Heterocyclic compounds, both naturally exiting and man-made, are of prime importance in modern chemistry, medicine, and materials science because they serve as indispensable core structural elements in functional molecules such as drugs and electronic materials. Our group has been committed to the development of mechanistically unique and practically useful catalytic methods for their synthesis.
Tan, W. W.; Ong, Y. J.; Yoshikai, N. Synthesis of Highly Substituted Pyridines through Copper-Catalyzed Condensation of Oximes and α,β-Unsaturated Imines. Angew. Chem. Int. Ed. 2017, 56, 8240-8244.
Wu, B.; Melvina; Wu, X.; Yeow, E. K. L.; Yoshikai, N. Versatile Telluracyclc Synthesis via the Sequential Electrophilic Telluration of C(sp2)–Zn and C(sp2)–H Bonds. Chem. Sci. 2017, 8, 4527-4532.
Wu, J.; Yoshikai, N. Modular Synthesis of Multisubstituted Furans through Palladium-Catalyzed Three-Component Condensation of Alkynylbenziodoxoles, Carboxylic Acids, and Imines. Angew. Chem. Int. Ed. 2015, 54, 11107-11111.