Contact Information:
Graduate School of Pharmaceutical Sciences, Tohoku University
6-3 Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan
Phone: +81-22-795-6887 Fax: +81-22-795-6877
e-mail: tokuyama@mail.pharm.tohoku.ac.jp
Professor Hidetoshi Tokuyama - Biographical Information
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Contact Information: Graduate School of Pharmaceutical Sciences, Tohoku University Phone: +81-22-795-6887 Fax: +81-22-795-6877 e-mail: tokuyama@mail.pharm.tohoku.ac.jp
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Research Interests
Synthetic Studies on Complex Natural Products
Development of Synthetic Methodologies
Research Summary
We are interested in invention of new reaction and strategies that allow complex molecules to be assembled efficiently.
We are particularly interested in development of versatile indole synthesis and its application to total synthesis of indole alkaloids.
By featuring our indole synthesis, we have recently completed total syntheses of the representative vinca alkaloids,
vinblastine and vincristine. In the past several years we have established synthetic routes to natural products, gelsemine,
FR-900482, eudistomin, aspidophytine, and duocarmycins. In other studies of new and useful chemical transformations,
exceptionally mild ketone synthesis by palladium-catalyzed coupling reaction of thiol esters with zinc reagents was reported.
The reaction was further extended to the development of 1-acetylenic ketones by Sonogashira-type coupling reaction.
Other new reactions of synthetic utility that have been developed include a conversion of primary amines to N-alkylhydroxylamines,
a novel conversion of alpha-aminonitriles to amide, and a mild copper-mediated amination of aryl halides.
Experience
5/2006-present |
Professor Graduate School of Pharmaceutical Sciences, Tohoku University |
2/2003-4/2006
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Associate Professor Graduate School of Pharmaceutical Sciences, University of Tokyo |
11/2002-3/2006 |
Researcher, PRESTO, The Japan Science and Technology Corporation |
4/2001-1/2003
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Lecturer Graduate School of Pharmaceutical Sciences, University of Tokyo |
11/1995-3/2001
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Assistant Professor Graduate School of Pharmaceutical Sciences, University of Tokyo |
4/1994-11/1995
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Postdoctoral Fellow with Professor Amos B. Smith, III, Department of Chemistry, University of Pennsylvania |
4/1990-9/1994
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Graduate Student with Professor Eiichi Nakamura, Graduate School of Science and Engineering, Tokyo Institute of Technology |
6/1990-8/1990 |
Summer Intern, Pharma Division, Sandoz AG (Basel, Switzerland) |
Education
Tokyo Institute of Technology, Ph.D., Chemistry, 1994
Tokyo Institute of Technology, B.S., Chemistry, 1990
Awards
2011 |
Nagase Foundation Award 2011 |
2009 |
Lectureship Award (Thailand), The 4th International Conference on Cutting-Edge Organic Chemistry in Asia |
2009 |
Lectureship Award (China), The 4th International Conference on Cutting-Edge Organic Chemistry in Asia |
2007 |
Young Scientist's Prize: The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology, Japan |
2006 |
Banyu Young Chemist Award 2006 |
2006 |
Lectureship Award to Taiwan, The 1st International Conference on Cutting-Edge Organic Chemistry in Asia |
2005 |
Banyu Young Chemist Award 2005 |
2003 |
The Pharmaceutical Society Japan Award for Young Scientist |
2002 |
The Sankyo Award in Synthetic Organic Chemistry, Japan |
1999 |
Young Investigator Award at the 41th Symmposium on Natural Products Chemistry |
1995 |
The JSPS Postdoctoral Fellowships for Research Abroad |
1992 |
The JSPS Fellowships for Young Scientists |