Publication List (Kentaro Okano)


Original Papers

(35) Synthetic Studies toward Penitrem E: Enantiocontrolled Construction of B-E Rings
  Y. Yoshii, T. Otsu, N. Hosokawa, K. Takasu, K. Okano, H. Tokuyama
  Chem. Commun., 51, 1070-1073 (2015)

(34) Stereochemistry of Vinylogous Rubottom Oxidation of Proline-fused Cyclohexadienol Silyl Ether
   K. Okano, S. Okaya, T. Kurogi, H. Fujiwara, H. Tokuyama
  Heterocycles, 90, 1299-1308 (2015)

(33) Total Synthesis of (-)-Haouamine B Pentaacetate and Structural Revision of Haouamine B
   Y. Momoi, K. Okuyama, H. Toya, K. Sugimoto, K. Okano, H. Tokuyama
  Angew. Chem. Int. Ed., 53, 13215-13219 (2014)

(32) Generation of Aryl Grignard Reagent from Arene Chromium Tricarbonyl Complex by Mg(TMP)2·2LiCl and Its Application to Murahashi Coupling
   Y. Momoi, K. Okano, H. Tokuyama
  Synlett, 25, 2503-2507 (2014)

(31) Stereocontrolled Total Synthesis and Biological Evaluation of (–)- and (+)-Petrosin, and Its Derivatives
   H. Toya, T. Satoh, K. Okano, K. Takasu, M. Ihara, A. Takahashi, H. Tanaka, H. Tokuyama
  Tetrahedron, 70, 8129-8141 (2014)

(30) Synthesis of a Human Urate Transporter-1 Inhibitor, an Arginine Vasopressin Antagonist, and a 17β-Hydroxysteroid Dehydrogenase
   Type 3 Inhibitor, Using Ring-Expansion of Cyclic Ketoximes with DIBALH
   H. Cho, Y. Iwama, K. Okano, H. Tokuyama
  Chem. Pharm. Bull., 62, 354-363 (2014)

(29) Formation of Xanthone Oxime and Related Compounds Using a Combination of tert-Butyl Nitrite and Potassium Hexamethyldisilazide
  Y. Iwama, T. Noro, K. Okano, H. Cho, H. Tokuyama
  Heterocycles, 88, 1433-1444 (2014)

(28) Total Synthesis of PDE-I and -II by Copper-Mediated Double Aryl Amination
  K. Okano, N. Mitsuhashi, H. Tokuyama
  Tetrahedron, 69, 10946-10954 (2013)

(27) Formal Synthesis of Hepatitis C Virus NS5B Polymerase Inhibitor
  T. Noro, K. Okano, H. Tokuyama
  Synlett, 2143-2147 (2013)

(26) Enantiocontrolled Total Synthesis of (–)-Mersicarpine
  Y. Iwama, K. Okano, K. Sugimoto, H. Tokuyama
  Chem. Eur. J., 19, 9325-9334 (2013)

(25) Synthesis of Substituted Indoline and Carbazole by Benzyne-Mediated Cyclization-Functionalization
  T. Noji, H. Fujiwara, K. Okano, H. Tokuyama
  Org. Lett., 15, 1946-1949 (2013)

(24) Construction of Dibenzazocine Skeleton by Regiocontrolled Ring-expansion Reaction of Cyclic Oxime with DIBALH:
  Facile Synthesis of 17β-Hydroxysteroid Dehydrogenase Type 3 Inhibitor
  H. Cho, Y. Iwama, K. Okano, H. Tokuyama
  Synlett, 813-816 (2013)

(23) Total Synthesis of (–)-Acetylaranotin
  H. Fujiwara, T. Kurogi, S. Okaya, K. Okano, H. Tokuyama
  Angew. Chem. Int. Ed., 51, 13062-13065 (2012)

(22) Total Synthesis of Makaluvamine A/D, Damirone B, Batzelline C, Makaluvone, and Isobatzelline C
  Featuring One-Pot Benzyne-Mediated Cyclization-Functionalization
  T. Oshiyama, T. Satoh, K. Okano, H. Tokuyama
  Tetrahedron, 68, 9376-9383 (2012)

(21) Ring-Expansion Reaction of Oximes with Aluminum Reductants
  H. Cho, Y. Iwama, N. Mitsuhashi, K. Sugimoto, K. Okano, H. Tokuyama
  Molecules, 17, 7348-7355 (2012)

(20) Total Synthesis of Batzelline C and Isobatzelline C
  T. Oshiyama, T. Satoh, K. Okano, H. Tokuyama
  RSC Adv., 2, 5147-5149 (2012)

(19) Concise Total Synthesis of (–)-Mersicarpine
  Y. Iwama, K. Okano, K. Sugimoto, H. Tokuyama
  Org. Lett., 14, 2320-2322 (2012)

(18) Synthetic Studies on Paspaline: Lewis Acid-Mediated Sequential Construction of A-E Ring Skeleton
  K. Okano, Y. Yoshii, H. Tokuyama
  Heterocycles, 84, 1325-1334 (2012)

(17) Synthesis of Acylsilanes by Palladium-catalyzed Cross-coupling Reaction of Thiol Esters and Silylzinc Chlorides
  H. Azuma, K. Okano, H. Tokuyama
  Chem. Lett., 40, 959-961 (2011)

(16) An Intramolecular Amination of Aryl Halides with a Combination of Copper(I) Iodide and Cesium Acetate:
  Preparation of 5,6-Dimethoxyindole-1,2-dicarboxylic Acid 1-Benzyl Ester 2-Methyl Ester
  T. Noji, K. Okano, T. Fukuyama, H. Tokuyama
  Org. Synth., 88, 388-397 (2011)

(15) Preparation of Horner-Wadsworth-Emmons Reagent:
  Methyl 2-Benzyloxycarbonylamino-2-(dimethoxyphosphinyl)acetate
  H. Azuma, K. Okano, T. Fukuyama, H. Tokuyama
  Org. Synth., 88, 152-161 (2011)

(14) Synthetic Studies toward Haouamine B: Construction of Indenotetrahydropyridone Skeleton
  K. Okuyama, Y. Momoi, K. Sugimoto, K. Okano, H. Tokuyama
  Synlett, 73-76 (2011)

(13) Regiospecific Rearrangement of Hydroxylamines to Secondary Amines using Diisobutylaluminum Hydride
  H. Cho, K. Sugimoto, Y. Iwama, N. Mitsuhashi, K. Okano, H. Tokuyama
  Heterocycles, 82, 1633-1644 (2011)

(12) Total Synthesis of Dictyodendrins A–E
  H. Tokuyama, K. Okano, H. Fujiwara, T. Noji, T. Fukuyama
  Chem. Asian J., 6, 560-572 (2011)

(11) Enantioselective Total Synthesis of (–)- and (+)-Petrosin
  H. Toya, K. Okano, K. Takasu, M. Ihara, A. Takahashi, H. Tanaka, H. Tokuyama
  Org. Lett., 12, 5196-5199 (2010)

(10) Total Synthesis of Dictyodendrin A and B
  K. Okano, H. Fujiwara, T. Noji, T. Fukuyama, H. Tokuyama
  Angew. Chem. Int. Ed., 49, 5925-5929 (2010)

(9) Total Synthesis of PDE-II by Copper-Mediated Double Amination
  K. Okano, N. Mitsuhashi, H. Tokuyama
  Chem. Commun., 46, 2641-2643 (2010)

(8) Total Synthesis of (±)-Lepadiformine A via Radical Translocation/Cyclization Reaction
  M. Fujitani, M. Tsuchiya, K. Okano, K. Takasu, M. Ihara, H. Tokuyama
  Synlett, 822-826 (2010)

(7) Protection of Diols with p-(tert-Butyldimethylsilyloxy)benzylidene Acetal and Its Deprotection:
  (4-((4R,5R)-4,5-Diphenyl-1,3-dioxolan-2-yl)phenoxy)(tert-butyl)dimethylsilane
  H. Osajima, H. Fujiwara, K. Okano, H. Tokuyama, T. Fukuyama
  Org. Synth., 86, 130-140 (2009)

(6) A Mild Inter- and Intramolecular Amination of Aryl Halides with a Combination of CuI and CsOAc
  T. Kubo, C. Katoh, K. Yamada, K. Okano, H. Tokuyama, T. Fukuyama
  Tetrahedron, 64, 11230-11236 (2008)

(5) Mild Debenzylation of Aryl Benzyl Ether with BCl3 in the Presence of Pentamethylbenzene as a Non-Lewis-Basic Cation Scavenger
  K. Okano, K. Okuyama, T. Fukuyama, H. Tokuyama
  Synlett, 1977-1980 (2008)

(4) Total Synthesis of (+)-Yatakemycin
  K. Okano, H. Tokuyama, T. Fukuyama
  Chem. Asian J., 3, 296-309 (2008)

(3) Total Synthesis of (+)-Yatakemycin
  K. Okano, H. Tokuyama, T. Fukuyama
  J. Am. Chem. Soc., 128, 7136-7137 (2006)

(2) Hydroesterification of Vinylarenes Catalyzed by Palladium Complexes of Dialkylmonoaryl- and Monoalkyldiarylphosphines
  Y. Kawashima, K. Okano, K. Nozaki, T. Hiyama
  Bull. Chem. Soc. Jpn., 77, 347-355 (2004)

(1) Synthesis of Secondary Arylamines through Copper-Mediated Intermolecular Aryl Amination
  K. Okano, H. Tokuyama, T. Fukuyama
  Org. Lett., 5, 4987-4990 (2003)

 

Reviews

(7) Copper-mediated aromatic amination reaction and its application to the total synthesis of natural products
  K. Okano, H. Tokuyama, T. Fukuyama
  Chem. Commun., 50, 13650-13663 (2014)

(6) 不安定な七員環をいかにつくるか?ーアセチルアラノチンの全合成
  H. Tokuyama, K. Okano
  Kagaku (Kyoto), 69, 68-69 (2014)

(5) Synthetic Studies on Natural Products with Aromatic Nitrogen Heterocycles Based on Development of the Methods for the Formation of Aryl Carbon–Nitrogen Bond
  K. Okano
  Yakugaku Zasshi, 133, 1065-1078 (2013)

(4) Total Syntheses of Mersicarpine
  Y. Iwama, K. Okano, H. Tokuyama
  J. Synth. Org. Chem., Jpn, 71, 926-934 (2013)

(3) Total Syntheses of Nitrogen-Containing Cyclic Natural Products Based on Aryl Amination
  K. Okano, T. Fukuyama, H. Tokuyama
  J. Synth. Org. Chem., Jpn, 68, 1036-1046 (2010)

(2) アリル位C-H酸化が切り開くマクロリド合成の新展開
  K. Okano
  Farumashia, 46, 548-549 (2010)

(1) Synthetic Studies on Haouamines with Highly Strained Paracyclophane Skeleton
  K. Okano
  J. Synth. Org. Chem., Jpn, 66, 387-388 (2008)

 

Books

(3) 「天然物合成で活躍した反応」分担執筆、有機合成化学協会編、化学同人、2011

(2) 「天然物の全合成 2000〜2008(日本)」分担執筆、有機合成化学協会編、化学同人、2009

(1) 「演習で学ぶ 有機反応機構」分担執筆、有機合成化学協会編、化学同人、2005