Graduate School of Pharmaceutical Sciences, Tohoku University 東北大学大学院薬学研究科・分子設計化学分野
2025.9 当分野では、助教(任期なし)を公募しています。 公募情報はこちらをご覧ください。
2025.9 Ryoga Nambu received the poster award at 41th Seminar on Synthetic Organic Chemistry. 南部凌我さんが第41回有機合成化学セミナーで優秀ポスター賞を受賞しました。
2025.8 A paper on the iodo(III)cyclization cascade of diynes by Kikuchi et al. has been published in Org. Lett.
2025.8 A paper on the formal cyclopropylation of imines with cyclopropanol by Tsukiji et al. has been published in Angew. Chem. Int. Ed.
2025.5 Daichi Ikeshita received the best poster award at 36th Banyu Sendai Symposium. 池下大智さんが第36回万有仙台シンポジウムでポスター賞を受賞しました。
2025.4. A paper on the merger of HDDA reaction and hypervalent iodine chemistry by Morohashi et al. has been published in Org. Lett.
2025.4. A paper on the novel reactivity of diazomethyl-λ3-iodanes toward arynes by Otsuki et al. has been published in Chem. Sci.
2025.4. A paper on the atropisomerism around a carbon-iodine bond by Abe et al. has been publihsed in Chem. プレスリリース
考えたことを、かたちにする。それが有機化学の根源的な魅力です。
分子を設計し、反応を構築し、実在する“もの”として立ち上げる過程には、 想像を超えた面白さがあります。
To shape what we think into tangible form — this is the fundamental allure of organic chemistry.
The design of molecules, the creation of reactions, and the realization of ideas in physical, observable matter — these processes offer a unique sense of intellectual satisfaction.
未知への跳躍、その軌跡を示す
かつて、低原子価コバルト種の潜在能力を引き出し、ベースメタル触媒の化学とC–H結合活性化に新境地を拓きました。
時を隔てて、シクロプロパノールという小員環分子に秘められた反応性を見出し、新奇な多官能性三次元骨格の創出へと展開しました。
またかつて、パラジウム触媒を用いたC–H活性化により、創薬の鍵となるインドール骨格を効率的に構築する新手法を開発しました。
時を経て、炭素–ヨウ素結合という最も長く脆い鎖に、精緻な分子設計を施し、軸性キラリティ(アトロプ異性)の制御に成功しました。
Leaping into the Unknown — A Singular Trajectory
We once uncovered the latent potential of low-valent cobalt species, pioneering new frontiers in base-metal catalysis and C–H bond activation.
Years later, we identified the hidden reactivity of cyclopropanol, a small starined ring, and expanded its utility toward the construction of novel, multifunctional three-dimensional frameworks.
We also developed a new strategy for the efficient synthesis of indole scaffolds, a key structural motif in drug discovery, via palladium-catalyzed C–H activation.
And again, after the passage of time, we imposed precision molecular design upon the carbon–iodine bond, the longest and weakest among common covalent bonds, and achieved control over axial chirality (atropisomerism) along this fragile axis.
Professional Appointment
2021-Present: Professor, Tohoku University
2016-2021: Associate Professor (tenured), NTU Singapore
2009-2016: Assistant Professor, NTU Singapore
2009-2014: NRF Research Fellow, National Research Foundation (Singapore)
2005-2009: Assistant Professor, The University of Tokyo
Education
2005 Ph.D. in Chemistry, The University of Tokyo (Prof. E. Nakamura)
2002 M.Sc. in Chemistry, The University of Tokyo (Prof. E. Nakamura)
2000 B.Sc. in Chemistry, The University of Tokyo (Prof. E. Nakamura)
2002-2005: JSPS Fellow
2002: Visiting Student, Stockholm University (Prof. Jan Bäckvall)
Awards/Recognition
2022: Mukaiyama Award
2020: TCI-SNIC Industry Award in Synthetic Chemistry
2015: Asian Core Program (ACP) Lectureship (from Thailand)
2014: Asian Core Program (ACP) Lectureship (from China and Korea)
2014: The 63rd Chemical Society of Japan Award for Young Chemists
2014: SPMS Young Researcher Awards
2011: Asian Core Program Lectureship (from Japan)
2011: Thieme Chemistry Journals Award
2008: Takasago Award in Synthetic Organic Chemistry, Society of Synthetic Organic Chemistry in Japan
2007: Inoue Research Award for Young Scientists, Inoue Research Foundation
吉戒 直彦
東北大学大学院薬学研究科・分子設計化学分野
980-8578 仙台市青葉区荒巻字青葉6-3
E-mail: naohiko.yoshikai.c5@tohoku.ac.jp; Tel: 022-795-6812
Naohiko Yoshikai
Graduate School of Pharmaceutical Sciences
Tohoku University
6-3 Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan
E-mail: naohiko.yoshikai.c5@tohoku.ac.jp; Tel: +81-22-795-6812