PUBLICATIONS

    2025
  1. "Lactoferrin attenuates renal fibrosis and uremic sarcopenia in a mouse model of adenine-induced chronic kidney disease"
    Iwamoto Y, Yamakoshi S, Sekimoto A, Hosomi K, Toyama T, Saito Y, Kunisawa J, Takahashi N, Mishima E, Sato E
    The Journal of Nutritional Biochemistry, 2025, in press, DOI: 10.1016/j.jnutbio.2025.110039
    2. "Nicotinamide ameliorates podocyte injury and albuminuria in adriamycin-induced nephropathy"
    Takahashi K, Sato E, Yamakoshi S, Ogane M, Sekimoto A, Ishikawa T, Kisu K, Oe Y, Okamoto K, Miyazaki M, Tanaka T, Takahashi N
    American Journal of Physiology. Renal physiology, 2025, 328(4), F501-F516, DOI: 10.1152/ajprenal.00297.2024
  2. "The Many Faces of Protease-Activated Receptor 2 in Kidney Injury"
    Oe Y, Tanaka T, Takahashi N
    Biomedicines13(2), 414, 2025, DOI: 10.3390/biomedicines13020414
  3. "Hemodialysis employing molecular hydrogen (H2)-enriched dialysis solution improves dialysis-related fatigue through impact on energy metabolism"
    Nakayama M, Watanabe K, Sato E, Ito Y, Kadota N, Konishi K, Aizawa C, Maruyama Y, Fujimaru T, Nagahama M, Taki F, Suzuki M
    Scientific Reports, 15, 5039, 2025, DOI: 10.1038/s41598-025-88827-2

    4. 2024
  4. "Generation of thiyl radicals in a spatiotemporal controlled manner by light: Applied for the cis to trans isomerization of unsaturated fatty acids/phospholipids"
    Roy B, Kojima R, Shah O, Shieh M, Das E, Ezzatpour S, Sato E, Hirata Y, Lindahl S, Matsuzawa A, Aguilar HC, Xian M
    Redox Biology,103475, 2024, DOI: 10.1016/j.redox.2024.103475
  5. "Conjugated fatty acids drive ferroptosis through chaperone-mediated autophagic degradation of GPX4 by targeting mitochondria"
    Hirata Y, Yamada Y, Taguchi S, Kojima R, Masumoto H, Kimura S, Niijima T, Toyama T, Kise R, Sato E, Uchida Y, Ito J, Nakagawa K, Taguchi T, Inoue A, Saito Y, Noguchi T, Matsuzawa A
    Cell Death & Disease,15, 884, 2024, DOI: 10.1038/s41419-024-07237-w
  6. "Impacts of low birthweight on kidney development and intergenerational growth of the offspring"
    Sekimoto A, Takaso Y, Saruyama H, Ookawa M, Yamamoto M, Toyohara T, Saigusa D, Fukuuchi T, Otsuka M, Fushiki Y, Yamakoshi S, Tanaka K, Ikeda T, Tanaka T, Takahashi N, Mishima E, Sato E
    iScience 111159, 2024, DOI:10.1016/j.isci.2024.111159
  7. "Industrially produced trans-fatty acids are potent promoters of DNA damage-induced apoptosis"
    Hirata Y, Kojima R, Ashida R, Noda Y, Kimura S, Sato E, Noguchi T, Matsuzawa A
    The Journal of Toxicological Sciences, 49(1), 27, 2024, DOI:10.2131/jts.49.27

    8. 2023
  8. "Exercise Training Prevents High Fructose-Induced Hypertension and Renal Damages in Male Dahl Salt-Sensitive Rats"
    Xu L, Hu G, Qiu J, Miura T, Yamakoshi S, Namai-Takahashi A, Kohzuki M, Ito O
    Medicine & Science in Sports & Exercise, 55(5), 803, 2023, DOI: 10.1249/MSS.0000000000003100
  9. "Changes in Metabolomic Profiles Induced by Switching from an Erythropoiesis-Stimulating Agent to a Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor in Hemodialysis Patients: A Pilot Study"
    Watanabe K, Sato E, Mishima E, Moriya S, Sakabe T, Sato A, Fujiwara M, Fujimaru T, Ito Y, Taki F, Nagahama M, Tanaka K, Kazama JJ, Nakayama M
    International Journal of Molecular Sciences , 24(26), 12752, 2023, DOI: 10.3390/ijms241612752
  10. "A comprehensive toxicological analysis of trans-fatty acids (TFAs) reveals a pro-apoptotic action specific to industrial TFAs counteracted by polyunsaturated FAs."
    Hirata Y, Kashiwabara N, Nada Y, Inoue A, Sato E, Noguchi T, Matsuzawa A
    Scientific Reports,3, 5883, 2023, DOI: 10.1038/s41598-023-32083-9

    11. 2022
  11. "Tissue Factor, Thrombosis, and Chronic Kidney Disease."
    Oe Y, Takahashi N
    Biomedicines , 10(11), 737, 2022, DOI: 10.3390/biomedicines10112737
  12. "Inhibition of Platelet-Derived Growth Factor Pathway Suppresses Tubulointerstitial Injury in Renal Congestion"
    Hoshino K, Anan G, Hirose T, Yamakoshi S, Tajima R, Sato T, Miyake Y, Fukunaga T, Kato T, Endo A, Seki T, Nakayama S, Oba-Yabana I, Nakamura H, Tani J, Mori T
    Clinical and Experimental Nephrology , 26(8), 835, 2022, DOI: 10.1007/s10157-022-02214-z
  13. "Impact of preoperative factors on catheter position in peritoneal dialysis: a prospective cohort study"
    Matsuki T, Hirose T, Ohsaki Y, Shimada S, Endo A, Ito H, Takahashi C, Yamakoshi S, Oba-Yabana I, Anan G, Kato T, Tajima R, Nakayama S, Kimura T, Nakamura H, Tani J, Takahashi K, Kure S, Mori T,
    Journal of Hypertension , 40(10), 1935, 2022, DOI: 10.1097/HJH.0000000000003191
  14. "Whatfs New in the Molecular Mechanisms of Diabetic Kidney Disease: Recent Advances"
    Watanabe K, Sato E, Mishima E, Miyazaki M, Tanaka E
    International Journal of Molecular Sciences , 24(1), 570, 2022, DOI: 10.1038/s41586-022-05022-3
  15. "A non-canonical vitamin K cycle is a potent ferroptosis suppressor"
    Mishima E, Ito J, Wu Z, Nakamura T, Wahida A, Doll A, Tonnus W,Nepachalovich P, Eggenhofer E, Aldrovandi M, Henkelmann B, Yamada K, Wanninger J, Zilka O, Sato E, Feederle R, Hass D, Maida A, Mourao ASD, Linkermann A, Geissler EK, Nakagawa K, Abe T, Fedorova M, Proneth B, Pratt DA, Conrad M
    Nature , 608(7924), 778-783, 2022, DOI: 10.1038/s41586-022-05022-3
  16. "Methylglyoxal Induces Inflammation, Metabolic Modulation and Oxidative Stress in Myoblast Cells"
    Todoriki S, Hosoda Y, Yamamoto T, Watanabe M, Sekimoto A, Sato H, Mori T, Miyazaki M, Takahashi N, Sato E.
    Toxins, 2022, 14, 263, DOI: 10.3390/toxins14040263

    17. 2021
  17. "Myeloid cell-derived coagulation tissue factor is associated with renal tubular damage in mice fed an adenine diet"
    Yamakage S, Oe Y, Sato E, Okamoto K, Sekimoto A, Kumakura S, Sato H, Yoshida M, Nagasawa T, Miyazaki M, Ito S, Mackman N, Takahashi N.
    Sci Rep, 2021, 11, 12159, DOI: 10.1038/s41598-021-91586-5
  18. "Lack of Endothelial Nitric Oxide Synthase Accelerates Ectopic Calcification in Uremic Mice Fed an Adenine and High Phosphorus Diet"
    Oe Y, Mitsui S, Sato E, Shibata N, Kisu K, Sekimoto A, Miyazaki M, Sato H, Ito S, Takahashi N.
    The American Journal of Pathology, 2021, 191(2), 283, DOI: 10.1016/j.ajpath.2020.10.012
  19. "Effect of uremic toxins on hippocampal cell damage: analysis in vitro and in rat model of chronic kidney disease"
    Watanabe K, Sato E, Mishima E, Watanabe M, Abe T, Takahashi N, Nakayama M.
    Heliyon, 2021,7(2), e06221
  20. "Nicotinamide Attenuates the Progression of Renal Failure in a Mouse Model of Adenine-Induced Chronic Kidney Disease"
    Kumakura S, Sato E, Sekimoto A, Hashizume Y, Yamakage S, Miyazaki M, Ito S, Harigae H, Takahashi N.
    Toxins, 2021, 13, 50, DOI: 10.3390/toxins13010050

    21. 2020
  21. "Oral high dose vitamin B12 decreases renal superoxide and post-ischemia/reperfusion injury in mice"
    Li F, Bahnson EM, Wilder J, Siletzky R, Hagaman J, Nickekeit V, Hiller S, Ayesha A, Feng L, Levine JS, Takahashi N, Maeda-Smithies N.
    Redox Biology,, 2020, 32, 101504
  22. "Beneficial effects of nicotinamide on hypertensive mice with impaired endothelial nitric oxide function"
    Huynh PK, Wilder J, Hiller S, Hagaman J, Takahashi N, Maeda-Smithies N, Li F.
    Journal of Experimental Nephrology, 2020, 1(1), 1
  23. "Protease-activated receptor 2 contributes to placental development and fetal growth in mice"
    Yamakage S, Oe Y, Sekimoto A, Obata H, Yasuta M, Sato E, Kumakura S, Sato H, Sugawara J, Ito S, Takahashi N.
    Thrombo Res, 2020, 193, 173-179 DOI: 10.1016/j.thromres.2020.06.039
  24. "Lack of endothelial nitric oxide synthase accelerates ectopic calcification in uremic mice fed an adenine and high phosphorus diet"
    Oe Y, Mitsui S, Sato E, Shibata N, Kisu K, Sekimoto A, Miyazaki M, Sato H, Takahashi N.
    Am J Phathol, 2020, in press, DOI: 10.1016/j.ajpath.2020.10.012
  25. "The effect of aldosterone on adiposity - The role of glucose absorption in the small intestine"
    Shirai H, Sato E, Sekimoto A, Uchida T, Oe Y, Ito S, Sato H, Takahashi N.
    Biochem Biophys Res Commun, 2020, 531(4), 628-635 DOI: 10.1016/j.bbrc.2020.07.119
  26. "Metabolomics of a Mouse Model of Preeclampsia Induced by Overexpressing Soluble Fms-like Tyrosine Kinase 1"
    Sato E, Tsunokuni Y, Kaneko M, Saigusa D, Saito R, Shimma S, Sekimoto A, Kawana Y, Oe Y, Ito S, Sato H, Takahashi N.
    Biochem Biophys Res Commun, 2020, 527(4), 1064-1071 DOI: 10.1016/j.bbrc.2020.04.079
  27. "Dual blockade of protease-activated receptor 1 and 2 additively ameliorates diabetic kidney disease"
    Mitsui S, Oe Y, Sekimoto A, Sato E, Hashizume Y, Yamakage S, Kumakura S, Sato H, Takahashi N.
    Am J Physiol Renal Physiol, 2020, 318 (5), F1067-F1073, DOI: 10.1152/ajprenal.00595.2019
  28. "Effects of the oral adsorbent AST-120 on fecal p-cresol and indole levels and on the gut microbiota composition"
    Sato E, Hosomi K, Sekimoto A, Mishima E, Oe Y, Saigusa D, Ito S, Abe T, Sato H, Kunisawa J, Niwa T, Takahashi N.
    Biochem Biophys Res Commun, 2020, 525 (3), 773-779, DOI: 10.1016/j.bbrc.2020.02.141
  29. "Tadalafil alleviates preeclampsia and fetal growth restriction in RUPP model of preeclampsia in mice"
    Sekimoto A, Tanaka K, Hashizume Y, Sato E, Ikeda T, Takahashi N.
    Biochem Biophys Res Commun, 2020, 521 (4), 769-774 DOI: 10.1016/j.bbrc.2019.10.186
  30. "Oral high dose vitamin B12 decreases renal superoxide and post-ischemia/reperfusion injury in mice"
    Li F, Wilder J, Bahnson EM, Siletzky R, Hagaman J, Nickekeit V, Hiller S, Ayesha A, Feng L, J S. Levine, Takahashi N, Maeda-Smithies N.
    Redox Biology, 2020, 32, 101504 DOI: 10.1016/j.redox.2020.101504
  31. "Uremic toxins alter coagulation and fibrinolysis-related genes expression in human endothelial cells"
    Oe Y, Sato E, Sato H, Miyazaki M, Ito S, Takahashi N.
    Thromb Res, 2020, 186, 75-77, DOI: 10.1016/j.thromres.2019.12.017.

    32. 2019
  32. "Drugs Repurposed as Antiferroptosis Agents Suppress Organ Damage, Including AKI, by Functioning as Lipid Peroxyl Radical Scavengers"
    Mishima E, Sato E, Ito J, Yamada KI, Suzuki C, Oikawa Y, Matsuhashi T, Kikuchi K, Toyohara T, Suzuki T, Ito S, Nakagawa K, Abe T.
    J Am Soc Nephrol, 2019, in press, DOI: 10.1681/ASN.2019060570.
  33. "Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease"
    Kikuchi K, Saigusa D, Kanemitsu Y, Matsumoto Y, Thanai P, Suzuki N, Mise K, Yamaguchi H, Nakamura T, Asaji K, Mukawa C, Tsukamoto H, Sato T, Oikawa Y, Iwasaki T, Oe Y, Tsukimi T, Fukuda NN, Ho HJ, Nanto-Hara F, Ogura J, Saito R, Nagao S, Ohsaki Y, Shimada S, Suzuki T, Toyohara T, Mishima E, Shima H, Akiyama Y, Akiyama Y, Ichijo M, Matsuhashi T, Matsuo A, Ogata Y, Yang CC, Suzuki C, Breeggemann MC, Heymann J, Shimizu M, Ogawa S, Takahashi N, Suzuki T, Owada Y, Kure S, Mano N, Soga T, Wada T, Kopp JB, Fukuda S, Hozawa A, Yamamoto M, Ito S, Wada J, Tomioka Y, Abe T.
    Nat Commun, 2019, 10(1), 1835, DOI:10.1038/s41467-019-09735-4.
  34. "Glomerular Injury Is Exacerbated in Lupus-Prone MRL/lpr Mice Treated with a Protease-Activated Receptor 2 Antagonist"
    Itto R, Oe Y, Imaruoka K, Sato E, Sekimoto A, Yamakage S, Kumakura S, Sato H, Ito S, Takahashi N.
    Tohoku J Exp Med, 2019, 249(2), 127-133, DOI: 10.1620/tjem.249.127.
  35. "Protease-activated receptor 2 protects against VEGF inhibitor-induced glomerular endothelial and podocyte injury"
    Oe Y, Fushima T, Sato E, Sekimoto A, Kisu K, Sato H, Sugawara J, Ito S, Takahashi N.
    Sci Rep, 2019, 9 (1), 2986. DOI: 10.1038/s41598-019-39914-8.
  36. "Protease-activated receptor 2 exacerbates cisplatin-induced nephrotoxicity"
    Watanabe M, Oe Y, Sato E, Sekimoto A, Sato H, Ito S, Takahashi N.
    Am J Physiol Renal Physiol, 2019, 316(4), F654-F659, DOI:10.1152/ajprenal.00489.2018.
  37. "Nicotinamide alleviates kidney injury and pregnancy outcomes in lupus-prone MRL/lpr mice treated with lipopolysaccharide"
    Imaruoka K, Oe Y, Fushima T, Sato E, Sekimoto A, Sato H, Sugawara J, Ito S, Takahashi N.
    Biochem Biophys Res Commun, 2019, 510 (4), 587-593 DOI: 10.1016/j.bbrc.2019.01.110.

    38. 2018
  38. "Vitamin B3 Nicotinamide: A Promising Candidate for Treating Preeclampsia and Improving Fetal Growth"
    Takahashi N, Li F, Fushima T, Oyanagi G, Sato E, Oe Y, Sekimoto A, Saigusa D, Sato H, Ito S.
    Tohoku J Exp Med, 2018, 244(3), 243-248 DOI: 10.1620/tjem.244.243.
  39. "Urinary angiotensinogen excretion level is associated with elevated blood pressure in the normotensive general population"
    Sato E, Wang AY, Satoh M, Nishikiori Y, Oba-Yabana I, Yoshida M, Sato H, Ito S, Hida W, Mori T.
    Am J Hypertens, 2018, DOI: 10.1093/ajh/hpy020
  40. "Hepatic dysfunction and thrombocytopenia induced by excess sFlt-1 in mice lacking endothelial nitric oxide synthase"
    Oe Y, Ko M, Fushima T, Sato E, Karumanchi SA, Sato H, Sugawara J, Ito S, Takahashi N.
    Sci Rep, 2018, 8(1), 102
  41. "Impact of the oral adsorbent AST-120 on organ-specific accumulation of uremic toxins: LC-MS/MS and MS imaging techniques"
    Sato E, Saigusa D, Mishima E, Uchida T, Miura D, Morikawa-Ichinose T, Kisu K, Sekimoto A, Saito R, Oe Y, Matsumoto Y, Tomioka Y, Mori T, Takahashi N, Sato H, Abe T, Niwa T, Ito S.
    Toxins, 2018, 10(1), 19

    42. 2017
  42. "Diabetes mellitus as a cause or comorbidity of chronich kidney disease and its outcomes: the Gonryo study"
    Iwai T, Miyazaki M, Yamada G, Yamamoto T, Satoh M, Sato H, Ito S.
    Clin Exp Nephrol, 2017, DOI: 10.1007/s10157-017-1451-4
  43. "Protease-activated receptor 2 exacerbates adenine-induced renal tubulointerstitial injury in mice"
    Hayashi S, Oe Y, Fushima T, Sato E, Sato H, Ito S, Takahashi N.
    Biochem Biophys Res Commun, 2017, 483(1), 547-552
  44. "Nicotinamide ameliorates a preeclampsia-like condition in mice with reduced uterine perfusion pressure"
    Fushima T, Sekimoto A, Oe Y, Sato E, Ito S, Sato H, Takahashi N.
    Am J Physiol Renal Physiol, 2017, 312(2), F366-372

    45. 2016
  45. "Nicotinamide benefits both mothers and pups in two contrasting mouse models of pre-eclampsia"
    Li F, Fushima T, Oyanagi G, Nakada H, Townley-Tilson HWD, Masujima N, Ishida A, Oe Y, Hagaman JR, Wilder J, Li M, Sekimoto A, Sato E, Sato H, Ito S, Jennette JC, Maeda N, Karumanchi SA, Smithies O, Takahashi N.
    Proc Natl Acad Sci USA, PMID: 27821757, DOI: 10.1073/pnas.16149471132016, 2016
  46. "Metabolic alteration by indoxyl sulfate in skeletal muscle induce uremic sarcopenia in chronic kidney disease"
    Sato E, Mori T, Mishima E, Suzuki A, Sugawara S, Kurasawa N, Saigusa D, Miura D, Ichinose M. T, Saito R, Yabana O. I, Oe Y, Kisu K, Naganuma E, Koizumi K, Mokudai T, Niwano Y, Kudo T, Suzuki C, Takahashi N, Sato H, Abe T, Niwa T, Ito S.
    Sci Rep,doi:10.1038/srep36618, 2016
  47. "Coagulation factor Xa and PAR2 as novel theputic targets for diabetic nephropathy"
    Oe Y, Hayashi S, Fushima T, Sato E, Kisu K, Sato H, Ito S, Takahashi N.
    Arterioscler Thromb Vasc Biol, 2016, 36(8): 1525-1533
  48. "Reduced Uterine Perfusion Pressure (RUPP) model of preeclampsia in mice"
    Fushima T, Sekimoto A, Minato T, Oe Y, Kisu K, Sato E, Funamoto K, Hayase T, Kimura Y, Ito S, Sato H, Takahashi N.
    PLoS One, 2016, 11(5):e0155426
  49. "Metabolomic analysis of a mouse model of preeclampsia unduced by overproducing sFlt-1"
    Sato E, Tsunokuni Y, Fushima T, Kaneko M, Saito R, Sekimoto A, Saigusa D, Ito S, Sato H, Takahashi N.
    J Hypertens, 2016, 34, Suppl 1, e69
  50. "Novel reduced uterine perfusion pressure (RUPP) model of preeclampsia in mice"
    Fushima T, Sekimoto A, Minato T, Ito T, Oe Y, Kisu K, Sato E, Funamoto K, Kimura Y, Ito S, Sato H, Takahashi N.
    J Hypertens, 2016, 34, Suppl 1, e237
  51. "Pivotal role of heme oxygenase in amelioration by nicotinamide of fetal growth restriction associated with preeclampsia"
    Nakada H, Fushima T, Sekimoto A, Oe Y, Sato E, Ito S, Sato H, Takahashi N.
    J Hypertens, 2016, 34, Suppl 1, e237
  52. "Urinary angiotensinogen excretion is associated with blood pressure in obese young adults"
    Sato E, Mori T, Satoh M, Fujiwara M, Nakamichi Y, Oba I, Ogawa S, Kinouchi Y, Sato H, Ito S, Hida W.
    Clin Exp Hypertens, 2016, 38(2), 203-208

    53. 2015
  53. "A Novel and Sensitive Assay for Heme Oxygenase Activity"
    Iwamori S, Sato E, Saigusa D, Yoshinari K, Ito S, Sato H, Takahashi N.
    Am J Physiol Renal Physiol, 2015, 309(7), F667-671
  54. "A simple and rapid ultra-high-performance liquid chromatography-tandem mass spectrometry method to determine plasma biotin in hemodialysis patients"
    Yagi S, Nishizawa M, Ando I, Oguma S, Sato E, Imai Y, Fujiwara M.
    Biomed Chromatogr, 2015, 30(8), 1285-1290
  55. "Chronic Running Exercise Alleviates Early Progression of Nephropathy with Upregulation of Nitric Oxide Synthases and Suppression of Glycation in Zucker Diabetic Rats"
    Ito D, Cao P, Kakihana T, Sato E, Suda C, Muroya Y, Ogawa Y, Hu G, Ishii T, Ito O, Kohzuki M, Kiyomoto H
    PLoS One, 2015, 10(9), e0138037
  56. "A functional (pro)renin receptor is expressed in human lymphocytes and monocytes"
    Narumi K, Hirose T, Sato E, Mori T, Kisu K, Ishikawa M, Totsune K, Ishii T, Ichihara A, Nguyen G, Sato H, Ito S.
    Am J Physiol Renal Physiol, 2015, 308(5), F487-499

    57. 2014
  57. "Pathology of glomerular lipidosis"
    Sato H, Takahashi N, Sato E, Kisu K, Ito S.
    Clin Exp Nephrol, 2014, 18, 194-196
  58. "Therapeutic effect of nicotinamide on IgA Nephropathy"
    Fushima T, Oe Y, Iwamori S, Sato E, Suzuki Y, Tomino Y, Ito S, Sato H, Takahashi N.
    Nephrology, 2014, 19, 146
  59. "Bartter syndrome, Gitelman syndrome, Liddle syndrome"
    Takahashi N, Ito S.
    Kidney diseases/hemodialysis updates, 2014, 2014, 217-219

    60. 2012
  60. "Evaluation of pre-hospital clinical training in advanced pharmacy education in Japan"
    Hashimoto T, Ohkubo T, Takahashi N, Murai Y, Sato K, Terata S, Metoki H, Kikuya M, Hirasawa N, Tomioka Y, Oba M, Imai Y, and Sato H.
    pn J Pharm Health Care Sci, 2012, 38, 322-331
  61. "eNOS and diabetic nephropathy"
    Li F and Takahashi N.
    J Nephrol Therapeutic, 2012, 10, S2-004
  62. "Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes"
    Bordicchia M, Liu D, Amri E-Z, Ailhaud G, Fulgheri D, Takahashi N, Sarzani R, Collins S.
    J Clin Invest, 2012, 122(3), 1022-1036
  63. "eNOS deficiency acts through endothelin to aggravate sFlt-1-induced pre-eclampsia-like phenotype"
    Li F, Hagaman JR, Kim H-S, Maeda N, Jennette JC, Faber JE, Karumanchi SA, Smithies O, Takahashi N.
    J Am Soc Nephrol, 2012, 23, 652-660

    64. 2011
  64. "A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy"
    Wang C-H, Li F, Hiller S, Kim H-S, Maeda N, Smithies O, Takahashi N.
    Proc Natl Acad Sci USA , 2011, 108, 2070-2075

    65. 2010
  65. "Elevated tissue factor expression contributes to exacerbated diabetic nephropathy in mice lacking eNOS fed a high fat diet"
    Li F, Wang C-H, Thai T, Boysen G, Xu L, Turner AL, Wolberg AS, Mackman N, Maeda N, Takahashi N.
    J Thromb and Hemost, 2010, 8, 2122-2132
  66. "The renin angiotensin system and metabolic syndrome"
    Wang C-H. Li F, Takahashi N
    Open Hypertens J, 2010, 3, 1-13
  67. "Cardiac Contractility and Mitochondrial Function Following Genetic Deletion of Bradykinin Receptors B1 and B2 in Type 1 Diabetic Akita Mice"
    Wende AR, Soto J, Olsen CD, Pires KMP, Schell JC, Litwin SE, Kakoki M, Takahashi N, Smithies O, and Abel ED.
    Endocrinology, 2010, 151, 3536-3546