Professor Hidetoshi Tokuyama - Biographical Information

tokuyama

Contact Information:

Graduate School of Pharmaceutical Sciences, Tohoku University
6-3 Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan

Phone: +81-22-795-6887  Fax: +81-22-795-6877

e-mail: tokuyama@mail.pharm.tohoku.ac.jp

 

Research Interests

 Synthetic Studies on Complex Natural Products
 Development of Synthetic Methodologies

Research Summary

 We are interested in invention of new reaction and strategies that allow complex molecules to be assembled efficiently.
We are particularly interested in development of versatile indole synthesis and its application to total synthesis of indole alkaloids.
By featuring our indole synthesis, we have recently completed total syntheses of the representative vinca alkaloids,
vinblastine and vincristine. In the past several years we have established synthetic routes to natural products, gelsemine,
FR-900482, eudistomin, aspidophytine, and duocarmycins. In other studies of new and useful chemical transformations,
exceptionally mild ketone synthesis by palladium-catalyzed coupling reaction of thiol esters with zinc reagents was reported.
The reaction was further extended to the development of 1-acetylenic ketones by Sonogashira-type coupling reaction.
Other new reactions of synthetic utility that have been developed include a conversion of primary amines to N-alkylhydroxylamines,
a novel conversion of alpha-aminonitriles to amide, and a mild copper-mediated amination of aryl halides.

Experience

5/2006-present

Professor
Graduate School of Pharmaceutical Sciences, Tohoku University
2/2003-4/2006

Associate Professor
Graduate School of Pharmaceutical Sciences, University of Tokyo
11/2002-3/2006
Researcher, PRESTO, The Japan Science and Technology Corporation
4/2001-1/2003

Lecturer
Graduate School of Pharmaceutical Sciences, University of Tokyo
11/1995-3/2001

Assistant Professor
Graduate School of Pharmaceutical Sciences, University of Tokyo
4/1994-11/1995

Postdoctoral Fellow with Professor Amos B. Smith, III,
Department of Chemistry, University of Pennsylvania
4/1990-9/1994

Graduate Student with Professor Eiichi Nakamura,
Graduate School of Science and Engineering, Tokyo Institute of Technology
6/1990-8/1990
Summer Intern, Pharma Division, Sandoz AG (Basel, Switzerland)

Education

 Tokyo Institute of Technology, Ph.D., Chemistry, 1994
 Tokyo Institute of Technology, B.S., Chemistry, 1990

Awards

2011
Nagase Foundation Award 2011
2009
Lectureship Award (Thailand), The 4th International Conference on Cutting-Edge Organic Chemistry in Asia
2009
Lectureship Award (China), The 4th International Conference on Cutting-Edge Organic Chemistry in Asia
2007

Young Scientist's Prize: The Commendation for Science and Technology by the Minister of Education,
Culture, Sports, Science and Technology, Japan
2006
Banyu Young Chemist Award 2006
2006
Lectureship Award to Taiwan, The 1st International Conference on Cutting-Edge Organic Chemistry in Asia
2005
Banyu Young Chemist Award 2005
2003
The Pharmaceutical Society Japan Award for Young Scientist
2002
The Sankyo Award in Synthetic Organic Chemistry, Japan
1999
Young Investigator Award at the 41th Symmposium on Natural Products Chemistry
1995
The JSPS Postdoctoral Fellowships for Research Abroad
1992
The JSPS Fellowships for Young Scientists

 

Publication List

Invited Lectures

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