{"id":991,"date":"2022-05-16T14:10:30","date_gmt":"2022-05-16T05:10:30","guid":{"rendered":"http:\/\/www.pharm.tohoku.ac.jp\/research_center\/?page_id=991"},"modified":"2022-06-07T09:04:49","modified_gmt":"2022-06-07T00:04:49","slug":"meneki_hirasawa","status":"publish","type":"page","link":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/outview\/meneki_hirasawa\/","title":{"rendered":"\u514d\u75ab\u5236\u5fa1\u30af\u3099\u30eb\u30fc\u30d5\u309a\uff08\u5e73\u6fa4\u5178\u4fdd\u6559\u6388\uff09"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"991\" class=\"elementor elementor-991\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7552a12 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7552a12\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-52f1a69\" data-id=\"52f1a69\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-de34c96 elementor-widget elementor-widget-text-editor\" data-id=\"de34c96\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2>\u4e0a\u76ae\u7d30\u80de\u3092\u6a19\u7684\u3068\u3057\u305f\u6297\u30a2\u30ec\u30eb\u30ae\u30fc\u85ac\u306e\u958b\u767a<\/h2><div id=\"attachment_77\" style=\"width: 160px\" class=\"wp-caption alignright\"><img decoding=\"async\" aria-describedby=\"caption-attachment-77\" class=\"wp-image-77\" src=\"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-content\/uploads\/2019\/07\/hirasawa.jpg\" alt=\"\" width=\"150\" height=\"152\" \/><p id=\"caption-attachment-77\" class=\"wp-caption-text\">\u5e73\u6fa4 \u5178\u4fdd \u6559\u6388<\/p><\/div><p>\u3000\u65b0\u305f\u306a\u4f5c\u7528\u6a5f\u5e8f\u3092\u6301\u3064\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306e\u6cbb\u7642\u85ac\u30fb\u5897\u60aa\u5316\u4e88\u9632\u85ac\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u76ae\u819a\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u62c5\u3046\u3068\u3068\u3082\u306b\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u5fdc\u7b54\u306e\u5236\u5fa1\u306b\u3082\u95a2\u308f\u308b\u4e0a\u76ae\u7d30\u80de\uff08\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\uff09\u304c\u7523\u751f\u3059\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3(thymic stromal lymphopoietin, TSLP)\u306e\u7523\u751f\u963b\u5bb3\u85ac\u53ca\u3073\u4f5c\u7528\u6291\u5236\u85ac\u306e\u63a2\u7d22\u3068\u305d\u306e\u5206\u5b50\u4f5c\u7528\u6a5f\u5e8f\u306b\u3064\u3044\u3066\u89e3\u6790\u3057\u3066\u3044\u307e\u3059\u3002TSLP\u3092\u6052\u5e38\u7684\u306b\u9ad8\u7523\u751f\u3059\u308b\u30de\u30a6\u30b9\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\u7d30\u80de\u682a\u3092\u767a\u898b\u3057\u3001\u672c\u7d30\u80de\u3092\u6d3b\u7528\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u52b9\u7387\u7684\u306bTSLP\u7523\u751f\u963b\u5bb3\u85ac\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3059\u308b\u3053\u3068\u3092\u53ef\u80fd\u306b\u3057\u307e\u3057\u305f<sup>1)<\/sup>\u3002\u307e\u305f\u5316\u5408\u7269\u30e9\u30a4\u30d6\u30e9\u30ea\u30fc\u304b\u3089\u898b\u3044\u51fa\u3057\u305fTSLP\u7523\u751f\u963b\u5bb3\u85ac\u306e\u6a19\u7684\u5206\u5b50\u3092\u63a2\u7d22\u3057\u3001Brd4\u306a\u3069BET\u30d5\u30a1\u30df\u30ea\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u7d50\u5408\u3057\u3001\u305d\u306e\u6d3b\u6027\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3082\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f<sup>2)<\/sup>\u3002\u73fe\u5728\u3001\u30de\u30a6\u30b9\u30a2\u30ec\u30eb\u30ae\u30fc\u6027\u76ae\u819a\u708e\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3066\u3001BET\u963b\u5bb3\u85ac\u306e\u6297\u30a2\u30ec\u30eb\u30ae\u30fc\u52b9\u679c\u3092\u691c\u8a3c\u3059\u308b\u3068\u3068\u3082\u306b\u3001\u3055\u3089\u306b\u7570\u306a\u308b\u4f5c\u7528\u6a5f\u5e8f\u3092\u6301\u3064TSLP\u7523\u751f\u963b\u5bb3\u85ac\u306e\u958b\u767a\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001TSLP\u53d7\u5bb9\u4f53\u3092\u6a19\u7684\u3068\u3059\u308b\u5275\u85ac\u7814\u7a76\u3082\u5b9f\u65bd\u3057\u3066\u3044\u307e\u3059\u3002<\/p><p>1) J. Immunol. Methods 402: 9-14 (2014)<br \/>2) Biochem. Pharmacol. 194:114819 (2021)<\/p><p>\u9023\u7d61\u5148\uff1a\u5e73\u6fa4\u5178\u4fdd\u3000<a href=\"mailto:noriyasu.hirasawa.c7@tohoku.ac.jp\">noriyasu.hirasawa.c7@tohoku.ac.jp<\/a><br \/><a href=\"http:\/\/www.pharm.tohoku.ac.jp\/~seikatsu\/mysite1\/index.html\" target=\"_blank\" rel=\"noopener\">http:\/\/www.pharm.tohoku.ac.jp\/~seikatsu\/mysite1\/index.html<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u4e0a\u76ae\u7d30\u80de\u3092\u6a19\u7684\u3068\u3057\u305f\u6297\u30a2\u30ec\u30eb\u30ae\u30fc\u85ac\u306e\u958b\u767a \u3000\u65b0\u305f\u306a\u4f5c\u7528\u6a5f\u5e8f\u3092\u6301\u3064\u30a2\u30c8\u30d4\u30fc\u6027\u76ae\u819a\u708e\u306e\u6cbb\u7642\u85ac\u30fb\u5897\u60aa\u5316\u4e88\u9632\u85ac\u306e\u958b\u767a\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u76ae\u819a\u30d0\u30ea\u30a2\u6a5f\u80fd\u3092\u62c5\u3046\u3068\u3068\u3082\u306b\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u5fdc\u7b54\u306e\u5236\u5fa1\u306b\u3082\u95a2\u308f\u308b\u4e0a\u76ae\u7d30\u80de\uff08\u30b1\u30e9\u30c1\u30ce\u30b5\u30a4\u30c8\uff09\u304c\u7523 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":20,"menu_order":11,"comment_status":"closed","ping_status":"closed","template":"","meta":{"vkexunit_cta_each_option":"","footnotes":""},"class_list":["post-991","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/pages\/991","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/comments?post=991"}],"version-history":[{"count":10,"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/pages\/991\/revisions"}],"predecessor-version":[{"id":1203,"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/pages\/991\/revisions\/1203"}],"up":[{"embeddable":true,"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/pages\/20"}],"wp:attachment":[{"href":"https:\/\/www.pharm.tohoku.ac.jp\/research_center\/wp-json\/wp\/v2\/media?parent=991"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}