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最終更新日：2012／11／5

（2013年）

REVIEW ARTICLES / BOOKS（現在2報）

Biochemical Assay of G Protein-Coupled Receptor Oligomerization: Adenosine A1 and Thromboxane A2 Receptors Form the Novel Functional Hetero-oligomer
Natsumi Mizuno, Tokiko Suzuki, Yu Kishimoto, Noriyasu Hirasawa
Methods in Cell Biology, 117, 213-227 (2013)

Hetero-oligomerization and Specificity Changes of G Protein-Coupled Purinergic Receptors: Novel Insight into Diversification of Signal Transduction
Tokiko Suzuki, Kazunori Namba, Natsumi Mizuno, Hiroyasu Nakata
Methods in Enzymology, 521, 239-257 (2013)

REGULAR ARTICLES（現在3報）

（2012年）

REGULAR ARTICLES（4報）

Involvement of lipid rafts in multiple signal transductions mediated by two isoforms of thromboxane A2 receptor: dependency on receptor isoforms and downstream signaling types
Shinji Goto, Masaki Saito, Yutaro Obara, Takahiro Moriya, Norimichi Nakahata
European Journal of Pharmacology, 693, 15-24 (2012)

Plasma Brain-Derived Neurotrophic Factor Levels Predict the Clinical Outcome of Depression Treatment in a Naturalistic Study Masatake Kurita, Satoshi Nishino, Maiko Kato, Yukio Numata, Tadahiro Sato
PLoS ONE, 7, e39212 (2012)

Apoptotic effects of satratoxin H is mediated through DNA double-stranded break in PC12 cells
Punnee Nusuetrong, Masaki Saito, Haruhisa Kikuchi, Yoshiteru Oshima, Takahiro Moriya, Norimichi Nakahata
The Journal of Toxicological Sciences, 37, 803-812 (2012)

Hetero-oligomerization between adenosine A(1) and thromboxane A(2) receptors and cellular signal transduction on stimulation with high and low concentrations of agonists for both receptors
Natsumi Mizuno, Tokiko Suzuki, Noriyasu Hirasawa, Norimichi Nakahata
Eur J Pharmacol, 677, 5-14 (2012)

（2011年）

REVIEW ARTICLES / BOOKS（2報）

漢方薬は古くて新しい薬-現代科学的手法を用いた作用機序の解明
中畑則道
日本小児東洋医学会会誌in press (2011)

中枢神経系作用薬の時間治療への応用の可能性
守屋孝洋
ファルマシア．47, 618-622 (2011)

REGULAR ARTICLES（9報）

Functional interaction between purinergic receptors: effect of ligands for A2A and P2Y12 receptors on P2Y1 receptor function
Tokiko Suzuki, Yutaro Obara, Takahiro Moriya, Hiroyasu Nakata, Norimichi Nakahata
FEBS Lett., 585, 3978-3984 (2011)

Lysophosphatidylinositol causes neurite retraction via GPR55 G13 and RhoA in PC12 cells
Yutaro Obara, Sanae Ueno, Yoshimi Yanagihata, Norimichi Nakahata
PLoS ONE, 6(8), e24284 (2011)

Divergent effects of lithium and sodium valproate on brain-derived neurotrophic factor (BDNF) production in human astrocytoma cells at therapeutic cencentrations
Satoshi Nishino, Koji Ohtomo, Yukio Numata, Tadahiro Sato, Norimichi Nakahata, Masatake Kurita
Prog. Neuro-Psychoph., in press

Distinctive effects of arachidonic acid and docosahexaenoic acid on neural stem/progenitor cells
Nobuyuki Sakayori, Motoko Maekawa, Keiko Numayama-Tsuruta, Takashi Katura, Takahiro Moriya, Noriko Osumi
Genes to Cells, 16, 778-790 (2011)

認知症患者の中核症状、周辺症状および日常生活動作能力の関係について
寺西美佳、栗田征武、西野　敏、武吉健児、沼田由紀夫、佐藤忠宏、中畑則道、舘野　周、大久保善朗
老年精神医学雑誌．22, 185-193 (2011)

A synthetic cannabinoid, CP55940, inhibits lipopolysaccharide-induced cytokine mRNA expression in a cannabinoid receptor-independent mechanism in rat cerebellar granule cells
Toshiki Chiba, Sanae Ueno, Yutaro Obara and Norimichi Nakahata
J. Pharm. Pharmacol. 63, 636-647 (2011)

Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice
Koichiro Mori, Yutaro Obara, Takahiro Moriya, Satoshi Inatomi, Norimichi Nakahata
Biomed. Res. 32, 67-72 (2011)

Lyconadins D and E, and complanadine E, new lycopodium alkaloids from lycopodium complanatum
Kan'ichiro Ishiuchi, Takaaki Kubota, Haruaki Ishiyama, Shigeki Hayashi, Toshiro Shibata, Koichiro Mori, Yutaro Obara, Norimichi Nakahata and Jun'ichi Kobayashi
Bioorg. Med. Chem. 19, 749-753 (2011)

Basic fibroblast growth factor promotes glial cell-derived neurotrophic factor gene expression mediated by activation of ERK5 in rat C6 glioma cells
Yutaro Obara, Wataru Nemoto, Susumu Kohno, Tomiyasu Murata, Norio Kaneda and Norimichi Nakahata
Cell Signal. 23, 666-672 (2011)

（2010年）

REVIEW ARTICLES / BOOKS（11報）

インテグレーテッドシリーズ4薬理学：感染症の治療、中枢神経系
守屋孝洋
（分担翻訳：東京化学同人　平成22年4月1日発行）

インテグレーテッドシリーズ4薬理学：薬物動態、薬力学作用およびシグナル伝達、血液、炎症性疾患
中畑則道
（分担翻訳：東京化学同人　平成22年4月1日発行）

会合蛋白質によるG蛋白質共役型受容体の制御
斎藤将樹、中畑則道
医学のあゆみ 233, 668-673 (2010)

GPCRのヘテロダイマー形成
鈴木登紀子、中田裕康
医学のあゆみ 233, 675-679 (2010)

Period遺伝子の発現制御を介した概日時計のリセット機構に関する研究
守屋孝洋
日薬理誌 135, 230-234 (2010)

マストパランの薬理活性：シグナル伝達への関与
中畑則道、須釜淳
日薬理誌 136, 145-149 (2010)

脳由来神経栄養因子（BDNF）広範囲血液・尿化学検査、免疫学的検査-その数値をどう読むか　[第7版]　(4)
栗田征武、西野敏、中畑則道
日本臨床 68, 131-133 (2010)

The signaling pathway leading to ERK5 activation via G-proteins and ERK5-dependent neurotrophic effects
Yutaro Obara, Norimichi Nakahata
Mol. Pharmacol. 77, 10-16 (2010)

PKA融合ホタルルシフェラーゼを用いた細胞内cAMPレベルの測定
小原祐太郎、中畑則道
日薬理誌 136, 285-289 (2010)

血漿のMHPGとBDNFがうつ症状と躁症状ともに有意な相関を示した双極性感情障害の1症例
栗田征武、西野敏、加藤舞子、沼田由紀夫、佐藤忠宏、中畑則道
（Bipolar Disorder 8 p53-p60 Bipolar Disorder研究会編：アルタ出版　平成22年6月1日発行）

Dimerization of G protein-coupled purinergic receptors: increasing the diversity of purinergic receptor signal responses and receptor functions
Hiroyasu Nakata, Tokiko Suzuki, Kazunori Namba, Koshi Oyanagi
J. Recept. Signal. Transduct. Res. 30, 337-346 (2010)

REGULAR ARTICLES（6報）

Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation
Koichiro Mori, Haruhisa Kikuchi, Yutaro Obara, Masaya Iwashita, Yoshihito Azumi, Satomi Kinugasa, Satoshi Inatomi, Yoshiteru Oshima, Norimichi Nakahata
Phytomedicine17, 1082-1085 (2010)

P2Y2 receptor-Gq/11 signaling at lipid rafts is required for UTP-induced cell migration in NG 108-15 cells
Koji Ando, Yutaro Obara, Jun Sugama, Atsushi Kotani, Nobuyuki Koike, Satoko Ohkubo, Norimichi Nakahata
J. Pharmacol. Exp. Ther. 334, 809-819 (2010)

The Uterus Sustains Stable Biological Clock during Pregnancy.
Shizuko Akiyama, Hidenobu Ohta, Shimpei Watanabe, Takahiro Moriya, Aya Hariu, Norimichi Nakahata, Hiroshi Chisaka, Tadashi Matsuda, Yoshitaka Kimura, Shigeru Tsuchiya, Hajime Tei, Kunihiro Okamura, Nobuo Yaegashi
Tohoku Journal of Experimental Medicine. 221, 287-298 (2010)

15-Deoxy-Δ^12,14-Prostaglandin J₂ Biphasically Regulates the Proliferation of Mouse Hippocampal Neural Progenitor Cells by Modulating the Redox State
Takashi Katura, Takahiro Moriya, Norimichi Nakahata
Mol. Pharmacol. 77, 601-611(2010)

Effects of medial hypothalamic lesions on feeding-induced entrainment of locomotor activity and liver Per2 expression in Per2::luc mice
Yu Tahara, Akiko Hirao, Takahiro Moriya, Takashi Kudo, Shigenobu Shibata
J. Biol. Rhythms 25, 9-18 (2010)

Involvement of aquaporin in thromboxane A₂ receptor-mediated, G_12/13/RhoA/NHE-sensitive cell swelling in 1321N1 human astrocytoma cells
Masaki Saito, Hiroyuki Tanaka, Masako Sasaki, Hitoshi Kurose and Norimichi Nakahata
Cell. Signal. 22, 41-46 (2010)

（2009年）

REVIEW ARTICLES / BOOKS（6報）

躁状態へのバルプロ酸急速飽和療法により血漿のノルアドレナリン代謝産物MHPGが低下した1例
栗田征武、西野敏、加藤舞子、佐藤忠宏、中畑則道
（Bipolar Disorder 7 p77-p83 Bipolar Disorder研究会編：アルタ出版　平成21年5月1日発行）

トロンボキサンA₂受容体の二量体形成および受容体会合タンパク質による活性制御
中畑則道
日薬理誌 134, 259-263 (2009)

Gタンパク質共役型受容体の新規機能
中畑則道
日薬理誌 134, 243 (2009)

天然物の魅力
中畑則道
漢方研究 12 (276) (2009)

標準医療薬学　薬理学テキスト：血液中畑則道（p287-p307分担執筆：辻本豪三 小池勝夫編：医学書院　平成21年6月15日発行）

神経系細胞におけるcAMPによるERK1/2活性化のシグナル伝達について
小原祐太郎、中畑則道、Philip J. S. Stork
日薬理誌 133, 63-68 (2009)

REGULAR ARTICLES（10報）

Thromboxane A₂ receptor-mediated epidermal growth factor receptor (EGFR) transactivation: involvement of PKC-δ and PKC-ε in shedding of EGFR ligands
Kotomi Uchiyama, Masaki Saito, Masako Sasaki, Yutaro Obara, Shigeki Higashiyama and Norimichi Nakahata
Eur. J. Pharm. Sci. 38, 504-511 (2009)

Phospholipase C-β4 is essential for the progression of the normal sleep sequence and ultradian body temperature rhythms in mice.
Masayuki Ikeda, Moritoshi Hirono, Takashi Sugiyama, Takahiro Moriya, Masami Ikeda-Sagara, Naomi Eguchi, Yoshihiro Urade, Tohru Yoshioka
PLoS One 4, e7737 (2009)

Nicotine enhances skin necrosis and expression of inflammatory mediators in a rat pressure ulcer model
Shusei Tsutakawa, Daisaku Kobayashi, Miho Kusama, Takahiro Moriya, and Noromichi Nakahata
Brit. J. Dermatol. 161, 1020-1027 (2009)

High-dose aripiprazole rapidly improves symptoms of acute schizophrenia with psychomotor excitement : a case report (J)
Masatake Kurita, Satoshi Nishino, Yukio Numata, Tadahiro Sato, and Norimichi Nakahata
Japan. J. Clin. Psychopharmacol. 12, 2011-2015 (2009)

ERK5 acitivity is required for NGF-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells
Yutaro Obara, Arata Yamauchi, Shin Takehara, Wataru Nemoto, Maho Takahashi, Philip J.S. Stork and Norimichi Nakahata
J. Biol. Chem. 284, 23564-23573 (2009)

A reduction of epidermal growth factor receptor is involved in brefelamide-induced inhibition of phosphorylation of ERK in human astrocytoma cells
Shigeyoshi Honma, Masaki Saito, Haruhisa Kikuchi, Yoshinori Saito, Yoshiteru Oshima, Norimichi Nakahata, and Makoto Yoshida
Eur. J. Pharmacol. 616, 38-42 (2009)

A highly conserved tryptophan residue in the fourth transmembrane domain of the A1 adenosine receptor is essential for ligand binding, but not receptor homodimerization
Tokiko Suzuki, Kazunori Namba, Ryosuke Yamagishi, Hiroki Kaneko, Tatsuya Haga, and Hiroyasu Nakata
J. Neurochem. 110, 1352-1362 (2009)

Inhibitory effects of Atractylodis Lanceae Rhizoma and Poria on collagen- or thromboxane A₂-induced aggregation in rabbit platelets
Yuiko Nasu, Masaya Iwashita, Masaki Saito, Shinji Fushiya and Norimichi Nakahata
Biol. Pharm. Bull. 32,　856-860 (2009)

The dorsomedial hypothalamic nucleus is not necessary for food-anticipatory circadian rhythms of behavior, temperature or clock gene expression in mice
Takahiro Moriya, Reiko Aida, Takashi Kudo, Masashi Akiyama, Masao Doi, Naomi Hayasaka, Norimichi Nakahata, Ralph Mistlberger, Hitoshi Okamura and Shigenobu Shibata
Eur. J. Neurosci. 29, 1447-1460 (2009)

Thromboxane A₂-induced signal transduction is negatively regulated by KIAA1005 that directly interacts with thromboxane A₂ receptor
Shin-ichi Tokue, Masako Sasaki and Norimichi Nakahata
Prostaglandins & Other Lipid Mediators 89, 8-15 (2009)

（2008年）

REVIEW ARTICLES / BOOKS（1報）

Thromboxane A2: physiology/pathophysiology, cellular signal transduction and pharmacology.
Norimichi Nakahata
Pharmacol. Ther. 18-35 (2008)

REGULAR ARTICLES（11報）

The olfactory conditioning in the early postnatal period stimulated neuronal stem/progenitor cells in the subventricular zone and increased neurogenesis in the olfactory bulb of rats
Kenji So, Takahiro Moriya, Shota Nishitani, Haruo Takahashi and Kazuyuki Shinohara
Neuroscience 151, 120-128 (2008)

Cholecystokinin-A receptors regulate photic input pathways to the circadian clock.
Takao Shimazoe, Mitsuo Morita, Shinichiro Ogiwara, Tomoyoshi Kojiya, Junpei Goto, Masaaki Kamakura, Takahiro Moriya, Kazuyuki Shinohara, Soichi Takiguchi, Akira Kono, Kyoko Miyasaka, Akihiro Funakoshi and Masayuki Ikeda
FASEB J. 22, 1479-1490 (2008)

Type 1 angiotensin receptor (AT1-R)-mediated decrease in type 2 angiotensin receptor mRNA level is dependent on Gq and extracellular signal-regulated kinase 1/2 in AT1-R-transfected PC12 cells
Masaki Saito, Yuki Shinohara, Hitomi Sasaki, Yuki Netsu, Makoto Yoshida and Norimichi Nakahata
J. Neuroendocrinol. 20, 299-308 (2008)

Calyciphyllines H-M, new Daphniphyllum alkaloids from Daphniphyllum calycinum
Shizuka Saito, Hiroko Yahata, Takaaki Kubota, Yutaro Obara, Norimichi Nakahata and Jun'ichi Kobayashi
Tetrahedron 64, 1901-1908 (2008)

βγsubunits of Gi/o suppress EGF-induced ERK5 phosphorylation, whereas ERK1/2 phosphorylation is enhanced
Yutaro Obara, Yumiko Okano, Sachiko Ono, Arata Yamauchi, Tomohiro Hoshino, Hitoshi Kurose and Norimichi Nakahata
Cell. Signal. 20, 1275-1283 (2008)

Satratoxin H generates reactive oxygen species and lipid peroxides in PC12 cells
Punnee Nusuetrong, Thitima Pengsuparp, Duangdeun Meksuriyen, Masa-aki Tanitsu, Haruhisa Kikuchi, Michinao Mizugaki, Ken-ichi Shimazu, Yoshiteru Oshima, Norimichi Nakahata and Makoto Yoshida
Biol. Pharm. Bull. 31, 1115-1120 (2008)

Maternal Feeding Controls Fetal Biological Clock
Hidenobu Ohta, Shanhai Xu, Takahiro Moriya, Masayuki Iigo, Tatsuya Watanabe, Norimichi Nakahata, Hiroshi Chisaka, Takushi Hanita, Tadashi Matsuda, Toshihiro Ohura, Yoshitaka Kimura, Nobuo Yaegashi, Shigeru Tsuchiya, Hajime Tei and Kunihiro Okamura
PLoS ONE, 3, e2601 (2008)

Involvement of cyclooxygenase-2 in lipopolysaccharide-induced impairment of the newborn cell survival in the adult mouse dentate gyrus
Gilmara N Bastos, Takahiro Moriya, Fumie Inui, Takashi Katura and Norimichi Nakahata
Neuroscience 155, 454-462 (2008)

Nerve growth factor-inducing activity of Hericium erinaceum in 1321N1 human astrocytoma cells
Koichiro Mori, Yutaro Obara, Mitsuru Hirota, Yoshihito Adumi, Satomi Kinugasa, Satoshi Inatomi and Norimichi Nakahata
Biol. Pharm. Bull. 31, 1727-1732 (2008)

Contractile responses of prostatic and epididymal portions of isolated rabbit vas deferens to electrical field stimulation. Hironori Nakanishi, Isao Matsuoka and Norimichi Nakahata Fukushima J. Med. Sci. 54, 4-10 (2008)

Effects of Oxygen Concentration on the Proliferation and Differentiation of Mouse Neural Stem Cells In Vitro
Nobutaka Horie, Kenji So, Takahiro Moriya, Naoki Kitagawa, Keisuke Tsutsumi, Izumi Nagata and Kazuyuki Shinohara
Cell. Mol. Neurobiol., 28, 833-845 (2008)

（2007年）

REVIEW ARTICLES / BOOKS（3報）

Gタンパク質共役型受容体の新たな機能および調節機構
中畑則道
薬学雑誌　127, 1-2 (2007)

Gタンパク質共役型受容体に会合するタンパク質による機 能調節
中畑 則道，斎藤 将樹
薬学雑誌　127, 3-14 (2007)

三量体Gタンパク質を介する情報伝達における脂質ラフトの役割
大久保聡子、中畑則道
薬学雑誌　127, 27-40 (2007)
TICLES

REGULAR ARTICLES（19報）

Distinct effects of Z-335, a new thromboxane A2 receptor antagonist, on rabbit platelets and aortic smooth muscles
Makoto Yoshida, Yukari Sato, Tokuro Shimura, Satoko Ohkubo, Shigeyoshi Honma, Takao Tanaka, Tadashi Kurimoto and Norimichi Nakahata
Pharmacology 79, 50-56 (2007)

Effect of 2-(6-cyano-1-hexyn-1-yl)adenosine on the ocular blood flow in rabbits
Takashi Konno, Takehiko Uchibori, Akihiko Nagai, Kentaro Kogi and Norimichi Nakahata
Life Sci. 80, 1115-1122 (2007)

Sodium valproate at therapeutic concentrations changes Ca2+ response accompanied with its weak inhibition of protein kinase C in human astrocytoma cells
Masatake Kurita, Satoshi Nishino, Kouji Ohtomo, Mayumi Rai, Hisayoshi Shirakawa, Hirobumi Mashiko, Shin-Ichi Niwa and Norimichi Nakahata
Prog. Neuropsychopharmacol. Biol. Psychiat. 31, 600-604 (2007)

The requirement of Ras and Rap1 for the activation of ERKs by cAMP, PACAP, and KCl in cerebellar granule cells
Yutaro Obara, Angela M. Horgan and Philip J. Stork
J. Neurochem. 101, 470-482 (2007)

Complanadines C and D, new dimeric alkaloids from Lycopodium complanatum
Kan'ichiro Ishiuchi, Takaaki Kubota, Yuzuru Mikami, Yutaro Obara, Norimichi Nakahata and Jun'ichi Kobayashi
Bioorg Med Chem. 15, 413-417 (2007)

Low expression of cell-surface thromboxane A2 receptor -isoform through the negative regulation of its membrane traffic by proteasomes
Masako Sasaki, Jun Sukegawa, Katsutoshi Miyosawa, Teruyuki Yanagisawa, Satoko Ohkubo and Norimichi Nakahata
Prostagland. Other Lipid Mediat. 83, 237-249 (2007)

A novel cyathane diterpene, cyrneine A, induces neurite outgrowth in a Rac1-dependent　　mechanism in PC12 cells.
Yutaro Obara, Tomohiro Hoshino, Maria Carla Marcotullio, Rita Pagiotti and Norimichi Nakahata
Life Sci. 80, 1669-1677 (2007)

Cyathane diterpenes from Sarcodon cyrneus and evaluation of their activities of neuritegenesis and nerve growth factor production
Maria Carla Marcotullio, Rita Pagiotti, Federica Maltese, Gildas Norbert Oball-Mond Mwankie, Tomohiro Hoshino, Yutaro Obara and Norimichi Nakahata
Bioorg. Med. Chem. 15, 2878-2882 (2007)

Melatonin influences the proliferative and differentiative activity of neural stem cells
Takahiro Moriya, Nobutaka Horie, Masato Mitome and Kazuyuki Shinohara
J. Pineal. Res. 42, 411-418 (2007)

Correlative association between circadian expression of mPer2 gene and the proliferation of the neural stem cells
Takahiro Moriya, Keizo Hiraishi, Nobutaka Horie, Masato Mitome and Kazuyuki Shinohara
Neuroscience 146, 494-498 (2007)

Expression of steroid receptor coactivator-1 is elevated during neuronal differentiation of murine neural stem cells.
Eijun Nishihara, Takahiro Moriya and Kazuyuki Shinohara
Brain Res. 1135, 22-30 (2007)

Inhibitory effect of ethanol extract of Piper Longum L. on rabbit platelet aggregation through antagonizing thromboxane A2 receptor
Masaya Iwashita, Masaki Saito, Yasunaga Yamaguchi, Rhoji Takagaki and Norimichi Nakahata
Biol. Pharm. Bull. 30, 1221-1225 (2007)

Piperlongumine, a constituent of Piper longum L., inhibits rabbit platelet aggregation as a thromboxane A2 recepter antagonist
Masaya Iwashita, Nobuaki Oka, Satoko Ohkubo, Masaki Saito and Norimichi Nakahata
Eur. J. Pharmacol. 570, 38-42 (2007)

Mastoparan inhibits -adrenoceptor-Gs signaling by changing the localization of G s in lipid rafts
Jun Sugama, Jiang-Zhou Yu, Mark M. Rasenick and Norimichi Nakahata
Cell. Signal. 19, 2247-2254 (2007)

Cooperation of calcineurin and ERK for UTP-induced IL-6 production in HaCaT keratinocytes
Daisaku Kobayashi, Satoko Ohkubo and Norimichi Nakahata
Eur. J. Pharmacol. 573, 249-252 (2007)

Alteration of adenylyl cyclase 6 expression in human astrocytoma cells after exposure to simulated microgravity.
Ryota Matsuoka, Satoko Ohkubo, Makoto Yoshida and Norimichi Nakahata
J. Health Sci. 53, 534-542 (2007)

Adenosine uptake-dependent C6 cell growth inhibition
Satoko Ohkubo Koichi Nagata and Norimichi Nakahata
Eur. J. Pharmacol. 577, 35-43 (2007)

5,19-cyclo-9β,10 -androstane-3, 17 dione promotes neurotrophic factor biosynthesis in 1321N1 human astrocytoma cells and improves passive avoidance learning impairment
Yutaro Obara, Asami Haganuma, Shinsuke Murakami, Toshiki Chiba, Koichiro Mori, Osamu Nakagawasai, Takeshi Tadano, Haruhisa Kikuchi, Yoshiteru Oshima and Norimichi Nakahata
Brain Res. 1184, 57-64 (2007)

Lycopladine E, a new C16N1-type alkaloid from Lycopodium complanatum
Takaaki Kubota, Hiroko Yahata, Kan'ichiro Ishiuchi, Yutaro Obara, Norimichi Nakahata and Jun'ichi Kobayashi
Heterocycles 74, 843-848 (2007)

(2006年)

REVIEW ARTICLES / BOOKS（4報）

人体生理学
守屋孝洋
p26-p45分担執筆：朝倉書店　平成18年3月25日発行 (2006)

神経栄養因子関連化合物の抗認知症薬の開発について
小原祐太郎　
薬学雑誌 126, 747-755 (2006).

思考回路―細胞内旅行は可能か？
斎藤将樹
日本薬理学雑誌　128, 59-60 (2006)

高血圧症の圧-利尿関係における腎レニン-アンジオテンシ ン系の役割
吉田　真
薬学研究の進歩 22, 67-74 (2006)

REGULAR ARTICLES（15報）

Lycovatine A, a C16N-type quaternary alkaloid from Lycopodium Clavatum Var. Robustum.
Takaaki Kubota, Tomoe Sunaura, Hiroshi Morita, Yuzuru Mikami, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata and Jun’ichi Kobayashi
Heterocycles, 69, 469-474 (2006)

Nankakurine B, a new alkaloid from Lycopodium Hamiltonii and revised stereostructure of Nankakurine A.
Yusuke Hirasawa, Jun’ichi Kobayashi, Yutaro Obara, Norimichi Nakahata, Nobuo Kawahara, Yukihiro Goda and Hiroshi Morita
Heterocycles, 68, 2357-2364 (2006)

Effects of fluvoxamine on behavioral and psychological symptoms of dementia in alzheimer ’s disease: a report of three cases.
Masatake Kurita, Tadahiro Sato, Satoshi Nishino, Koji Ohtomo, Hisayoshi Shirakawa, Hirobumi Mashiko, Shin-ichi Niwa and Norimichi Nakahata
Fukushima J. Med. Sci. 52, 143-148 (2006)

Nitric oxide modulates biphasic contractile response of guinea-pig vas deferens to electrical field stimulation.
Hironori Nakanishi, Isao Matsuoka and Norimichi Nakahata
Fukushima J. Med. Sci. 52, 45-57 (2006)

Contribution of extracellular signal-regulated kinase to UTP-induced IL-6 biosynthesis in HaCaT keratinocytes.
Daisaku Kobayashi, Satoko Ohkubo and Norimichi Nakahata
J. Pharmacol. Sci. 102, 368-376 (2006)

Thromboxane A2 receptor-mediated G12/13-dependent glial morphological change.
Shigeroshi Honma, Manami Saika, Satoko Ohkubo, Hitoshi Kurose and Norimichi Nakahata
Eur. J. Pharmacol. 545, 100-108 (2006)

Lycopladines B-D and lyconadin B, new alkaloids from Lycopodium complanatum.
Kan'ichiro Ishiuchi, Takaaki Kubota, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata and Jun'ichi Kobayashi
Bioorg. Med. Chem. 14, 5995-6000 (2006)

Neurite outgrowth activity of cyathane diterpenes from Sarcodon cyrneus, Cyrneines A and B.
Maria Carla Marcotullio, Rita Pagiotti, Federica Maltese, Yutaro Obara, Tomohiro Hoshino, Norimichi Nakahata and Massimo Curini
Planta Medica 72, 819-823 (2006)

Inhibitory effect of naringin on lipopolysaccharide (LPS)-induced endotoxin shock in mice and nitric oxide production in RAW 264.7 macrophages.
Syu-ichi Kanno, Ai Shouji, Ayako Tomizawa, Takako Hiura, Yuu Osanai, Mayuko Ujibe, Yutaro Obara, Norimichi Nakahata and Masaaki Ishikawa
Life Sci. 78, 673-681 (2006)

Different pathways for activation of extracellular signal-regulated kinase through thromboxane A2 receptor isoforms
Katsutoshi Miyosawa, Masako Sasaki, Satoko Ohkubo and Norimichi Nakahata
Biol. Pharm. Bull. 29, 719-724 (2006)

Adenosine A2A receptor-mediated protective effect of 2-(6-cyano-1-hexyn-1-yl)adenosine on retinal ischemia/reperfusion damage in rats
Takashi Konno, Ayumi Sato, Takehiro Uchibori, Akihiko Nagai, Kentaro Kogi and Norimichi Nakahata
Brit. J. Ophthalmol. 90, 900-905 (2006)

Physiological Significance of thromboxane A2 receptor dimerization
Masako Sasaki, Katsutoshi Miyosawa, Satoko Ohkubo and Norimichi Nakahata
J. Pharmacol. Sci. 100, 263-270 (2006)

Neurotrophic factor production in human astrocytoma cells by 2,5,6-tribromogramine via activation of epsilon isoform of protein kinase C
Masaki Saito, Megumi Hori, Yutaro Obara, Yasushi Ohizumi, Satoko Ohkubo and Norimichi Nakahata
Eur. J. Pharm. Sci. 28, 263-271(2006)

Participation of epoxygenase activation in Saikogenin D-induced inhibition of prostaglandin E2 synthesis
Yasufumi Toriniwa, Lu Xiaochuan, Yasuo Kodama, Yasushi Ohizumi, Makoto Yoshida and Norimichi Nakahata
J. Pharm. Pharamacol. 58, 859-866 (2006)

ATP stimulates interleukin-6 production via P2Y2 receptor in human HaCaT keratinocytes.
Hirohide Yoshida, Daisaku Kobayashi, Satoko Ohkubo and Norimichi Nakahata
Eur. J. Pharmacol. 540, 1-9 (2006)

(2005年)

REGULAR ARTICLES（10報）

Involvement of reactive oxygen species and stress-activated MAPKs in Satratoxin H-induced apoptosis
Punnee Nusuetrong, Makoto Yoshida, Masa-Aki Tanitsu, Haruhisa Kikuchi, Michinao Mizugaki, Ken-Ichi Shimazu, Thithima Pengsuparp, Duangdeun Meksuriyen, Yoshiteru Oshima and Norimichi Nakahata
Eur. J. Pharmacol. 507, 239-246 (2005)

Daphmanidins C and D, novel pentacyclic alkaloids from Daphniphyllum teijsmanii
Hirosho Morita, Nozomi Ishioka, Hiroshi Takatsu, Takakazu Shinzato, Yutaro Obara, Norimichi Nakahata and Jun'ichi Kobayashi
Org Lett. 7, 459-462 (2005)

Complanadine B, obscurumine A and B, new alkaloids from two species of Lycopodium
Hiroshi Morita, Kan'ichiro Ishiuchi Asami Haganuma, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata and Jun'ichi Kobayashi
Tetrahedron 61, 1955-1960 (2005)

Involvement of adenosine A2a receptor in intraocular pressure decrease induced by 2-(1-octyn-1-yl)adenosine or 2-(6-cyano-1-hexyn-1-yl)adenosine
Takashi Konno, Akira Murakami, Takehiro Uchibori, Akihiko Nagai, Kentaro Kogi, and Norimichi Nakahata
J. Pharmacol. Sci. 97, 501-509 (2005)

2-(1-Hexyn-1-yl)adenosine-induced intraocular hypertension is mediated via K+ channel opening through adenosine A2a receptor.
Takashi Konno, Takehiro Uchibori, Akihiko Nagai, Kentaro Kogi, Norimichi Nakahata
Eur. J. Pharmacol. 518, 203-211 (2005)

Lannotinidines A-G new alkaloids from two species of Lycopodium
Koichiro Koyama, Hiroshi Morita Yusuke Hirasawa, Miwa Yoshinaga, Tomohiro Hoshino, Yutaro Obara, Norimichi Nakahata and Jun'ichi Kobayashi
Tetrahedron 61, 3681-3690 (2005)

Thromboxane A2 promotes interleukin-6 biosynthesis mediated by an activation of cyclic AMP-response element binding protein in 1321N1 human astrocytoma cells.
Yutaro Obara, Hitoshi Kurose and Norimichi Nakahata
Mol. Pharmacol. 68, 670-679 (2005)

Increase in cell surface localization of parathyroid hormone receptor by cytoskeletal protein 4.1G
Masaki Saito, Maki Sugai, Yuriko Katsushima, Teruyuki Yanagisawa, Jun Sukegawa and Norimichi Nakahata
Biochemcal J. 392, 75-81 (2005)

Mastoparan changes the cellular localization of G q/11 and G through its binding to gangliosides in lipid rafts.
Jun Sugama, Satoko Ohkubo, Masanori Atsumi and Norimichi Nakahata
Mol. Pharmacol. 68, 1466-1474 (2005)

Isolation and synthesis of a new aromatic compound, brefelamide, from Dictyostelium cellular slime molds and its inhibitory effect on the proliferation of astrocytoma cells.
Haruhisa Kikuchi, Yoshinori Saito, Jun'ichi Sekiya, Yumiko Okano, Masaki Saito, Norimichi Nakahata, Yuzuru Kubohara and Yoshiteru Oshima
J. Org. Chem. 70, 8854-8858 (2005)

(2004年)

REVIEW ARTICLES / BOOKS（2報）

細胞情報伝達を司る機能分子の同定
中畑則道
CYRIC News 35, 10-13 (2004)

新薬理学テキスト：総論
中畑則道
p1-p40分担執筆：佐藤進編：廣川書店　平成16年3月20日発行

REGULAR ARTICLES（9報）

Novel spirocyclic trichothecanes, spirotenuipesine A and B, isolated from entomopathogenic fungus, Paecilomyces tenuipes
Haruhisa Kikuchi, Yasuhiro Miyagawa, Yuko Sahashi, Satoshi Inatomi, Asami Haganuma, Norimichi Nakahata and Yoshiteru Oshima
J. Org. Chem. 69, 352-356 (2004)

Effects of 2-alkynyladenosine derivatives on intraocular pressure in rabbits
Takashi Konno, Shin-ya Ohnuma, Kazuhiro Uemoto, Takehiro Uchibori, Akihiko Nagai, Kentaro Kogi, Kazuki Endo, Tomokazu Hosokawa, and Norimichi Nakahata
Eur. J. Pharmacol. 486, 307-316 (2004)

Ephedra Herba in Mao-Bushi-Saishin-To inhibits IgE-mediated histamine release and increases cAMP content in RBL-2H3 cells
Shin-ya Saito, Yukiko Maruyama, Sachie Kamiyama, Norimichi Nakahata and Yasushi Ohizumi
J. Pharmacol. Sci. 95, 41-46 (2004)

Inhibitory effect of Mao-Bushi-Saishin-to on prostaglandin E2 synthesis in C6 rat glioma cells
Shin-ya Saito, Sachie Kamiyama, Mayumi Oda, Norimichi Nakahata and Yasushi Ohizumi
Biol. Pharm. Bull. 27, 1133-1135 (2004)

Novel trichothecanes, paecilomycines A, B and C, isolated from entomopathogenic fungus Paecilomyces tenuipes
Haruhisa Kikuchi, Yasuhiro Miyagawa, Yuko Sahashi, Satoshi Inatomi, Asami Haganuma, Norimichi Nakahata and Yoshiteru Ohshima
Tetrahedron Letters 45, 6225-6228 (2004)

A comparative study on contractile responses of rabbit and guinea-pig vasa deferentia to electrical field stimulation
Hironori Nakanishi, Satoko Ohkubo, Tomoyuki Ono, Isao Matsuoka and Norimichi Nakahata
Fukushima J. Med. Sci. 50, 55-64 (2004)

PKA phosphorylation of Src mediates Rap1 activation in NGF and cAMP signaling in PC12 cells
Yutaro Obara, Kirstin Labudda, Tara Dillon and Philip Stork
J. Cell. Sci. 117, 6085-6094 (2004)

Neurofilament measurement for quantitative evaluation of the differentiation of PC-12 cells
Norimichi Nakahata, Megumi Hori, Asami Haganuma, Yutaro Obara and Yasushi Ohizumi
Pharmacometrics 67, 353-358 (2004)

Adenosine as an active constituent of Auricularia auricula for the inhibition of rabbit platelet aggregation
Atsumobu Murata, Nobuaki Oka, Satoko Ohkubo, Yukari Sato, Masako Funamori, Haruhisa Kikuchi, Masa-Aki Tanitsu, Kentaro Kogi, Susumu Satoh, Takeshi Tadano, Yoshiteru Oshima and Norimichi Nakahata
Pharmacometrics 67, 359-364 (2004)

（2003年）

REVIEW ARTICLES / BOOKS（2報）

脂質ラフトとその解析法
中畑則道、大久保聡子
日薬理誌 122, 419-425 (2003)

くすりと健康
中畑則道
HITACHI IT USER 470 (9), 4-7 (2003)

REGULAR ARTICLES（6報）

Theonezolide A, a novel marine macrolide, induces drastic shape change in rabbit platelets by reorganization of microtubules.
Minori Mitsui-Saito, Satoko Ohkubo, Yutaro Obara, Teruyuki Yanagisawa, Jun-Ichi Kobayashi, Yasushi Ohizumi and Norimichi Nakahata
Thrombosis Res. 108, 133-138 (2003)

Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma cells
Norimichi Nakahata, Chikako Tsuchiya, Keigo Nakatani, Yasushi Ohizumi and Satoko Ohkubo
Eur. J. Pharmacol. 461, 1-7 (2003)

Mastoparan binds to glycogen phosphorylase to regulate sarcoplasmic reticulum Ca2+ release in skeletal muscle
Yutaka Hirata, Masanori Atsumi, Yasushi Ohizum and Norimichi Nakahata
Biochem. J. 371, 81-88 (2003)

Dual Effect of Saikogenin D; In vitro Inhibition of Prostaglandin E2 Production and Elevation of Intracellular Free Ca2+ Concentration in C6 rat glioma cells
Yasuo Kodama, Xiaochuan Lv, Chikako Tsuchiya, Yasushi Ohizumi, Makoto Yoshida and Norimichi Nakahata
Planta Med. 69, 765-767 (2003)

PTH/PTH-related protein receptor interacts directly with Tetex-1 throught its COOH teminus
Maki Sugai, Masaki Saito, Izumi Sukegawa, Yuriko Katsushima, Yoshitaka Kinouchi, Norimichi Nakahata, Tooru Shimosegawa, Teruyuki Yanakisawa and Jun Sukegawa
Biochem. Biophys. Res. Commun. 331, 24-31 (2003)

Tricholomalides A-C, new neurotrophic diterpenes from the mushroom Tricholoma sp.
Sachiko Tsukamoto, Abder Gafur Macabalang, Keigo Nakatani, Yutaro Obara, Norimichi Nakahata and Tomihisa Ohta
J. Nat. Prod. 66, 1578-1581 (2003)

（2002年）

REVIEW ARTICLES / BOOKS（3報）

The Signaling Pathway of Neurotrophic Factor Biosynthesis
Yutaro Obara and Norimichi Nakahata
Drug News and Perspective 115(5), 290-298 (2002)

身体を守るアデノシン
大久保聡子
ファルマシア38, 974-975 (2002)

皮膚保護作用を有するセラミドの生理作用発現機構に関する研究
中畑則道、大久保聡子
コスメトロジー研究振興財団研究報告書（Cosmetology）10, 56-61 (2002)

REGULAR ARTICLES（7報）

Adenine nucleotide-induced activation of adenosine A2B receptors expressed in Xenopus laevis oocytes: involvement of a rapid and localized adenosine formation by ectonucleotidases
Isao Matsuoka, Satoko Ohkubo, Junko Kimura, Yasuhito Uezono
Mol Pharmacol. 61, 606-13 (2002)

Role of K+ channels on PACAP-induced catecholamine secretion from the rat adrenal gland
Yasuo Fukushima, Takahiro Nagayama, Hirohiko Hikichi, Kazuhiko Mizukami, Makoto Yoshida, Mizue Suzuki-Kusaba, Hiroaki Hisa, Tomohiko Kimura, Susumu Satoh
Eur. J. Pharmacol. 437, 69-72 (2002)

Facilitatory role of NO in neural norepinephrine release in the rat kidney
Hideki Tanioka, Kohichi Nakamura, Shinsei Fujimura, Makoto Yoshida, Mizue Suzuki-Kusaba, Hiroaki Hisa, Susumu Satoh
Am. J. Physiol, 282, R1436- R1442 (2002)

Inhibition of cyclooxygenase and prostaglandin E2 synthesis by γ-mangositine, a xanthone derivative in mangosteen, in C6 rat glioma cell
Keigo Nakatani, Norimichi Nakahata, Tsutomu Arakawa, Hideyuki Yasuda and Yasushi Ohizumi
Biochem. Pharmacol. 63, 73-79 (2002)

The isolation and synthesis of two novel N-acetylglucosamine derivatives from Dictyostelium cellular slime molds which exhibit neurite outgrowth activity
Haruhisa Kikuchi, Jun Komiya, Yoshinori Saito, Jun-ichi Sekiya, Shigeyoshi Honma, Norimichi Nakahata and Yoshiteru Oshima
Tetrahedron Lett. 43, 1477-1480 (2002)

Lithium chloride at a therapeutic concentration reduces Ca2+ response in protein kinase C-down regulated human astrocytoma cells
Masatake Kurita, Hirobumi Mashiko, Mayumi Rai, Tadanori Kumasaka, Sou-ichi Kouno, Shin-ichi Niwa and Norimichi Nakahata
Eur. J. Pharmacol. 442, 17-22 (2002)

Inhibitions of histamine release and prostaglandin E2 synthesis by mangosteen, a Thai medicinal plant
Keigo Nakatani, Masanori Atsumi, Tsutomu Arakawa, Kenji Oosawa, Susumu Shimura, Norimichi Nakahata and Yasushi Ohizumi
Biol. Pharm. Bull. 25, 1137-1141 (2002)

（2001年）

REVIEW ARTICLES / BOOKS（2報）

H1-Histamine receptor communicates to G14 with a relatively higher affinity than to G11
Norimichi Nakahata, Yukari Sato, Satoko Ohkubo and Toshihide Nukata
Histamine Research in the New Millennium pp167-171 (2001) ed.by T. Watanabe, H. Timmerman and K. Yanai. Elsevier Science B.V. (Amsterdam)

グリア細胞の神経保護作用
中畑則道
ファルマシア 37, 1114-1118 (2001)
[Nakahata, N. Neuroprotective actions of glial cells, Farumashia 37, 1114-1118 (2001)

REGULAR ARTICLES（8報）

Role of endogenous PACAP in catecholamine secretion from the rat adrenal gland
Yasuo Fukushima, Hirohiko Hikichi, Kazuhiko Mizukami, Takahiro Nagayama, Makoto Yoshida, Mizue Suzuki-Kusaba, Hiroaki Hisa, Tomohiko Kimura and Susumu Satoh
Am. J. Physiol. Regul. Integr. Comp. Physiol. 281, R1562-R1567 (2001)

Role of calcium channels and adenylate cyclase in the PACAP-induced adrenal catecholamine secretion
Yasuo Fukushima, Takahiro Nagayama, Hisako Kawashima, Hirohiko Hikichi, Makoto Yoshida, Mizue Suzuki-Kusaba, Hiroaki Hisa, Tomohiko Kimura and Susumu Satoh
Am. J. Physiol. Regul. Integr. Comp. Physiol. 281, R495-501 (2001)

βg-methylene ATP-induced cAMP formation in C6Bu-1 cells: involvement of local metabolism and subsequent stimulation of adenosine A2B receptor
Satoko Ohkubo, Keiko Kumazawa, Koji Sagawa, Junko Kimura and Isao Matsuoka
J . Neurochem. 76, 872-80 (2001)

Inhibitory effect of 2,3-butanedione monoxime (BDM) on Na+/Ca2+ exchange current in guinea-pig cardiac ventricular myocytes
Yasuhide Watanabe, Takahiro Iwamoto, Isao Matsuoka, Satoko Ohkubo, Tomoyuki Ono, Tomokazu Watano, Munekazu Shigekawa and Junko Kimura Br. J. Pharmacol. 32, 1317-25 (2001)

Qualitatively different response of isolated rabbit aorta to metylene blue administrated from intimal and adventitial surface
Hironori Nakanishi, Isao Matsuoka, Tomoyuki Ono, Satoko Ohkubo and Norimichi Nakahata
Fukushima J. Med. Sci. 47, 63-73 (2001)

Scabronine G-methylester enhances secretion of neurotrophic factors mediated by an activation of protein kinase C-ζ
Obara, Y., Kobayashi, H., Ohta, T., Ohizumi, Y. and Nakahata, N
Mol. Pharmacol. 59, 1287-1297 (2001)

Preconditioning of 3T3 cells by fresh medium together with genistein enhances prostaglandin E(2) release
Nakatani, K., Nakahata, N., Tsurufuji, S. and Ohizumi, Y.
Eur J Pharmacol. 432, 135-142 (2001)

Furanodictine A and B: Amino Sugar Analogues Produced by Cellular Slime Mold Dictyostelium discoideum Showing Neuronal Differentiation Activity
Kikuchi, H., Saito, Y., Komiya, J., Takaya, Y., Honma, S., Nakahata N, Ito A, Oshima Y
J Org Chem. 66(21):6982-7 (2001)

（2000年）

REVIEW ARTICLES（3報）

神経系培養細胞を用いた細胞内情報伝達機能の検討―その有用性とリチウムの作用機序について―
栗田征武、尾形真由美、熊坂忠則、増子博文、丹羽真一、中畑則道
脳と精神の医学 11, 9-14 (2000)

三量体Gタンパク質G12ファミリーの機能
中畑則道
日薬理誌 116, 197 (2000)

麻黄附子細辛湯の作用機序に関する検討
大泉康、中畑則道
漢方研究 12, 474-477 (2000)

REGULAR ARTICLES（10報）

Thromboxane A2 receptor-mediated tonic contraction is attributed to an activation of phosphatidylcholine-specific phospholipase C in rabbit aortic smooth muscles
Norimichi Nakahata, Hiromichi Takano and Yasushi Ohizumi
Life Sci. 66, PL71-76 (2000)

Inhibition of microbubule polymerization by SK&F96365, a blocker of receptor-linked Ca2+ entry
Minori Mitui-Saito, Norimichi Nakahata and Yasushi Ohizumi
Jpn. J. Pharmacol. 82, 269-271 (2000)

Involvement of phosphatidylcholine-specific phospholipase C in thromboxane A2-induced activation of mitogen-activated protein kinase in human astrocytoma cells
Hiroshi Kobayashi, Shigeyoshi Honma, Norimich Nakahata and Yasushi Ohizumi
J. Neurochem. 74, 2167-2173 (2000)

Discrimination of H1-histamine and muscarinic receptor-mediated signaling pathways by phorbol ester in human astrocytoma cells
Masatake Kurita, Hirobumi Mashiko, Mayumi Ogata, Shin-ichi Niwa, Norimichi Nakahata , Shizuko Takano and Hironori Nakanishi
Clin. Exp. Pharmacol. Physiol. 27, 208-211 (2000)

Identification of 97 kDa mastoparan binding protein involving in Ca2+ release from skeletal muscle sarcoplasmic reticulum
Yutaka Hirata, Norimichi Nakahata, and Yasushi Ohizumi
Mol. Pharmacol. 57, 1235-1242 (2000)

Differentiation of rat pheochromocytoma cells by fomitellic acids, specific DNA polymerase inhibitors
Yutaro Obara, Norimichi Nakahata, Yoshiyuki Mizushina, Fumio Sugawara, Kenzo Sakaguchi and Yasushi Ohizumi
Life Sci. 67, 1659-1665 (2000)

Ecto-alkaline phosphatase in NG108-15 cells: a key enzyme mediating P1 antagonist sensitive ATP response
Satoko Ohkubo, Junko Kimura, and Isao Matsuoka
Br. J. Pharmacol. 131, 1667-1672 (2000)

Effects of AMP derivatives on cyclic AMP levels in NG108-15 cells
Satoko Ohkubo, Hironori Nakanishi, Junko Kimura, and Isao Matsuoka
Br. J. Pharmacol., 129, 1244-1250 (2000)

Effects of P1 and P2 receptor antagonists on b,g-methyleneATP- and CGS21680-induced cyclic AMP formation in NG108-15 cells
Satoko Ohkubo, Isao Matsuoka, Junko Kimura, and Hironori Nakanishi
Br.J. Pharmacol., 129, 291-298 (2000)

Correlation between adenine nucleotide-induced cyclic AMP elevation and extracellular adenosine formation in NG108-15 cells
Satoko Ohkubo, Junko Kimura and Isao Matsuoka
Jpn. J. Pharmacol., 84, 325-333 (2000)


（1999年）

REVIEW ARTICLES（1報）

Prostanoid Receptors (J)
Nakahata N and Ohizumi Y
Yakkyoku, 50, 1365-1373 (1999)

REGULAR ARTICLES（9報）

Stimulation of neurotrophic factor secretion from 1321N1 human astrocytoma cells by novel diterpenoids, scabronines A and G
Obara Y, Nakahata N, Kita T, Takaya Y, Kobayashi H, Hosoi S, Kiuchi F, Ohta T, Oshima Y and Ohizumi Y
Eur. J. Pharmacol., 370, 79-84 (1999)

Thromboxane A2-induced phosphatidylcholine hydrolysis in porcine vascular smooth muscle cells
Nakahata N, Takano H and Ohizumi Y
Eur. J. Pharmacol., 374, 157-160 (1999)

Structure-activity relationship of gramine derivatives in Ca2+ release from sarcoplasmic reticulum
Nakahata N, Harada Y, Makoto Tsuji, Kazumi Kon-ya, Yoshikazu Shizuri, and Yasushi Ohizumi
Eur. J. Phamracol., 382, 129-132 (1999)

Maitotoxin-induced nerve growth factor production accompanied with the activation of voltage-insensitive Ca2+ channel in C6-BU-1 glioma cells
Yutaro Obara, Masami Takahashi, Norimichi Nakahata, and Yasushi Ohizumi
Brit. J. Pharmacol., 127, 1577-1582 (1999)

Identification of 30 kDa protein for Ca2+ releasing action of myotoxin a with a mechanism common to DIDS in skeletal muscle sarcoplasmic reticulum
Yutaka Hirata, Norimichi Nakahata, Masamichi Ohkura, and Yasushi Ohizumi
Biochim. Biophys. Acta, 1451, 132-140 (1999)

Comparison of maitotoxin with thromboxane A2 in rabbit platelet activation
Norimichi Nakahata, Satoko Ohkubo, Emiko Ito, Masayuki Nakano, Kiyoshi Terao, and Yasushi Ohizumi
Toxicon, 37, 1375-1389 (1999)

Decrease in thromboxane A2 receptor expression by differentiation with dibutyryl cyclic AMP in 1321N1 human astrocytoma cells
Shigeyoshi Honma, Norimichi Nakahata, Hiroshi Kobayashi, Shizuyo Ikeda, Noriko Takeda, and Yasushi Ohizumi
Prostaglandins Lipid Mediators, 58, 51-62 (1999)

Maitotoxin-induced phosphoinositide hydrolysis is dependent on extracellular but not intracellular Ca2+ in human astrocytoma cells
Norimichi Nakahata, Toshiko Yaginuma, and Yasushi Ohizumi
Jpn. J. Pharmacol., 81, 240-243 (1999)

Antagonism of saikosaponins-induced prostagalandin E2 release by baicalein in C6 rat glioma cells
Reiki Kyo, Norimichi Nakahata, Yasuo Kodama, Yoichiro Nakai, Masayoshi Kubo, and Yasushi Ohizumi
Biol. Pharm. Bull., 22, 1385-1387 (1999)