{"id":903,"date":"2022-05-16T13:19:34","date_gmt":"2022-05-16T04:19:34","guid":{"rendered":"http:\/\/www.pharm.tohoku.ac.jp\/research_center\/?page_id=903"},"modified":"2022-06-07T08:55:36","modified_gmt":"2022-06-06T23:55:36","slug":"kinou_mano","status":"publish","type":"page","link":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/outview\/kinou_mano\/","title":{"rendered":"\u6a5f\u80fd\u751f\u4f53\u5206\u5b50\u5275\u6210\u30e6\u30cb\u30c3\u30c8\uff08\u771e\u934b\u53f2\u4e43\u6559\u6388\uff09"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"903\" class=\"elementor elementor-903\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7552a12 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7552a12\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-52f1a69\" data-id=\"52f1a69\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-de34c96 elementor-widget elementor-widget-text-editor\" data-id=\"de34c96\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2>\u7cd6\u9396\u30fb\u8907\u5408\u7cd6\u8cea\u3092\u57fa\u76e4\u3068\u3059\u308b\u751f\u7269\u6d3b\u6027\u7269\u8cea\u306e\u5275\u6210<\/h2><div id=\"attachment_905\" style=\"width: 160px\" class=\"wp-caption alignright\"><img decoding=\"async\" aria-describedby=\"caption-attachment-905\" class=\"wp-image-905\" src=\"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-content\/uploads\/2022\/05\/mano.png\" alt=\"\" width=\"150\" height=\"187\" \/><p id=\"caption-attachment-905\" class=\"wp-caption-text\">\u771e\u934b \u53f2\u4e43 \u6559\u6388<\/p><\/div><p>\u3000\u7cd6\u9396\u30fb\u8907\u5408\u7cd6\u8cea\u306e\u7cbe\u5bc6\u5408\u6210\u306b\u3088\u308b\u7cd6\u9396\u5275\u85ac\u3092\u76ee\u6307\u3057\u305f\u7814\u7a76\u3092\u884c\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u5177\u4f53\u7684\u306b\u306f\u30011) \u65b0\u898f\u7acb\u4f53\u9078\u629e\u7684\u30b0\u30ea\u30b3\u30b7\u30eb\u5316\u53cd\u5fdc\u306e\u958b\u767a\u3068\u751f\u7269\u6d3b\u6027\u7cd6\u9396\u30fb\u8907\u5408\u7cd6\u8cea\u306e\u5408\u6210\u30012) \u7db2\u7f85\u7684\u7cd6\u9396\u5747\u4e00\u6539\u5909\u6297\u4f53\u306e\u4f5c\u88fd\u30013) \u6297\u4f53\u30fb\u85ac\u7269\u8907\u5408\u4f53\u304a\u3088\u3073\u03b1\u7dda\u653e\u51fa\u6838\u7a2e\u4ed8\u52a0\u6297\u4f53\u958b\u767a\u306b\u304a\u3044\u3066\u306e\u7cd6\u9396\u3092\u5229\u7528\u3057\u305fsite-specific \u9023\u7d50\u6cd5\u3001\u53ca\u3073\u30ea\u30f3\u30ab\u30fc\u958b\u767a\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<br \/>\u3000\u30a8\u30f3\u30c9\u578b\u958b\u88c2\u306b\u3088\u308b\u7cd6\u9396\u306e\u7acb\u4f53\u5909\u63db\u306f\u3001\u5f93\u6765\u306e\u30b0\u30ea\u30b3\u30b7\u30eb\u5316\u53cd\u5fdc\u3067\u306f\u56f0\u96e3\u3067\u3042\u308b\u7acb\u4f53\u9078\u629e\u76841,2-cis \u30a2\u30df\u30ce\u7cd6\u306e\u69cb\u7bc9\u3092\u53ef\u80fd\u3068\u3057\u3001\u65e2\u5b58\u306e\u8907\u6570\u306e\u30a2\u30ce\u30de\u30fc\u4f4d\u7f6e\u306e\u7acb\u4f53\u5316\u5b66\u3092\u4e00\u6319\u306b\u5909\u63db\u3067\u304d\u307e\u3059<sup>1)<\/sup>\u3002\u5de6\u53f3\u975e\u5bfe\u79f0\u578b\u3092\u542b\u3080\u5747\u4e00\u7cd6\u9396\u3092\u6301\u3064\u6297\u4f53\u306e\u4f5c\u88fd\u6cd5\u306e\u958b\u767a\u306b\u3088\u308a\u3001\u7cd6\u9396\u69cb\u9020\u3068\u6297\u4f53\u6a5f\u80fd\u306e\u660e\u78ba\u306a\u69cb\u9020\u76f8\u95a2\u6d3b\u6027\u3092\u660e\u3089\u304b\u306b\u3057\u3066\u3044\u307e\u3059\u3002\u3055\u3089\u306b\u7cd6\u9396\u6539\u5909\u306b\u3088\u308b\u5747\u4e00\u69cb\u9020ADC \u306e\u4f5c\u88fd\u306b\u5c55\u958b\u3057\u3066\u3044\u307e\u3059<sup>2)<\/sup>\u3002C-\u578b\u7cd6\u9396\u4fee\u98fe\u3067\u3042\u308bC-Man-Trp \u306f\u3001\u5375\u5de3\u304c\u3093\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u671f\u5f85\u3055\u308c\u307e\u3059<sup>3)<\/sup>\u3002<\/p><p>\u6587\u732e<br \/>1) Chem. Eur. J. 20:124\u2013132 (2014)<br \/>2) Bioconj. Chem. 30:1343-1355 (2019)<br \/>3) Oncol. Lett. 19:908-919 (2020)<\/p><p>\u9023\u7d61\u5148\uff1a\u771e\u934b\u53f2\u4e43\u3001<a href=\"mailto:shino.manabe.e1@tohoku.ac.jp\">shino.manabe.e1@tohoku.ac.jp<\/a><br \/><a href=\"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/sosei\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.pharm.tohoku.ac.jp\/research_center\/sosei\/<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u7cd6\u9396\u30fb\u8907\u5408\u7cd6\u8cea\u3092\u57fa\u76e4\u3068\u3059\u308b\u751f\u7269\u6d3b\u6027\u7269\u8cea\u306e\u5275\u6210 \u3000\u7cd6\u9396\u30fb\u8907\u5408\u7cd6\u8cea\u306e\u7cbe\u5bc6\u5408\u6210\u306b\u3088\u308b\u7cd6\u9396\u5275\u85ac\u3092\u76ee\u6307\u3057\u305f\u7814\u7a76\u3092\u884c\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u5177\u4f53\u7684\u306b\u306f\u30011) \u65b0\u898f\u7acb\u4f53\u9078\u629e\u7684\u30b0\u30ea\u30b3\u30b7\u30eb\u5316\u53cd\u5fdc\u306e\u958b\u767a\u3068\u751f\u7269\u6d3b\u6027\u7cd6\u9396\u30fb\u8907\u5408\u7cd6\u8cea\u306e\u5408\u6210\u30012) \u7db2\u7f85\u7684\u7cd6\u9396 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":20,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"vkexunit_cta_each_option":"","footnotes":""},"class_list":["post-903","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/pages\/903","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/comments?post=903"}],"version-history":[{"count":14,"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/pages\/903\/revisions"}],"predecessor-version":[{"id":1185,"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/pages\/903\/revisions\/1185"}],"up":[{"embeddable":true,"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/pages\/20"}],"wp:attachment":[{"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/media?parent=903"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}