臨床分析化学分野

Ryo kajita, Takaaki Goto, Seon Hwa Lee and Tomoyuki Oe:
Aldehyde stress-mediated novel modification of proteins: epimerization of the N-terminal amino acid.
Chem. Res. Toxicol., 26, 1926-1936 (2013)

Takaaki Goto, Kazuyuki Murata, Seon Hwa Lee and Tomoyuki Oe:
Complete amino acid sequencing and immunoaffinity clean-up can facilitate screening of various chemical modifications on human serum albumin.
Anal. Bioanal. Chem., 405, 7383-7395 (2013)

Ryo Satoh, Takaaki Goto, Seon Hwa Lee and Tomoyuki Oe:
Can Edman degradation be used for quantification Isotope-dilution? liquid chromatography electrospray ionization tandem mass spectrometry and the long-term stability of 20 phenylthiohydantoin-amino acids.
Anal. Bioanal. Chem., 405, 8001-8010 (2013)

Seon Hwa Lee, Takuro Masuda, Takaaki Goto, Tomoyuki Oe:
MALDI-TOF/MS-based label-free binding assay for angiotensin Ⅱ type 1 recepter: application for novel angiotensin peptides.
Anal. Biochem., 437, 10-16 (2013)

Takaaki Goto, Shota Kojima, Shohei Shitamichi, Seon Hwa Lee and Tomoyuki Oe:
Chemical modificomics: a novel strategy for efficient biomarker discovery through chemical modifications on a target peptide.
Anal. methods, 4, 1945-1952 (2012)

Seon Hwa Lee, Kohei Miyamoto, Takaaki Goto and Tomoyuki Oe:
Non-invasive proteomic analysis of human skin keratins: screening of methionine oxidation in keratins by mass spectrometry.
J. Proteomics, 75, 435-449 (2011)

Jasbir S. Arora, Tomoyuki Oe and Ian A. Blair:
Synthesis of deuterium-labeled analogs of the lipid hydroperoxide-derived bifunctional electrophile 4-oxo-2(E)-nonenal.
J. Label Compd. Radiopharm., 54, 247-251 (2011)

Tomoyuki Oe, Masamitsu Maekawa, Ryo Satoh, Seon Hwa Lee and Takaaki Goto:
Combing [¹³C₆]-phenylisothiocyanate and the Edman degradation reaction: a possible breakthrough for absolute quantative proteomics together with protein identification.
Rapid Commun. Mass Spectrom., 24, 173-179 (2010)

Takao Sanaki, Mao Suzuki, Seon Hwa Lee, Takaaki Goto and Tomoyuki Oe:
A simple and efficient approach to improve protein identification by the peptide mass fingerprinting method: concomitant use of negative ionization.
Anal. methods, 2, 1144-1151 (2010)

Seon Hwa Lee, Ryo Takahashi, Takaaki Goto and Tomoyuki Oe:
Mass spectrometric characterization of modification to angiotensin Ⅱ by lipid peroxidation products, 4-oxo-2(E)-nonenal and 4-Hydroxy-2(E)-nonenal.
Chem. Res. Toxicol., 23, 1771-1785 (2010)

Clementina Mesaros, Bogdan G. Gugiu, Rong Zhou, Seon Hwa Lee, Jaewoo Choi, James Laird, Ian A. Blair and Robert G. Salomon:
A 13-oxo-9,10-epoxytridecenoate phospholipid analogue of the genotoxic 4,5-epoxy-2(E)-decenal: detection in vivo, chemical synthesis, and adduction with DNA.
Chem. Res. Toxicol., 23, 516-527 (2010)

Trevor M. Penning, Seon Hwa Lee, Yi Jin, Alejandro Gutierrez and Ian A. Blair:
Liquid chromatography-mass spectrometry (LC-MS) of steroid hormone metabolites and its applications.
J. Steroid Biochem. Mol. Biol., 121, 546-555 (2010)

Michael C. Byrns, Ling Duan, Seon Hwa Lee, Ian A. Blair and Trevor M. Penning:
Aldo-keto reductase 1C3 expression in MCF-7 cells reveals roles in steroid hormone and prostaglandin metabolism that may explain its over-expression in breast cancer.
J. Steroid Biochem. Mol. Biol., 118, 177-187 (2009)

Wenying Jian, Seon Hwa Lee, Michelle V. Williams and Ian A. Blair:
5-Lipoxygenase-mediated endogenous DNA damage.
J. Biol. Chem., 284, 16799-16807 (2009)

Dipti Mangal, Daljit Vudathala, Jong Heum Park, Seon Hwa Lee, Trevor M. Penning and Ian A. Blair:
Analysis of 7,8-dihydro-8-oxo-2'-deoxyguanosine in cellular DNA during oxidative stress.
Chem. Res. Toxicol., 22, 788-797 (2009)

Yi Jin, Ling Duan, Seon Hwa Lee, Helenius J. Kloosterboer, Ian A. Blair and Trevor M. Penning:
Human cytosolic hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily catalyze reduction of conjugated steroids: Implications for phase I and phase II steroid hormone metabolism.
J. Biol. Chem., 284, 10013-10022 (2009)

Sarah Dunn Keene, Todd M. Greco, Ioannis Parastatidis, Seon-Hwa Lee, Ethan G. Hughes, Rita J. Balice-Gordon, David W. Speicher, Harry Ischiropoulos:
Mass spectrometric and computational analysis of cytokine-induced alterations in the astrocyte secretome.
Proteomics, 9, 768-782 (2009)

Seon Hwa Lee, Takaaki Goto and Tomoyuki Oe:
A novel 4-oxo-2(E)-nonenal-derived modification to angiotensin II: Oxidative decarboxylation of N-terminal aspartic acid.
Chem. Res. Toxicol., 21, 2237-2244 (2008)

David P. Paulson, Waleed Abuzeid, Hao Jiang, Tomoyuki Oe, Bert W. O'Malley and Daqing Li:
A novel controlled local drug delivery system for inner ear disease.
Laryngoscope, 118, 706-711 (2008)

Peijuan Zhu, Tomoyuki Oe, and Ian A. Blair:
Determination of cellular redox status by stable isotope dilution liquid chromatography/mass spectrometry analysis of glutathione and glutathione disulfide.
Rapid Commun. Mass Spectrom., 22, 432-440 (2008)