff09
\u7b2c\uff14\u56de\u3000\u7406\u7814\u30fb\u661f\u85ac\u79d1\u5927\u5b66\u30fc\u6771\u5317\u5927\u5b66\u5927\u5b66\u9662\u85ac\u5b66\u7814\u7a76\u79d1\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 (2021\u5e7412\u670824\u65e5)\uff08\u30dd\u30b9\u30bf\u30fc<\/a>\uff09
\u7b2c\uff13\u56de\u3000\u7406\u7814\u30fb\u661f\u85ac\u79d1\u5927\u5b66\u30fc\u6771\u5317\u5927\u5b66\u5927\u5b66\u9662\u85ac\u5b66\u7814\u7a76\u79d1\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0 (2020\u5e7412\u670824\u65e5)\uff08\u30dd\u30b9\u30bf\u30fc<\/a>\uff09<\/p>

\u7b2c\uff19\u56de\u3000\u533b\u85ac\u54c1\u958b\u767a\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u3000\u300c\u4f4e\u5206\u5b50\u3067\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7e70\u308b\u300d(2024\u5e743\u670815\u65e5\uff09\uff08\u30dd\u30b9\u30bf\u30fc<\/a>\uff09
\u7b2c\uff18\u56de\u3000\u533b\u85ac\u54c1\u958b\u767a\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u3000\u300c\u6311\u6226\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u304b\u3089\u5275\u85ac\u3078\u300d(2023\u5e748\u67087\u65e5\uff09\uff08\u30dd\u30b9\u30bf\u30fc<\/a>\uff09
\u7b2c\uff17\u56de\u3000\u533b\u85ac\u54c1\u958b\u767a\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u3000\u300c\u5909\u6027\u30fb\u640d\u50b7\u3068\u305d\u306e\u9632\u5fa1\u300d\u3000\uff082023\u5e743\u67087\u65e5\uff09\uff08\u30dd\u30b9\u30bf\u30fc<\/a>\uff09
\u7b2c\uff16\u56de\u3000\u533b\u85ac\u54c1\u958b\u767a\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u3000\u300c\u5148\u5c0e\u3059\u308b\u89e3\u6790\u529b\u300d\u3000\uff082022\u5e748\u67082\u65e5\uff09\uff08\u30dd\u30b9\u30bf\u30fc<\/a>\uff09
\u7b2c\uff15\u56de\u3000\u533b\u85ac\u54c1\u958b\u767a\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u3000\u300c\u5275\u85ac\u3078\u306e\u9769\u65b0\u7684\u30a2\u30d7\u30ed\u30fc\u30c1\u300d\u3000\uff082022\u5e742\u670822\u65e5\uff09\uff08\u30dd\u30b9\u30bf\u30fc<\/a>\uff09
\u7b2c\uff14\u56de\u3000\u533b\u85ac\u54c1\u958b\u767a\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u3000\u300c\u8133\u3068\u5275\u85ac\u300d\uff082021\u5e748\u67086\u65e5\uff09\uff08\u30dd\u30b9\u30bf\u30fc<\/a>\uff09
\u7b2c\uff13\u56de\u3000\u533b\u85ac\u54c1\u958b\u767a\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u3000\u300c\u514d\u75ab\u3068\u5275\u85ac\u300d\uff082020\u5e7412\u670810\u65e5\uff09\uff08\u30dd\u30b9\u30bf\u30fc<\/a>\uff09
\u7b2c\uff12\u56de\u3000\u533b\u85ac\u54c1\u958b\u767a\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u3000\u300c\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u5275\u85ac\u300d(2020\u5e747\u670828\u65e5\uff09\uff08\u30dd\u30b9\u30bf\u30fc<\/a>\uff09
\u7b2c\uff11\u56de\u3000\u533b\u85ac\u54c1\u958b\u767a\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u3000(2019\u5e7411\u670815\u65e5\uff09\uff08\u30dd\u30b9\u30bf\u30fc<\/a>\uff09<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

2023<\/h2>

Original Articles<\/h3>
  1. The Mycobacterium tuberculosis mycothiol S-transferase is divalent metal-dependent for mycothiol binding and transfer
    Yahani P. Jayasinghe, Michael T. Banco, Jared J. Lindenberger, Lorenza Favrot, Zuzana Pal\u010dekov\u00e1, Mary Jackson, Shino Manabe, Donald R. Ronning, RSC Med. Chem.<\/strong> in press.<\/em> doi.org\/10.1039\/D2MD00401A<\/a><\/li>
  2. Tumor targeting of 211<\/sup>At-labeled antibody under sodium ascorbate protection against radiolysis
    Hiroki Takashima, Kazunobu Ohnuki, Shino Manabe, Yoshikatsu Koga, Ryo Tsumura, Takahiro Anzai, Yang Wang, Xiaojie Yin, Nozomi Sato, Yudai Shigekawa, Akihiro Nambu, Sachiko Usuda, Hiromitsu Haba, Hirofumi Fujii, Masahiro Yasunaga, Mol. Pharm.<\/strong> 20(2), 1156\u20131167 (2023).     doi.10.1021\/acs.molpharmaceut.2c00869<\/a><\/li>
  3. LiHMDS-mediated deprotonative coupling of toluenes with ketone
    Masanori Shigeno, Akihisa Kajima, Eito Toyama, Toshinobu Korenaga, Hiroyuki Yamakoshi, Kanako Nozawa-Kumada, Yoshinori Kondo, Chem. Eur. J.<\/strong> e202203549 (2023)     doi.org\/10.1002\/chem.202203549<\/a><\/li><\/ol>

    Reviews<\/h3>
    1. Function of protein C-mannosylation in physiology and pathology
      Kazuchika Nishitsuji, Midori Ikezaki, Shino Manabe, Yoshito Ihara Trends Glycosci.<\/strong> Glycotechnol. 35, E23\u2013E27 (2023); 35, J23\u2013J27 (2023).       doi.org\/10.4052\/tigg.2218.1e<\/a><\/li><\/ol>

      Proceedings<\/h3>
      1. Prevention of radionuclide-induced antibody denaturation maintains active targeting and maximizes antitumor efficacy in 211At-radioimmunotherapy, Hiroki Takashima, Kazunobu Ohnuki, Shino Manabe, Yoshikatsu Koga, Ryo Tsumura, Takashiro, Anzai, Yang Wang, Xiaojie Yin, Nozomi Sato, Yudai Shigekawa, Akihiro Nambu, S. Usuda, Hiromitsu Haba, Hirofumi Fujii, Masahiro Yasunaga, RIKEN Accel. Prog. Rep<\/strong>. in press.<\/em><\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
        \n\t\t\t\t\t\t
        \n\t\t\t\t\t
        \n\t\t\t
        \n\t\t\t\t\t\t
        \n\t\t\t\t
        \n\t\t\t\t\t\t\t
        \n\t\t\t
        <\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
        \n\t\t\t\t\t\t
        \n\t\t\t\t\t
        \n\t\t\t
        \n\t\t\t\t\t\t
        \n\t\t\t\t
        \n\t\t\t\t\t\t\t\t\t

        2022<\/h2>

        Original Articles<\/h3>
        1. Stereoselective synthesis of the DE ring portion of kadcoccilactone A by a radical addition\/cyclization approach, Kimihiro Noguchi, Sayuri Saito, Hiroyuki Yamakoshi, Seiichi Nakamura, Eur. J. Org. Chem.<\/strong> e202201201 (2022) doi.org\/10.1002\/ejoc.202201201<\/a><\/li>
        2. Protection from contamination by 211At, an enigmatic but promising alpha emitter Kazunobu Ohnuki, Mitsuyoshi Yoshimoto, Hiromitsu Haba, Shino Manabe, Hiroki Takashima, Masahiro Yasunaga, Hirofumi Fujii, EJNMMI Physics<\/strong>, 9, 39 (2022). doi.org\/10.1186\/s40658\u2010022\u201000469\u20109<\/a><\/li>
        3. Structure-activity relationship and mechanistic study on gugglesterone derivatives; discovery of new anti-pancreatic cancer candidate
          Kohyama, A.; Kim, M. J.; Yokoyama, R.; Sun, S.; Omar, A. M.; Phan, N. D.; Meselhy, M. R.; Tsuge, K.; Awale, S.; Matsuya, Y. Bioorg. Med. Chem.<\/strong> 54(15), 116563 (2022).           doi.org\/10.1016\/j.bmc.2021.116563<\/a><\/li>
        4. Direct C-H carboxylation forming polyfunctionalized aromatic carboxylic acids by combined Bronsted bases
          Masanori Shigeno, Kazuya Hanasaka, Itsuki Tohara, Koki Izumi, Hiroyuki Yamakoshi, Eunsang Kwon, Kanako Nozawa- Kumada, Yoshinori Kondo
          Org. Lett.<\/strong> 24(3), 809-814 (2022)           DOI:10.1021\/acs.orglett.1c03866<\/a><\/li>
        5. Thrombospondin type 1 repeat-derived C-mannosylated peptide attenuates synaptogenesis of cortical neurons induced by primary astrocytes via TGF-\u03b2
          Kazuchika Nishitsuji, Midori Ikezaki, Shino Manabe, Kenji Uchimura, Yukishige Ito, Yoshito Ihara
          Glycoconj. J.<\/strong> 39(5), 701-710.           DOI:10.1007\/s10719-021-10030-y<\/a><\/li>
        6. C-Mannosylated tryptophan-containing peptide binds 1 to actinin-4 and suppresses E2 cadherin-dependent cell-cell interactions in lung epithelial-like A549 cells
          Midori Ikezaki, Kazuchika Nishitsuji, Ko Matsumura, Shino Manabe, Yukinao Shibukawa, Yoshinao Wada, Yukishige Ito, Yoshito Ihara
          Biochimie<\/strong>, 192, 136-146 (2022)           DOI:10.1016\/j.biochi.2021.10.007<\/a><\/li><\/ol>

          Reviews<\/h3>
          1. Sodium ascorbate protects 211At-labeled antibodies from reactive oxygen species damage
            Shino Manabe, Hiroki Takashima, Yoshikatsu Koga, Kazunobu Onuki, Ryo Tsumura, Takahiro Anzai, Nozomu Iwata, Masahiro Yasunaga, Yang Wang, Takuya Yokokita, Yukiko Komori, Daiki Mori, Hiromitsu Haba, Hirofumi Fujii, Yasuhiro Matsumura, RIKEN <\/em>Accel. Prog. Rep<\/strong>.<\/strong> 55, S25 (2022).<\/em><\/li><\/ol>

            Proceedings<\/h3>
            1. Sodium ascorbate protects 211At-labeled antibodies from reactive oxygen species damage Shino Manabe, Hiroki Takashima, Yoshikatsu Koga, Kazunobu Onuki, Ryo Tsumura, Takahiro Anzai, Nozomu Iwata, Masahiro Yasunaga, Yang Wang, Takuya Yokokita, Yukiko Komori, Daiki Mori, Hiromitsu Haba, Hirofumi Fujii, Yasuhiro Matsumura, RIKEN Accel. Prog. Rep.<\/strong> 55, S25 (2022).<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
              \n\t\t\t\t\t\t
              \n\t\t\t\t\t
              \n\t\t\t
              \n\t\t\t\t\t\t
              \n\t\t\t\t
              \n\t\t\t\t\t\t\t
              \n\t\t\t
              <\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
              \n\t\t\t\t\t\t
              \n\t\t\t\t\t
              \n\t\t\t
              \n\t\t\t\t\t\t
              \n\t\t\t\t
              \n\t\t\t\t\t\t\t\t\t

              2021<\/h2>

              Regular papers<\/h3>
              1. Stabilization of an 211<\/sup>At-labelled antibody with sodium ascorbate
                Shino Manabe, Hiroki Takashima, Kazunobu Ohnuki, Yoshikatsu Koga, Ryo Tsumura, Nozomi Iwata, Yang Wang, Takuya Yokokita, Yukiko Komori, Sachiko Usuda, Daiki Mori, Hiromitsu Haba, Hirofumi Fujii, Masahiro Yasunaga, Yasuhiro Matsumura
                ACS Omega,<\/em> in press.<\/em> DOI:10.1021\/acsomega.1c00684<\/a><\/li>
              2. Antitumor effect of an 211<\/sup>At-labeled anti-tissue factor antibody protected by sodium ascorbate in gastric cancer xenograft models
                Hiroki Takashima, Yoshikatsu Koga, Shino Manabe, Kazunobu Onuki, Ryo Tsumura, Takahiro Anzai, Nozomi Iwata, Yan Wang, Takuya Yokokita, Yukiko Komori, Daiki Mori, Hiromitsu Haba, Hirofumi Fujii, Yasuhiro Matsumura, Masahiro Yasunaga,
                Cancer Sci.<\/em> 112<\/strong>(5), 1975\u20131986 (2021)                 DOI:10.1111\/cas.14857<\/a><\/li>
              3. Quantification of serum C-mannosyl tryptophan by novel assay to evaluate renal function and vascular complications in patients with type 2 diabetes
                Shuhei Morita, Yoko Inai, Shiho Minakata, Shohei Kishimoto, Shino Manabe, Naoyuki Iwahashi, Kazuhiko Ino, Yukishige Ito, Takashi Akamizu, Yoshito Ihara
                Sci. Rep.<\/em> 11<\/strong>, 1946 (2021)                 DOI:10.1038\/s41598-021-81479-y<\/a><\/li>
              4. Antitumor effect of humanized anti-tissue factor antibody-drug conjugate in peritoneal disseminated pancreatic cancer model
                Ryo Tsumura, Takahiro Anzai, Shino Manabe, Hiroki Takashima, Yoshikatsu Koga, Masashiro Yasunaga, Yasuhiro Matsumura
                Oncol. Rep.<\/em> 45<\/strong>(1), 329-336 (2021)                 DOI:10.3892\/or.2020.7850<\/a><\/li>
              5. Stereoselective 1,4-Addition of Primary Alcohols to \u03b3-Alkoxy-\u03b1,\u03b2-unsaturated Esters
                Saki Inatomi, Yuta Takayanagi, Kento Watanabe, Akinori Toita, Hiroyuki Yamakoshi, Seiichi Nakamura
                Synthesis<\/em> 53<\/strong>(01), 161\u2013174 (2021)                 DOI:10.1055\/s-0040-1707274<\/a><\/li><\/ol>

                Reviews<\/h3>
                1. Antibody glycoengineering and homogeneous antibody-drug conjugate preparation
                  Shino Manabe, Yoshiki Yamaguchi
                  Chem. Rec.<\/strong> 21 (11) 3005-3014 (2021)
                  DOI:10.1002\/tcr.202100054<\/a><\/li>
                2. Recent development of stereoselective glycosylation reactions
                  Shino Manabe
                  Heterocycles,<\/em> 102<\/strong>(2) 177-201 (2021)                   DOI:10.3987\/REV-20-933<\/a><\/li>
                3. Protein C-mannosylation and C-mannosyl tryptophan in chemical biology and medicine
                  Shiho Minakata, Shino Manabe, Yoko Inai, Midori Ikezaki, Kazuchika Nishitsuji, Yukishige Ito, Yoshito Ihara
                  Molecules<\/em>, 26, 5258 (2021)                   DOI:10.3390\/molecules26175258<\/a><\/li><\/ol>

                  Proceedings<\/h3>
                  1. Development of radioimmunotherapy with astatine-211-counjugated antibodies Hiroki Takashima, Yoshikatsu Koga, K. Onuki, Shino Manabe, Ryo Tsumura T. Anzai, N. Iwata, Masahiro Yasunaga, W. Yang, T. Yokokita, Yukiko Komori, Daiki Mori, Hitomitsu Haba, Hirofumi Fujii, Yasuhiro Matsumura
                    RIKEN Accel. Prog. Rep.<\/em> in press.<\/em><\/li><\/ol>

                    Books<\/h3>
                    1. C-Mannosyl tryptophan: from chemistry to biology
                      Yoshito Ihara, Shino Manabe, Yoko Inai, Yukishige Ito, in \u201cComprehensive Glycoscience, IV Second Edition<\/em>\u201c Johannis P. Karmerling, Gert. J. Boons, Yuan Chan Lee, Akemi Suzuki, Naoyuki Taniguchi, A. G. J. Voragen eds.
                      Elsevier, in press.<\/em><\/li>
                    2. Spontaneous Raman and SERS microscopy for Raman tag imaging
                      Hiroyuki Yamakoshi, Katsumasa Fujita
                      \u201cStimulated Raman scattering microscopy techniques and applications\u201d, 1st Edition
                      Eds by J.-X. Cheng, W. Min, Y. Ozeki, D. Polli; Elsevier;<\/em> pp 275-287 (2021)<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
                      \n\t\t\t\t\t\t
                      \n\t\t\t\t\t
                      \n\t\t\t
                      \n\t\t\t\t\t\t
                      \n\t\t\t\t
                      \n\t\t\t\t\t\t\t
                      \n\t\t\t
                      <\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
                      \n\t\t\t\t\t\t
                      \n\t\t\t\t\t
                      \n\t\t\t
                      \n\t\t\t\t\t\t
                      \n\t\t\t\t
                      \n\t\t\t\t\t\t\t\t\t

                      2020\u5e74<\/h2>

                      Regular papers<\/h3>
                      1. Monomeric C-mannosyl tryptophan is a degradation product of autophagy in cultured cells
                        Shiho Minakata, Yoko Inai, Shino Manabe, Kazuchika Nishitsuji, Yukishige Ito, Yoshito Ihara
                        Glycoconj. J.<\/em> 37<\/strong>(5), 635-645 (2020) DOI:10.1007\/s10719-020-09938-8<\/a><\/li>
                      2. C-Mannosyl tryptophan increases in the plasma of ovarian cancer
                        Naoyuki Iwahashi, Yoko Inai, Shiho Minakata, Sho Sakurai, Shino Manabe, Yukishige Ito, Kazuhiko Ino, Yoshito Ihara
                        Oncol. Lett.<\/em> 19<\/strong>(1), 908-919 (2020)                         DOI:10.3892\/ol.2019.11161<\/a><\/li>
                      3. Quantitative Drug Dynamics Visualized by Alkyne-Tagged Plasmonic-Enhanced Raman microscopy
                        Kota Koike, Kazuki Bando, Jun Ando, Hiroyuki Yamakoshi, Naoki Terayama, Kosuke Dodo, Nicholas Isaac Smith, Mikiko Sodeoka, and Katsumasa Fujita,
                        ACS Nano<\/em> 14<\/strong>(11), 15032\u201315041 (2020)                         DOI:10.1021\/acsnano.0c05010<\/a><\/li>
                      4. Kir6.1 heterozygous mice exhibit aberrant amygdala-dependent cued fear memory
                        Ryo Inagaki\u2020, Shigeki Moriguchi\u2020, and Kohji Fukunaga, \uff08\u2020Contributd equally to this work\uff09
                        Mol Neurobio<\/em>l 57<\/strong>, 1622-1635 (2020)                         DOI:10.1007\/s12035-019-01840-1<\/a><\/li>
                      5. Memantine improves depressive-like behaviors via Kir6.1 channel inhibition in olfactory bulbectomized mice
                        Shigeki Moriguchi, Ryo Inagaki, Hirotsugu Shimojo, Yoshihiko Sugimura, and Kohji Fukunaga
                        Neuroscience<\/em> 442<\/strong>, 264-273 (2020)                         DOI:10.1016\/j.neuroscience.2020.06.002<\/a><\/li>
                      6. Nicotine rescues depressive-like behaviors via \u03b17-type nicotinic acetylcholine receptor activation in CaMKIV null mice
                        Shigeki Moriguchi, Ryo Inagaki, Lusha Yi, Mikako Shibata, Hiroyuki Sakagami, and Kohji Fukunaga
                        Mol Neurobiol<\/em> 57<\/strong>, 4929-4940 (2020)                         DOI:10.1007\/s12035-020-02077-z<\/a><\/li>
                      7. Scabronine G methyl ester improves memory-related behavior and enhances hippocampal cell proliferation and long-term potentiation via the BDNF-CREB pathway in olfactory bulbectomized mice
                        Osamu Nakagawasai, Lin Jia-Rong, Takayo Odaira, Kohei Takahashi, Wataru Nemoto, Shigeki Moriguchi, Yasushi Yabuki, Yu Kobayakawa, Kohji Fukunaga, Masahisa Nakada, and Koichi Tan-No
                        Front Pharmacol<\/em> 11<\/strong>, 583291 (2020)                         DOI:10.3389\/fphar.2020.583291<\/a><\/li><\/ol>

                        Reviews<\/h3>
                        1. Glycan-conjugated homogeneous antibody-drug conjugate synthesis
                          Shino Manabe
                          Translate. Regulat. Sci.<\/em> 2<\/strong>(3), 84\u201389 (2020)                           DOI:10.33611\/trs.2020_012<\/a><\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
                          \n\t\t\t\t\t\t
                          \n\t\t\t\t\t
                          \n\t\t\t
                          \n\t\t\t\t\t\t
                          \n\t\t\t\t
                          \n\t\t\t\t\t\t\t
                          \n\t\t\t
                          <\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
                          \n\t\t\t\t\t\t
                          \n\t\t\t\t\t
                          \n\t\t\t
                          \n\t\t\t\t\t\t
                          \n\t\t\t\t
                          \n\t\t\t\t\t\t\t\t\t

                          2019\u5e74<\/h2>

                          BOOK<\/h3>
                          1. Recent Progress in Linker Technology for Antibody-drug Conjugates: Methods for Connection and Release
                            Shino Manabe
                            Cancer Drug Delivery Systems based on the Tumor Microenvironment. eds.<\/em> by Yasuhiro Matsumura and David Tarin, Springer, pp. 93-123 (2019)<\/li>
                          2. Preclinical Studies of ADC Therapy for Solid Tumors
                            Yoshikatsu Koga, Ryo Tsumura, Shino Manabe, Yasuhiro Matsumura
                            Cancer Drug Delivery Systems based on the Tumor Microenvironment. eds.<\/em> by Yasuhiro Matsumura and David Tarin Springer, pp. 125-154 (2019)<\/li>
                          3. CAST Therapy
                            Masahiro Yasunaga, Shino Manabe, Yasuhiro Matsumura
                            Cancer Drug Delivery Systems based on the Tumor Microenvironment. eds.<\/em>\u00a0by Yasuhiro Matsumura and David Tarin Springer, pp. 269-288 (2019)<\/li><\/ol>

                            REVIEWS<\/h3>
                            1. Tips for DDS; Normal and Reverse phase DDS (J)
                              Shino Manabe
                              Drug Delivery Syst.<\/em> 35,<\/strong> 147-149 (2020)<\/li>
                            2. Importance of Linker Design in ADC Development (J)
                              Shino Manabe and Yoshiki Yamaguchi
                              Medical Review,<\/em> 17,<\/strong> 11-15 (2019)<\/li>
                            3. Antibody-drug conjugate preparation though Glycan Remodeling (J)
                              Shino Manabe and Yoshiki Yamaguchi
                              Fine Chemical,<\/em>\u00a048,<\/strong>\u00a051-59 (2019)<\/li><\/ol>

                              REGULAR ARTICLES<\/h3>
                              1. Aberrant amygdala-dependent cued fear memory in Na+<\/sup>\/Ca2+<\/sup>\u00a0 exchanger 1 heterozygous mice
                                Shigeki Moriguchi, Satomi Kita, Ryo Inagaki, Yasushi Yabuki, Yuzuru Sasaki, Shun Ishikawa, Hiroyuki Sakagami, Takahiro Iwamoto and Kohji Fukunaga
                                Mol. Neurobiol.<\/em> 56<\/strong>, 4381-4394 (2019)<\/li>
                              2. Synthesis of Propargylic Ethers by Gold-Mediated Reaction of Terminal Alkynes with Acetals
                                Miyu Furuta, Kyoko Sugiyama, Minami Yamaguchi, Hirofumi Ueda, Hidetoshi Tokuyama
                                Chem. Pharm. Bull.<\/em>, 67<\/strong>, 872-876 (2019)<\/li>
                              3. Selenoprotein P; P for Plasma, Prognosis, Prophylaxis, and More
                                Ryouhei Tsutsumi and Yoshiro Saito
                                Biological and Pharmaceutical Bulletin<\/em>,\u00a043<\/strong>, 366-374(2020)<\/li>
                              4. Protease-activated receptor 2 exacerbates cisplatin-induced nephrotoxicity.
                                Mari Watanabe, Yuji Oe, Emiko Sato, Akiyo Sekimoto, Hiroshi Sato, Sadayoshi Ito, and Nobuyuki
                                Takahashi
                                American Journal of Physiology Renal Physiology<\/em>, 316(4), F654-F659, (2019)<\/li>
                              5. Nicotinamide alleviates kidney injury and pregnancy outcomes in lupus-prone MRL\/lpr mice treated
                                with lipopolysaccharide.
                                Kenta Imaruoka, Yuji Oe, Tomofumi Fushima, Emiko Sato, Akiyo Sekimoto, Hiroshi Sato, Junichi
                                Sugawara, Sadayoshi Ito, Nobuyuki Takahashi
                                Biochemical and Biophysical Research Communications<\/em>, 510(4), 587-593, (2019)<\/li>
                              6. Protease-activated receptor 2 protects against VEGF inhibitor-induced glomerular endothelial and
                                podocyte injury.
                                Yuji Oe, Tomofumi Fushima, Emiko Sato, Akiyo Sekimoto, Kiyomi Kisu, Hiroshi Sato, Junichi
                                Sugawara, Sadayoshi Ito, Nobuyuki Takahashi
                                Scientific Reports<\/em>, 9, 2986, (2019)<\/li>
                              7. Tadalafil alleviates preeclampsia and fetal growth restriction in RUPP model of preeclampsia in mice.
                                Akiyo Sekimoto, KayoTanaka , Yamato Hashizume, Emiko Sato, Tomoaki Ikeda, Nobuyuki Takahashi
                                Biochemical and Biophysical Research Communications<\/em>, 521(3), 769-774, (2020)<\/li>
                              8. Glomerular Injury Is Exacerbated in Lupus-Prone MRL\/lpr Mice Treated with a Protease-Activated
                                Receptor 2 Antagonist.
                                Rina Itto, Yuji Oe, Kenta Imaruoka, Emiko Sato, Akiyo Sekimoto, Shu Yamakage, Satoshi Kumakura,
                                Hiroshi Sato, Sadayoshi Ito, Nobuyuki Takahashi
                                Tohoku Journal of Experimental Medicine<\/em>, 249(2), 127-133, (2019)<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

                                \u8a2a\u554f\u8a18\u9332 \u30fb2022\u5e7412\u670805\u65e5\u3000\u30b7\u30e3\u30ea\u30d5\u30fb\u30d2\u30c0\u30fc\u30e4\u30c3\u30c8\u30a5\u30e9\u56fd\u7acb\u30a4\u30b9\u30e9\u30e0\u5927\u5b66\u30b8\u30e3\u30ab\u30eb\u30bf\u5065\u5eb7\u79d1\u5b66\u90e8\u304b\u3089 Zilhadia\u5065\u5eb7\u5316\u5b66\u90e8\u9577\u3001Yuli Amran\u5065\u5eb7\u5316\u5b66\u526f\u5b66\u90e8\u9577\u3001Fajar Ariyanti\u516c\u8846\u885b\u751f\u30d7\u30ed\u30b0\u30e9\u30e0\u30b3 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"vkexunit_cta_each_option":"","footnotes":""},"class_list":["post-492","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/pages\/492","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/comments?post=492"}],"version-history":[{"count":85,"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/pages\/492\/revisions"}],"predecessor-version":[{"id":1332,"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/pages\/492\/revisions\/1332"}],"wp:attachment":[{"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/media?parent=492"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}