{"id":866,"date":"2022-05-11T13:08:10","date_gmt":"2022-05-11T04:08:10","guid":{"rendered":"http:\/\/www.pharm.tohoku.ac.jp\/research_center\/?page_id=866"},"modified":"2024-05-21T10:47:35","modified_gmt":"2024-05-21T01:47:35","slug":"module_iwabuchi","status":"publish","type":"page","link":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/outview\/module_iwabuchi\/","title":{"rendered":"\u30e2\u30b8\u30e5\u30fc\u30eb\u578b\u5275\u85ac\u30e6\u30cb\u30c3\u30c8\uff08\u5ca9\u6e15\u597d\u6cbb\u6559\u6388\uff09"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"866\" class=\"elementor elementor-866\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7552a12 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7552a12\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container 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src=\"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-content\/uploads\/2024\/05\/kuriyama.jpg\" alt=\"\" width=\"100\" height=\"134\" \/><p id=\"caption-attachment-1424\" class=\"wp-caption-text\">\u6817\u5c71 \u4f51\u4e16 \u7279\u4efb\u7814\u7a76\u54e1<\/p><\/div><div id=\"attachment_871\" style=\"width: 110px\" class=\"wp-caption alignright\"><img decoding=\"async\" aria-describedby=\"caption-attachment-871\" class=\"wp-image-871\" src=\"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-content\/uploads\/2022\/05\/yamakoshi.png\" alt=\"\" width=\"100\" height=\"133\" \/><p id=\"caption-attachment-871\" class=\"wp-caption-text\">\u5c71\u8d8a \u535a\u5e78 \u52a9\u6559<\/p><\/div><div id=\"attachment_868\" style=\"width: 110px\" class=\"wp-caption alignright\"><img decoding=\"async\" aria-describedby=\"caption-attachment-868\" class=\"wp-image-868\" src=\"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-content\/uploads\/2022\/05\/iwabuchi.png\" alt=\"\" width=\"100\" height=\"138\" \/><p id=\"caption-attachment-868\" class=\"wp-caption-text\">\u5ca9\u6e15 \u597d\u6cbb \u6559\u6388<\/p><\/div><p>\u3000\u5225\u3005\u306e\u751f\u7269\u5b66\u7684\u30a4\u30d9\u30f3\u30c8\u306b\u95a2\u4e0e\u3059\u308b\u5206\u5b50\uff08\u30e2\u30b8\u30e5\u30fc\u30eb\uff09\u3092\u6226\u7565\u7684\u306b\u9023\u7d50\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u5358\u72ec\u30e2\u30b8\u30e5\u30fc\u30eb\u306e\u6295\u4e0e\u3067\u306f\u8d77\u3053\u308a\u3048\u306a\u3044\u7279\u7570\u3067\u6709\u7528\u306a\u85ac\u7406\u6d3b\u6027\u3092\u60f9\u8d77\u3059\u308b\u6a5f\u80fd\u6027\u5206\u5b50\u304a\u3088\u3073\u4e2d\u5206\u5b50\u533b\u85ac\u54c1\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u5f93\u6765\u306e\u5275\u85ac\u5316\u5b66\u7814\u7a76\u3067\u306f\u793e\u4f1a\u7684\u8981\u671b\u306b\u5fdc\u3048\u308b\u3053\u3068\u304c\u96e3\u3057\u3044\u75be\u60a3\u539f\u56e0\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6a19\u7684\u3068\u3057\u305f\u4e2d\u5206\u5b50\u533b\u85ac\u54c1\u3092\u5275\u88fd\u3057\u307e\u3059\u3002\u3053\u308c\u307e\u3067\u306b\u3001\u751f\u7269\u6d3b\u6027\u5316\u5408\u7269\u306e\u30d3\u30aa\u30c1\u30f3\u5316\u306b\u3088\u308b\u6a19\u7684\u5206\u5b50\u306e\u540c\u5b9a\u3001GSH\u5316\u306b\u3088\u308b\u6c34\u6eb6\u5316\u3001E3\u30ea\u30ac\u30f3\u30c9\u306e\u5c0e\u5165\u306b\u3088\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u8a98\u5c0e\u5264\u306e\u958b\u767a\u306b\u53d6\u308a\u7d44\u307f\u3001biotynylated TK-285\u3001GO-Y140\u3001GO-Y205\u306a\u3069\u3092\u5275\u88fd\u3057\u3066\u304d\u307e\u3057\u305f<sup>1\u20133)<\/sup>\u3002\u73fe\u5728\u3001\u65b0\u898f\u30bf\u30f3\u30d1\u30af\u8cea\u5206\u89e3\u8a98\u5c0e\u5264\u3092\u5275\u88fd\u3001\u306a\u3089\u3073\u306b\u72ec\u81ea\u306e\u30e2\u30b8\u30e5\u30fc\u30eb\u9023\u7d50\u6cd5\u306e\u958b\u767a\u3092\u5b9f\u65bd\u3057\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u4ed6\u306e\u30e6\u30cb\u30c3\u30c8\u3068\u9023\u643a\u4f53\u5236\u306e\u3082\u3068\u3001\u5408\u6210\u3057\u305f\u5206\u5b50\u306e\u6d3b\u6027\u8a55\u4fa1\u3068\u88fd\u5264\u5316\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002<\/p><p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-870 size-full\" src=\"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-content\/uploads\/2022\/05\/module.png\" alt=\"\" width=\"540\" height=\"393\" srcset=\"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-content\/uploads\/2022\/05\/module.png 540w, https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-content\/uploads\/2022\/05\/module-300x218.png 300w\" sizes=\"(max-width: 540px) 100vw, 540px\" \/><\/p><p>1) Pharmacol. 194:114819 (2021)<br \/>2) Biomol. Chem. 14:10683 (2016)<br \/>3) ACS Med. Chem. Lett. 1:341 (2010)<\/p><p>\u9023\u7d61\u5148\uff1a\u5ca9\u6e15\u597d\u6cbb\u3000<a href=\"mailto:y-iwabuchi@tohoku.ac.jp\">y-iwabuchi@tohoku.ac.jp<\/a><br \/>\u7814\u7a76\u5ba4HP\uff1a<a href=\"http:\/\/www.pharm.tohoku.ac.jp\/~gousei\/synthetic\/index.html\" target=\"_blank\" rel=\"noopener\">http:\/\/www.pharm.tohoku.ac.jp\/~gousei\/synthetic\/index.html<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u4e2d\u5206\u5b50\u5275\u85ac\u304a\u3088\u3073\u4e2d\u5206\u5b50\u5275\u85ac\u624b\u6cd5\u306e\u958b\u767a \u3000\u5225\u3005\u306e\u751f\u7269\u5b66\u7684\u30a4\u30d9\u30f3\u30c8\u306b\u95a2\u4e0e\u3059\u308b\u5206\u5b50\uff08\u30e2\u30b8\u30e5\u30fc\u30eb\uff09\u3092\u6226\u7565\u7684\u306b\u9023\u7d50\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u5358\u72ec\u30e2\u30b8\u30e5\u30fc\u30eb\u306e\u6295\u4e0e\u3067\u306f\u8d77\u3053\u308a\u3048\u306a\u3044\u7279\u7570\u3067\u6709\u7528\u306a\u85ac\u7406\u6d3b\u6027\u3092\u60f9\u8d77\u3059\u308b\u6a5f\u80fd\u6027\u5206\u5b50\u304a\u3088\u3073\u4e2d\u5206\u5b50\u533b\u85ac\u54c1\u306e\u958b [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":20,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"vkexunit_cta_each_option":"","footnotes":""},"class_list":["post-866","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/pages\/866","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/comments?post=866"}],"version-history":[{"count":29,"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/pages\/866\/revisions"}],"predecessor-version":[{"id":1427,"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/pages\/866\/revisions\/1427"}],"up":[{"embeddable":true,"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/pages\/20"}],"wp:attachment":[{"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/media?parent=866"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}