{"id":39,"date":"2024-02-09T11:09:41","date_gmt":"2024-02-09T02:09:41","guid":{"rendered":"https:\/\/www.pharm.tohoku.ac.jp\/~genome\/?page_id=39"},"modified":"2026-08-17T08:26:44","modified_gmt":"2026-08-16T23:26:44","slug":"people-en","status":"publish","type":"page","link":"https:\/\/www.pharm.tohoku.ac.jp\/~genome\/people-en\/","title":{"rendered":"People"},"content":{"rendered":"\n

People<\/h2>\n\n\n\n

Faculty<\/h3>\n\n\n\n
\n
\n
\"\"<\/figure>\n<\/div><\/div>\n\n\n\n
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Professor<\/strong><\/h4>\n\n\n\n

Masahiro HIRATSUKA<\/p>\n\n\n\n

masahiro.hiratsuka.a8*tohoku.ac.jp<\/p>\n<\/div>\n<\/div>\n\n\n\n

Message from the Professor<\/h5>\n\n\n\n

In April 2025, we launched a new laboratory, the Laboratory of Pharmacogenomics<\/strong>, at the Graduate School of Pharmaceutical Sciences, Tohoku University. Our mission is to elucidate the mechanisms behind the significant individual differences observed in drug efficacy and adverse reactions (i.e., drug responsiveness), and to apply this knowledge to achieve optimal pharmacotherapy tailored to each patient.<\/p>\n\n\n\n

Genomic variations among individuals play a critical role in drug responsiveness. In particular, interindividual differences in the activity of drug-metabolizing enzymes are closely related to drug plasma concentrations, therapeutic effects, and the occurrence of side effects. Understanding these molecular mechanisms is essential for the realization of safe and effective personalized medicine<\/strong>.<\/p>\n\n\n\n

Our laboratory employs cutting-edge research techniques, including comprehensive genomic analysis using next-generation sequencing (NGS)<\/strong>, functional studies using our proprietary high-expression recombinant enzyme systems<\/strong>, and high-sensitivity quantification of drugs and metabolites via LC-MS\/MS<\/strong>. By integrating knowledge from pharmacokinetics<\/strong>, pharmacodynamics<\/strong>, and pharmacogenomics<\/strong>, we are tackling the challenge of applying individualized pharmacotherapy in clinical settings.<\/p>\n\n\n\n

However, genetic information alone does not fully explain individual differences in drug response. Looking ahead, we aim to incorporate multi-omics approaches<\/strong>\u2014including transcriptomics, proteomics, and metabolomics\u2014to capture a more comprehensive picture of the biological factors influencing drug action. Through this systems-level integration, we hope to contribute to the next generation of personalized medicine.<\/p>\n\n\n\n

Delivering the right drug to the right patient \u2014 together, let us build a future where this becomes the standard of care.
We warmly welcome undergraduate and graduate students interested in genome medicine and pharmacotherapy to join us in this exciting journey of research, discovery, and global contribution.<\/p>\n\n\n\n

Associate Professor<\/h4>\n\n\n\n

Yuu MIYAUCHI<\/p>\n\n\n\n

yuu.miyauchi.b6*tohoku.ac.jp<\/p>\n\n\n\n

Associate Professor<\/h4>\n\n\n\n

Takamitsu SASAKI<\/p>\n\n\n\n

takamitsu.sasaki.c3*tohoku.ac.jp (Affiliation: Pharmacy Education and Research Center)<\/p>\n\n\n\n

Assistant Professor<\/strong><\/h4>\n\n\n\n

Hayato YOKOTA<\/p>\n\n\n\n

hayato.yokota.e3*tohoku.ac.jp<\/p>\n\n\n\n

Research Fellow<\/h4>\n\n\n\n

Akiko UEDA<\/p>\n\n\n\n

akiko.ueda.d1*tohoku.ac.jp\uff08Affiliation: Center for Innovative Integrated Medical Sciences: INGEM, Tohoku University\uff09<\/p>\n\n\n\n

Please replace the asterisk (*) with @ before using the email address.<\/p>\n\n\n\n

Students<\/h3>\n\n\n\n

D2<\/h4>\n\n\n\n

Yuuma SUZUKI<\/p>\n\n\n\n

D1<\/h4>\n\n\n\n

Yuki OMORI<\/p>\n\n\n\n

M2<\/h4>\n\n\n\n

Shota NISHIHARA<\/p>\n\n\n\n

B6<\/h4>\n\n\n\n

Ayano HANIU<\/p>\n\n\n\n

M1<\/h4>\n\n\n\n

Sae NAKAJIMA<\/p>\n\n\n\n

B5<\/h4>\n\n\n\n

Chihiro KOBAYASHI<\/p>\n\n\n\n

Rei KOYAMA<\/p>\n\n\n\n

Miki SAITO<\/p>\n\n\n\n

Shinnosuke MATSUOKA<\/p>\n\n\n\n

B4<\/h4>\n\n\n\n

Shoko ISHII<\/p>\n\n\n\n

Takumi KUWABARA<\/p>\n\n\n\n

Kaho KONDO<\/p>\n\n\n\n

Momoyo SHIBUYA<\/p>\n\n\n\n

Kotono MIZUUCHI<\/p>\n\n\n\n

B3<\/h4>\n\n\n\n

<\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

People Faculty Professor Masahiro HIRATSUKA masahiro.hiratsuka.a8*tohoku.ac.jp M … <\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-39","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.pharm.tohoku.ac.jp\/~genome\/wp-json\/wp\/v2\/pages\/39","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.pharm.tohoku.ac.jp\/~genome\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.pharm.tohoku.ac.jp\/~genome\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.pharm.tohoku.ac.jp\/~genome\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.pharm.tohoku.ac.jp\/~genome\/wp-json\/wp\/v2\/comments?post=39"}],"version-history":[{"count":18,"href":"https:\/\/www.pharm.tohoku.ac.jp\/~genome\/wp-json\/wp\/v2\/pages\/39\/revisions"}],"predecessor-version":[{"id":470,"href":"https:\/\/www.pharm.tohoku.ac.jp\/~genome\/wp-json\/wp\/v2\/pages\/39\/revisions\/470"}],"wp:attachment":[{"href":"https:\/\/www.pharm.tohoku.ac.jp\/~genome\/wp-json\/wp\/v2\/media?parent=39"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}