Yoshikai Group

Graduate School of Pharmaceutical Sciences, Tohoku University 東北大学大学院薬学研究科・分子設計化学分野

Our group is committed to the development and mechanistic study of novel molecular transformations for organic synthesis. Our research programs are driven by a desire to uncover and understand unprecedented chemical reactivities and to exploit such reactivities in the design and development of efficient and selective organic reactions.


2023.3 New papers by Asanuma, Kanemoto et al. and Saito et al. have been published in Angewandte Chemie.

2022.12 Science of Synthesis: Base-Metal Catalysis Vol. 1 has been published.

2022.12 Dr. Liejin Zhou has joined the group.

2022.10 New undergraduate students have joined the group.

2022.9 Yuri Saito received a poster award at Joint Meeting of the Tohoku Area Chemistry Societies. 齋藤友理さんが化学系学協会東北大会でポスター賞を受賞しました

2022.9 A new paper by Kikuchi et al. has been published in Org. Lett.

2022.8 A new paper by Tsukiji et al. has been published in Chem. Lett.


Earth-Abundant Metal Catalysis

C–H activations, cycloadditions, asymmetric catalysis

Heterocyclic Chemistry

Novel synthetic methods for heterocycles relevant to pharmaceuticals and materials

Hypervalent Iodine Chemistry

Novel reactivity and synthetic applications

Recent Publications

Full Publication List

Site-Selective C–H Alkenylation of N-Heteroarenes by Ligand-Directed Co/Al and Co/Mg Cooperative Catalysis

Saito, Y.; Kikuchi, J.; Wang, C.; Yoshikai, N. Angew. Chem. Int. Ed. 2023, e202301006.

N-(Morpholine-4-dithio)phthalimide: A Shelf-Stable, Bilateral Platform Molecule Enabling Access to Diverse Unsymmetrical Disulfides

Asanuma, H.; Kanemoto, K.; Watanabe, T.; Fukuzawa, S. Angew. Chem. Int. Ed. 2023, e202219156.

Science of Synthesis Base-Metal Catalysis

Science of Synthesis Base-Metal Catalysis; Yoshikai, N. Ed.; Thieme; Stuttgart, 2022.

Exploring New Reactions and Syntheses of Trivalent Iodine Compounds

Yoshikai, N. J. Synth. Org. Chem. Jpn. 2022, 80, 1011-1018.

Stereoselective Synthesis of β-Alkoxy-β-amido Vinylbenziodoxoles via Iodo(III)etherification of Ynamides

Kikuchi, J.; Maesaki, K.; Sasaki, S.; Wang, W.; Ito, S.; Yoshikai, N. Org. Lett. 2022, 24, 6914-6918.

Diastereoselective Conversion of Cyclopropanols to Cyclopentane-1,3-diols via Aldol Dimerization of Zinc Homoenolates

Tsukiji, K.; Sekiguchi, Y.; Kanemoto, K.; Yoshikai, N. Chem. Lett. 2022, 51, 1012-1014.


KIKUCHI Jun 菊池 隼

Assistant Professor


ZHOU Liejin 周 列錦

Postdoctoral Fellow


SAITO Yuri 齋藤 友理

Graduate Student (M2)


ARAKAWA Chisaki 荒川 千紗貴

Graduate Student (M1)


TSUKIJI Kento 築地 健人

Graduate Student (M1)


NAGATA Toya 長田 透弥

Graduate Student (M1)



Graduate Student (M1)


ABE Shohei 阿部 将平

Undergraduate Student (B4)


OTSUKI Shinya 大槻 真也

Undergraduate Student (B4)


SASAKI Shuma 佐々木 脩磨

Undergraduate Student (B4)


NAKAJIMA Roi 中島 呂維

Undergraduate Student (B4)


IWATA Masaki 岩田 真輝

Research Student


TAKAMI Yuzuki 鷹見 優月

Undergraduate Student (B3)


NAMBU Ryoga 南部 凌我

Undergraduate Student (B3)


MACHINAGA Tomoya 町永 智哉

Undergraduate Student (B3)


MOROHASHI Shunya 諸橋 駿矢

Undergraduate Student (B3)

YOSHIKAI Naohiko 吉戒 直彦

YOSHIKAI Naohiko 吉戒 直彦


Professional Appointment

2021-Present: Professor, Tohoku University

2016-2021: Associate Professor (tenured), NTU Singapore

2009-2016: Assistant Professor, NTU Singapore

2009-2014: NRF Research Fellow, National Research Foundation (Singapore)

2005-2009: Assistant Professor, The University of Tokyo


2005 Ph.D. in Chemistry, The University of Tokyo (Prof. E. Nakamura)

2002 M.Sc. in Chemistry, The University of Tokyo (Prof. E. Nakamura)

2000 B.Sc. in Chemistry, The University of Tokyo (Prof. E. Nakamura)

2002-2005: JSPS Fellow

2002: Visiting Student, Stockholm University (Prof. Jan Bäckvall)


2022: Mukaiyama Award

2020: TCI-SNIC Industry Award in Synthetic Chemistry

2015: Asian Core Program (ACP) Lectureship (from Thailand)

2014: Asian Core Program (ACP) Lectureship (from China and Korea)

2014: The 63rd Chemical Society of Japan Award for Young Chemists

2014: SPMS Young Researcher Awards

2011: Asian Core Program Lectureship (from Japan)

2011: Thieme Chemistry Journals Award

2008: Takasago Award in Synthetic Organic Chemistry, Society of Synthetic Organic Chemistry in Japan

2007: Inoue Research Award for Young Scientists, Inoue Research Foundation

Download CV


吉戒 直彦


980-8578 仙台市青葉区荒巻字青葉6-3

E-mail: naohiko.yoshikai.c5@tohoku.ac.jp; Tel: 022-795-6812

Naohiko Yoshikai

Graduate School of Pharmaceutical Sciences

Tohoku University

6-3 Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan

E-mail: naohiko.yoshikai.c5@tohoku.ac.jp; Tel: +81-22-795-6812