発表論文
2019年
An automated microliter-scale high-throughput screening system (MSHTS) for real-time monitoring of protein aggregation using quantum-dot nanoprobes. | |
Sasaki, R.; Tainaka, R.; Ando, Y.; Hashi, Y.; Deepak, H. V.; Suga, Y.; Murai, Y.; Anetai, M.; Monde, K.; Ohta, K.; Ito, I.; Kikuchi, H.; Oshima, Y.; Endo, Y.; Nakao, H.; Sakono, M.; Uwai, K.; Tokuraku, K. |
|
Sci. Rep. , 9, 2587 (2019) | |
Construction of a Meroterpenoid-like Compounds Library Based on Diversity-Enhanced Extracts. | |
Kikuchi, H.; Kawai, K.; Nakashiro, Y.; Yonezawa, T.; Kawaji, K.; Kodama, E. N.; Oshima, Y. |
|
Chem.–Eur. J. , 25, 1106-1102 (2019) | |
Dictyostelium: An Important Source of Structural and Functional Diversity in Drug Discovery. | |
Kubohara, Y.; Kikuchi, H. |
|
Cells, 8, 6 (2019) | |
Prenylated quinolinecarboxylic acid derivative prevents neuronal cell death through inhibition of MKK4. | |
Ogura, M.; Kikuchi, H.; Shakespear, N. B.; Suzuki, T.; Yamaki, J.; Homma, M. K.; Oshima, Y.; Homma, Y. |
|
Biochem. Pharmacol., 162, 109-122 (2019) | |
2018年
Removal of the E-olefin Barrier of Humulene Leading to Unnatural Terpenoid-like Skeletons. | |
Nishimura, T.; Kawai, J.; Oshima, Y.; Kikuchi, H. |
|
Org. Lett. , 20, 7317-7320 (2018) | |
Effect of brefelamide on proliferation of 1321N1 human astrocytoma cells induced by glial cell line-derived neurotrophic factor. | |
Honma, S.; Kouno, K.; Takasaka, S.; Mitazaki, S.; Abe, S.; Kikuchi, H.; Oshima, Y.; Yoshida, M. |
|
Pharmazie , 73, 22-28 (2018) | |
Developments toward the Production of Diverse Natural-Product-Like Compounds: Diversity-Oriented Synthesis and Diversity-Enhanced Extracts. | |
Kikuchi, H.; Oshima, Y. |
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Heterocycles, 96, 1509-1527 (2018) | |
2017年
Isolation, Synthsis, and Biological Activity of Chlorinated Alkylresorcinols from Dictyostelium Cellular Slime Molds. | |
Kikuchi, H.; Ito, I.; Takahashi, K.; Ishigaki, H.; Iizumi, K.; Kubohara, Y.; Oshima, Y. |
|
J. Nat. Prod. , 80, 2716-2722 (2017) | |
Biological activities of novel derivatives of differentiation-inducing factor 3 from Dictyostelium discoideum. | |
Takahashi, K.; Kikuchi, H.; Nguyen, V. H.; Oshima, Y.; Ishigaki, H.; Nakajima-Shimada, J.; Kubohara, Y. |
|
Biol. Phram. Bull. , 40, 1941-1947 (2017) | |
Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis. | |
Jain, V.; Yogavel, M.; Kikuchi, H.; Oshima, Y.; Hariguchi, N.; Matsumoto, M.; Goel, P.; Touquet, B.; Jumani, R. S.; Tacchini-Cottier, F.; Harlos, K.; Huston, C. D.; Hakimi, M.-A.; Sharma, A. |
|
Structure , 25, 1495-1505 (2017) | |
Evidence that differentiation-inducing factor-1 controls chemotaxis and cell differentiation, at least in part, via mitochondria in Dictyostelium discoideum. | |
Kubohara, Y.; Kikuchi, H.; Nguyen, V. H.; Kuwayama, H.; Oshima, Y. |
|
Biology Open , 6, 741-751 (2017) | |
Induction of Osteopontin by Dengue Virus-3 infection in THP-1 cells -Inhibition of the synthesis by Brefelamide and its derivative- | |
Pascapurnama, D. N.; Labayo, H. K. M.; Dapat, I.; Nagarajegowda, D. D.; Zhao, J.; Zhang, J.; Yamada, O.; Kikuchi, H.; Egawa, S.; Oshima, Y.; Chagan-Yasutan, H.; Hattori, T. |
|
Front. Microbiol. , 8, 521 (2017) | |
1-Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation. | |
Tsuchida, K.; Tsujita, T.; Hayashi, M.; Ojima, A.; Keleku-Lukwete, N.; Katsuoka, F.; Otsuki, A.; Kikuchi, H.; Oshima, Y.; Suzuki, M.; Yamamoto, M. |
|
Free Radical Biol. Med. , 103, 236-247 (2017) | |
Production of Novel Bispyrone Metabolites in the Cellular Slime Mold Dictyostelium giganteum Induced by Zinc(II) Ion. | |
Nguyen, V. H.; Kikuchi, H.; Sasaki, H.; Iizumi, K.; Kubohara, Y.; Oshima, Y. |
|
Tetrahedron, 73, 583-588 (2017) | |
Alkaloids from aerial parts of Annona senegalensis against Streptococcus mutans. | |
Lall, N.; Kishore, N.; Bodiba, G.; More, E.; Tshikanlange, H.; Kikuchi, H.; Oshima, Y. |
|
Nat. Prod. Res. , 16, 1944-1947 (2017) | |
多様性拡大抽出物が生み出す薬理活性指向型化合物ライブラリー | |
菊地晴久,大島吉輝 |
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有機合成化学協会誌, 75, 349-359 (2017) | |
2016年
Monoterpene Indole Alkaloid-like Compounds Based on Diversity-enhanced Extracts of Iridoid-Containing Plants and Their Immune Checkpoint Inhibitory Activity. | |
Kikuchi, H.; Ichinohe, K.; Kida, S.; Murase, S.; Yamada, O.; Oshima, Y. |
|
Org. Lett. , 18, 5948-5951 (2016) | |
Glutathione S-transferase 4 is a putative DIF-binding protein that regulates the size of fruiting bodies in Dictyostelium discoideum. | |
Kuwayama, H.; Kikuchi, H.; Oshima, Y.; Kubohara, Y. |
|
Biochem. Biophys. Rep. , 8, 216-226 (2016) | |
Identification of brefelamide as a novel inhibitor of osteopontin that suppresses invasion of A549 lung cancer cells. | |
Zhang, J.; Yamada, O.; Kida, S.; Matsushita, Y.; Murase, S.; Hattori, T.; Kubohara, Y.; Kikuchi, H.; Oshima, Y. |
|
Oncol. Rep. , 36, 2357-2364 (2016) | |
Development of Terpenoid Alkaloid-like Compound Library Based on a Humulene Skeleton. | |
Kikuchi, H.; Nishimura, T.; Kwon, E.; Kawai, J.; Oshima, Y. |
|
Chem.–Eur. J. , 22, 15819-15825 (2016) | |
Oral administration of Dictyostelium differentiation-inducing factor-1 lowers blood glucose levels in streptozotocin-induced diabetic rats. | |
Kawaharada, R.; Nakamura, A.; Takahashi, K.; Kikuchi, H.; Oshima, Y.; Kubohara, Y. |
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Life Sci. , 155, 56-62 (2016) | |
1-Methyl-2-undecyl-4(1H)-quinolone, a derivative of quinolone alkaloid evocarpine, attenuates high phosphate-induced calcification of human aortic valve interstitial cells by inhibiting phosphate cotransporter PiT-1. | |
Seya, K.; Furukawa, K.; Chiyoya, M.; Yu, Z.; Kikuchi, H.; Daitoku, K.; Motomura, S.; Murakami, M.; Oshima Y.; Fukuda, I. |
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J. Pharmacol. Sci., 131, 51-57 (2016) | |
Design and Synthesis of Structure-Simplified Derivatives of Gonytolide for the Promotion of Innate Immune Responses. | |
Kikuchi, H.; Hoshikawa, T.; Kurata, S.; Katou, Y.; Oshima Y. |
|
J. Nat. Prod., 79, 1259-1266 (2016) | |
Prenylated quinolinecarboxylic acid derivative suppresses immune response through inhibition of PAK2. | |
Ogura, M.; Kikuchi, H.; Suzuki, T.; Yamaki, J.; Homma, M. K.; Oshima, Y.; Homma, Y. |
|
Biochem. Pharmacol. , 105, 55-65 (2016) | |
Agarol, an ergosterol derivative from Agaricus blazei, induces caspase-independent apoptosis in human cancer cells. | |
Shimizu, T.; Kawai, J.; Ouchi, K.; Kikuchi, H.; Oshima, Y.; Hidemi, R. |
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Int. J. Oncol., 48, 1670-1678 (2016) | |
2015年
Development of novel DIF-1 derivatives that selectively suppress innate immune responses. | |
Nguyen, V. H.; Kikuchi, H.; Kubohara, Y.; Takahashi, K.; Katou, Y.; Oshima, Y. |
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Bioorg. Med. Chem. , 23, 4311-4315 (2015) | |
Derivatives of Dictyostelium differentiation-inducing factors inhibit lysophosphatidic acid–stimulated migration of murine osteosarcoma LM8 cells. | |
Kubohara, Y.; Komachi, M.; Homma, Y.; Kikuchi, H., Oshima, Y. |
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Biochem. Biophys. Res. Commun. , 463, 800-805 (2015) | |
Structure of Prolyl-tRNA Synthetase-Halofuginone Complex Provides Basis for Development of Novel Drugs against Malaria and Toxoplasmosis. | |
Jain, V.; Yogavel, M; Oshima, Y.; Kikuchi, H.; Touquet, B.; Hakimi, M.-A.; Sharma, A. |
|
Structure, 23, 819-829 (2015) | |
Weight loss by Ppc-1, a novel small molecule mitochondrial uncoupler derived from slime mold. | |
Suzuki, T.; Kikuchi, H.; Ogura, M.; Homma, M. K.; Oshima, Y.; Homma, Y. |
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PLOS ONE, 10, e0117078 (2015) | |
Isolation of a Cyclic Depsipetide, Aspergillicin F, and Synthesis of Aspergillicins with Innate Immune Modulating Activity. | |
Kikuchi, H.; Hoshikawa, T.; Fujimura, S.; Sakata, N.; Kurata, S.; Katou, Y.; Oshima, Y. |
|
J. Nat. Prod., 78, 1949-1956 (2015) | |
Synthesis of prenylated quinolinecarboxylic acid derivatives and their anti-obesity activities. | |
Kikuchi, H.; Suzuki, T.; Ogura, M.; Homma, M. K.; Homma, Y.; Oshima, Y. |
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Bioorg. Med. Chem., 23, 66-72 (2015) | |
2014年
ZFC3H1, a zinc finger protein, modulates IL-8 transcription by binding with Celastramycin A, a potential immune suppressor.
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Tomita, T.; Ieguchi, K.; Coin, F.; Kato, Y.; Kikuchi, H.; Oshima, Y.; Kurata, S.; Maru, Y. |
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PLOS ONE, 9, e108957 (2014) | |
Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase.
|
|
Jain, V.; Kikuchi, H.; Oshima, Y.; Sharma, A.; Yogavel, M. |
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J. Struct. Funct. Genomics, 15, 181-190 (2014) | |
Defects
in the synthetic pathway prevent DIF-1 mediated stalk lineage
specification cascade in the non-differentiating social amoeba Acytostelium
subglobosum |
|
Kurato
Mohri, Takashi Hata, Haruhisa Kikuchi,
Yoshiteru Oshima and Hideko Urushihara |
|
Biology Open, 3, 553-560 (2014) | |
Properties
of a non-bioactive fluorescent derivative of differentiation-inducing
factor-3, an anti-tumor agent found in Dictyostelium discoideum |
|
Yuzuru Kubohara, Haruhisa Kikuchi, Yusuke Matsuo, Yoshiteru Oshima and Yoshimi Homma | |
Biology Open, 3, 289-296 (2014) | |
Development
of Diversity-Enhanced Extracts of Curcuma
zedoaria and Their New Sesquiterpene-like Compounds |
|
Haruhisa
Kikuchi, Kazuyoshi Sakurai and Yoshiteru Oshima |
|
Org. Lett., 16, 1916-1919 (2014) | |
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Metarhizin
A suppresses cell proliferation by inhibiting cytochrome c oxidase
activity |
|
Yasuhiro
Katou, Naoya Endo, Toshiyuki Suzuki, Jiang Yu, Haruhisa Kikuchi,
Yoshiteru Oshima and Yoshimi Homma |
|
Life Sci., 103, 1-7 (2014) | |
Synthesis
of febrifugine derivatives and development of an effective and safe
tetrahydroquinazoline-type antimalarial |
|
Haruhisa
Kikuchi, Seiko Horoiwa, Ryota Kasahara, Norimitsu Hariguchi, Makoto
Matsumoto and Yoshiteru Oshima |
|
Eur. J. Med. Chem., 76, 10-19 (2014) | |
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2013年
The
Dictyostelium prestalk
inducer DIF-1 directs phosphorylation of a bZIP transcription factor |
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Yoko Yamada, Yuzuru Kubohara, Haruhisa Kikuchi, Yoshiteru Oshima, Hong-Yu Wang, Susan Ross and Jeffrey G. Williams | |
Int. J. Dev. Biol., 57, 375-381 (2013) | |
Mitochondria
are the target organelle of differentiation-inducing factor-3, an
anti-tumor agent isolated from Dictyostelium discoideum |
|
Yuzuru Kubohara, Haruhisa Kikuchi, Yusuke Matsuo, Yoshiteru Oshima and Yoshimi Homma | |
PLoS One, 8, e72118 (2013) | |
Press release | |
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Structures
of spiroindicumides A and B, unprecedented carbon skeletal
spirolactones, and determination of the absolute configuration by a
vibrational circular dichroism exciton approach |
|
Teigo Asai, Tohru Taniguchi, Takashi Yamamoto, Kenji Monde and Yoshiteru Oshima | |
Org. Lett., 15, 4320-4323 (2013) | |
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Suberoylanilide
hydroxamic acid, a histone deacetylase inhibitor, induces the
production of anti-inflammatory cyclodepsipeptides from Beauveria
felina |
|
Yu-Ming
Chung, Mohamed
El-Shazly, Da-Wei
Chuang, Tsong-Long
Hwang, Teigo
Asai, Yoshiteru Oshima, Mohamed L. Ashour, Yang-Chang Wu and Fang-Rong
Chang |
|
J. Nat. Prod., 76, 1260-1266 (2013) | |
Structurally
diverse chaetophenol productions induced by chemically mediated
epigenetic manipulation of fungal gene expression |
|
Teigo Asai, Takashi Yamamoto, Naoki Shirata, Tohru Taniguchi, Kenji Monde, Isao Fujii, Katsuya Gomi, and Yoshiteru Oshima | |
Org. Lett., 15, 3346-3349 (2013) | |
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Novel
chlorinated dibenzofurans isolated from the cellular slime mold, Polysphondylium filamentosum, and
their biological activities |
|
Haruhisa Kikuchi, Yuzuru Kubohara, Van Hai Nguyen, Yasuhiro Katou, and Yoshiteru Oshima | |
Bioorg. Med. Chem., 21, 4628-4633 (2013) | |
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Structures
and absolute configurations of short-branched fatty acid dimers from an
endophytic fungus of Aloe arborescens |
|
Teigo Asai, Sae Otsuki, Tohru Taniguchi, Kenji Monde, Kouwa Yamashita, Hiroaki Sakurai, Tomoji Ozeki and Yoshiteru Oshima | |
Tetrahedron Lett., 54, 3402-3405 (2013) | |
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An
epigenetic modifier enhances the production of anti-diabetic and
anti-inflammatory sesquiterpenoids from Aspergillus sydowii |
|
Yu-Ming Chung, Chien-Kei Wei, Da-Wei Chuang, Mohamed El-Shazly, Chi-Ting Hsieh, Teigo Asai, Yoshiteru Oshima, Tusty-Jiuan Hsieh, Tsong-Long Hwang and Yang-Chang Wu | |
Bioorg. Med. Chem., 21, 3866-3872 (2013) | |
Benzophenones
from an Endophytic Fungus, Graphiopsis
chlorocephala, from Paeonia lactiflora Cultivated in the
Presence of an NAD+-Dependent HDAC Inhibitor |
|
Teigo Asai, Sae Otsuki, Hiroaki Sakurai, Kouwa Yamashita, Tomoji Ozeki and Yoshiteru Oshima | |
Org. Lett., 15, 2058-2061 (2013) | |
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Structures
and Biomimetic Synthesis of Polyketides of an Endophytic Penicillium
sp. of Cataranthus roseus |
|
Teigo Asai, Dan Luo, Kouwa Yamashita, and Yoshiteru Oshima | |
Org. Lett., 15, 1020-1023 (2013) | |
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Ectopic
Antenna Induction by Overexpression of CG17836/Xrp1 Encoding
an AT-Hook DNA Binding Motif Protein in Drosophila |
|
Noriko Tsurui-Nishimura, Thanh Quang Nguyen, Tomonori Katsuyama, Tatsurou Minami, Hirofumi Furuhashi, Yoshiteru Oshima, and Shoichiro Kurata | |
Biosci. Biotechnol. Biochem., 77, 339-344 (2013) | |
Derivatives of Dictyostelium discoideum Differentiation-inducing Factor-3 Suppress the Activities of Trypanosoma cruzi in vitro and in vivo | |
Junko Nakajima-Shimada, Toshimitsu Hatabu, Yukari Hosoi, Yoko Onizuka, Haruhisa Kikuchi, Yoshiteru Oshima and Yuzuru Kubohara | |
Biochem. Pharmacol., 85, 1603-1610 (2013) | |
Terresterol, a Polyoxygenated Lanostanoid, Isolated from Oomycete Saprolegnia terrestris, and Its Innate Immune Promoting Activity | |
Haruhisa Kikuchi, Yuichi Sato, Shoichiro Kurata Yasuhiro Katou and Yoshiteru Oshima | |
Tetrahedron, 69, 3536-3542 (2013) | |
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糸 状菌二次代謝のエピジェネティック制御と天然物探索 | |
浅井禎吾、大島吉輝 | |
化 学と生物, 51, 13-21 (2013) | |
2012年
Isolation, Synthesis and Biological Activity of Biphenyl and m-Terphenyl-type Compounds from Dictyostelium Cellular Slime Molds | |
Haruhisa Kikuchi, Yusuke Matsuo, Yasuhiro Katou, Yuzuru Kubohara, and Y. Oshima | |
Tetrahedron, 68, 8884-8889 (2012) | |
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Stigmastane Derivatives from the Roots of Vernonia guineensis and Their Antimicrobial Activity | |
Arno R.N. Donfack, Ngeh J. Toyang, Hippolyte K. Wabo, Pierre Tane, Maurice D. Awouafack, Hasuhisa Kikuchi, Jean D.D. Tamokou, Jules R. Kuiate, and Yoshiteru. Oshima | |
Phytochemistry Lett., 5, 596-599 (2012) | |
Structural Diversity of New C13-Polyketides Produced by Chaetomium mollipilium Cultivated in the Presence of NAD+-Dependent Histone Deacetylase Inhibitor | |
Teigo Asai, Shuntaro Morita, Naoki Shirata, Tohru Taniguchi, Kenji Monde, Hiroaki Sakurai, Tomoji Ozeki, and Yoshiteru Oshima | |
Org. Lett., 14, 5456-5459 (2012) | |
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Labdane-type Diterpenes and Flavones from Dodonaea viscose | |
Hippolyte K. Wabo, Philippe.Chabert, Pierre Tane, Olivier Note, Michel F. Tala, Jean Peluso, Christian Muller, Haruhisa Kikuchi, Yoshiteru Oshima, and Annelise Lobstein | |
Fitoterapia, 83, 859-863 (2012) | |
Apoptotic Effects of Satratoxin H Is Mediated Through DNA Double-stranded Break in PC12 Cells | |
Punnee Nusuetrong, Masaki Saito, Harushisa Kikuchi, Yoshiteru Oshima, Takahiro Moriya, and Norimichi Nakahata | |
J. Toxicol. Sci., 37, 803-812 (2012) | |
New Dimeric and Monomeric Chromanones, Gonytolides D-G, Isolated from the Fungus Gonytrichum sp. | |
Harushisa Kikuchi, Masato Isobe, Shoichiro Kurata, Yasuhiro Katou, and Yoshiteru Oshima | |
Tetrahedron, 68, 6218-6223 (2012) | |
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Highly Oxidized Ergosterols and Isariotin Analogs, from an Entomopathogenic Fungus, Gibellula formosana, Cultivated in the Presence of Epigenetic Modifying Agents | |
Teigo Asai, Yu-Ming Chung, Hiroaki Sakurai, Tomoji Ozeki, Fang-Rong Chang, Yang-Chang Wu, Kouwa Yamashita, and Yoshiteru Oshima | |
Tetrahedron, 68, 5817-5823 (2012) | |
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Aromatic
Polyketide Production in Cordyceps indigotica, an
Entomopathogenic Fungus, Induced by Exposure to a Histone Deacetylase
Inhibitor |
|
Teigo Asai, Takashi Yamamoto, Kouwa Yamashita, and Yoshiteru Oshima | |
Org. Lett., 14, 2006-2009 (2012) | |
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Dihydrobenzofurans as Cannabinoid Receptor Ligands, from Cordyceps annullata, an Entomopathogenic Fungus, Cultivated in the Presence of HDAC Inhibitor | |
Teigo Asai, Luo Dan, Yutaro Obara, Tohru Taniguchi, Kenji Monde, Kouwa Yamashita, and Yoshiteru Oshima | |
Tetrahedron Lett., 53, 2239-2243 (2012) | |
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Br-DIF-1 Accelerates Cardiomyocyte Differentiation from P19CL6 Embryonic Carcinoma Cells Induced by 1% Dimethyl Sulfoxide | |
K. Seya, K. Kanemaru, M. Matsuki, K. Hongo, K. Nakamura, M. Ishikawa, H. Kitahara, S. Motomura, H. Kikuchi, Y. Oshima, Y. Kubohara, and K. Furukawa | |
Brit. J. Pharmacol., 165, 870-879 (2012) | |
Tenuipyrone, a Novel Skeletal Polyketide from the Entomopathogenic Fungus, Isaria tenuipes, Cultivated in the Presence of Epigenetic Modifiers | |
Teigo Asai, Yu-Ming Chung, Hiroaki Sakurai, Tomoji Ozeki, Fang-Rong Chang, Kouwa Yamashita, and Yoshiteru Oshima | |
Org. Lett., 14, 513-515 (2012) | |
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Aromatic Polyketide Glycosides from an Entomopathogenic Fungus, Cordyceps indigotica | |
Teigo
Asai, Takashi Yamamoto, Yu-Ming Chung, Fang-Rong Chang, Yang-Chang Wu,
Kouwa Yamashita, and Yoshiteru Oshima |
|
Tetrahedron Lett., 53, 277-280 (2012) | |
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Phenolic Compounds and Terpenoids from Hypericum lanceolatum | |
Hippolyte K. Wabo, Theodora K. Kowa, Antoine H.N. Lonfouo, Alembert T. Tchinda, Pierre Tane, Haruhisa Kikuchi, Michel Frederich, and Yoshiteru Oshima | |
Rec. Nat. Prod., 6, 94-100 (2012) |
2011年
Histone Deacetylase Inhibitor Induced the Production of Three Novel Prenylated Tryptophan Analogs in the Entomopathogenic Fungus, Torrubiella luteorostrata | |
T. Asai, T. Yamamoto, and Y. Oshima | |
Tetrahedron Lett., 52, 7042-7045 (2011) | |
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Coupling of Two Diazotized 3-Aminothieno[3,4-c]coumarins with Aromatic Amines | |
Emmanuel
S. Fondjo, Joseph Tsemeugne, Beibam L. Sondengam, Thomas Oppenlaender,
Hippolyte K. Wabo, Pierre Tane, Joseph D. Connolly, Wim Dehaen, Taoufik
Rohand, Haruhisa Kikuchi, and Yoshiteru OShima |
|
J. Heterocyclic Chem., 48, 1295-1301 (2011) | |
Structures of the Dimeric and Monomeric Chromanones, Gonytolides A-C, Isolated from the Fungus Gonytrichum sp. and Their Promoting Activities of Innate Immune Responses | |
Haruhisa
Kikuchi, Masato Isobe, Mizuki Sekiya, Yuko Abe, Tsuyoshi Hoshikawa,
Kazunori Ueda, Shoichiro Kurata, Yasuhiro Katou, and Yoshiteru Oshima |
|
Org. Lett.,
13, 4624-4627 (2011) |
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A
Phytoceramide Analog Stimulates the Production of Chemokines Through
CREB Activation in Human Endothelial Cells |
|
Mizuki
Sekiya, Kazunori Ueda, Kaori Okazaki, Jun Tashima, Yasuhiro Katou,
Haruhisa Kikuchi, Shoichiro Kurata, and Yoshiteru Oshima |
|
Int. Immunopharmacol., 11, 1497-1503 (2011) | |
Autophagy Allows Second-signalled Autophagic Cell Death in Dictyostelium | |
Marie-Francoise Luciani, Corinne Giusti, Birthe Harms, Yoshiteru Oshima, Haruhisa Kikuchi, Yuzuru Kubohara, and Pierre Golstein | |
Autophagy, 7, 501-508 (2011) | |
Synthesis and Innate Immune Suppressive Effect of 1,2-Cyclopentanediol Derivatives | |
Haruhisa
Kikuchi, Kaori Okazaki, Mizuki Sekiya, Yasuyuki Uryu, Kazunori Ueda,
Shoichiro Kurata, Yasuhiro Katou, and Yoshiteru Oshima |
|
Eur.
J. Med. Chem., 46, 1263-1273 (2011) |
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Derivatives of Dictyostelium Differentiation-inducing Factors Promote Mitogen-activated IL-2 Production via AP-1 in Jurkat Cells | |
Katsunori Takahashi, Masami Murakami, Haruhisa Kikuchi, Yoshiteru Oshima, and Yuzuru Kubohara | |
Life Sci., 88, 480-485 (2011) |
2010年
KSRP/FUBP2 is a Binding Protein of GO-Y086, a Cytotoxic Curcumin Analogue | |
Hiroyuki Yamakoshi, Naoki Kanoh, Chieko Kudo, Atsuko Sato, Kazunori Ueda, Makoto Muroi, Shunsuke Kon, Masanobu Satake, Hisatsugu Ohori, Chikashi Ishioka, Yoshiteru Oshima, Hiroyuki Osada, Natsuko Chiba, Hiroyuki Shibata, and Yoshiharu Iwabuchi | |
ACS Medicinal Chemistry Letters, 1, 273-276 (2010) | |
Inhibitory Effect of Hericenone B from Hericium erinaceus on Collagen-induced Platelet Aggregation | |
Koichiro
Mori, Haruhisa Kikuchi, Yutaro Obara, Masaya Iwashita, Yoshihito Azumi,
Satomi Kinugasa, Satoshi Inatomi, Yoshiteru Oshima, and Norimichi
Nakahata |
|
Phytomedicine,
17, 1082-1085 (2010) |
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Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds | |
Haruhisa Kikuchi, Shinya Ishiko, Koji Nakamura, Yuzuru Kubohara, and Yoshiteru Oshima | |
Tetrahedron, 66, 6000-6007 (2010) | |
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Preparation
of an Antibody That Recognizes and Neutralizes Dictyostelium
Differentiation-Inducing Factor-1 |
|
Yuzuru
Kubohara, Haruhisa Kikuchi, Koji Nakamura, Yusuke Matsuo, and Yoshiteru
Oshima |
|
Biochem. Biophy. Res. Commun., 396, 364-369 (2010) | |
Cooperative
Regulation of the Induction of the Novel Antibacterial Listericin by
PGRP-LE and the JAK-STAT Pathway |
|
Akira Goto, Tamaki Yano, Jun Terashima, Sshinzo Iwashita, Yoshiteru Oshima, and Shoichiro Kurata | |
J. Biol. Chem., 285, 15731-15738 (2010) | |
Xanthones and a Benzophenone from the Roots of Pentadesma butyracea and Their Antiproliferative Activity | |
Hippolyte K. Wabo, Haruhisa Kikuchi, Yasuhiro Katou, Pierre Tane, and Yoshiteru Oshima | |
Phytochemistry Letters, 3, 104-107 (2010) |
2009年
Revised Structure and Synthesis of Celastramycin A, a Potent Innate Immune Suppressor | |
H. Kikuchi, M. Sekiya, Y. Katou, K. Ueda, T. Kabeya, S. Kurata, and Y. Oshima | |
Org. Lett., 11, 1693-1695 (2009) | |
Peltophorum
Africanum, a Traditional South African Medicinal Plant, Contains
an Anti HIV-1 Constituent, Betulinic Acid |
|
A. Theo, T. Masebe, Y. Suzuki, H. Kikuchi, S. Wada, C.L. Obi, P.O.Bessong, M. Usuzawa, Y. Oshima, and T. Hattori | |
Tohoku J. Exp. Med., 217, 93-99 (2009) | |
Autophagic
or Necrotic Cell Death Triggered by Distinct Motifs of the
Differentiation Factor DIF-1 |
|
M.F.
Luciani, Y. Kubohara, H. Kikuchi, Y. Oshima, and P. Golstein |
|
Cell Death Differ., 16, 564-570 (2009) | |
New Diterpene Pyrone-Type Compounds, Metarhizin A and B, Isolated from Entomopathogenic Fungus, Metarhizium flavoviride and Their Inhibitory Effects on Cellular Proliferation | |
H.
Kikuchi, T. Hoshi, M. Kitayama, M. Sekiya, Y. Katou, K. Ueda, Y.
Kubohara, H. Sato, M. Shimazu, S. Kurata, and Y. Oshima |
|
Tetrahedron, 65, 469-477 (2009) | |
Opposite Effects of Two Resveratrol (trans-3,5,4'-Trihydroxystilbene) Tetramers, Vitisin A and Hopeaphenol, on Apoptosis of Myocytes Isolated from Adult Rat Heart | |
K. Seya, K. Kanemaru, C. Sugimoto, M. Suzuki, T. Takeo, S. Motomura, H. Kitahara, M. Niwa , Y. Oshima, and K. Furukawa | |
J. Pharmacol. Exp. Ther., 328, 90-98 (2009) |
2008年
Biological Activities of Novel Derivatives of DIF-1 Isolated from Dictyostelium | |
H. Kikuchi, S. Ishiko, Y. Oshima, N. Gokan, K. Hosaka, and Y. Kubohara | |
Biochem. Biophy. Res. Commun, 377,1012-1017 (2008) | |
Exploitation of the Derivatives of Dictyostelium Differentiation-Inducing Factor-1, Which Promote Glucose Consumption in Mammalian Cells | |
Y. Kubohara, H. Kikuchi, and Y. Oshima | |
Life Sci., 83,608-612 (2008) | |
Autophagic Control of Listeria through Intracellular Innate Immune Recognition in Drosophila | |
T. Yano, S. Mita, H. Ohmori, Y. Oshima, Y. Fujimoto, R. Ueda, H. Takada, W. E. Goldman, K. Fukase, N. Silverman, T. Yoshimori, and S. Kurata | |
Nature Immunol., 9, 908-916 (2008) | |
Satratoxin H Generates Reactive Oxygen Species and Lipid Peroxides in PC12 Cells | |
P. Nusuetrong, T. Pengsuparp, D. Meksuriyen, M. Tanitsu, H. Kikuchi, M. Mizugaki, K. Shimazu, Y. Oshima, N. Nakahata, and M. Yoshida | |
Biol. Pharm. Bull., 31, 1115-1120 (2008) | |
A Cyclopentanediol Analogue Selectively Suppresses the Conserved Innate Immunity Pathways, Drosophila IMD and TNF-a Pathways | |
M. Sekiya, K. Ueda, K. Okazaki, H. Kikuchi, S. Kurata, and Y. Oshima | |
Biochem. Pharmacol., 75, 2165-2174 (2008) |
2007年
Novel
Biologically Active Compounds Isolated from Unexploited Organism,
Cellular Slime Molds |
|
H.
Kikuchi |
|
Yakugaku Zasshi, 127, 1431-1439 (2007) | |
MalariaCount: An Image Analysis-Based Program for the Accurate Determination of Parasitemia | |
S.W.S. Sio, W. Sun, S. Kumar, W.Z. Bin, S.S. Tan, S.H. Ong, H. Kikuchi, Y. Oshima, and K.S.W. Tan | |
J. Microbiol. Meth., 68, 11-18 (2007) | |
Dictyostelium Differentiation-Inducing Factor-1 Induces Glucose Transporter 1 Translocation and Promotes Glucose Uptake in Mammalian Cells | |
W. Omata, H. Shibata, M. Nagasawa, I. Kojima, H. Kikuchi, Y. Oshima, K. Hosaka, and Y. Kubohara | |
FEBS J., 274, 3392-3404 (2007) | |
Dihydrodictyopyrone A and C: New Members of Dictyopyrone Family Isolated from Dictyostelium Cellular Slime Molds | |
H.
Kikuchi, K. Nakamura, Y. Kubohara, N. Gokan, K. Hosaka, Y. Maeda, and
Y. Oshima |
|
Tetrahedron Lett., 48, 5905-5909 (2007) | |
Synthesis of Dictyomedins Using Phosphazene Base Catalyzed Diaryl Ether Formation | |
M.
Ebisawa , M. Ueno , Y. Oshima, and Y. Kondo |
|
Tetrahedron Lett., 48, 8918-8921 (2007) | |
5,19-Cyclo-9b,10e-androstane-3,17-dione Promotes Neurotrophic Factor Biosynthesis in 1321N1 Human Astrocytoma Cells and Improves Passive Avoidance Learning Impairment | |
Y.
Obara, A. Haganuma, S. Murakami, T. Chiba, K. Mori, O. Nakagawasai, T.
Tadano, H. Kikuchi, Y. Oshima, and N. Nakahata |
|
Brain Res., 1184, 57-64 (2007) |
2006年
The Drosophila Immune Response to Monomeric DAPtype Peptidoglycan Relies on Two PGRPs and a RHIMlike Domain | |
T. Kaneko, T. Yano, K. Aggarwal, J.-H. Lim, K. Ueda, Y. Oshima, C. Peach1, D. Erturk-Hasdemir, W. E. Goldman, B.-H. Oh, S. Kurata, and N. Silverman | |
Nature Immunol., 7, 715-723 (2006) | |
Exploration of a New Type of Antimalarial Compounds Based on Febrifugine | |
H. Kikuchi, K. Yamamoto, S. Horoiwa, N. Hariguchi, M. Matsumoto, and Y. Oshima | |
J. Med. Chem., 49, 4698-4706 (2006) | |
Structural Basis for Preferential Recognition of Diaminopimelic Acid-type Peptidoglycan by a Subset of Peptidoglycan Recognition Proteins | |
J.-H.
Lim, M.-S. Kim, H.-E. Kim, T. Yano, Y. Oshima, K. Aggarwal, W. E.
Goldman, N. Silverman, S. Kurata, and B.-H. Oh |
|
J. Biol. Chem., 281, 8286-8295 (2006) | |
Isolation
of Cholest-5-en-3-ol Fromate from the Red Alga Grateloupia turturu
Yamada and Its Chemotaxonomic Significance |
|
E. Plouguerne, H. Kikuchi, Y. Oshima, E. Deslandes, and V. Stiger-Pouvreau | |
Biochem. Syst. Ecol., 34, 714-717 (2006) | |
Establishment of ex vivo Systems to Identify Compounds Acting in Innate Immune Responses and to Determine Their Target Molecules Using Transgenic Drosophila | |
M. Sekiya, K. Ueda, T. Fujita, M. Kitayama, H. Kikuchi, Y. Oshima, and S. Kurata | |
Life Sci., 80, 113-119 (2006) | |
Anti-leukemic Activities of Dictyostelium Secondary Metabolites: A Novel Aromatic Metabolite, 4-Methyl-5-n-Pentylbenzene-1,3-Diol, Isolated from Dictyostelium mucoroides Suppresses Cell Growth in Human Leukemia K562 and HL-60 Cells | |
H. Kikuchi, Y. Oshima, A. Ichimura, N. Gokan, A. Hasegawa, K. Hosaka, and Y. Kubohara | |
Life Sci., 80, 160-165 (2006) |
2005年
Involvement
of Reactive Oxygen Species and Stress -activated MAPKs in Satratoxin
H-Induced Apotosis |
|
P.
Nusuetrong, M. Yoshida, H. Kikuchi, M. Tanitsu, M. Mizugaki, K.
Shimazu, Y. Oshima, T. Pengsuparp, D. Meksuriyen, N. Nakahata Eur. J. Pharmacol., 507, 239-246 (2005) |
|
Adenosine as an Active Constituent of Auricularia auricula for the Inhibition of Rabbit Platelet Aggregation | |
A.
Murata, N. Oka, S. Ohkubo, Y. Sato, M. Funamori, H. Kikuchi, M.
Tanitsu, K. Koga, S. Sato, T. Tadano, Y. Oshima, and N. Nakahata Pharmacometrics, 67 (3/4), 359-364 (2005) |
|
Structural Requirements of Dictyostelium Differentiation-Inducing Factors for Their Stalk-Cell-Inducing Activity in Dictyostelium Cells and Anti-Proliferative Activity in K562 Human Leukemic Cells | |
N.
Gokan, H. Kikuchi, K. Nakamura, Y. Oshima, K. Hosaka, and Y. Kubohara Biochem. Pharmacol., 70, 676-685 (2005) |
|
Dictyopyrones, Novel a-Pyronoids Isolated from Dictyostelium spp., Promote Stalk Cell Differentiation in Dictyostelium discoideum | |
A.
Arai, K. Hosaka, H. Kikuchi, Y. Oshima, S. Tanaka, Y. Kubohara Differentiation, 73, 377-384 (2005) |
|
The Isolation and Synthesis of a Novel Aromatic Compound, Brefelamide, from Dictyostelium Cellular Slime Molds, and Its Inhibitory Effect on the Proliferation of Astrocytoma Cells | |
H.
Kikuchi, Y. Saito, J. Sekiya, Y. Okano, M. Saito, N. Nakahata, Y.
Kubohara, and Y. Oshima J. Org. Chem., 70, 8854-8858 (2005) |
|
Involvement of Winged Eye Encoding a Chromatin-Associated Bromo-Adjacent Homology Domain Protein in Disc Specification | |
T.
Katsuyama, T. Sugawara, M. Tatsumi, Y. Oshima, W. J. Gehring, T.
Aigaki, and S. Kurata Proc. Natl. Acad. Sci. U.S.A., 102, 15918-15923 (2005) |
2004年
Novel Aromatics Bearing 4-O-Methylglucose Unit Isolated from the Oriental Crude Drug Bombyx Batryticatus | |
H.
Kikuchi, N. Takahashi, and Y. Oshima Tetrahedron Lett., 45, 367-370 (2004) |
|
First Spirocyclic Trichothecanes, Spirotenuipesine A and B, Isolated from Entomopathogenic Fungus, Paecilomyces tenuipes | |
H.
Kikuchi, Y. Miyagawa, Y. Sahashi, S. Inatomi, A. Haganuma, N. Nakahata,
and Y. Oshima J. Org. Chem., 69, 352-356 (2004) |
|
Structural Requirements of Dictyopyrones Isolated from Dictyostelium spp. in the Regulation of Dictyostelium Development and in Anti-leukemic Activity | |
H.
Kikuchi, K. Sasaki, J. Sekiya, Y. Maeda, A. Amagai, Y. Kubohara, and Y.
Oshima Bioorg. Med. Chem., 12, 3203-3214 (2004) |
|
Novel
Trichothecanes, Paecilomycines A, B, and C, Isolated from
Entomopathogenic Fungus, Paecilomyces tenuipes |
|
H.
Kikuchi, Y. Miyagawa, Y. Sahashi, S. Inatomi, A. Haganuma, N. Nakahata,
and Y. Oshima Tetrahedron Lett., 45, 6225-6228 (2004) |
|
Peptidoglycan
Recognition Protein (PGRP)LE and PGRP-LC act synergistically in
Drosophila immunity |
|
A.
Takehana, T. Yano, S. Mita, A. Kotani, Y. Oshima, and S. Kurata EMBO J., 23, 4690-4700 (2004) |
|
A Novel Carbon Skeletal Trichothecane, Tenuipesine A, Isolated from Entomopathogenic Fungus, Paecilomyces tenuipes | |
H.
Kikuchi, Y. Miyagawa, K. Nakamura, Y. Sahashi, S. Inatomi, and Y. Oshima Org. Lett., 6, 4531-4533 (2004) |
2003年
A
Newly Established in Vitro Culture Using Transgenic Drosophila Reveals
Functional Coupling between the Phospholipase A2-generated Fatty Acid
Cascade and Lipopolysaccharide-dependent Activation of the immune
deficiency (imd) Pathway in Insect Immunity |
|
M.
Yajima, M. Takada, N. Takahashi, H. Kikuchi, S. Natori, Y. Oshima, and
S. Kurata Biochem. J., 371, 205-210 (2003) |
|
Endothelium-dependent
Vasodilatory Effect of Vitisin C, a Novel Plant Oligostilbene from
Vitis Plants (Vitaceae) in Rabbit Aorta |
|
K.
Seya, K. Furukawa, S. Taniguchi, G. Kodzuka, Y. Oshima, M. Niwa, and S.
Motomura Clin. Sci., 105, 73-79 (2003) |
|
Multiple Activities of a Novel Substance, Dictyopyrone C Isolated from Dictyostelium discoideum, in Cellular Growth and Differentiation | |
Y.
Maeda, H. Kikuchi, K. Sasaki, A. Amagai, J. Sekiya, Y. Takaya, and Y.
Oshima Protoplasma, 221, 185-192 (2003) |
|
Metabolites
of Febrifugine and Its Synthetic Analogue by Mouse Liver S9 and Their
Antimalarial Activity against Plasmodium Malaria Parasite |
|
S.
Hirai, H. Kikuchi, H. Kim, K. Begum, Y. Wataya, H. Tasaka, Y. Miyazawa,
K. Yamamoto, and Y. Oshima J. Med. Chem., 46, 4351-4359 (2003) |
2002年
Guaiane- and Aristolane-Type Sesquiterpenoids of Nardostachys chinensis Roots | |
M.
Tanitsu, Y. Takaya, M. Akasaka, M. Niwa, and Y. Oshima Phytochemistry, 59, 845-849 (2002) |
|
The Isolation and Synthesis of Two Novel N-Acetyl glucosamine Derivatives from Dictyostelium Cellular Slime Molds Which Exhibit Neurite Outgrowth Activity | |
H.
Kikuchi J. Komiya, Y. Saito, J. Sekiya, S. Honma, N. Nakahata, and Y.
Oshima Tetrahedron Lett., 43, 1477-1480 (2002) |
|
Potent Antimalarial Febrifugine Analogues against the Plasmodium Malaria Parasite | |
H.
Kikuchi, H. Tasaka, S. Hirai, Y. Takaya, Y. Iwabuchi, H. Ooi, S.
Hatakeyama, H. Kim, Y. Wataya, and Yoshiteru Oshima J. Med. Chem., 45, 2563-2570 (2002) |
|
Overexpression of a Pattern Recognition Receptor, Peptidoglycan Recognition Protein-LE, Activates Imd/Relish-Mediated Antibacterial Defense and the Prophenoloxidase Cascade in Drosophila larvae | |
A.
Takehana, T. Katsuyama, T. Yano, Y. Oshima, H. Takada, T. Aigaki, and
S. Kurata Proc. Natl. Acad. Sci. U.S.A., 99, 13705-13710 (2002) |
2001年
Novel Aromatic Substances, Dictyomedin A and B, from Dictyostelium Cellular Slime Molds and Their Inhibitory Effects on Dictyostelium Development | |
Y.
Takaya, H. Kikuchi, Y. Terui, J. Komiya, Y. Maeda, A. Ito, and Y. Oshima Tetrahedron Lett., 42, 61-63 (2001) |
|
Virol
A, a Toxic trans-Polyacetylenic Alcohol of Cicuta virosa, Selectively
Inhibits the GABA-Induced Cl(-) Current in Acutely Dissociated Rat
Hippocampal CA1 Neurons |
|
K.
Uwai, K. Ohashi, Y. Takaya, Y. Oshima, K. Furukawa, K. Yamagata, T.
Omura, and S. Okuyama Brain Res., 889, 174-180 (2001) |
|
Furanodictine A and B, Amino Sugar Analogues Produced by Cellular Slime Mold Dictyostelium discoideum, Showing Neuronal Differentiation Activity | |
H.
Kikuchi, Y. Saito, J. Komiya, Y. Takaya, S. Honma, N. Nakahata, A. Ito,
and Y. Oshima J. Org. Chem., 66, 6982-6987 (2001) |
2000年
Novel Acyl a-Pyronoids, Dictyopyrone A, B, and C, from Dictyostelium Cellular Slime Molds | |
Y.
Takaya, H. Kikuchi, Y. Terui, J. Komiya, K. Furukawa, K. Seya, S.
Motomura, A. Ito, and Y. Oshima J. Org. Chem., 65, 985-989 (2000) |
|
Novel
Guaiane Endoperoxides, Nardoguaianone A-D, from Nardostachys
chinensis Roots and Their Antinociceptive and Antimalarial
Activities |
|
Y.
Takaya, Y. Takeuji, M. Akasaka, O. Nakagawasai, T. Tadano, K. Kisara,
H. Kim, Y. Wataya, M. Niwa, and Y. Oshima Tetrahedron, 56, 7673-7678 (2000) |
|
Novel Guaianoids, Nardoguaianone E-I, from Nardostachys chinensis Roots | |
Y.
Takaya, M. Akasaka, Y. Takeuji, M. Tanitsu, M. Niwa, and Yoshiteru
Oshima Tetrahedron, 56, 7679-7683 (2000) |
|
Exploring
the Structural Basis of Neurotoxicity in C17-Polyacetylenes Isolated
from Water Hemlock |
|
K.
Uwai, K. Ohashi, Y. Takaya, T. Ohta, T. Tadano, K. Kisara, K.
Shibusawa, R. Sakakibara, and Y. Oshima J. Med. Chem., 43, 4508-4515 (2000) |
1999年
New Oligostilbenes Having a Benzofuran from Vitis vinifera 'Kyohou' | |
J.
Ito, Y. Takaya, Y. Oshima, and M. Niwa Tetrahedron, 55, 2529-2544 (1999) |
|
Stimulation of Neurotrophic Factor Secretion from 1321N1 Human Astrocytoma Cells by Novel Diterpenoids, Scabronines A and G | |
Y.
Obara, N. Nakahata, T. Kita, Y. Takaya, H. Kobayashi, S. Hosoi, F.
Kiuchi, T. Ohta, Y. Oshima, and Y. Ohizumi Eur. J. Pharmacol., 370, 79-84 (1999) |
|
New Type of Febrifugine Analogues, Bearing a Quinolizidine Moiety, Show Potent Antimalarial Activity against Plasmodium Malaria Parasite | |
Y.
Takaya, H. Tasaka, T. Chiba, K. Uwai, M. Tanitsu, H. Kim, Y. Wataya, M.
Miura, M. Takeshita, and Y. Oshima J. Med. Chem., 42, 3163-3166 (1999) |
|
Absolute Stereochemistry of Cicutoxin and Related Toxic Polyacetylenic Alcohols from Cicuta virosa | |
T.
Ohta, Koji Uwai, Rikako Kikuchi, Shigeo Nozoe, Yoshiteru Oshima, Kenrou
Sasaki and Fumihiko Yoshizaki Tetrahedron, 55, 12087-12098 (1999) |
|
Syntheses and Stereochemical Assignment of Toxic C17-Polyacetylenic Alcohols, Virols A, B, and C, Isolated from Water Hemlock (Cicuta virosa) | |
K.
Uwai, Y. Oshima, T. Sugihara, and T. Ohta Tetrahedron, 55, 9469-9480 (1999) |
|
Febrifugine Fortifies Host Defence in Mice Against Plasmodium berghei NK65 | |
K.
Murata, F. Takano, S. Fushiya, and Y. Oshima Biochem. Pharmacol., 58, 1593-1601 (1999) |
1998年
Novel Antimalarial Guaiane-type Sesquiterpenoids from Nardostachys chinensis Roots | |
Y.
Takaya, K. Kurumada, Y. Takeuji, H. Kim, Y. Shibata, N. Ikemoto, Y.
Wataya, and Y. Oshima Tetrahedron Lett., 39, 1361-1364 (1998) |
|
Lepiotins A and B, New Alkaloids from the Mushrooms, Macrolepiota neomastoidea and Chlorophyllum molybdites | |
T.
Ohta, H. Inoue, G. Kusano, and Y. Oshima Heterocycles, 47, 883-891 (1998) |
|
Postischemic Changes of [3H]Nimodipine and [3H]Ryanodine Binding in the Gerbil Striatum and Hippocampus | |
T.
Araki, H. Kato, K. Shuto, Y. Oshima, and Y. Itoyama Eur. J. Neurol., 5, 195-201 (1998) |
|
Absolute Configurations of Some Oligostilbenes from Vitis coignetiae and Vitis vinifera 'Kyohou' | |
J.
Ito, K. Gobaru, T. Shimamura, M. Niwa, Y. Takaya, and Y. Oshima Tetrahedron, 54, 6651-6660 (1998) |
|
Studies on Constituent of "KAKO-BUSHI-MATSU” | |
M.
Matsui, Y. Sato, H. Bando, M. Murayama, T. Osawa, T. Miura, and Y.
Oshima Natural Medicines, 52, 232-235 (1998) |
|
Effect of NG-Nitro-L-Arginine Methyl Ester, a Nitric Oxide Synthase Inhibitor, on Neurotransmitter Receptor Systems in Aged Rats | |
T.
Araki, Y. Oshima, H. Kato, K. Shuto, and Y. Itoyama Eur. J. Neurol., 5, 601-608 (1998) |
|
Scabronine A, a Novel Diterpenoid Having a Potent Inductive Activity of Nerve Growth Factor Synthesis, Isolated From the Mushroom Sarcodon scabrosus | |
T.
Ohta, T. Kita, N. Kobayashi, Y. Obara, N. Nakahata, Y. Ohizumi, Y.
Takaya, and Y. Oshima Tetrahedron Lett., 39, 6229-6232 (1998) |
|
Scabronines B, C, D, E and F, Novel Diterpenoids Showing Stimulating Activity of Nerve Growth Factor-Synthesis, from the Mushroom Sarcodon scabrosus | |
T.
Kita, Y. Takaya, Y. Oshima, T. Ohta, K. Aizawa, T. Hirano, and T.
Inakuma Tetrahedron, 54, 11877-11886 (1998) |
|
Pharmacological Properties of Pteleprenine, a Quinoline Alkaloid Extracted from Orixa japonica, on Guinea Pig Ileum and Canine Left Atrium | |
K.
Seya, I. Miki, K. Murata, H. Junke, S. Motomura, T. Araki, Y. Itoyama,
and Y. Oshima J. Pharm. Pharmacol., 50, 803-807 (1998) |
|
Enhancement of NO Production in Activated Macrophages in Vivo by an Anti-malarial Crude Drug, Dichroa febrifuga | |
K.
Murata, F. Takano, S. Fushiya, and Y. Oshima J. Nat. Prod., 61, 729-733 (1998) |
1997年
A New Hydroxystilbene Tetramer Named Isohopeaphenol from Vitis vinifera 'Kyohou' | |
J.
Ito, M. Niwa, and Y. Oshima Heterocycles, 45, 1809-1813 (1997) |
|
Effect of NG-Nitro-L-Arginine on Age-Related Changes of Glutamate Receptor Systems and Immunophilin in Rats | |
T.
Araki, Y. Oshima, H. Kato, K. Shuto, and Y. Itoyama Meth. Find. Exp. Clin. Pharmacol., 19, 373-381 (1997) |
|
Synthesis and Cataleptic Effects of Optically Active Dihydrohaloperidols and Dihydrobromoperidols | |
M.
Takeshita, M. Miura, T. Hongo, T. Ohkubo, K. Sugawara, K. Kosaka, Y.
Takeshita, T. Araki, and Y. Oshima Chirality, 9, 443-445 (1997) |
|
Specific CYP3A4 Inhibitors in Grapefruit Juice: Furocoumarin Dimers as Components of Drug Interaction | |
K.
Fukuda, T. Ohta, Y. Oshima, N. Ohashi, M. Yoshikawa, and Y. Yamazoe Pharmacogenetics, 7, 391-396 (1997) |
|
Effects of L-DOPA and Bromocriptine on Haloperidol-induced Motor Deficits in Mice | |
T.
Kobayashi, T. Araki, Y. Itoyama, M. Takeshita, T. Ohta, and Y. Oshima Life Sci., 61, 2529-2538 (1997) |
|
Vitisins D and E, Novel Oligostilbenes from Vitis coignetiae Stem Barks | |
K.
Shinoda, Y. Takaya, T. Ohta, K. Hisamichi, M. Takeshita, M. Niwa, and
Y. Oshima Heterocycles, 46, 169-172 (1997) |
|