Full Publications

Journal Publications

  1. Morohashi, S.; Zhou, L.; Kanemoto, K.; Kwon, E.; Yoshikai, N. Hexadehydro Diels–Alder/Alkynyliodanation Cascade: A Highly Regioselective Entry to Polycyclic Aromatics. Org. Lett. 2025, DOI:10.1021/acs.orglett.5c00956.

  1. Otsuki, S.; Kanemoto, K.; Martos, D. C.; Kwon, E.; Wencel-Delord, J.; Yoshikai, N. Diazomethyl-λ3-iodane meets aryne: dipolar cycloaddition and C-to-N iodane shift leading to indazolyl-λ3-iodanes. Chem. Sci. 2025, DOI:10.1039/D5SC00266D.

  1. Abe, S.; Kikuchi, J.; Matsumoto, A.; Yoshikai, N. Stable and responsive atropisomerism around a carbon–iodine bond. Chem 2025, DOI: 10.1016/j.chempr.2025.102527.

  1. Iwata, M.; Takami, Y.; Asanuma, H.; Hosono, K.; Ohno, H.; Yoshikai, N.; Kanemoto, K. A versatile entry to unnatural, disulfide-linked amino acids and peptides through the disulfuration of azlactones. Chem. Sci. 2025, DOI: 10.1039/D4SC07187E.

  1. Tsukiji, K.; Matsumoto, A.; Kanemoto, K.; Yoshikai, N. Stereoselective Hydroxyallylation of Cyclopropenes with Cyclopropanols via NHC Catalysis of Transient Organozinc Species. Angew. Chem. Int. Ed. 2024, 63, e202412456.

  1. Kikuchi, J.; Nagata, T.; Ito, S.; Yoshikai, N. Three-component Friedel–Crafts-type difunctionalization of ynamides with (hetero)arenes and iodine(iii) electrophile Org. Chem. Front. 2024, 11, 3072-3079.

  1. Kanemoto, K.; Yoshimura, K.; Ono, K.; Ding, W.; Ito, S.; Yoshikai, N. Amino- and Alkoxybenziodoxoles: Facile Preparation and Use as Arynophiles Chem. Eur. J. 2024, 30, e202400894.

  1. Kikuchi, J.; Nakajima, R.; Yoshikai, N. Three-component N-alkenylation of azoles with alkynes and iodine(III) electrophile: synthesis of multisubstituted N-vinylazoles. Beilstein J. Org. Chem. 2024, 20, 891-897.

  1. Han, H.; Goh, G. W. Z.; Li, Y.; Yoshikai, N.; Ito, S. 1,3-Dipolar Cycloaddition of Polycyclic Aromatic Azomethine Ylides and Alkynylbenziodoxoles for Synthesis of Functional Dibenzoullazines. Chin. J. Chem. 2024, 42, 1079-1083.

  1. Arakawa, C.; Kanemoto, K.; Nakai, K.; Wang, C.; Morohashi, S.; Kwon, E.; Ito, S.; Yoshikai, N. Carboiodanation of Arynes: Organoiodine(III) Compounds as Nucleophilic Organometalloids. J. Am. Chem. Soc. 2024, 146, 3910-3919.

  1. Machida, H.; Kanemoto, K. N-Terminal-Specific Dual Modification of Peptides through Copper-Catalyzed (3+2) Cycloaddition. Angew. Chem. Int. Ed. 2024, 63, e202320012.

  1. Asanuma, H.; Kanemoto, K. Amination of N-(Organodithio)phthalimides for the Modular Synthesis of Aminodisulfides. Org. Lett. 2024, 26, 438-443.

  1. Sasaki, S.; Kikuchi, J.; Ito, S.; Yoshikai, N. Stereoselective Approach to Multisubstituted Enolates from Unactivated Alkynes: Oxyalkylidenation of Alkynyl Ketone Enolates with Aldehydes. J. Org. Chem. 2023, 88, 14096-14104.

  1. Tsukiji, K.; Hayakawa, T.; Kanemoto, K.; Yoshikai, N. Zinc-Mediated Diastereoselective Annulation of Cyclopropanols with Alkylidenemalononitriles via Enolized Homoenolate. Asian J. Org. Chem. 2023, 12, e202300114 (Prof. Keiji Maruoka’s 70th birthday collection).

  1. Saito, Y.; Kikuchi, J.; Wang, C.; Yoshikai, N. Site-Selective C–H Alkenylation of N-Heteroarenes by Ligand-Directed Co/Al and Co/Mg Cooperative Catalysis. Angew. Chem. Int. Ed. 2023, 62, e202301006.

  1. Asanuma, H.; Kanemoto, K.; Watanabe, T.; Fukuzawa, S. N-(Morpholine-4-dithio)phthalimide: A Shelf-Stable, Bilateral Platform Molecule Enabling Access to Diverse Unsymmetrical Disulfides. Angew. Chem. Int. Ed. 2023, 62, e202219156.

  1. Yoshikai, N. Exploring New Reactions and Syntheses of Trivalent Iodine Compounds. J. Synth. Org. Chem. Jpn. 2022, 80, 1011-1018.

  1. Kikuchi, J.; Maesaki, K.; Sasaki, S.; Wang, W.; Ito, S.; Yoshikai, N. Stereoselective Synthesis of β-Alkoxy-β-amido Vinylbenziodoxoles via Iodo(III)etherification of Ynamides. Org. Lett. 2022, 24, 6914-6918.

  1. Tsukiji, K.; Sekiguchi, Y.; Kanemoto, K.; Yoshikai, N. Diastereoselective Conversion of Cyclopropanols to Cyclopentane-1,3-diols via Aldol Dimerization of Zinc Homoenolates. Chem. Lett. 2022, DOI: 10.1246/cl.220311.

  1. Kikuchi, J.; Yoshikai, N. Cobalt Selectively Annulates. Nat. Synth. 2022, DOI: 10.1038/s44160-022-00126-0 (News & Views).

  1. Wang, C.-S.; Yu, Y.; Sunada, Y.; Wang, C.; Yoshikai, N. Cobalt-Catalyzed Carbo- and Hydrocyanation of Alkynes via C-CN Bond Activation. ACS Catal. 2022, 12, 4054-4066.

  1. Sekiguchi, Y.; Yoshikai, N. Zinc-Mediated Hydroxyallylation of Aldehydes with Cyclopropanols: Direct Access to Vicinal anti-sec,tert-Diols via Enolized Homoenolate. Org. Lett. 2022, 24, 960-965 (Preprint: Sekiguchi, Y.; Yoshikai, N. ChemRxiv 2021, DOI: 10.26434/chemrxiv-2021-swc95)

  1. Wang, C.-S.; Tan, P. S. L.; Ding, W.; Ito, S.; Yoshikai, N. Regio- and Stereoselective Synthesis of Enol Carboxylate, Phosphate, and Sulfonate Esters via Iodo(III)functionalization of Alkynes. Org. Lett. 2022, 24, 430-434.

  1. Chai, J.; Ding, W.; Wang, C.; Ito, S.; Wu, J.; Yoshikai, N. Ritter-Type Iodo(III)amidation of Unactivated Alkynes for the Stereoselective Synthesis of Multisubstituted Enamides. Chem. Sci. 2021, 12, 15128-15133 (Preprint: Chai, J.; Ding, W.; Ito, S.; Wu, J.; Yoshikai, N. ChemRxiv 2021, DOI: 10.33774/chemrxiv-2021-c2ftp).

  1. Sekiguchi, Y.; Yoshikai, N. Zinc-Catalyzed β-Functionalization of Cyclopropanols via Enolized Homoenolate. J. Am. Chem. Soc. 2021, 143, 18400-18405 (Preprint: Sekiguchi, Y.; Yoshikai, N. ChemRxiv 2021, DOI: 10.33774/chemrxiv-2021-4jlsp).

  1. Sekiguchi, Y.; Lee, Y. Y.; Yoshikai, N. Nickel-Catalyzed Ring-Opening Allylation of Cyclopropanols via Homoenolate. Org. Lett. 2021, 23, 5993-5997.

  1. Sekiguchi, Y.; Yoshikai, N. Enantioselective Conjugate Addition of Catalytically Generated Zinc Homoenolate. J. Am. Chem. Soc. 2021, 143, 4775-4781 (Preprint: Sekiguchi, Y.; Yoshikai, N. ChemRxiv 2021, DOI: 10.26434/chemrxiv.13607438.v1).

  1. Wang, C.-S.; Sun, Q.; Garcia, F.; Wang, C.; Yoshikai, N. Robust Cobalt Catalyst for Nitrile/Alkyne [2+2+2] Cycloaddition: Synthesis of Polyarylpyridines and Their Mechanochemical Cyclodehydrogenation to Nitrogen-Containing Polyaromatics. Angew. Chem. Int. Ed. 2021, published online (Preprint: Wang, C.-S.; Sun, Q.; Garcia, F.; Wang, C.; Yoshikai, N. ChemRxiv 2021, DOI: 10.26434/chemrxiv.13465697.v1)

  1. Laskar, R. A.; Ding, W.; Yoshikai, N. Iodo(III)-Meyer-Schuster Rearrangement of Propargylic Alcohols Promoted by Benziodoxole Triflate. Org. Lett. 2021, 23, 1113-1117.

  1. Sekiguchi, Y.; Yoshikai, N. Metal-Catalyzed Transformations of Cyclopropanols via Homoenolates. Bull. Chem. Soc. Jpn. 2021, 1, 265-280.

  1. Xu, W.; Wu, M.; Yoshikai, N. Iron-Catalyzed Remote C-H Alkylation of 8-Amidoquinolines with Cycloalkanes. Synthesis 2020, published online.

  1. Chai, J.; Ding, W.; Wu, J.; Yoshikai, N. Fluorobenziodoxole-BF3 Reagent for Iodo(III)etherification of Alkynes in Ethereal Solvent. Chem. Asian J. 2020, 15, 2166-2169.

  1. Ding, W.; Wang, C.; Tan, J. R.; Ho, C. C.; León, F.; García, F.; Yoshikai, N. Site-selective aromatic C-H λ3-iodanation with cyclic iodine(III) electrophile in solution and solid phases. Chem. Sci. 2020, 11, 7356-7361.

  1. Yang, J.; Mori, Y.; Yamanaka, M.; Yoshikai, N. Cobalt‐Catalyzed Intramolecular Hydroacylation Involving Cyclopropane Cleavage. Chem. Eur. J. 2020, 26, 8302-8307.

  1. Ding, W.; Chai, J.; Wang, C.; Wu, J.; Yoshikai, N. Stereoselective Access to Highly Substituted Vinyl Ethers via trans-Difunctionalization of Alkynes with Alcohols and Iodine(III) Electrophile. J. Am. Chem. Soc. 2020, 142, 8619-8624 (Preprint: Ding, W.; Chai, J.; Wu, J.; Yoshikai, N. ChemRxiv 2020, DOI: 10.26434/chemrxiv.11770092.v1.)

  1. Wang, C.-S.; Di Monaco, S.; Thai, A. N.; Rahman, M. S.; Pang, B. P.; Wang, C.; Yoshikai, N. Cobalt/Lewis Acid Catalysis for Hydrocarbofunctionalization of Alkynes via Cooperative C–H Activation. J. Am. Chem. Soc. 2020, 142, 12878-12889 (Preprint: Wang, C.-S.; Di Monaco, S.; Thai, A. N.; Wang, C.; Yoshikai, N. ChemRxiv 2020, DOI: 10.26434/chemrxiv.11760519.v1.)

  1. Rahman, M. S.; Yoshikai, N. Synthesis of Triphenylene-Fused Phosphole Oxides via C-H Functionalizations. Beilstein J. Org. Chem. 2020, 16, 524-529.

  1. Laskar, R. A.; Yoshikai, N. Cobalt-Catalyzed, N–H Imine-Directed Arene C–H Benzylation with Benzyl Phosphates. J. Org. Chem. 2019, 84, 13172-13178.

  1. Ding, W.; Ho, Y. K. T.; Okuda, Y.; Wijaya, K. C.; Tan, Z. H.; Yoshikai, N. Cobalt-Catalyzed Hydroacylative Dimerization of Allenes Leading to Skipped Dienes. Org. Lett. 2019, 21, 6173-6178.

  1. Sun, Q.; Yoshikai, N. Cobalt-Catalyzed Tandem Radical Cyclization/C–C Coupling Initiated by Directed C–H Activation. Org. Lett. 2019, 21, 5238-5242.

  1. Rahman, M. S.; Yoshikai, N. Synthesis and Properties of Phospha[5]helicenes Bearing Inner-Rim Phosphorus Center. Org. Lett. 2019, 21, 3232-3236.

  1. Yang, J.; Sekiguchi, Y.; Yoshikai, N. Cobalt-Catalyzed Enantioselective and Chemodivergent Addition of Cyclopropanols to Oxabicyclic Alkenes. ACS Catal. 2019, 9, 5638-5644.

  1. Wu, J.; Deng, X.; Yoshikai, N. Stereocontrolled Synthesis of Halovinylbenziodoxoles via Hydro- and Iodochlorination of Ethynylbenziodoxoles. Chem. Eur. J. 2019, 25, 7839-7842.

  1. Xu, W.; Yoshikai, N. Iron‐Catalyzed ortho C−H Arylation and Methylation of Pivalophenone N−H Imines. ChemSusChem 2019, 12, 3049-3053.

  1. Yan, J.; Rahman, M. S.; Yoshikai, N. Pd‐Catalyzed Annulation of 1‐Halo‐8‐arylnaphthalenes and Alkynes Leading to Heptagon‐Embedded Aromatic Systems. Chem. Eur. J. 2019, 25, 9395-9399.

  1. Yang, J.; Sun, Q.; Yoshikai, N. Cobalt-Catalyzed Regio- and Diastereoselective Formal [3+2] Cycloaddition between Cyclopropanols and Allenes. ACS Catal. 2019, 9, 1973-1978.

  1. Ding, W.; Yoshikai, N. Cobalt-Catalyzed Intermolecular [2+2] Cycloaddition between Alkynes and Allenes. Angew. Chem. Int. Ed. 2019, 58, 2500-2504.

  1. Ding, W.; Ho, C. C.; Yoshikai, N. Photosensitized, Energy-Transfer-Mediated Cyclization of 2-(1-Arylvinyl)benzaldehydes to Anthracen-9-(10H)-ones. Org. Lett. 2019, 21, 1202-1206.

  1. Yoshikai, N. Recent Advances in Enantioselective C-C Bond Formation via Organocobalt Species. Synthesis 2019, 51, 135-145.

  1. Yang, J.; Shen, Y.; Lim, Y. J.; Yoshikai, N. Divergent ring-opening coupling between cyclopropanols and alkynes under cobalt catalysis. Chem. Sci. 2018, 9, 6928-6934.

  1. Sun, Q.; Yoshikai, N. Cobalt-catalyzed directed ortho-methylation of arenes with methyl tosylate. Org. Chem. Front. 2018, 7, 2214-2218.

  1. Wu, C.; Yoshikai, N. Cobalt-Catalyzed Intramolecular Reactions between a Vinylcyclopropane and an Alkyne: Switchable [5+2] Cycloaddition and Homo-Ene Pathways. Angew. Chem. Int. Ed. 2018, 57, 6558-6562.

  1. Xu, W.; Pek, J. H.; Yoshikai, N. Iron-Catalyzed Directed C–H Silylation of Pivalophenone N–H Imines. Asian J. Org. Chem. 2018, 14, 1351-1354.

  1. Xu, W.; Yoshikai, N. Cobalt-Catalyzed Directed C–H Alkenylation of Pivalophenone N–H Imine with Alkenyl Phosphates. Beilstein J. Org. Chem. 2018, 14, 709-715.

  1. Sun, Q.; Yoshikai, N. Cobalt-Catalyzed C(sp2)–H/C(sp3)–H Coupling via Directed C– H Activation and 1,5-Hydrogen Atom Transfer. Org. Chem. Front. 2018, 5, 582-585.

  1. Tan, W. W.; Wu, B.; Wei, Y.; Yoshikai, N. Copper and Secondary Amine-Catalyzed Pyridine Synthesis from O-Acetyl Oximes and α,β-Unsaturated Aldehydes. Org. Synth. 2018, 95, 1-14.

  1. Xu, W.; Yoshikai, N. Cobalt-Catalyzed, N–H Imine-Directed Hydroarylation of Styrenes. Org. Lett. 2018, 20, 1392-1395.

  1. Lee, P.-S.; Xu, W.; Yoshikai, N. Directed C–H Alkenylation of Aryl Imines with Alkenyl Phosphates Promoted by a Cobalt–N-Heterocyclic Carbene Catalyst. Adv. Synth. Catal. 2017, 359, 4340-4347 (Very Important Paper).

  1. Yan, J.; Yoshikai, N. Phenanthrene Synthesis via Chromium-Catalyzed Annulation of 2-Biaryl Grignard Reagents and Alkynes. Org. Lett. 2017, 19, 6630-6633.

  1. Wu, B.; Wu, J.; Yoshikai, N. Benziodoxole Triflate as a Versatile Reagent for Iodo(III)cyclization of Alkynes. Chem. Asian J. 2017, 12, 3123-3127.

  1. Yoshikai, N. Iron-Catalyzed C–C Bond Formation via Chelation-Assisted C–H Activation. Isr. J. Chem. 2017, 57, 1117-1130.

  1. Yan, J.; Yoshikai, N. Chromium-Catalyzed Migratory Arylmagnesiation of Unactivated Alkynes. Org. Chem. Front. 2017, 4, 1972-1975.

  1. Xu, W.; Yoshikai, N. Pivalophenone Imine as a Benzonitrile Surrogate for Directed C–H Bond Functionalization. Chem. Sci. 2017, 8, 5299-5304.

  1. Yoshikai, N.; Santra, M.; Wu, B. Synthesis of Donor-Acceptor-Type Benzo[b]phosphole and Naphtho[2,3-b]phosphole Oxides and Their Solvatochromic Properties. Organometallics 2017, 20, 1392-1395.

  1. Tan, W. W.; Ong, Y. J.; Yoshikai, N. Synthesis of Highly Substituted Pyridines through Copper-Catalyzed Condensation of Oximes and α,β-Unsaturated Imines. Angew. Chem. Int. Ed. 2017, 56, 8240-8244.

  1. Wu, B.; Melvina; Wu, X.; Yeow, E. K. L.; Yoshikai, N. Versatile Telluracyclc Synthesis via the Sequential Electrophilic Telluration of C(sp2)–Zn and C(sp2)–H Bonds. Chem. Sci. 2017, 8, 4527-4532.

  1. Yang, J.; Rérat, A.; Lim, Y. J.; Gosmini, C.; Yoshikai, N. Cobalt-Catalyzed Enantio- and Diastereoselective Hydroacylation of Trisubstituted Alkenes. Angew. Chem. Int. Ed. 2017, 56, 2449-2453.

  1. Wu, J.; Xu, K.; Hirao, H.; Yoshikai, N. Pd-Catalyzed, Ligand-Enabled Stereoselective 1,2-Iodine(III) Shift/1,1-Carboxyalkynylation of Alkynylbenziodoxoles. Chem. Eur. J. 2017, 23, 1521-1525.

  1. Xu, W.; Yoshikai, N. N–H Imine as a Powerful Directing Group for Cobalt-Catalyzed Olefin Hydroarylation. Angew. Chem. Int. Ed. 2016, 55, 12731-12735.

  1. Xu, W.; Pek, J. H.; Yoshikai, N. Cobalt-Catalyzed, Imine-Directed Olefin Hydroarylation under Grignard-Free Conditions. Adv. Synth. Catal. 2016, 358, 2564-2568.

  1. Wu, J.; Deng, X.; Hirao, H.; Yoshikai, N. Pd-Catalyzed Conversion of Alkynyl-λ3-iodanes to Alkenyl-λ3-iodanes via Stereoselective 1,2-Iodine(III) Shift/1,1- Hydrocarboxylation. J. Am. Chem. Soc. 2016, 138, 9105-9108.

  1. Tan, W. W.; Yoshikai, N. Copper-Catalyzed Coupling of 2-Siloxy-1-alkenes and Diazocarbonyl Compounds: Approach to Multisubstituted Furans, Pyrroles, and Thiophenes. J. Org. Chem. 2016, 81, 5566-5573.

  1. Yan, J.; Yoshikai, N. Cobalt-Catalyzed Arylative Cyclization of Acetylenic Esters and Ketones with Arylzinc Reagents through 1,4-Cobalt Migration. ACS Catal. 2016, 6, 3738-3742.

  1. Wu, B.; Yoshikai, N. Recent Developments in Synthetic Methods for Benzo[b]heteroles. Org. Biomol. Chem. 2016, 14, 5402-5416.

  1. Yang, J.; Yoshikai, N. Cobalt-Catalyzed Annylation of Salicylaldehydes and Alkynes to Form Chromones and 4-Chromanones. Angew. Chem. Int. Ed. 2016, 55, 2870-2874.

  1. Wu, J.; Yoshikai, N. Cobalt-Catalyzed Alkenylzincation of Unfunctionalized Alkynes. Angew. Chem. Int. Ed. 2016, 55, 336-340.

  1. Wu, B.; Chopra, R.; Yoshikai, N. One-Pot Benzo[b]phosphole Synthesis through Sequential Alkyne Arylmagnesiation, Electrophilic Trapping, and Intramolecular Phospha-Friedel–Crafts Cyclization. Org. Lett. 2015, 17, 5666-5669.

  1. Wu, J.; Yoshikai, N. Modular Synthesis of Multisubstituted Furans through Palladium-Catalyzed Three-Component Condensation of Alkynylbenziodoxoles, Carboxylic Acids, and Imines. Angew. Chem. Int. Ed. 2015, 54, 11107-11111.

  1. Xu, W.; Paira, R.; Yoshikai, N. Ortho-C–H Benzylation of Aryl Imines with Benzyl Phosphates under Cobalt–Pyphos Catalysis. Org. Lett. 2015, 17, 4192-4195.

  1. Tan, W. W.; Yoshikai, N. Copper-Catalyzed Condensation of Imines and α-Diazo-β-dicarbonyl Compounds: Modular and Regiocontrolled Synthesis of Multisubstituted Pyrroles. Chem. Sci. 2015, 6, 6448-6455.

  1. Wu, B.; Yoshikai, N. Conversion of 2-Iodobiaryls into 2,2-Diiodobiaryls via Oxidation- Iodination Sequences: A Versatile Route to Ladder-Type Heterofluorenes. Angew. Chem. Int. Ed. 2015, 54, 8736-8739.

  1. Yang, J.; Seto, Y. W.; Yoshikai, N. Cobalt-Catalyzed Intermolecular Hydroacylation of Olefins through Chelation-Assisted Imidoyl C–H Activation. ACS Catal. 2015, 5, 3054-3057.

  1. Yoshikai, N. Cp*CoIII-Catalyzed C–H Activation of (Hetero)arenes: Expanding the Scope of Base-Metal-Catalyzed C–H Functionalization. ChemCatChem 2015, 7, 732-734.(one of most accessed articles in Feb 2015)

  1. Wong, M. Y.; Yamakawa, T.; Yoshikai, N. Iron-Catalyzed Directed C2-Alkylation and Alkenylation of Indole with Vinylarenes and Alkynes. Org. Lett. 2015, 17, 442-445.

  1. Lee, P.-S.; Yoshikai, N. Cobalt-Catalyzed Enantioselective Directed C–H Alkylation of Indoles with Styrenes. Org. Lett. 2015, 17, 22-25.

  1. Yamakawa, T.; Seto, Y. W.; Yoshikai, N. Cobalt-Catalyzed Directed Alkylation of Olefinic C–H Bond with Primary and Secondary Alkyl Chlorides. Synlett 2015, 26, 340-344.

  1. Xu, W.; Yoshikai, N. Highly Linear-Selective Cobalt-Catalyzed Addition of Aryl Imines to Styrenes: Reversing Intrinsic Regioselectivity by Ligand Elaboration. Angew. Chem. Int. Ed. 2014, 53, 14166-14170.

  1. Yang, J.; Yoshikai, N. Cobalt-Catalyzed Enantioselective Intramolecular Hydroacylation of Ketones and Olefins. J. Am. Chem. Soc. 2014, 136, 16748-16751. [one of most accessed articles in Nov 2014]

  1. Yoshikai, N. Cobalt-Catalyzed C–C Bond-Forming Reactions via Chelation-Assisted C–H Activation. J. Synth. Org. Chem. Jpn. 2014, 72, 1198-1206.

  1. Tan, W. W.; Hou, X.; Yoshikai, N. Pd(II)/Bu4NBr/DMSO Catalytic System for Practical Synthesis of Indoles and Pyrroles from Imines through Aerobic Dehydrogenative Cyclization. Synthesis 2014, 46, 2727-2733.

  1. Lu, B.; Wu, J.; Yoshikai, N. Palladium-Catalyzed Condensation of N-Aryl Imines and Alkynylbenziodoxolones To Form Multisubstituted Furans. J. Am. Chem. Soc. 2014, 136, 11598-11601.

  1. Yoshikai, N. Development of Cobalt-Catalyzed C–H Bond Functionalization Reactions. Bull. Chem. Soc. Jpn. 2014, 87, 843-857.

  1. Karthikeyan, J.; Yoshikai, N. Rhodium(III)-Catalyzed Directed peri-C–H Alkenylation of Anthracene Derivatives. Org. Lett. 2014, 16, 4224-4227.

  1. Gao, K.; Yamakawa, T.; Yoshikai, N. Cobalt-Catalyzed Chelation-Assisted Alkylation of Arenes with Primary and Secondary Alkyl Halides. Synthesis 2014, 46, 2024-2039 (Feature Article).

  1. Wu, B.; Santra, M.; Yoshikai, N. A Highly Modular One-Pot Multicomponent Approach to Functionalized Benzo[b]phosphole Derivative. Angew. Chem. Int. Ed. 2014, 53, 7543-7546. [Highlighted in Synfacts 2014, 10, 928]

  1. Tan, B.-H.; Yoshikai, N. Cobalt-Catalyzed Addition of Arylzinc Reagents to Norbornene Derivatives through 1,4-Cobalt Migration. Org. Lett. 2014, 16, 3392-3395.

  1. Asako, S.; Norinder, J.; Ilies, L.; Yoshikai, N.; Nakamura, E. ortho-Allylation of 1- Arylpyrazole with Allyl Phenyl Ether via Iron-Catalyzed C–H Bond Activation under Mild Conditions. Adv. Synth. Catal. 2014, 356, 1481-1485.

  1. Gao, K.; Paira, R.; Yoshikai, N. Cobalt-Catalyzed Ortho-C–H Alkylation of 2-Arylpyridines via Ring-Opening of Aziridines. Adv. Synth. Catal. 2014, 356, 1486-1490.

  1. Yoshikai, N.; Gao, K. Cobalt-Catalyzed Directed Alkylation of Arenes with Primary and Secondary Alkyl Halides. Pure Appl. Chem. 2014, 86, 419-424.

  1. Yamakawa, T.; Yoshikai, N. Alkene Isomerization–Hydroarylation Tandem Catalysis: Indole C2-Alkylation with Aryl-Substituted Alkenes Leading to 1,1-Diarylalkanes. Chem. Asian J. 2014, 9, 1242-1246.

  1. Gao, K.; Yoshikai, N. Low-Valent Cobalt Catalysis: New Opportunities for C–H Functionalization. Acc. Chem. Res. 2014, 47, 1208-1219.

  1. Rijs, N. J.; Yoshikai, N.; Nakamura, E.; O’Hair, R. A. J. Unraveling Organocuprate Complexity: Fundamental Insights into Intrinsic Group Transfer Selectivity in Alkylation Reactions. J. Org. Chem. 2014, 79, 1320-1334.

  1. Harano, K.; Takenaga, S.; Okada, S.; Niimi, Y.; Yoshikai, N.; Isobe, H.; Suenaga, K.; Kataura, H.; Koshino, M.; Nakamura, E. Conformational Analysis of Single Perfluoroalkyl Chains by Single-Molecule Real-Time Transmission Electron Microscopic Imaging. J. Am. Chem. Soc. 2014, 136, 466-473.

  1. Wu, B.; Yoshikai, N. Versatile Synthesis of Benzothiophenes and Benzoselenophenes by Rapid Assembly of Arylzinc Reagents, Alkynes, and Elemental Chalcogens. Angew. Chem. Int. Ed. 2013, 52, 10496-10499.

  1. Deb, I.; Yoshikai, N. Phenanthridine Synthesis through Iron-Catalyzed Intramolecular N-Arylation of O-acetyl Oxime. Org. Lett. 2013, 15, 4254-4257.

  1. Ding, Z.; Yoshikai, N. Cobalt-Catalyzed Intramolecular Olefin Hydroarylation Leading to Dihydropyrroloindoles and Tetrahydropyridoindoles. Angew. Chem. Int. Ed. 2013, 52, 8574-8578.

  1. Dong, J.; Lee, P.-S.; Yoshikai, N. Cobalt-Catalyzed Branched-Selective Addition of Aromatic Ketimines to Styrenes under Room Temperature Conditions. Chem. Lett. 2013, 42, 1140-1142.

  1. Gao, K.; Yoshikai, N. Cobalt-Catalyzed Ortho Alkylation of Aromatic Imines with Primary and Secondary Alkyl Halides. J. Am. Chem. Soc. 2013, 135, 9279-9282.

  1. Chen, Z.; Lu, B.; Ding, Z.; Gao, K.; Yoshikai, N. α-Palladation of Imines as Entry to Dehydrogenative Heck Reaction: Aerobic Oxidative Cyclization of N-Allylimines to Pyrroles. Org. Lett. 2013, 15, 1966-1969.

  1. Yoshikai, N.; Wei, Y. Synthesis of Pyrroles, Indoles, and Carbazoles through Transition Metal-Catalyzed C–H Functionalization. Asian J. Org. Chem. 2013, 2, 466-478.

  1. Yamakawa, T.; Yoshikai, N. Cobalt-Catalyzed ortho-Alkenylation of Aromatic Aldimines via Chelation-Assisted C–H Bond Activation. Tetrahedron 2013, 69, 4459-4465.

  1. Wei, Y.; Yoshikai, N. Modular Pyridine Synthesis from Oximes and Enals through Synergistic Copper/Iminium Catalysis. J. Am. Chem. Soc. 2013, 135, 3756-3759.

  1. Yamakawa, T.; Yoshikai, N. Annulation of α,β-Unsaturated Imines and Alkynes via Cobalt-Catalyzed Olefinic C–H Activation. Org. Lett. 2013, 15, 196-199.

  1. Lee, P.-S.; Yoshikai, N. Aldimine-Directed Branched-Selective Hydroarylation of Styrenes. Angew. Chem. Int. Ed. 2013, 52, 1240-1244.

  1. Hajra, A.; Wei, Y.; Yoshikai, N. Palladium-Catalyzed Aerobic Dehydrogenative Aromatization of Cyclohexanone Imines to Arylamines. Org. Lett. 2012, 14, 5488-5491.

  1. Ilies, L.; Matsumoto, A.; Kobayashi, M.; Yoshikai, N.; Nakamura, E. Synthesis of Polysubstituted Naphthalenes by Iron-Catalyzed [2+2+2] Annulation of Grignard Reagents with Alkynes. Synlett 2012, 2381-2384.

  1. Tan, B.-H.; Dong, J.; Yoshikai, N. Cobalt-Catalyzed Addition of Arylzinc Reagents to Alkynes to Form ortho-Alkenylarylzinc Species through 1,4-Cobalt Migration. Angew. Chem. Int. Ed. 2012, 51, 9610-9614.

  1. Ding, Z.; Yoshikai, N. C2-Alkylation of N-Pyrimidylindole with Vinylsilanes via Cobalt-Catalyzed C-H Bond Activation. Beilstein J. Org. Chem. 2012, 8, 1536-1542.

  1. Gao, K.; Lee, P.-S.; Long, C.; Yoshikai, N. Cobalt-Catalyzed Ortho-Arylation of Aromatic Imines with Aryl Chlorides. Org. Lett. 2012, 14, 4234-4237.

  1. Nakamura, Y.; Yoshikai, N.; Ilies, L.; Nakamura, E. Nickel-Catalyzed Monosubsitution of Polyfluoroarenes with Organozinc Reagents Using Alkoxydiphosphine Ligand. Org. Lett. 2012, 14, 3316-3319.

  1. Adak, L.; Yoshikai, N. Iron-Catalyzed Annulation Reaction of Arylindium Reagents and Alkynes to Produce Substituted Naphthalenes. Tetrahedron 2012, 68, 5167-5171.

  1. Wei, Y.; Deb, I.; Yoshikai, N. Palladium-Catalyzed Aerobic Oxidative Cyclization of N-Aryl Imines: Indole Synthesis from Anilines and Ketones. J. Am. Chem. Soc. 2012, 134, 9098-9101.

  1. Ding, Z.; Yoshikai, N. Mild and Efficient C2-Alkenylation of Indoles with Alkynes Catalyzed by a Cobalt Complex. Angew. Chem. Int. Ed. 2012, 51, 4698-4701.

  1. Gao, K.; Yoshikai, N. Cobalt-Catalyzed Arylation of Aldimines via Directed C–H Bond Functionalization: Addition of 2-Arylpyridines and Self-Coupling of Aromatic Aldimines. Chem. Commun. 2012, 48, 4305-4307.

  1. Yoshikai, N.; Nakamura, E. Mechanisms of Nucleophilic Organocopper(I) Reactions. Chem. Rev. 2012, 112, 2339-2372.

  1. Ilies, L.; Kobayashi, M.; Matsumoto, A.; Yoshikai, N.; Nakamura, E. Iron-Catalyzed Nitrogen-Directed Coupling of Arene and Aryl Bromides Mediated by Metallic Magnesium. Adv. Synth. Catal. 2012, 354, 593-596.

  1. Rijs, N.; Yoshikai, N.; Nakamura, E.; O’Hair, R. A. J. Gas-Phase Reactivity of Group 11 Dimethylmetallates with Allyl Iodide. J. Am. Chem. Soc. 2012, 134, 2569-2580.

  1. Yoshikai, N.; Asako, S.; Yamakawa, T.; Ilies, L.; Nakamura, E. Iron-Catalyzed C–H Bond Activation for the ortho-Arylation of Aryl Pyridines and Imines with Grignard Reagents. Chem. Asian. J. 2011, 6, 3059-3065.

  1. Lee, P.-S.; Fujita, T.; Yoshikai, N. Cobalt-Catalyzed, Room-Temperature Addition of Aromatic Imines to Alkynes via Directed C–H Bond Activation. J. Am. Chem. Soc. 2011, 133, 17283-17295.

  1. Wei, Y.; Yoshikai, N. Oxidative Cyclization of 2-Arylphenols to Dibenzofurans under Pd(II)/Peroxybenzoate Catalysis. Org. Lett. 2011, 13, 5504-5507.

  1. Adak, L.; Yoshikai, N. Cobalt-Catalyzed Preparation of Arylindium Reagents from Aryl and Heteroaryl Bromides. J. Org. Chem. 2011, 76, 7563-7568.

  1. Gao, K.; Yoshikai, N. Cobalt–Phenanthroline Catalysts for the ortho Alkylation of Aromatic Imines under Mild Conditions. Angew. Chem. Int. Ed. 2011, 50, 6888-6892.

  1. Ding, Z.; Yoshikai, N. Cobalt-Catalyzed Alkenylation of Thiazoles with Alkynes via C–H Bond Functionalization. Synthesis 2011, 2561-2566.

  1. Chen, Q.; Ilies, L.; Yoshikai, N.; Nakamura, E. Cobalt-Catalyzed Coupling of Alkyl Grignard Reagent with Benzamide and 2-Phenylpyridine Derivatives through Directed C–H Bond Activation under Air. Org. Lett. 2011, 13, 3232-3234.

  1. Yoshikai, N. Cobalt-Catalyzed, Chelation-Assisted C-H Bond Functionalization. Synlett 2011, 1047-1051. * Invited highlight article

  1. Jin, M.-Y.; Yoshikai, N. Cobalt–Xantphos Catalyzed, LiCl-Mediated Preparation of Arylzinc Reagents from Aryl Iodides, Bromides, and Chlorides. J. Org. Chem. 2011, 76, 1972-1978 (Featured Article).

  1. Gao, K.; Yoshikai, N. Regioselectivity-Switchable Hydroarylation of Styrenes. J. Am. Chem. Soc. 2011, 133, 400-402.

  1. Adak, L.; Chan, W. C.; Yoshikai, N. Nickel-Catalyzed, Directing Group-Assisted [2 + 2 + 2] Cycloaddition of Imine and Alkynes. Chem. Asian. J. 2011, 6, 359-362.

  1. Ding, Z.; Yoshikai, N. Cobalt-Catalyzed Addition of Azoles to Alkynes. Org. Lett. 2010, 12, 4180-4183.

  1. Gao, K.; Lee, P.-S.; Fujita, T.; Yoshikai, N. Cobalt-Catalyzed Hydroarylation of Alkynes through Chelation-Assisted C-H Bond Activation. J. Am. Chem. Soc. 2010, 132, 12249-12251.

  1. Nakamura, E.; Yoshikai, N. Low-Valent Iron-Catalyzed C–C Bond Formation— Addition, Substitution, and C–H Bond Activation. J. Org. Chem. 2010, 75, 6061-6067.

  1. Ilies, L.; Okabe, J.; Yoshikai, N.; Nakamura, E. Iron-Catalyzed, Directed Oxidative Arylation of Olefins with Organozinc and Grignard Reagents. Org. Lett. 2010, 12, 2838-2840.

  1. Gärtner, T.; Yoshikai, N.; Neumeier, M.; Nakamura, E.; Gschwind, R. M. Ligand Exchange Reactions in Cu(III) Complexes: Mechanistic Insights by Combined NMR and DFT Studies. Chem. Commun. 2010, 46, 4625-4626.

  1. Yoshikai, N.; Mieczkowski, A.; Matsumoto, A.; Ilies, L.; Nakamura, E. Iron-Catalyzed C-C Bond Formation at α-Position of Aliphatic Amines via C-H Bond Activation through 1,5-Hydrogen Transfer. J. Am. Chem. Soc. 2010, 132, 5568-5569.

  1. Yoshikai, N.; Matsumoto, A.; Norinder, J.; Nakamura, E. Iron-Catalyzed Direct Arylation of Aryl Pyridines and Imines Using Oxygen as an Oxidant. Synlett 2010, 313-316.

  1. Yoshikai, N.; Matsuda, H.; Nakamura, E. Hydroxyphosphine Ligand for Nickel-Catalyzed Cross-Coupling through Nickel/Magnesium Bimetallic Cooperation. J. Am. Chem. Soc. 2009, 131, 9590-9599.

  1. Yoshikai, N.; Miura, K.; Nakamura, E. Enantioselective Copper-Catalyzed Allylic Substitution with Aminohydroxyphosphine Ligand. Adv. Synth. Catal. 2009, 351, 1014-1018.

  1. Yoshikai, N.; Matsumoto, A.; Norinder, J.; Nakamura, E. Iron-Catalyzed Chemoselective ortho Arylation of Aryl Imines by Directed C-H Bond Activation. Angew. Chem. Int. Ed. 2009, 48, 2925-2928.

  1. Yoshikai, N.; Zhang, S.-L.; Yamagata, K.-i.; Tsuji, H.; Nakamura, E. Mechanistic Study of the Manganese-Catalyzed [2 + 2 + 2] Annulation of 1,3-Dicarbonyl Compounds and Terminal Alkynes. J. Am. Chem. Soc. 2009, 131, 4099-4109.

  1. Yoshikai, N.; Matsuda, H.; Nakamura, E. Ligand Exchange as the First Irreversible Step in the Nickel-Catalyzed Cross-Coupling Reaction of Grignard Reagents. J. Am. Chem. Soc. 2008, 130, 15258-15259.

  1. Yoshikai, N.; Zhang, S.-L.; Nakamura, E. Origin of the Regio- and Stereoselectivity of Allylic Substitution of Organocopper Reagents. J. Am. Chem. Soc. 2008, 130, 12862-12863.

  1. Norinder, J.; Matsumoto, A.; Yoshikai, N.; Nakamura, E. Iron-Catalyzed Direct Arylation through Directed C-H Bond Activation. J. Am. Chem. Soc. 2008, 130, 5858-5859.

  1. Yoshikai, N.; Iida, R.; Nakamura, E. Mechanism of Nucleophilic Substitution of Acyl Electrophiles using Lithium Organocuprates. Adv. Synth. Catal. 2008, 350, 1063-1072.

  1. Hajra, A.; Yoshikai, N.; Nakamura, E. Aminohydroxyphosphine Ligands for Copper-Catalyzed Enantioselective Conjugate Addition of Organozinc Reagents. Org. Lett. 2006, 8, 4153-4155.

  1. Yoshikai, N.; Yamanaka, M.; Ojima, I.; Morokuma, K.; Nakamura, E. Bimetallic Synergism in Alkyne Silylformylation Catalyzed by Cobalt-Rhodium Mixed-Metal Cluster. Organometallics 2006, 25, 3867-3875.

  1. Yoshikai, N.; Yamashita, T.; Nakamura, E. Mechanism of Remote Conjugate Addition of a Lithium Organocuprate to Polyconjugated Carbonyl Compounds. Chem. Asian. J. 2006, 1, 322-330.

  1. Norinder, J.; Bäckvall, J.-E.; Yoshikai, N.; Nakamura, E. Unusual Homo-Coupling in the Reaction of Diorganocuprates with an Allylic Halide. Organometallics 2006, 25, 2129-2132.

  1. Yoshikai, N.; Mashima, H.; Nakamura, E. Nickel-Catalyzed Cross-Coupling Reaction of Aryl Fluorides and Chlorides with Grignard Reagents under Nickel/Magnesium Bimetallic Cooperation. J. Am. Chem. Soc. 2005, 127, 17978-17979.

  1. Yoshikai, N.; Yamashita, T.; Nakamura, E. Mechanism of Remote Conjugate Addition of a Lithium Organocuprate to a Polyconjugated Carbonyl Compound. Angew. Chem. Int. Ed. 2005, 44, 4721-4723.

  1. Ammal, S. C.; Yoshikai, N.; Inada, Y.; Nishibayashi, Y.; Nakamura, E. Synergistic Dimetallic Effects in Propargylic Substitution Reaction Catalyzed by Thiolate-Bridged Diruthenium Complex. J. Am. Chem. Soc. 2005, 127, 9428-9438.

  1. Kinoshita, N.; Marx, K. H.; Tanaka, K.; Tsubaki, K.; Kawabata, T.; Yoshikai, N.; Nakamura, E. Enantioselective Allylic Substitution of Cinnamyl Esters Catalyzed by Iridium-Chiral Aryl Phosphite Complex: Conspicuous Change in the Mechanistic Spectrum by a Counter Cation and Solvent. J. Org. Chem. 2004, 69, 7960-7964.

  1. Yoshikai, N.; Ammal, S. C.; Nakamura, E. L-shaped Three-center Two-electron (C-C-C)+ Bonding Array. J. Am. Chem. Soc. 2004, 126, 12941-12948.

  1. Yoshikai, N.; Nakamura, E. Mechanism of Substitution Reaction on sp2-Carbon Center with Lithium Organocuprate. J. Am. Chem. Soc. 2004, 126, 12264-12265.

  1. Nakamura, E.; Yoshikai, N. On the Mechanism of “Higher-Order Cuprate”, Alias Lipshutz Cuprate. Bull. Chem. Soc. Jpn. 2004, 77, 1-12.

  1. Yoshikai, N.; Nakamura, E. Theoretical Studies on Diastereo- and Enantioselective Rhodium-Catalyzed Cyclization of Diazo Compound via Intramolecular C-H Bond Insertion. Adv. Synth. Catal. 2003, 345, 1159-1171.

  1. Nakamura, E.; Yoshikai, N.; Yamanaka, M. Mechanism of C-H Bond Activation/C-C Bond Formation Reaction between Diazo Compound and Alkane Catalyzed by Dirhodium Tetracarboxylate. J. Am. Chem. Soc. 2002, 124, 7181-7192.

  1. Nakamura, M.; Yoshikai, N.; Nakamura, E. Carbozincation of Dipolar Trimethylenemethane. A New Route to Functionalized Organozinc Reagents. Chem. Lett. 2002, 146-147.

  1. Nakamura, M.; Yoshikai, N.; Toganoh, M.; Nakamura, E. [3 + 3] Cycloaddition of Dipolar Trimethylenemethane with Active Methylene Compound. Synlett 2001, 1030-1033.

  1. Nakamura, E.; Yamanaka, M.; Yoshikai, N.; Mori, S. Kinetic Reactivity of “Higher Order Cuprate” in SN2 Alkylation Reaction. Angew. Chem. Int. Ed. 2001, 40, 1935-1938.

Book Chapters

  1. Organocobalt Complexes in C–H Activation, Yoshikai, N. In Comprehensive Organometallic Chemistry IV, Mayer, K.; O’Hare, D.; Parkin, G. Eds., Elsevier, 2022.

  1. Cobalt-Catalyzed Asymmetric C–H Functionalization, Yoshikai, N. In Handbook of C–H Functionalization, Maiti, D. Ed., Wiley, 2022.

  1. Cobalt-Catalyzed C–H Activation, Yoshikai, N. In Chemistry of Organocobalt Compounds, Gosmini, C.; Marek, I. Eds., Wiley, 2022.

  1. Benzo[b]thiophenes, Yoshikai, N.; Rayner, C. M.; Graham, M. A. In Science of Synthesis Knowledge Updates, (2020) 2, 53 .

  1. Cobalt-Catalysed C–H Functionalization, Yoshikai, N. In Cobalt Catalysis in Organic Synthesis: Methods and Reactions, Hapke, M.; Hilt, G. Eds., Wiley, 2020.

  1. Hydroarylation of Alkynes and Alkenes using Group 7–9 First Row Transition Metal Catalysts, Yoshikai, N. In Catalytic Hydroarylation of Carbon-Carbon Multiple Bonds, Ackermann, L.; Gunnoe, T. B.; Habgood, L. G. Eds., Wiley, 2018.

  1. Heterocycle Synthesis via Co-Catalyzed C–H Activation/Functionalization, Yoshikai, N. In Transition Metal-Catalyzed Heterocycle Synthesis via C–H Activation, Wu, X.-F. Ed., Wiley, 2016.

  1. Iron-Catalyzed C–C Bond Formation with C–H Bond Activation, Yoshikai, N. In The Chemistry of Organoiron Compounds, Rappoport, Z.; Marek, I. Eds., Wiley, 2014.

  1. Theory of Organocopper-Mediated Reactions, Nakamura, E.; Yoshikai, N. In The Chemistry of Organocopper Compounds, Rappoport, Z.; Marek, I. Eds., Wiley, 2009.