Cobalt-Catalyzed Ortho-Arylation of Aromatic Imines with Aryl Chlorides

Abstract

An ortho-arylation reaction of aromatic imines with aryl chlorides has been achieved using a cobalt-N-heterocyclic carbene catalyst in combination with a neopentyl Grignard reagent. The reaction takes place at room temperature to afford biaryl products in moderate to good yields.

Publication
Gao, K.; Lee, P.-S.; Long, C.; Yoshikai, N. Org. Lett. 2012, 14, 4234-4237.