Yoshikai Group

Graduate School of Pharmaceutical Sciences, Tohoku University 東北大学大学院薬学研究科・分子設計化学分野

Our group is committed to the development and mechanistic study of novel molecular transformations for organic synthesis. Our research programs are driven by a desire to uncover and understand unprecedented chemical reactivities and to exploit such reactivities in the design and development of efficient and selective organic reactions.

2025.2. Dr. Kanemoto has been promoted to Lecturer (Junior Associate Professor).

2025.1. A new paper on the synthesis of disulfide-linked amino acids/peptides by Iwata et al. has been published in Chem. Sci. プレスリリース 日経新聞 日刊工業新聞

2024.10. 大槻真也さんが第53回複素環化学討論会で 学生優秀発表賞(ポスター)を受賞しました.

2024.10. New members have joined the laboratory.

2024.8. A paper on stereoselective hydroxyallylation of cyclopropenes by Tsukiji et al. has been published in Angew. Chem. Int. Ed. プレスリリース Chem-Station

Research

Earth-Abundant Metal Catalysis

C–H activations, cycloadditions, asymmetric catalysis

Heterocyclic Chemistry

Novel synthetic methods for heterocycles relevant to pharmaceuticals and materials

Hypervalent Iodine Chemistry

Novel reactivity and synthetic applications

Recent Publications

Full Publication List

A versatile entry to unnatural, disulfide-linked amino acids and peptides through the disulfuration of azlactones

Iwata, M.; Takami, Y.; Asanuma, H.; Hosono, K.; Ohno, H.; Yoshikai, N.; Kanemoto, K. Chem. Sci. 2025, 10.1039/D4SC07187E.

Diazomethyl-λ3-iodane Meets Aryne: Dipolar Cycloaddition and C-to-N Iodane Shift Leading to Indazolyl-λ3-iodanes

Otsuki, S.; Kanemoto, K.; Martos, D. C.; Kwon, E.; Wencel-Delord, J.; Yoshikai, N. ChemRxiv DOI:10.26434/chemrxiv-2024-dn8c5

Stable and responsive atropisomerism around a carbon–iodine bond

Abe, S.; Kikuchi, J.; Matsumoto, A.; Yoshikai, N. ChemRxiv DOI:10.26434/chemrxiv-2024-t16qt

Stereoselective Hydroxyallylation of Cyclopropenes with Cyclopropanols via NHC Catalysis of Transient Organozinc Species

Tsukiji, K.; Matsumoto, A.; Kanemoto, K.; Yoshikai, N. Angew. Chem. Int. Ed. 2024, 63, e202412456.

Three-component Friedel–Crafts-type difunctionalization of ynamides with (hetero)arenes and iodine(III) electrophile

Kikuchi, J.; Nagata, T.; Ito, S.; Yoshikai, N. Org. Chem. Front. 2024, 11, 3072-3079.

Amino- and Alkoxybenziodoxoles: Facile Preparation and Use as Arynophiles

Kanemoto, K.; Yoshimura, K.; Ono, K.; Ding, W.; Ito, S.; Yoshikai, N. Chem. Eur. J. 2024, 30, e202400894.

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KIKUCHI Jun 菊池 隼

Assistant Professor

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ASANUMA Hayato 浅沼 隼人

Graduate Student (D2)/JSPS DC1

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IKESHITA Daichi 池下 大智

Graduate Student (D2)/JSPS DC1

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TSUKIJI Kento 築地 健人

Graduate Student (D1)

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LI Bin 李 斌

Research Student

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ABE Shohei 阿部 将平

Graduate Student (M2)

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OTSUKI Shinya 大槻 真也

Graduate Student (M2)

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SASAKI Shuma 佐々木 脩磨

Graduate Student (M2)

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NAKAJIMA Roi 中島 呂維

Graduate Student (M2)

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IWATA Masaki 岩田 真輝

Graduate Student (M2)

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TAKAMI Yuzuki 鷹見 優月

Graduate Student (M1)

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NAMBU Ryoga 南部 凌我

Graduate Student (M1)

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MACHINAGA Tomoya 町永 智哉

Graduate Student (M1)

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OTSUKA Takafumi 大塚 貴史

Graduate Student (M1)

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MOROHASHI Shunya 諸橋 駿矢

Graduate Student (M1)

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ATARASHI Mao 新敷 茉央

Undergraduate Student (B4)

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OHNO Hibiki 大野 響己

Undergraduate Student (B4)

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KAMIOKA Shungo 上岡 駿吾

Undergraduate Student (B4)

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TOIZUMI Yugo 戸泉 友吾

Undergraduate Student (B4)

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YAMAMOTO Riku 山本 璃玖

Undergraduate Student (B4)

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IIZUKA Kosuke 飯塚 恒介

Undergraduate Student (B3)

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GINOZA Yuma 宜野座 侑真

Undergraduate Student (B3)

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SHIBATA Riku 柴田 陸

Undergraduate Student (B3)

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MIURA Sena 三浦 聖奈

Undergraduate Student (B3)

YOSHIKAI Naohiko 吉戒 直彦

YOSHIKAI Naohiko 吉戒 直彦

Professor

Professional Appointment

2021-Present: Professor, Tohoku University

2016-2021: Associate Professor (tenured), NTU Singapore

2009-2016: Assistant Professor, NTU Singapore

2009-2014: NRF Research Fellow, National Research Foundation (Singapore)

2005-2009: Assistant Professor, The University of Tokyo

Education

2005 Ph.D. in Chemistry, The University of Tokyo (Prof. E. Nakamura)

2002 M.Sc. in Chemistry, The University of Tokyo (Prof. E. Nakamura)

2000 B.Sc. in Chemistry, The University of Tokyo (Prof. E. Nakamura)


2002-2005: JSPS Fellow

2002: Visiting Student, Stockholm University (Prof. Jan Bäckvall)

Awards/Recognition

2022: Mukaiyama Award

2020: TCI-SNIC Industry Award in Synthetic Chemistry

2015: Asian Core Program (ACP) Lectureship (from Thailand)

2014: Asian Core Program (ACP) Lectureship (from China and Korea)

2014: The 63rd Chemical Society of Japan Award for Young Chemists

2014: SPMS Young Researcher Awards

2011: Asian Core Program Lectureship (from Japan)

2011: Thieme Chemistry Journals Award

2008: Takasago Award in Synthetic Organic Chemistry, Society of Synthetic Organic Chemistry in Japan

2007: Inoue Research Award for Young Scientists, Inoue Research Foundation

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Contact

吉戒 直彦

東北大学大学院薬学研究科・分子設計化学分野

980-8578 仙台市青葉区荒巻字青葉6-3

E-mail: naohiko.yoshikai.c5@tohoku.ac.jp; Tel: 022-795-6812

Naohiko Yoshikai

Graduate School of Pharmaceutical Sciences

Tohoku University

6-3 Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan

E-mail: naohiko.yoshikai.c5@tohoku.ac.jp; Tel: +81-22-795-6812