{"id":930,"date":"2022-05-16T13:38:25","date_gmt":"2022-05-16T04:38:25","guid":{"rendered":"http:\/\/www.pharm.tohoku.ac.jp\/research_center\/?page_id=930"},"modified":"2022-06-07T09:00:15","modified_gmt":"2022-06-07T00:00:15","slug":"kakusan_akita","status":"publish","type":"page","link":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/outview\/kakusan_akita\/","title":{"rendered":"\u6838\u9178\u30fbRNA\u30ca\u30ce\u5275\u5264\u30e6\u30cb\u30c3\u30c8\uff08\u79cb\u7530\u82f1\u4e07\u6559\u6388\uff09"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"930\" class=\"elementor elementor-930\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7552a12 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7552a12\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-52f1a69\" data-id=\"52f1a69\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-de34c96 elementor-widget elementor-widget-text-editor\" data-id=\"de34c96\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2>\u751f\u4f53\u74b0\u5883\u5fdc\u7b54\u6027\u6750\u6599\u3092\u57fa\u76e4\u3068\u3057\u305fRNA\u5275\u85ac<\/h2><div id=\"attachment_932\" style=\"width: 160px\" class=\"wp-caption alignright\"><img decoding=\"async\" aria-describedby=\"caption-attachment-932\" class=\"wp-image-932\" src=\"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-content\/uploads\/2022\/05\/akita-221x300.jpg\" alt=\"\" width=\"150\" height=\"204\" srcset=\"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-content\/uploads\/2022\/05\/akita-221x300.jpg 221w, https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-content\/uploads\/2022\/05\/akita.jpg 225w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/><p id=\"caption-attachment-932\" class=\"wp-caption-text\">\u79cb\u7530 \u82f1\u4e07 \u6559\u6388<\/p><\/div><p>\u3000mRNA\u3092\u5c0e\u5165\u3059\u308b\u3053\u3068\u3067\u86cb\u767d\u8cea\u3092\u751f\u4f53\u5185\u3067\u3064\u304f\u3089\u305b\u308bmRNA\u533b\u85ac\u306f\u65b0\u3057\u3044\u907a\u4f1d\u5b50\u6cbb\u7642\u7528\u30e2\u30c0\u30ea\u30c6\u30a3\u3067\u3059\u3002mRNA\u30ef\u30af\u30c1\u30f3\u306e\u627f\u8a8d\u3092\u3046\u3051\u3066\u3001\u4eca\u5f8c\u3001\u76ca\u3005RNA\u5275\u85ac\u7814\u7a76\u306f\u52a0\u901f\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002\u72ec\u81ea\u306e\u8102\u8cea\u69d8\u6750\u6599ssPalm(SS-cleavable and pH-activated lipid-like material)\u3092\u958b\u767a\u3057\u3001\u65e5\u6cb9\u682a\u5f0f\u4f1a\u793e\u3088\u308aGMP\u57fa\u6e96\u3067\u306e\u88fd\u9020\u30fb\u4f9b\u7d66\u304c\u3059\u3059\u3093\u3067\u3044\u307e\u3059\u3002\u7279\u306b\u7d30\u80de\u8cea\u5185\u3067\u306e\u5206\u89e3\u6027\u3092\u9ad8\u3081\u308b\u5206\u5b50\u6539\u826f\u3092\u65bd\u3057\u305f\u7b2c\u4e09\u4e16\u4ee3ssPalm\u306b\u304a\u3044\u3066\u306f\u3001\u65e2\u5b58\u85ac\u30aa\u30f3\u30d1\u30c8\u30ed<sup>\u00ae<\/sup>\u306b\u63a1\u7528\u3055\u308c\u3066\u3044\u308b\u6280\u8853\u3068\u6bd4\u8f03\u3057\u3066\u3082\u9ad8\u3044\u5b89\u5168\u6027\u3068mRNA\u5c0e\u5165\u52b9\u7387\u3092\u8a87\u308b\u3053\u3068\u3092\u898b\u3044\u3060\u3057\u3066\u3044\u307e\u3059\u3002\u4eca\u5f8c\u3001\u672c\u30c7\u30ea\u30d0\u30ea\u30fc\u30b7\u30b9\u30c6\u30e0\u3068\u3057\u3066\u306e\u6027\u80fd\u3092\u9ad8\u3081\u308b\u3068\u3068\u3082\u306b\u3001\u514d\u75ab\u5fdc\u7b54\u306e\u5236\u5fa1\u3084\u81d3\u5668\u6a19\u7684\u5316\u3092\u5b9f\u73fe\u3059\u308b\u6280\u8853\u3092\u958b\u767a\u3057\u306a\u304c\u3089\u3001\u65e5\u672c\u767a\u3001\u6771\u5317\u767a\u306e\u6b21\u4e16\u4ee3RNA\u3092\u7528\u3044\u305f\u907a\u4f1d\u5b50\u6cbb\u7642\u3001\u3042\u308b\u3044\u306f\u3001RNA\u30ef\u30af\u30c1\u30f3\u88fd\u5264\u3092\u5275\u51fa\u3057\u305f\u3044\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p><p>\u6587\u732e<br \/>1) Adv Funct Mater. 30: 1910575 (2020)<br \/>2) Adv Drug Deliv Rev.145-155: 210-226 (2020)<\/p><p>\u9023\u7d61\u5148\uff1a\u79cb\u7530\u82f1\u4e07\u3000<a href=\"mailto:hidetaka.akita.a4@tohoku.ac.jp\">hidetaka.akita.a4@tohoku.ac.jp<\/a><br \/><a href=\"http:\/\/www.pharm.tohoku.ac.jp\/~soutatsu\/drug_design\/\" target=\"_blank\" rel=\"noopener\">http:\/\/www.pharm.tohoku.ac.jp\/~soutatsu\/drug_design\/<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u751f\u4f53\u74b0\u5883\u5fdc\u7b54\u6027\u6750\u6599\u3092\u57fa\u76e4\u3068\u3057\u305fRNA\u5275\u85ac \u3000mRNA\u3092\u5c0e\u5165\u3059\u308b\u3053\u3068\u3067\u86cb\u767d\u8cea\u3092\u751f\u4f53\u5185\u3067\u3064\u304f\u3089\u305b\u308bmRNA\u533b\u85ac\u306f\u65b0\u3057\u3044\u907a\u4f1d\u5b50\u6cbb\u7642\u7528\u30e2\u30c0\u30ea\u30c6\u30a3\u3067\u3059\u3002mRNA\u30ef\u30af\u30c1\u30f3\u306e\u627f\u8a8d\u3092\u3046\u3051\u3066\u3001\u4eca\u5f8c\u3001\u76ca\u3005RNA\u5275\u85ac\u7814\u7a76\u306f\u52a0\u901f\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":20,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":{"vkexunit_cta_each_option":"","footnotes":""},"class_list":["post-930","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/pages\/930","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/comments?post=930"}],"version-history":[{"count":11,"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/pages\/930\/revisions"}],"predecessor-version":[{"id":1194,"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/pages\/930\/revisions\/1194"}],"up":[{"embeddable":true,"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/pages\/20"}],"wp:attachment":[{"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/media?parent=930"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}