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Original Papers


(145) Total Synthesis of (−)-Histrionicotoxin through a Stereoselective Radical Translocation–Cyclization Reaction
  M. Sato, H. Azuma, A. Daigaku, S. Sato, K. Takasu, K. Okano, H. Tokuyama
  Angew. Chem. Int. Ed., 56, 1087-1091 (2017)

 

(144) Structural determination of (–)-SCH 64874 and hirsutellomycin by semi-synthesis
  H. Tokuyama, K. Yamada, H. Fujiwara, J. Sakata, K. Okano, M. Sappan, M. Isaka
  J. Org. Chem., 82, 353-371 (2017)

  

(143) An obtuse-angled corner unit for fluctuating carbon nanohoops
  Z. Sun, N. Miyamoto, S. Sato, H. Tokuyama, H. Isobe
  Chem. Asian J.,12, 271-275 (2017)

  

(142) Total Syntheses of (+)-T988 B and C via AgNTf2-Mediated Coupling of Bromopyrroloindoline with Indole
  
S. Sato, A. Hirayama, H. Ueda, H. Tokuyama
  Asian J. Org. Chem., 6, 54-58 (2017)

  

(141) Bioinspired Total Synthesis of the Dimeric Indole Alkaloid (+)-Haplophytine by Direct Coupling
   and Late-Stage Oxidative Rearrangement
  H. Satoh, K. Ojima, H. Ueda, H. Tokuyama
  Angew. Chem. Int. Ed., 55, 15157-15161 (2016)

  

(140) Condensation of Carboxylic Acids with Non-Nucleophilic N-Heterocycles and Anilides Using Boc2O
  A. Umehara, H. Ueda, H. Tokuyama
  J. Org. Chem., 81, 11444-11453 (2016)

  

(139) Convergent Synthesis of 2-Aryl-Substituted Quinolines by Gold-Catalyzed Cascade Reaction
  H. Ueda, M. Yamaguchi, H. Tokuyama
  Chem. Pharm. Bull.,64, 824-829 (2016)

  

(138) Coversion of Vindoline into 11-Mesyloxytabersonine
  Y. Han-ya, T. Inui, S. Yokoshima, H. Tokuyama, T. Fukuyama
  Chem. Pharm. Bull., 64, 800-804 (2016)

  

(137) Trichloroboron-Promoted Deprotection of Phenolic Benzyl Ether using Pentamethylbenzene as a Non Lewis-Basic Cation Scavenger
  S. Okaya, K. Okuyama, K. Okano, H. Tokuyama
  Org. Synth., 93, 63-74
(2016)

  

(136) Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase
  J. Morita, K. Kano, K. Kato, H. Takita, H. Sakagami, Y. Yamamoto, E. Mihara, H. Ueda, T. Sato, H. Tokuyama, H. Arai,
  H. Asou, J. Takagi, R. Ishitani, H. Nishimasu, O. Nureki, J. Aoki
  Scientific Reports, 6, 20995 (2016)

(135) Total syntheses of codonopsinine and 4-epi-codonopsinine via gold-mediated tandem catalyzed pyrrole synthesis
  M. Yamaguchi, D. Itagaki, H. Ueda, H. Tokuyama
  J. Antibiot.,69, 253-258 (2016)

  

(134) DIBALH-Mediated Reductive Ring-Expansion Reaction of Cyclic Ketoxime
  T. Imaizumi, K. Okano, H. Tokuyama
  Org. Synth., 93, 1-13 (2016
)

  

(133) Synthesis of Substituted Quinolizidines via a Gold-Catalyzed Double Cyclization Cascade
  S. Nonaka, K. Sugimoto, H. Ueda, H. Tokuyama
  Adv. Synth. Catal., 358, 380-385 (2016)

  

(132) Synthetic Studies on Acochlearine: Construction of A/B/C/E/F Ring System
  K. Fujioka, N. Miyamoto, H. Toya, K. Okano, H. Tokuyama
  Synlett, 27, 621-625 (2016)

  

(131) Total Synthesis of (+)-MPC1001B
  T. Kurogi, S. Okaya, H. Fujiwara, K. Okano, H. Tokuyama
  Angew. Chem. Int. Ed., 55, 283-287 (2016)

  

(130) Total Synthesis of (–)-Isoschizogamine
  A. Takada, H. Fujiwara, K. Sugimoto, H. Ueda, H. Tokuyama
  Chem. Eur. J., 21, 16400-16403 (2015)

  

(129) A Concise Total Synthesis of (–)-Indolactam V
  T. Noji, K. Okano, H. Tokuyama
  Tetrahedron, 71, 3833-3837 (2015)

  

(128) Total Synthesis of (–)-Rhazinilam Using 1,3-Dipolar Cycloaddition of Optically Active Münchnone Intermediate
  K. Sugimoto, Y. Miyakawa, H. Tokuyama
  Tetrahedron,
71, 3619-3624 (2015) (Symposium-in-Print on Synthesis of Indole/Pyrrole-Containing Natural Products)

  

(127) Synthetic Studies toward Penitrem E: Enantiocontrolled Construction of B-E Rings
  Y. Yoshii, T. Otsu, N. Hosokawa, K. Takasu, K. Okano, H. Tokuyama
  Chem. Commun., 51, 1070-1073 (2015)

  

(126) Stereochemistry of Vinylogous Rubottom Oxidation of Proline-fused Cyclohexadienol Silyl Ether
   K. Okano, S. Okaya, T. Kurogi, H. Fujiwara, H. Tokuyama
  Heterocycles, 90, 1299-1308 (2015)

  

(125) Synthetic studies on lycopodine: construction of hexahydrojulolidine core by intramolecular Mannich reaction
   T. Sato, H. Ueda, H. Tokuyama
  Tetrahedron Lett., 55, 7177-7180 (2014)

  

(124) Total Synthesis of (-)-Haouamine B Pentaacetate and Structural Revision of Haouamine B
   Y. Momoi, K. Okuyama, H. Toya, K. Sugimoto, K. Okano, H. Tokuyama
  Angew. Chem. Int. Ed., 53, 13215-13219 (2014)

  

(123) Generation of Aryl Grignard Reagent from Arene Chromium Tricarbonyl Complex by Mg(TMP)2·2LiCl and Its Application to Murahashi   Coupling
   Y. Momoi, K. Okano, H. Tokuyama
  Synlett, 25, 2503-2507 (2014)

  

(122) Auto tandem Catalysis: Synthesis of Pyrroles by Gold-Catalyzed Cascade Reaction
   H. Ueda, M. Yamaguchi, H. Kameya, K. Sugimoto, H. Tokuyama
  Org. Lett., 16, 4948-4951 (2014)

  

(121) Stereocontrolled Total Synthesis and Biological Evaluation of (–)- and (+)-Petrosin, and Its Derivatives
   H. Toya, T. Satoh, K. Okano, K. Takasu, M. Ihara, A. Takahashi, H. Tanaka, H. Tokuyama
  Tetrahedron, 70, 8129-8141 (2014)

  

(120) Acetic Acid-Promoted Metal-Free Aerobic Carbon-Carbon Bond Forming Reactions at α-Position of Tertiary Amines
   H. Ueda, K. Yoshida, H. Tokuyama
  Org. Lett.,
16, 4194-4197 (2014)

  

(119) Total Syntheses of Leuconoxine, Leuconodine B, and Melodinine E by Oxidative Cyclic Aminal Formation
   and Diastereoselective Ring-Closing Metathesis
   A. Umehara, H. Ueda, H. Tokuyama
   Org. Lett., 16, 2526-2529 (2014)

  119

(118) Synthesis of a Human Urate Transporter-1 Inhibitor, an Arginine Vasopressin Antagonist, and a 17β-Hydroxysteroid Dehydrogenase
   Type 3 Inhibitor, Using Ring-Expansion of Cyclic Ketoximes with DIBALH
   H. Cho, Y. Iwama, K. Okano, H. Tokuyama
  Chem. Pharm. Bull., 62, 354-363 (2014)

  118

(117) Overexprssion of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by
  hypo-sphingosine-1-phosphate signaling in zebrafish embryo
  K. Nakanaga, K. Hama, K. Kano, T. Sato, H. Yukiura, A. Inoue, D. Saigusa, H. Tokuyama, Y. Tomioka, H. Nishina, A. Kawahara, J. Aoki
  J. Biochem., 155, 235-241 (2014)

(116) Formation of Xanthone Oxime and Related Compounds Using a Combination of tert-Butyl Nitrite and Potassium Hexamethyldisilazide
  Y. Iwama, T. Noro, K. Okano, H. Cho, H. Tokuyama
  Heterocycles, 88, 1433-1444 (2014)

  116

(115) Synthetic Studies on Isoschizogamine: Construction of [3.3.1] Bicyclic Aminal Core by Using Oxidative Skeletal Rearrangement
  H. Ueda, A. Takada, H. Tokuyama
  Tetrahedron Lett., 54, 7115-7118 (2013)

  115

(114) Total Synthesis of PDE-I and -II by Copper-Mediated Double Aryl Amination
  K. Okano, N. Mitsuhashi, H. Tokuyama
  Tetrahedron, 69, 10946-10954 (2013)

  114

(113) Formal Synthesis of Hepatitis C Virus NS5B Polymerase Inhibitor
  T. Noro, K. Okano, H. Tokuyama
  Synlett,
2143-2147 (2013)

  113

(112) Protecting-Group-Free Total Synthesis of (–)-Rhazinilam and (–)-Rhazinicine using a Gold-Catalyzed Cascade Cyclization
  K. Sugimoto, K. Toyoshima, S. Nonaka, K. Kotaki, H. Ueda, H. Tokuyama
  Angew. Chem. Int. Ed., 52, 7168-7171 (2013)

  112

(111) Enantiocontrolled Total Synthesis of (–)-Mersicarpine
  Y. Iwama, K. Okano, K. Sugimoto, H. Tokuyama
  Chem. Eur. J., 19, 9325-9334 (2013)

  111

(110) Synthesis of Substituted Indoline and Carbazole by Benzyne-Mediated Cyclization-Functionalization
  T. Noji, H. Fujiwara, K. Okano, H. Tokuyama
  Org. Lett.
, 15, 1946-1949 (2013)

  110

(109) Construction of Dibenzazocine Skeleton by Regiocontrolled Ring-expansion Reaction of Cyclic Oxime with DIBALH:
  Facile Synthesis of 17β-Hydroxysteroid Dehydrogenase Type 3 Inhibitor
  H. Cho, Y. Iwama, K. Okano, H. Tokuyama
  Synlett, 813-816 (2013)

  109

(108) Divergent Total Synthesis of (–)-Aspidophytine and its Congeners via Fischer Indole Synthesis
  H. Satoh, H. Ueda, H. Tokuyama
  Tetrahedron, 69, 89-95 (2013)

  108

(107) Synthetic Studies on Strictamine: Unexpected Oxidation of Tertiary Amine in Ru-Catalyzed Ring-Closing Olefin Metathesis
  Y. Komatsu, K. Yoshida, H. Ueda, H. Tokuyama
  Tetrahedron Lett., 54, 377-380 (2013)

  107

(106) Toward the Total Synthesis of (±)-Andrastin C
  R. Okamoto, K. Takeda, H. Tokuyama, M. Ihara, M. Toyota
  J. Org. Chem.,
78, 93-103 (2013)

  106

(105) Total Synthesis of (–)-Acetylaranotin
  H. Fujiwara, T. Kurogi, S. Okaya, K. Okano, H. Tokuyama
  Angew. Chem. Int. Ed., 51, 13062-13065 (2012)

  105

(104) Total Synthesis of Makaluvamine A/D, Damirone B, Batzelline C, Makaluvone, and Isobatzelline C
  Featuring One-Pot Benzyne-Mediated Cyclization-Functionalization
  T. Oshiyama, T. Satoh, K. Okano, H. Tokuyama
  Tetrahedron, 68, 9376-9383 (2012)

  104

(103) Ring-Expansion Reaction of Oximes with Aluminum Reductants
  H. Cho, Y. Iwama, N. Mitsuhashi, K. Sugimoto, K. Okano, H. Tokuyama
  Molecules, 17, 7348-7355 (2012)

  103

(102) Facile Isomerization of Silyl Enol Ethers Catalyzed by Triflic Imide and Its Application to One-Pot
  Isomerization–(2+2) Cycloaddition
  K. Inanaga, Y. Ogawa, Y. Nagamoto, A. Daigaku, H. Tokuyama, Y. Takemoto, K. Takasu
  Beilstein J. Org. Chem., 8, 658-661 (2012)

  102

(101) Synthesis and biological evaluation of optically active Ki16425
  T. Sato, K. Sugimoto, A. Inoue, S. Okudaira, J. Aoki, H. Tokuyama
  Bioorg. Med. Chem. Lett., 22, 4323-4326 (2012)

  101

(100) Total Synthesis of Batzelline C and Isobatzelline C
  T. Oshiyama, T. Satoh, K. Okano, H. Tokuyama
  RSC Adv., 2, 5147-5149 (2012)

  100

(99) Concise Total Synthesis of (–)-Mersicarpine
  Y. Iwama, K. Okano, K. Sugimoto, H. Tokuyama
  Org. Lett., 14, 2320-2322 (2012)

  099

(98) Synthetic Studies on Paspaline: Lewis Acid-Mediated Sequential Construction of A-E Ring Skeleton
  K. Okano, Y. Yoshii, H. Tokuyama
  Heterocycles, 84, 1325-1334 (2012)

  098

(97) Synthesis of Acylsilanes by Palladium-catalyzed Cross-coupling Reaction of Thiol Esters and Silylzinc Chlorides
  H. Azuma, K. Okano, H. Tokuyama
  Chem. Lett., 40, 959-961 (2011)

(96) Total Synthesis of Tryprostatins A and B
  T. Yamakawa, E. Ideue, Y. Iwaki, A. Sato, H. Tokuyama, J. Shimokawa, T. Fukuyama
  Tetrahedron, 67, 6547-6560 (2011)

  096

(95) An Intramolecular Amination of Aryl Halides with a Combination of Copper(I) Iodide and Cesium Acetate:
  Preparation of 5,6-Dimethoxyindole-1,2-dicarboxylic Acid 1-Benzyl Ester 2-Methyl Ester
  T. Noji, K. Okano, T. Fukuyama, H. Tokuyama
  Org. Synth., 88, 388-397 (2011)

  095

(94) Total Synthesis of (–)-Conophylline and (–)-Conophyllidine
  Y. Han-ya, H. Tokuyama, T. Fukuyama
  Angew. Chem. Int. Ed., 50, 4884-4887 (2011)

  094

(93) Preparation of Horner-Wadsworth-Emmons Reagent:
  Methyl 2-Benzyloxycarbonylamino-2-(dimethoxyphosphinyl)acetate
  H. Azuma, K. Okano, T. Fukuyama, H. Tokuyama
  Org. Synth., 88, 152-161 (2011)

  093

(92) Synthetic Studies toward Haouamine B: Construction of Indenotetrahydropyridone Skeleton
  K. Okuyama, Y. Momoi, K. Sugimoto, K. Okano, H. Tokuyama
  Synlett, 73-76 (2011)

  092

(91) Regiospecific Rearrangement of Hydroxylamines to Secondary Amines using Diisobutylaluminum Hydride
  H. Cho, K. Sugimoto, Y. Iwama, N. Mitsuhashi, K. Okano, H. Tokuyama
  Heterocycles, 82, 1633-1644 (2011)

  091

(90) Total Synthesis of Dictyodendrins A–E
  H. Tokuyama, K. Okano, H. Fujiwara, T. Noji, T. Fukuyama
  Chem. Asian J., 6, 560-572 (2011)

  090

(89) Enantioselective Total Synthesis of (–)- and (+)-Petrosin
  H. Toya, K. Okano, K. Takasu, M. Ihara, A. Takahashi, H. Tanaka, H. Tokuyama
  Org. Lett., 12, 5196-5199 (2010)

  089

(88) Total Synthesis of Dictyodendrin A and B
  K. Okano, H. Fujiwara, T. Noji, T. Fukuyama, H. Tokuyama
  Angew. Chem. Int. Ed., 49, 5925-5929 (2010)

  088

(87) Selective Accumulation of Rhodacyanine in Plasmodial Mitochondria is Related to the Growth Inhibition of Malaria Parasites
  D. Morisaki, H.-S. Kim, H. Inoue, H. Terauchi, S. Kuge, A. Naganuma, Y. Wataya, H. Tokuyama, M. Ihara, K. Takasu
  Chem. Sci., 1, 206-209 (2010)

  087

(86) Total Synthesis of PDE-II by Copper-Mediated Double Amination
  K. Okano, N. Mitsuhashi, H. Tokuyama
  Chem. Commun., 46, 2641-2643 (2010)

  086

(85) Total Synthesis of (±)-Lepadiformine A via Radical Translocation/Cyclization Reaction
  M. Fujitani, M. Tsuchiya, K. Okano, K. Takasu, M. Ihara, H. Tokuyama
  Synlett, 822-826 (2010)

  085

(84) Regioselective Synthesis of Heterocycles containing Nitrogen Neighboring an Aromatic Ring
  by the Reductive Ring Expansion using Diisobutylaluminum Hydride (DIBALH) and Studies on the Reaction Mechanism
  H. Cho, Y. Iwama, K. Sugimoto, S. Mori, H. Tokuyama
  J. Org. Chem., 75, 627-636 (2010)

  084

(83) Total Synthesis of (+)-Haplophytine
  H. Ueda, H. Satoh, K. Matsumoto, K. Sugimoto, T. Fukuyama, H. Tokuyama
  Angew. Chem. Int. Ed., 48, 7600-7603 (2009)

  083

(82) Regiospecific Synthesis of Unsubstituted Basic Skeletons of Heterocycles Containing Nitrogen
  Neighboring an Aromatic Ring by the Reductive Ring Expansion Reaction using Diisobutylaluminum Hydride
  H. Cho, Y. Iwama, K. Sugimoto, E. Kwon, H. Tokuyama
  Heterocycles, 78, 1183-1190 (2009)

  082

(81) Synthesis of Lysergic Acid Methyl Ester via the Double Cyclization Strategy
  T. Kurokawa, M. Isomura, H. Tokuyama, T. Fukuyama
  Synlett, 775-778 (2009)

  081

(80) Protection of Diols with p-(tert-Butyldimethylsilyloxy)benzylidene Acetal and Its Deprotection:
  (4-((4R,5R)-4,5-Diphenyl-1,3-dioxolan-2-yl)phenoxy)(tert-butyl)dimethylsilane
  H. Osajima, H. Fujiwara, K. Okano, H. Tokuyama, T. Fukuyama
  Org. Synth., 86, 130-140 (2009)

  080

(79) Palladium-Catalyzed Coupling of N-Heteroaryl Sulfides with Organozinc Reagents
  T. Koshiba, T. Miyazaki, H. Tokuyama, T. Fukuyama
  Heterocycles, 77, 233-239 (2009)

  079

(78) Triflic Imide Catalyzed (3+2) Cycloaddition of Aldimines with α-,α-Dimethylallylsilane
  N. Shindoh, H. Tokuyama, Y. Takemoto, K. Takasu
  Heterocycles, 77, 187-192 (2009)

  078

(77) A Mild Inter- and Intramolecular Amination of Aryl Halides with a Combination of CuI and CsOAc
  T. Kubo, C. Katoh, K. Yamada, K. Okano, H. Tokuyama, T. Fukuyama
  Tetrahedron, 64, 11230-11236 (2008)

  077

(76) Auto-Tandem Catalysis in Synthesis of Substituted Quinolines from Aldimines and Electron-rich Olefins:
  Cascade Povarov-Hydrogen Transfer Reaction
  N. Shindoh, H. Tokuyama, Y. Takemoto, K. Takasu
  J. Org. Chem., 73, 7451-7456 (2008)

  076

(75) Mild Debenzylation of Aryl Benzyl Ether with BCl3 in the Presence of Pentamethylbenzene
  as a Non-Lewis-Basic Cation Scavenger
  K. Okano, K. Okuyama, T. Fukuyama, H. Tokuyama
  Synlett, 1977-1980 (2008)

  075

(74) (2 + 2) Cycloaddition Reaction of Alkyl Enol Ethers with Acrylates by in situ Generated Silyl Trifric Imide Catalyst
  K. Takasu, Y. Miyakawa, M. Ihara, H. Tokuyama
  Chem. Pharm. Bull., 56, 1205-1206 (2008)

(73) Synthesis of Eudistomin C and E: Improved Preparation of the Indole Unit
  H. Yamagishi, K. Matsumoto, K. Iwasaki, T. Miyazaki, S. Yokoshima, H. Tokuyama, T. Fukuyama
  Org. Lett., 10, 2369-2372 (2008)

  073

(72) Total Synthesis of (–)-Kainic Acid via Intramolecular Michael Addition: A Second-Generation Route
  H. Sakaguchi, H. Tokuyama, T. Fukuyama
  Org. Lett., 10, 1711-1714 (2008)

  072

(71) Total Synthesis of (+)-Yatakemycin
  K. Okano, H. Tokuyama, T. Fukuyama
  Chem. Asian J., 3, 296-309 (2008)

  071

(70) Synthetic Studies on Haplophytine: Protective Group Controlled Rearrangement
  K. Matsumoto, H. Tokuyama, T. Fukuyama
  Synlett, 3137-3140 (2007)

  070

(69) Synthesis of Vinyloxazolidinones by Palladium-Catalyzed CO2-Recycling Reaction of 4-(Benzylamino)-2-butenyl Carbonates
  M. Yoshida, Y. Ohsawa, K. Sugimoto, H. Tokuyama, M. Ihara
  Tetrahedron Lett., 48, 8678-8682 (2007)

  069

(68) Synthesis of (+)-Vinblastine and Its Analogs
  T. Miyazaki, S. Yokoshima, S. Shimizu, H. Osada, H. Tokuyama, T. Fukuyama
  Org. Lett., 9, 4737-4740 (2007)

  068

(67) Design and Synthesis of Thiazoline-Thiazole Hybrid Macrocycles Possessing Strong Binding Affinity to Pb2+ and Cd2+
  F. S. Han, H. Tokuyama, T. Fukuyama
  Chem. Commun., 3444-3446 (2007)

  067

(66) Cascade and One-pot Processes Providing Substituted Quinolines from Aldimines and Allylsilanes:
  Auto-tandem Catalysis of Triflic Imide
  N. Shindoh, H. Tokuyama, K. Takasu
  Tetrahedron Lett., 48, 4749-4753 (2007)

  066

(65) Stereocontrolled Total Synthesis of (–)-Kainic Acid
  H. Sakaguchi, H. Tokuyama, T. Fukuyama
  Org. Lett., 9, 1635-1638 (2007)

  065

(64) Novel Structural Motifs Consisting of Chiral Thiazolines: Synthesis, Molecular Recognition, and Anticancer Activity
  F. S. Han, H. Osajima, M. Cheung, H. Tokuyama, T. Fukuyama
  Chem. Eur. J., 13, 3026-3036 (2007)

  064

(63) A Novel Indole Synthesis via Conjugate Addition of Pyrrolidine to o-Nitrophenylacetylenes
  H. Tokuyama, T. Makido, Y. Han-ya, T. Fukuyama
  Heterocycles, 72, 191-197 (2007)

  063

(62) Catalytic Imino Diels-Alder Reaction by Triflic Imide and Its Application to One-pot Synthesis from Three Components
  K. Takasu, N. Shindoh, H. Tokuyama, M. Ihara
  Tetrahedron, 62, 11900-11907 (2006)

  062

(61) Total Synthesis of (+)-Yatakemycin
  K. Okano, H. Tokuyama, T. Fukuyama
  J. Am. Chem. Soc., 128, 7136-7137 (2006)

  061

(60) Synthesis of Chiral Cyclic Oligothiazolines: A Novel Structural Motif of Macrocyclic Molecule
  F. S. Han, H. Osajima, M. Cheung, H. Tokuyama, T. Fukuyama
  Chem. Commun., 1757-1758 (2006)

  060

(59) Stereocontrolled Total Synthesis of (–)-Eudistomin C
  T. Yamashita, N. Kawai, H. Tokuyama, T. Fukuyama
  J. Am. Chem. Soc., 127, 15038-15039 (2005)

  059

(58) Synthesis of Tetrahydro-β -carbolines via Radical Cyclization of 2-Alkenylthioanilides
  M. Iwadate, T. Yamashita, H. Tokuyama, T. Fukuyama
  Heterocycles, 66, 241-249 (2005)

(57) Stereocontrolled Total Synthesis of (–)-Kainic Acid. Regio- and Stereoselective Lithiation of Pyrrolidine Ring
  with the (+)-Sparteine Surrogate
  Y. Morita, H. Tokuyama, T. Fukuyama
  Org. Lett., 7, 4337-4340 (2005)

(56) Synthesis of 2,3-Dialkylindoles from 2-Alkenylphenylisocyanides and Imines by Silyltelluride- and Tin Hydride-Mediated
  Sequential Radical Reactions
  M. Kotani, S. Yamago, A. Satoh, H. Tokuyama, T. Fukuyama
  Synlett, 1893-1896 (2005)

(55) Fluorescence Enhancement by Hydroperoxides Based on the Change in Intramolecular Charge Transfer Character of Benzofurazan
  M. Onoda, H. Tokuyama, S. Uchiyama, K. Mawatari, T. Santa, K. Kaneko, K. Imai, K. Nakagomi
  Chem. Commun., 1848-1850 (2005)

(54) Thermal and Palladium-Catalyzed [3 + 2] Synthesis of Cyclopentadienone Acetals from Cyclopropenone Acetals and Acetylenes
  H. Isobe, S. Sato, T. Tanaka, H. Tokuyama, E. Nakamura
  Org. Lett., 6, 3569-3571 (2004)

(53) Stereocontrolled Total Synthesis of (+)-Vincristine
  T. Kuboyama, S. Yokoshima, H. Tokuyama, T. Fukuyama
  Proc. Natl. Acad. Sci. USA, 101, 11966-11970 (2004)

(52) Total Synthesis of (–)-Stychnine
  Y. Kaburagi, H. Tokuyama, T. Fukuyama
  J. Am. Chem. Soc., 126, 10246-10247 (2004)

(51) 4-(t-Butyldimethylsilyloxy)benzylidene Acetal: A Novel Benzylidene-type Protecting Group for 1,2-Diols
  Y. Kaburagi, H. Osajima, K. Shimada, H. Tokuyama, T. Fukuyama
  Tetrahedron Lett., 45, 3817-3821 (2004)

(50) Enanthioselective Total Synthesis of FR900482
  M. Suzuki, M. Kambe, H. Tokuyama, T. Fukuyama
  J. Org. Chem., 69, 2831-3843 (2004)

(49) New Odorless Protocols for the Synthesis of Aldehydes and Ketones from Thiol Esters
  T. Miyazaki, Y. Han-ya, H. Tokuyama, T. Fukuyama
  Synlett, 477-480 (2004)

(48) Synthesis of Secondary Arylamines through Copper-Mediated Intermolecular Aryl Amination
  K. Okano, H. Tokuyama, T. Fukuyama
  Org. Lett., 5, 4987-4990 (2003)

(47) Stereocontrolled Total Synthesis of (–)-Aspidophytine
  S. Sumi, K. Matsumoto, H. Tokuyama, T. Fukuyama
  Tetrahedron, 59, 8571-8587 (2003)

(46) A Novel Palladium-Catalyzed Coupling of Thiol Esters with 1-Alkynes
  H. Tokuyama, T. Miyazaki, S. Yokoshima, T. Fukuyama
  Synlett, 1512-1514 (2003)

(45) Total Synthesis of Duocarmycins
  K. Yamada, T. Kurokawa, H. Tokuyama, T. Fukuyama
  J. Am. Chem. Soc., 125, 6630-6631 (2003)

(44) Enantioselective Total Synthesis of Aspidophytine
  S. Sumi, K. Matsumoto, H. Tokuyama, T. Fukuyama
  Org. Lett., 5, 1891-1893 (2003)

(43) First Fluorescent Photoinduced Electron Transfer (PET) Reagent for Hydroperoxides
    M. Onoda, S. Uchiyama, A. Endo, H. Tokuyama, T. Santa, K. Imai
  Org. Lett., 5, 1459-1461 (2003)

(42) Stereoselective Formation of a β-Lactam Fused Oxathiazepin: A Synthetic Approach to Eudistomins
  T. Yamashita, H. Tokuyama, T. Fukuyama
  Synlett, 738-741 (2003)

(41) Transformation of Primary Amines to N-Monoalkylhydroxylamines: N-Hydroxy-(S)-phenylethylamine Oxalate
  H. Tokuyama, T. Kuboyama, T. Fukuyama
  Org. Synth., 80, 207-218 (2003)

(40) Stereocontrolled Total Synthesis of (+)-Vinblastine
  S. Yokoshima, T. Ueda, S. Kobayashi, A. Sato, T. Kuboyama, H. Tokuyama, T. Fukuyama
  Pure Appl. Chem., 75, 29-38 (2003)

(39) Facile Construction of N-Hydroxybenzazocine: Enantioselective Total Synthesis of (+)-FR900482
  M. Suzuki, M. Kambe, H. Tokuyama, T. Fukuyama
  Angew. Chem. Int. Ed., 41, 4686-4688 (2002)

(38) A Novel Estrogen Receptor Binding Assay Method for Endocrine Disruptors using Fluorescence Polarization
  K. Ohno, T. Santa, T. Fukushima, N. Waizumi, H. Tokuyama, M. Maeda, K. Imai
  Anal. Chem., 74, 4391-4396 (2002)

(37) Synthesis of 2,3-Disubstituted Indoles by Radical Cyclization with Hypophosphorous Acid and
  Its Application to Total Synthesis of (±)-Catharanthine
  M. T. Reding, Y. Kaburagi, H. Tokuyama, T. Fukuyama
  Heterocycles, 56, 313-330 (2002)

(36) One-Pot Claisen Rearrangement with n-Butyl Vinyl Ether
  H. Tokuyama, T. Makido, T. Ueda, T. Fukuyama
  Synth. Commun., 32, 869-873 (2002)

(35) A Mild Copper-Mediated Intramolecular Amination of Aryl Halides
  K. Yamada, T. Kubo, H. Tokuyama, T. Fukuyama
  Synlett, 231-234 (2002)

(34) A Novel Conversion of alpha-Aminonitrile to Amide
  S. Yokoshima, T. Kubo, H. Tokuyama, T. Fukuyama
  Chem. Lett., 122-124 (2002)

(33) Stereocontrolled Total Synthesis of Vinblastine
  S. Yokoshima, T. Ueda, S. Kobayashi, A. Sato, T. Kuboyama, H. Tokuyama, T. Fukuyama
  J. Am. Chem. Soc., 124, 2137-2139 (2002)

(32) Reduction of Ethanethiol Esters to Aldehydes
  H. Tokuyama, S. Yokoshima, S.-C. Lin, L. Li, T. Fukuyama
  Synthesis, 1121-1123 (2002)

(31) A Practical Route to Quinoline from Anilines
  H. Tokuyama, M. Sato, T. Ueda, T. Fukuyama
  Heterocycles, 54, 105-108 (2001)

(30) 1,3-Dipolor Cycloaddition Strategy for Enatioselective Total Synthesis of FR-900482 Analogues
  M. Kambe, E. Arai, M. Suzuki, H. Tokuyama, T. Fukuyama
  Org. Lett., 3, 2575-2578 (2001)

(29) A Novel Protocol for Construction of Indolylmethyl Group at Aldehydes or Ketones
  H. Tokuyama, M. Watanabe, Y. Hayashi, T. Kurokawa, G. Peng, T. Fukuyama
  Synlett, 1403-1406 (2001)

(28) Synthesis of 2,3-Disubstituted Indoles by Palladium-Mediated Coupling of 2-Iodoindoles
  H. Tokuyama, Y. Kaburagi, X. Chen, T. Fukuyama
  Synthesis, 429-434 (2000)

(27) A Novel Transformation of Primary Amines to N-Monoalkylhydroxylamines
  H. Tokuyama, T. Kuboyama, A. Amano, T. Yamashita, T. Fukuyama
  Synthesis, 1299-1304 (2000)

(26) Enatioselective Total Synthesis of (+)-Gelsemine: Determination of Its Absolute Configuration
  S. Yokoshima, H. Tokuyama, T. Fukuyama
  Angew. Chem. Int. Ed., 39, 4073-4075 (2000)

(25) Radical Cyclization of 2-Alkenylthioanilides: A Novel Synthesis of 2,3-Disubstituted Indoles
  H. Tokuyama, T. Yamashita, M. T. Reding, Y. Kaburagi, T. Fukuyama
  J. Am. Chem. Soc., 121, 3791-3792 (1999)

(24) Cyclopropenone-Containg Cysteine Proteinase Inhibitors. Synthesis and Enzyme Inhibitory Activites
  R. Ando, T. Sakaki, Y. Morinaka, C. Takahashi, Y. Tamao, N. Yoshii, S. Katayama, K. Saito, H. Tokuyama, M. Isaka, E. Nakamura
  Bioorg. Med. Chem., 7, 571-579 (1999)

(23) 2-(2-Aminophenyl)-Acetoaldehyde Dimethyl Acetal: A Novel Reagent for the Protection of Carboxylic Acids
  E. Arai, H. Tokuyama, M. S. Linsell, T. Fukuyama
  Tetrahedron Lett., 39, 71-74 (1998)

(22) A Novel Ketone Synthesis by a Palladium-Catalyzed Reaction of Thiol Esters and Organozinc Reagents
  H. Tokuyama, S. Yokoshima, T. Yamashita, T. Fukuyama
  Tetrahedron Lett., 39, 3189-3192 (1998)

(21) Facile Palladium-Mediated Conversion of Ethanethiol Esters to Aldehydes and Ketones
  H. Tokuyama, S. Yokoshima, T. Yamashita, S.-C. Lin, L. Li, T. Fukuyama
  J. Braz. Chem. Soc., 9, 381-387 (1998)

(20) Synthetic and Computational Studies on Symmetry-Defined Double Cycloaddition of a New Tris-Annulating Reagent to C60
  H. Isobe, H. Tokuyama, M. Sawamura, E. Nakamura
  J. Org. Chem., 62, 5034-5041 (1997)

(19) Nitrene Additions to [60]Fullerene Do Not Generate [6,5] Aziridines
  A. B. Smith, III, H. Tokuyama
  Tetrahedron, 52, 5257-5262 (1996)

(18) Biological Acitvity of Water-Soluble Fullerenes. Structure Dependence of DNA Cleavage, Cytotoxicity, and
  Enzyme Inhibitory Activities Including HIV-Protease Inhibition
  E. Nakamura, H. Tokuyama, S. Yamago, T. Shiraki, Y. Sugiura
  Bull. Chem. Soc. Jpn., 69, 2143-2151 (1996)

(17) Photocytotoxicity of Water-Soluble Fullerene Derivatives
  K. Irie, Y. Nakamura, H. Ohigashi, H. Tokuyama, S. Yamago, E. Nakamura
  Biosci. Biotech. Biochem., 60, 1359-1361 (1996)

(16) Regio- and Diastereo-Controlled Double Cycloaddition to [60]Fullerene: One-step Synthesis of Cs and C2 Chiral Organofullerenes
  with New Tris Annulating Reagents
  E. Nakamura, H. Isobe, H. Tokuyama, M. Sawamura
  J. Chem. Soc., Chem. Commun., 1747-1748 (1996)

(15) Structure of Fullerene Anchored by Five-membered-ring
  H. Amano, H. Uekusa, Yuji Ohashi, H. Tokuyama, E. Nakamura
  Mol. Cryst. Liq. Cryst., 276, 291-294 (1996)

(14) Methano- and Propanofullerenes by [1+2] and [3+2] Cycloaddition of Vinylcarbene Species
  H. Tokuyama, H. Isobe, E. Nakamura
  Bull. Chem. Soc. Jpn., 68, 935-941 (1995)

(13) In vivo Biological Behavior of a Water-Miscible Fullerene: 14C Labeling, Absorption, Distribution, Excretion and Acute Toxicity
  S. Yamago, H. Tokuyama, E. Nakamura, K. Kikuchi, S. Kananishi, K. Sueki, H. Nakahara, S. Enomoto, F. Ambe
  Chem. Biol., 2, 385-389 (1995)

(12) Synthesis of Cyclopropenone-Containing Amino Acid Mimic. Addition of Cyclopropenyl Cerium Reagent to -Amino Aldehydes
  H. Tokuyama, M. Isaka, E. Nakamura
  Synth. Commun., 25, 2005-2012 (1995)

(11) Synthesis of Oxo- and Methylene-Bridged C60 Dimers, the First Well-Characterized Species Containing Fullerene-Fullerene Bonds
  A. B. Smith, III, H. Tokuyama, R. M. Strongin, G. T. Furst, W. J. Romanow, B. T. Chait, U. A. Mirza, I. Haller
  J. Am. Chem. Soc., 117, 9359-9360 (1995)

(10) Photoaddition of Silyl Ketene Acetal to [60]Fullerene. Synthesis of -Fullerene-substituted Carboxylic Esters
  H. Tokuyama, H. Isobe, E. Nakamura
  J. Chem. Soc., Chem. Commun., 2753-2754 (1994)

(9) Synthetic Chemistry with Fullerenes. Photooxygenation of Olefins
  H. Tokuyama, E. Nakamura
  J. Org. Chem., 59, 1135-1138 (1994)

(8) Fullerene-Oligonucleotide Conjudates: Photo-induced Sequence-Specific DNA Cleavage
  A. S. Boutorine, H. Tokuyama, M. Takasugi, H. Isobe, E. Nakamura, C. Helene
  Angew. Chem. Int. Ed. Engl., 33, 2462-2465 (1994)

(7) A New Class of Proteinase Inhibitor. Cyclopropenone-Containing Inhibitor of Papain
  R. Ando, Y. Morinaka, H. Tokuyama, M. Isaka, E. Nakamura
  J. Am. Chem. Soc., 115, 1174-1175 (1993)

(6) Regioselective Generation and Stereoselective [1+2] Cycloaddition of Substituted Vinylcarbenes
  H. Tokuyama, T. Yamada, E. Nakamura
  Synlett, 589-591 (1993)

(5) Photoinduced Biochemical Activity of Fullerene Carboxylic Acid
  H. Tokuyama, S. Yamago, E. Nakamura, T. Shiraki Y. Sugiura
  J. Am. Chem. Soc., 115, 7918-7919 (1993)

(4) Chemical Derivatization of Organofullerenes through Oxidation, Reduction, and C-O and C-C Bond-Forming Reactions
  S. Yamago, H. Tokuyama, E. Nakamura, M. Prato, F. Wudl
  J. Org. Chem., 58, 4796-4798 (1993)

(3) [1+2] and [3+2] Cycloaddition Reaction of Vinylcarbenes with C60
  H. Tokuyama, M. Nakamura, E. Nakamura
  Tetrahedron Lett., 34, 7429-7432 (1993)

(2) Thermal Reactions of Substituted Cyclopropenone Acetals. Regio- and Stereochemistry of Vinylcarbene Formation and
  Low-Temperature [3+2] Cycloaddition
  H. Tokuyama, M. Isaka, E. Nakamura
  J. Am. Chem. Soc., 114, 5523-5530 (1992)

(1) Synthesis and Biological Activities of Cyclopropenone Antibiotic Penitricin and Congeners
  H. Tokuyama, M. Isaka, E. Nakamura
  J. Antibiot., 45, 1148-1154 (1992)

Reviews and Accounts

(25) 制御の難しいアミンの酸化をあえて有機合成に利用する
  植田浩史、徳山英利
  化学と教育、65, 190-191 (2017).

(24) 化学はどこに行くかー次世代の化学が目指すべきこと
  中村栄一、相田卓三、菅 裕明、徳山英利、内山真伸
  現代化学、No. 548, 2016年12月、44-48.

(23) The Total Synthesis of Biosynthetically Related Monoterpene Indole Alkaloids
  H. Tokuyama
  J. Synth. Org. Chem., Jpn, 73, 1120-1129 (2015)

(22) Copper-mediated aromatic amination reaction and its application to the total synthesis of natural products
  K. Okano, H. Tokuyama, T. Fukuyama
  Chem. Commun., 50, 13650-13663 (2014) Featured as a front cover ! PDF

(21) 不安定な七員環をいかにつくるか?ーアセチルアラノチンの全合成
  H. Tokuyama, K. Okano
  Kagaku (Kyoto), 69, 68-69 (2014)

(20) Total Syntheses of Mersicarpine
  Y. Iwama, K. Okano, H. Tokuyama
  J. Synth. Org. Chem., Jpn, 71, 926-934 (2013)

(19) Total Syntheses of Nitrogen-Containing Cyclic Natural Products Based on Aryl Amination
  K. Okano, T. Fukuyama, H. Tokuyama
  J. Synth. Org. Chem., Jpn, 68, 1036-1046 (2010)

(18) 現在の有機合成化学をもってしても合成困難な天然物とは?
  二量体型アルカロイド(+)-Haplophytineの全合成
  徳山英利,植田浩史,福山透
  化学と生物,48,450-453 (2010)

(17) Total Synthesis of (+)-Vinblastine: Control of the Stereochemistry at C18'
  S. Yokoshima, H. Tokuyama, T. Fukuyama
  Chem. Rec., 10, 101-118 (2010)

(16) Total Synthesis of Dimeric Alkaloid (+)-Haplophytine
  H. Tokuyama
  Farumashia, 46, 223-228 (2010)

(15) ついに合成!難攻不落のアザジラクチン
  K. Sugimoto, H. Tokuyama
  Kagaku (Kyoto), 62, 70-71 (2007)

(14) Total Syntheses of FR900482
  H. Tokuyama, M. Suzuki, T. Fukuyama,
  J. Synth. Org. Chem., Jpn, 65, 470-480 (2007)

(13) Acceleration of Reaction by Microwave Irradiation
  H. Tokuyama, M. Nakamura
  J. Synth. Org. Chem., Jpn, 63, 1893-1896 (2005)

(12) 「インドール合成の進展とその応用」
  徳山英利
  現代化学増刊43「最新有機合成化学ーさまざまな元素の活用」、東京化学同人、2005年

(11) Palladium-Mediated Synthesis of Aldehydes and Ketones from Thiol Esters
  T. Fukuyama, H. Tokuyama
  Aldrichimica Acta, 37, 87-96 (2004)

(10) 「世界をリードする日本の化学、実用的な有機合成を目指すービンブラスチン全合成の考え方ー」
  福山 透、徳山英利
  現代化学、2004年7月号、pp38-43

(9) Development of New Synthetic Methods and Their Application to Synthesis of Useful Compounds
  H. Tokuyama
  Yakugaku Zasshi, 123, 1007-1021 (2003)

(8) Synthesis of 2,3-Disubstituted Indoles by Radical Cyclization of 2-Alkenylphenylisocyanide
  H. Tokuyama and T. Fukuyama
  Chem. Rec., 2, 37-45 (2002)

(7) Development and Application of A Novel Indole Synthesis and Useful Functional Group Transformations
  H. Tokuyama and T. Fukuyama
  有機合成 創造の軌跡 126のマイルストーン 有機合成化学協会編、2002年、pp224-225

(6) New Development of Indole Synthesis using Radical Cyclization and Application to Indole Alkaloid Synthesis
  H. Tokuyama
  J. Synth. Org. Chem., Jpn, 59, 488-489 (2001)

(5) Development of new indole synthesis and application to synthesis of natural products
  H. Tokuyama, T. Fukuyama
  Kagaku Kogyo, 52, 416-421 (2001)

(4) Total Synthesis of Antibiotic Vancomycin
  H. Tokuyama, T. Fukuyama
  Kagaku (Kyoto), 55, 68-69 (2000)

(3) Efficient Synthesis of Nitrogen-Containing Natural Products
  H. Tokuyama, T. Fukuyama
  Farumashia, 34, 1208-1212 (1998)

(2) Pharmacokinetic and Toxicity Studies on Water-Miscible Fullerenes
  E. Nakamura, S. Yamago, H. Tokuyama, K. Kuchi, S. Kananishi, K. Sueki, H. Nakahara, S. Enomoto, and F. Ambe
  New Horizons in Organic Synthesis, V. Nair and S. Jumar, Eds., New Age International, New Delhi, 1997, pp. 207-212

(1) Synthesis of Organic Derivatives of Fullerenes
  S. Yamago, H. Tokuyama, E. Nakamura, M. Prato, and F. Wudl
  Trans. Mat. Res. Soc. Jpn, 14B, 1169-1172 (1994)

Books

(14) 「ジョーンズ有機化学(下)第5版」分担訳、東京化学同人、2016

(13) 「ジョーンズ有機化学(上)第5版」分担訳、東京化学同人、2016

(12) 「有機合成実験法ハンドブック 第2版」分担執筆、有機合成化学協会編、丸善、2015

(11)「大学院講義有機化学第2版」分担執筆、東京化学同人、2015

(10) 「スタンダード薬学シリーズII 化学系薬学 I. 化学物質の性質と反応」分担執筆、日本薬学会編、東京化学同人、2015

(9) 「トップドラッグから学ぶ創薬化学」分担執筆、有機合成化学協会編、東京化学同人、2012

(8) 「天然物合成で活躍した反応」分担執筆、有機合成化学協会編、化学同人、2011

(7) 「天然物全合成の最新動向」分担執筆、北泰行監修、シーエムシー出版、2009

(6) 「天然物の全合成 2000〜2008(日本)」分担執筆、有機合成化学協会編、化学同人、2009

(5) 「大学院講義有機化学演習編」分担執筆、野依良治ら編、東京化学同人、2007

(4) 「天然物化学ー植物編」分担執筆、山村庄亮、長谷川宏司編、アイピーシー、2007 

(3) 「演習で学ぶ 有機反応機構」共著、共編、有機合成化学協会編、化学同人、2005

(2) 「スタンダード薬学シリーズ 化学系薬学 I. 化学物質の性質と反応」分担執筆、日本薬学会編、東京化学同人、2004

(1) 「有機合成 創造の軌跡 126のマイルストーン」共編、有機合成化学協会編、化学同人、2002

 

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Last Updated December 11, 2014