Yoshikai Group

Graduate School of Pharmaceutical Sciences, Tohoku University 東北大学大学院薬学研究科・分子設計化学分野

Our group is committed to the development and mechanistic study of novel molecular transformations for organic synthesis. Our research programs are driven by a desire to uncover and understand unprecedented chemical reactivities and to exploit such reactivities in the design and development of efficient and selective organic reactions.


2022.8 A new paper by Tsukiji et al. has been published in Chem. Lett.

2022.8 A News & Views article has been published in Nat. Synth.

2022.3 Dr. Kazuya Kanemoto has joined our group as Assistant Professor.

2022.1 Dr. Jun Kikuchi has joined our group as Assistant Professor.

2021.11 Prof. Yoshikai has been selected as recipient of Mukaiyama Award 2022.


Earth-Abundant Metal Catalysis

C–H activations, cycloadditions, asymmetric catalysis

Heterocyclic Chemistry

Novel synthetic methods for heterocycles relevant to pharmaceuticals and materials

Hypervalent Iodine Chemistry

Novel reactivity and synthetic applications

Recent Publications

Full Publication List

Diastereoselective Conversion of Cyclopropanols to Cyclopentane-1,3-diols via Aldol Dimerization of Zinc Homoenolates

Tsukiji, K.; Sekiguchi, Y.; Kanemoto, K.; Yoshikai, N. Chem. Lett. 2022, DOI 10.1246/cl.220311.

Cobalt Selectively Annulates

Kikuchi, J.; Yoshikai, N. Nat. Synth. (News & Views) 2022, DOI 10.1038/s44160-022-00126-0 .

Cobalt-Catalyzed Carbo- and Hydrocyanation of Alkynes via C-CN Bond Activation

Wang, C.-S.; Yu, Y.; Sunada, Y.; Wang, C.; Yoshikai, N. ACS Catal. 2022, 12, 4054-4066.

Organocobalt Complexes in C–H Activation

Yoshikai, N. In Comprehensive Organometallic Chemistry IV, Mayer, K.; O’Hare, D.; Parkin, G. Eds., Elsevier, In Press.

Cobalt-Catalyzed Asymmetric C–H Functionalization

Yoshikai, N. In Handbook of C–H Functionalization, Maiti, D. Ed., Wiley, In Press.


KIKUCHI Jun 菊池 隼

Assistant Professor


SAITO Yuri 齋藤 友理

Graduate Student (M1)


ARAKAWA Chisaki 荒川 千紗貴

Undergraduate Student (B4)


TSUKIJI Kento 築地 健人

Undergraduate Student (B4)


NAGATA Toya 長田 透弥

Undergraduate Student (B4)



Undergraduate Student (B4)


ABE Shohei 阿部 将平

Undergraduate Student (B3)


OTSUKI Shinya 大槻 真也

Undergraduate Student (B3)


SASAKI Shuma 佐々木 脩磨

Undergraduate Student (B3)


NAKAJIMA Roi 中島 呂維

Undergraduate Student (B3)


IWATA Masaki 岩田 真輝

Research Student


SEKIGUCHI Yoshiya 関口 義也

Graduate Student (NTU)

YOSHIKAI Naohiko 吉戒 直彦

YOSHIKAI Naohiko 吉戒 直彦


Professional Appointment

2021-Present: Professor, Tohoku University

2016-2021: Associate Professor (tenured), NTU Singapore

2009-2016: Assistant Professor, NTU Singapore

2009-2014: NRF Research Fellow, National Research Foundation (Singapore)

2005-2009: Assistant Professor, The University of Tokyo


2005 Ph.D. in Chemistry, The University of Tokyo (Prof. E. Nakamura)

2002 M.Sc. in Chemistry, The University of Tokyo (Prof. E. Nakamura)

2000 B.Sc. in Chemistry, The University of Tokyo (Prof. E. Nakamura)

2002-2005: JSPS Fellow

2002: Visiting Student, Stockholm University (Prof. Jan Bäckvall)


2022: Mukaiyama Award

2020: TCI-SNIC Industry Award in Synthetic Chemistry

2015: Asian Core Program (ACP) Lectureship (from Thailand)

2014: Asian Core Program (ACP) Lectureship (from China and Korea)

2014: The 63rd Chemical Society of Japan Award for Young Chemists

2014: SPMS Young Researcher Awards

2011: Asian Core Program Lectureship (from Japan)

2011: Thieme Chemistry Journals Award

2008: Takasago Award in Synthetic Organic Chemistry, Society of Synthetic Organic Chemistry in Japan

2007: Inoue Research Award for Young Scientists, Inoue Research Foundation

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吉戒 直彦


980-8578 仙台市青葉区荒巻字青葉6-3

E-mail: naohiko.yoshikai.c5@tohoku.ac.jp; Tel: 022-795-6812

Naohiko Yoshikai

Graduate School of Pharmaceutical Sciences

Tohoku University

6-3 Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan

E-mail: naohiko.yoshikai.c5@tohoku.ac.jp; Tel: +81-22-795-6812