東北大学薬学部・
大学院薬学研究科
反応制御化学分野
土井研究室

論文リスト

• Destruxin E backbone modification effects on osteoclast Morphology: Synthesis and SAR study of N-Desmethyl and N-Methyl analogs, Hiroshi Sato, Hayato Murase, Yoshitaka Ishida, Haruki Sugiyama, Hidehiro Uekusa, Hiroshi Nakagawa, Masahito Yoshida, and Takayuki Doi,* Bioorg. Med. Chem. 2024, 108, 117777. Special Issue "Current Japanese Pharmaceutical Chemistry"
• New Dihydropyridine Derivative Attenuates NF-κB Activation via Suppression of Calcium Influx in a Mouse BV-2 Microglial Cell Line, Kota Sato, Yuto Sasaki, Michiko Ohno-Oishi, Kuniyuki Kano, Junken Aoki, Kosuke Ohsawa, Takayuki Doi, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi, Chihiro Kawano, Yoshiyuki Hirata, and Toru Nakazawa,* Tohoku J. Exp. Med. 2024,　263(2), 151－160.
• [BOOK] Total Synthesis of (+)-Siladenoserinol A, Masahito Yoshida, Koya Saito, and Takayuki Doi,* in Modern Natural Product Synthesis: Overcoming Difficulties, eds Masahisa Nakada, Keiji Tanino, Nazuo Nagasawa, and Satoshi Yokoshima, p83–101, Springer, 2024. [Open Access]

• Synthesis and Biological Evaluation of Lysophosphatidic Acid Analogues Using Conformational Restriction and Bioisosteric Replacement Strategies, Mazin A. S. Abdelwahid, Kosuke Ohsawa, Akiharu Uwamizu, Kuniyuki Kano, Junken Aoki,* and Takayuki Doi,* ACS Omega 2023, 8(51), 49278–49288.
• Synthesis and Biological Evaluation of Siladenoserinol A Analogs Possessing a Diastereomeric 6,8-Dioxabicyclo[3.2.1]octane Skeleton, Masahito Yoshida,* Kohei Sasaoka, Kohei Hano, Yoshiyuki Sugiyama, Yuki Hitora, Takayuki Doi, Sachiko Tsukamoto, and Hideo Kigoshi, Bull. Chem. Soc. Jpn, 2023, 96(11), 1283–1297.
• Identification of small-molecule inhibitors against the interaction of RNA-binding protein RSF and its target RNA for cancer treatment, Ken-ichi Takayama, Seiji Matsuoka, Shungo Adachi, Teruki Honma, Masahito Yoshida, Takayuki Doi, Kazuo Shin-ya, Minoru Yoshida, Hiroyuki Osada, and Satoshi Inoue, PNAS Nexus, 2023, 2, 1–10.
• Efficient and Scalable Asymmetric Total Synthesis of (-)-Emetine with Pharmaceutical Grade Quality; First Multigram Scale Synthesis, Masatoshi Yamada,* Kazuki Azuma, Iori Takizawa, Yuki Ejima, Mitsuhisa Yamano, Kimio Satoh, Takayuki Doi, Hirofumi Ueda, and Hidetoshi Tokuyama Org. Process Res. Dev. 2023, 27(2), 343–357.
• De Novo Synthesis of Polysubstituted 3-Hydroxypyridines Via "Anti-Wacker"-Type Cyclization, Kazuya Ito, Takayuki Doi, and Hirokazu Tsukamoto,* Catalysts 2023, 13(2), 319. Special Issue "Theme Issue in Memory to Prof. Jiro Tsuji (1927–2022)"
• Palladium(0)-Catalyzed Anti-Selective Addition-Cyclizations of Alkynyl Electrophiles, Hirokazu Tsukamoto,* Kazuya Ito, Tatsuhiko Ueno, Mitsugu Shiraishi, Yoshinori Kondo, and Takayuki Doi Chem. Eur. J. 2023, 29(6), e202203068.
• Cyclic Tetrapeptide Natural Product Asperterrestide A: Total Synthesis and Structural Revision, Takayuki Doi, Kosuke Ohsawa, Yuichi Masuda J. Synth. Org. Chem. Jpn. 2023, 81(6), 554–561.

• Photocatalyzed Oxidative Decarboxylation Forming Aminovinylcysteine Containing Peptides, Masaya Kumashiro, Kosuke Ohsawa and Takayuki Doi* Catalysts 2022, 12(12), 1615. Selected as a Feature Paper. Special Issue "Theme Issue in Memory to Prof. Jiro Tsuji (1927–2022)"
• Total Synthesis and Structural Determination of Cyclodepsipeptide Decatransin, Kosuke Ohsawa, Sakiko Fukaya and Takayuki Doi* Org. Lett. 2022, 24, 30, 5552－5556.
• Synthetic studies for destruxins and biological evaluation for osteoclast-like multinucleated cells: a review, Masahito Yoshida, Hiroshi Nakagawa, and Takayuki Doi* J. Antibiot. 2022, 75. 420－431.
• The Concise Synthesis of a tert-Butoxycarbonyl Derivative of (3R,4S)-4-Amino-3-hydroxy-7-(N-nitrosohydroxyamino)-2,2-dimethylheptanoate, a Component of JBIR-141, Kotaro Yasoshima, Masahito Yoshida, and Takayuki Doi,* Bull. Chem. Soc. Jpn. 2022, 95(5), 830－830.

• JBIR-155, a Specific Class D beta-Lactamase Inhibitor of Microbial Origin, Takehiro Nishimura, Teppei Kawahara, Noritaka Kagaya, Yusuke Ogura, Hirosato Takikawa, Hikaru Suenaga, Masaatsu Adachi, Takatsugu Hirokawa, Takayuki Doi, and Kazuo Shin-ya,* Org. Lett. 2021, 23(11), 4415－4419.
• Stereoselective Synthesis of 1-Aminocyclopropanecarboxylic Acid Carnosadines via Inter-intramolecular Double Alkylation with Optically Active 2-Methylaziridine Derivatives, Kosuke Ohsawa, Junya Kubota, Shota Ochiai, and Takayuki Doi,* J. Org. Chem. 2021, 86(10), 7304－7313.
• Gold-Catalyzed Amide/Carbamate-Linked N,O-Acetal Formation with Bulky Amides and Alcohols, Kosuke Ohsawa, Shota Ochiai, Junya Kubota, and Takayuki Doi,* J. Org. Chem. 2021, 86(1), 1281－1291.

• C-Methylation of S-adenosyl-L-Methionine Occurs Prior to Cyclopropanation in the Biosynthesis of 1-Amino-2-Methylcyclopropanecarboxylic Acid (Norcoronamic Acid) in a Bacterium, Chitose Maruyama, Yukiko Chinone, Shusuke Sato, Fumitaka Kudo, Kosuke Ohsawa, Junya Kubota, Junko Hashimoto, Ikuko Kozone, Takayuki Doi, Kazuo Shin-ya, Tadashi Eguchi, Yoshimitsu Hamano,* Biomolecules 2020, 10, 775.
• Scalable Total Syntheses and Structure‐Activity Relationships of Haouamine A, B, and their Derivatives as Stable Formate Salts, Hirokazu Tsukamoto,* Saki Nakamura, Akito Tomida, and Takayuki Doi, Chem. Eur. J. 2020, 26(55), 12528－12532.
　
• The anti-atherogenic activity of beauveriolide derivative BVD327, a sterol O-acyltransferase 2-selective inhibitor, in apolipoprotein E knockout mice, Taichi Ohshiro,* Satoshi Imuta, Ichiro Hijikuro, Hiroaki Yagyu, Takashi Takahashi, Takayuki Doi, Shun Ishibashi, and Hiroshi Tomoda,* Biol. Pharm. Bull. 2020, 43(6), 951－958.
• Stereoselective Synthesis of L-allo-Enduracididine and L-Enduracididine via Asymmetric Nitroaldol Reaction, Kosuke Ohsawa, Hongbin Zhao, Takuya Tokunaga, Carys Thomas, A. Ganesan, Yuichi Masuda, and Takayuki Doi,* Synthesis 2020, 52(6), 942－948.
• Structure－Activity Relationship Study on Col-003, a Protein－Protein Interaction Inhibitor between Collagen and Hsp47, Masahito Yoshida, Masazumi Saito, Shinya Ito, Koji Ogawa, Naoki Goshima, Kazuhiro Nagata,* and Takayuki Doi* Chem. Pharm. Bull. 2020, 68(3), 220－226.
• Synthesis of a Biphenylalanine Analogue of Apratoxin a Displaying Substantially Enhanced Cytotoxicity, Yuichi Onda, Kazuki Fukushi, Kosuke Ohsawa, Masahito Yoshida, Yuichi Masuda, and Takayuki Doi* Heterocycles 2020, 101(2), 679－691. [Professor Kaoru Fuji Special Issue]
• Electrochemical detection of kallikrein using a p-methoxyaniline-conjugated tripeptide towards simple diagnosis of primary aldosteronism, Kousuke Ohyama, Sun Sixiang, Kumi Y. Inoue, Tomokazu Matsue, and Takayuki Doi,* Chem. Lett. 2020, 49(1), 57－59.

• Palladium(0)-Catalyzed [4+2] Annulation of Salicylaldehydes and Propargyl Carbonates to Produce 3,4-Dihydro-2-Methylene-2H-1-Benzopyran-4-Ols, Ayumu Kawase, Hirotaka Omura, Takayuki Doi, and Hirokazu Tsukamoto,* Chem. Lett. 2019, 48(11), 1402－1405.
• Palladium(0)-Lithium Iodide-Cocatalyzed Asymmetric Hydroalkylation of Conjugated Enynes with Pronucleophiles Leading to 1,3-Disubstituted Allenes, Hirokazu Tsukamoto,* Tatsuya Konno, Kazuya Ito, and Takayuki Doi, Org. Lett. 2019, 21(17), 6811－6814.
• Key Factors for High Diastereo- and Enantioselectivity of Umpolung Cyclizations of Aldehyde-Containing Allylpalladium Intermediates, Hirokazu Tsukamoto,* Ayumu Kawase, Hirotaka Omura, and Takayuki Doi Bull. Chem. Soc. Jpn. 2019, 92(10), 1743－1753.
• Identification of Celastramycin as a Novel Therapeutic Agent for Pulmonary Arterial Hypertension-High-throughput Screening of 5,562 Compounds-, Ryo Kurosawa, Kimio Satoh, Nobuhiro Kikuchi, Haruhisa Kikuchi, Daisuke Saigusa, Md Elias Al-Mamun, Mohammad Abdul Hai Siddique, Junichi Omura, Taijyu Satoh, Shinichiro Sunamura, Masamichi Nogi, Kazuhiko Numano, Satoshi Miyata, Akira Uruno, Kuniyuki Kano, Yotaro Matsumoto, Takayuki Doi, Junken Aoki, Yoshiteru Oshima, Masayuki Yamamoto, and Hiroaki Shimokawa,* Circulation Research 2019, 125, 309－327.
• Palladium-Catalyzed Umpolung Type-II Cyclization of Allylic Carbonate-Aldehydes Leading to 3-Methylenecycloalkanol Derivatives, Hirokazu Tsukamoto,* Ayumu Kawase, and Takayuki Doi, Adv. Synth. Catal. 2019, 361(16), 3733－3738.
• Total Synthesis and Structural Revision of Cyclotetrapeptide Asperterrestide A, Kosuke Ohsawa, Masato Sugai, Linnan Zhang, Yuichi Masuda, Masahito Yoshida, and Takayuki Doi,* J. Org. Chem. 2019, 84(11), 6765－6779.
• Parallel Synthesis and Biological Evaluation of Destruxin E Analogs Modified with a Side Chain in the alfa-Hydroxycarboxylic Acid Moiety, Masahito Yoshida, Kenta Adachi, Hayato Murase, Hiroshi Nakagawa, and Takayuki Doi,* Eur. J. Org. Chem. 2019, 1669－1676.
• First Total Synthesis of Palmarumycin C6 Based on Double Oxa-Michael Addition of 1,8-Dihydroxynaphthalene to 3-Bromo-1-indenone, Hirokazu Tsukamoto, Yumi Nomura, and Takayuki Doi,* Heterocycles, 2019, 99(1), 549－565.[Professor Tohru Fukuyama Special Issue]

• Synthesis and biological evaluation of thielocin B1 analogues as protein-protein interaction inhibitors of PAC3 homodimer, Kosuke Ohsawa, Masahito Yoshida, Miho Izumikawa, Motoki Takagi, Kazuo Shin-ya, Naoki Goshima, Takatsugu Hirokawa, Tohru Natsume, and Takayuki Doi,* Bioorg. Med. Chem. 2018, 26(23-24), 6023–6034.
• Natural Products Apratoxins A and C and Their Analogs, Takayuki Doi,* Yuichi Masuda, and Masahito Yoshida, J. Synth. Org. Chem., Jpn. 2018, 76(11), 1170－1175.
• A novel potent ABCB1 modulator, phenethylisoquinoline alkaloid, reverses multidrug resistance in cancer cell, Norihiko Sugisawa, Shinobu Ohnuma,* Hirofumi Ueda, Megumi Murakami, Kyoko Sugiyama, Kosuke Ohsawa, Kuniyuki Kano, Hidetoshi Tokuyama, Takayuki Doi, Junken Aoki, Masaharu Ishida, Katsuyoshi Kudoh, Takeshi Naitoh, Suresh V. Ambudkar, and Michiaki Unno, Mol. Pharmaceutics, 2018, 15(9), 4021－4030.
• Total Synthesis of Spiromamakone A and Structure Revision of Spiropreussione A, Hirokazu Tsukamoto, Shogo Hanada, Yumi Nomura, and Takayuki Doi,* J. Org. Chem. 2018, 83(16), 9430－9441.
• Conjugate Addition to Acylketene Acetals Derived from 1,8-Dihydroxynaphthalene and Its Application To Synthesize the Proposed Structure of Spiropreussione A, Hirokazu Tsukamoto, Yumi Nomura, Koichi Fujiwara, Shogo Hanada, and Takayuki Doi,* Org. Lett. 2018, 20(10), 3140－3143.
• 生物活性環状デプシペプチド Spiruchostatin A の固相全合成，吉田将人，有機合成化学協会誌，2018, 76(5), 522－525.
• Synthesis of multiple-substituted dihydrofurans via palladium-catalysed coupling between 2,3-alkadienols and pronucleophiles, Hirokazu Tsukamoto,* Kazuya Ito, and Takayuki Doi, Chem. Comm. 2018, 54(40), 5102－5105.
• Total Synthesis and Biological Evaluation of Siladenoserinol A and its Analogues, Masahito Yoshida, Koya Saito, Hikaru Kato, Sachiko Tsukamoto, and Takayuki Doi* Angew. Chem. Int. Ed. 2018, 57(18), 5147－5150. [Selected by Synfacts] Synfacts 2018, 14(06), 0564.

• Total Synthesis and Stereochemistry Revision of Mannopeptimycin Aglycone，Shinichiro Fuse, Hiroshi Tanaka, Takashi Takahashi, and Takayuki Doi，J. Syn. Org. Chem. Jpn. 2017, 75(12), 1274－1285.
• A small compound inhibiting collagen-specific molecular chaperone as a potential remedy for fibrosis, Shinya Ito, Koji Ogawa, Koh Takeuchi, Motoki Takagi, Masahito Yoshida, Takatsugu Hirokawa, Shoshiro Hirayama, Kazuo Shin-ya, Ichio Shimada, Takayuki Doi, Naoki Goshima, Tohru Natsume,* and Kazuhiro Nagata,* J. Biol. Chem. 2017, 292(49), 20076－20085.
• Systematic Analysis of the Relationship among 3D Structure, Bioactivity, and Membrane Permeability of PF1171F, a Cyclic Hexapeptide with Paralyzing Effects on Silkworms, Yuichi Masuda,* Ren Tanaka, A. Ganesan, and Takayuki Doi,* J. Org. Chem. 2017, 82(21), 11447－11463.
• Facile Synthesis of Pyrrolyl 4-Quinolinone Alkaloids Quinolactacide by 9-AJ-Catalyzed Tandem Acyl Transfer-Cyclization of o-Alkynoylaniline Derivatives, Koya Saito, Masahito Yoshida, Hidehiro Uekusa, and Takayuki Doi,* ACS Omega 2017, 2, 4370－4381.
• Stereoselective Synthesis of beta-Amino Acid Derivatives by Asymmetric Mannich Reaction in Flow, Masahito Yoshida, Koji Umeda, and Takayuki Doi,* Bull. Chem. Soc. Jpn. 2017, 90(10), 1157－1163. [Selected Paper, Open Access]
• Conformation-based Design and Synthesis of Apratoxin A Mimetics Modified at the alfa,beta-Unsaturated Thiazoline Moiety, Yuichi Onda, Yuichi Masuda, Masahito Yoshida, and Takayuki Doi,* J. Med. Chem. 2017, 60(15), 6751－6765.
• Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6, Reiya Taniguchi, Asuka Inoue, Misa Sayama, Akiharu Uwamizu, Keitaro Yamashita, Kunio Hirata, Masahito Yoshida, Yoshiki Tanaka, Hideaki E. Kato, Yoshiko Nakada-Nakura, Yuko Otani, Tomohiro Nishizawa, Takayuki Doi, Tomohiko Ohwada, Ryuichiro Ishitani, Junken Aoki, and Osamu Nureki,* Nature, 2017, 548, 356－360.
• Selective inhibition of sterol O-acyltransferase 1 isozyme by beauveriolide III in intact cells, Taichi Ohshiro, Keisuke Kobayashi, Mio Ohba, Daisuke Matsuda, Lawrence L. Rudel, Takashi Takahashi, Takayuki Doi, and Hiroshi Tomoda,* Sci. Rep. 2017, 7, 4163.

• Synthesis of Spiromamakone A Benzo Analogues via Double Oxa-Michael Addition of 1,8-Dihydroxynaphthalene, Hirokazu Tsukamoto, Shogo Hanada, Koichi Kumasaka, Noritaka Kagaya, Miho Izumikawa, Kazuo Shin-ya, Takayuki Doi,* Org. Lett. 2016, 18(19), 4848－4851
• 生物活性環状ペプチドPF1171類とapratoxin Cの全合成と三次元構造解析, 増田裕一,* 土井隆行,* 化学工業，2016, 67(10), 18－25.
• Combinatorial Solid-Phase Synthesis and Biological Evaluation of Cyclodepsipeptide Destruxin B as a Negative Regulator for Osteoclast Morphology, Hiroshi Sato, Masahito Yoshida, Hayato Murase, Hiroshi Nakagawa, and Takayuki Doi,* ACS Comb. Sci. 2016, 18(9), 590－595.
• Synthesis of (2S,3R,4R)-3,4-dihydroxyarginine and its inhibitory activity against nitric oxide synthase, Yuichi Masuda, Chitose Maruyama, Kyuichi Kawabata, Yoshimitsu Hamano, and Takayuki Doi,* Tetrahedron 2016, 72(36), 5602－5611.
• Design, Synthesis, and Biological Evaluation of Beauveriolide Analogues Bearing Photoreactive Amino Acids, Yuichi Masuda, Kazumasa Aoyama, Masahito Yoshida, Keisuke Kobayashi, Taichi Ohshiro, Hiroshi Tomoda, and Takayuki Doi,* Chem. Pharm. Bull. 2016, 64(7), 754－765.[Special Collection of Papers Celebrating Professor Satoshi Omura's 2015 Nobel Prize in Physiology or Medicine]
• Palladium(II)-Catalyzed Annulation of Alkynes with 2-(Cyanomethyl)phenylboronates Leading to 3,4-Disubstituted 2-Naphthalenamides, Hirokazu Tsukamoto,* Taishi Ikeda, and Takayuki Doi, J. Org. Chem. 2016, 81(5), 1733－1745. Featured Article see here
• Potent Oxazoline Analogue of Apratoxin C: Synthesis, Biological Evaluation, and Conformational Analysis, Masahito Yoshida, Yuichi Onda, Yuichi Masuda, and Takayuki Doi,* Peptide Science, 2016, 106(4), 404－414. [Special Issue: Emerging Peptide Science from Japan]

• Solid-Phase Combinatorial Synthesis and Biological Evaluation of Destruxin E Analogues, Masahito Yoshida, Yoshitaka Ishida, Kenta Adachi, Hayato Murase, Hiroshi Nakagawa, and Takayuki Doi,* Chem. Eur. J. 2015, 21(50), 18417－18430.
• Foxo3a Inhibitors of Microbial Origin, JBIR-141 and JBIR-142, Teppei Kawahara, Noritaka Kagaya, Yuichi Masuda, Takayuki Doi, Miho Izumikawa, Kumiko Ohta, Atsushi Hirao, and Kazuo Shin-ya,* Org. Lett. 2015, 17(21), 5476－5479.
• Structure Revision of Similanamie to PF1171C by Total Synthesis, Yuichi Masuda, Ren Tanaka, A. Ganesan,* and Takayuki Doi* J. Nat. Prod. 2015, 78(9), 2286－2291.
• Pyrrolidine-containing peptides, JBIR-126, -148, and -149, from Streptomyces sp. NBRC 111228, Miho Izumikawa, Teppei Kawahara, Noritaka Kagaya, Hideki Yamamura, Masayuki Hayakawa, Motoki Takagi, Masahito, Takayuki Doi, and Kazuo Shin-ya,* Tetrahedron Lett. 2015, 56(39), 5333－5336.
• Total synthesis of cyclodepsipeptide spiruchostatin A on silyl-linked polymer-support, Masahito Yoshida, Ken-ichi Sasahara, and Takayuki Doi,* Tetrahedron 2015, 71(49), 7647－7653. [Selected by Synfacts]Synfacts 2015, 11(12), 1333.
• Study for diastereoselective aldol reaction in flow: synthesis of (E)-(S)-3-hydroxy-7-tritylthio-4-heptenoic acid, a key componet of cyclodepsipeptide HDAC inhibitors, Takayuki Doi,* Hiroyuki Otaka, Koji Umeda, Masahito Yoshida, Tetrahedron 2015,71(37), 6463－6470. [Professor Jiro Tsuji Special Issue]
• Asymmetric Palladium－Catalyzed Umpolung Cyclization of Allylic Acetate－Aldehyde using Formate as a Reductant, Hirokazu Tsukamoto,* Ayumu Kawase, and Takayuki Doi, Chem. Commun. 2015, 51, 8027－8030.
• Asymmetric Total Synthesis of ent-Pyripyropene A, Shinichiro Fuse,* Aayako Ikebe, Kazuya Oosumi, Tomoya Karasawa, Keisuke Matsumura, Miho Izumikawa, Kohei Johmoto, Hidehiro Uekusa, Kazuo Shin-ya, Takayuki Doi, and Takashi Takahashi,* Chem. Eur. J. 2015, 21(26), 9454－9460.
• Total Synthesis and Structure Determination of JBIR-108―A 2-Hydroxy-2-(1-hydroxyethyl)-2,3-dihydro-3(2H)-furanone Isolated from Streptomyces gramineus IR087Pi-4, Koichi Fujiwara, Hirokazu Tsukamoto, Miho Izumikawa, Takahiro Hosoya, Noritaka Kagaya, Motoki Takagi, Hideki Yamamura, Masayuki Hayakawa, Kazuo Shin-Ya,* and Takayuki Doi,* J. Org. Chem. 2015, 80(1), 114－132.
• Total Synthesis and Structure Elucidation of JBIR-39: A Linear Hexapeptide Possessing Piperazic Acid and γ-Hydroxypiperazic Acid Residues, Masahito Yoshida, Naoki Sekioka, Miho Izumikawa, Ikuko Kozone, Motoki Takagi, Kazuo Shin-ya, and Takayuki Doi,* Chem. Eur. J. 2015, 21(7), 3031－3041.
• An Efficient Synthesis of Aurone Derivatives by Tributylphosphine-Catalyzed Regioselective Cyclization of o-Alkynoylphenols, Koya Saito, Masahito Yoshida, and Takayuki Doi,* Chem. Lett. 2015, 44(2), 141－143.
• Synthesis and Biological Evaluation of C-Aromataxane Derivatives as P-Glycoprotein-Mediated Multi Drug Resistance Reversal Agents, Takayuki Doi,* Naoko Yamaguchi, Kosuke Ohsawa, Kazuoki Nakai, Masahito Yoshida, Kazuhiro Satake, Yuji Mitani, Hiroshi Nakagawa, Takashi Takahashi, and Toshihisa Ishikawa, Heterocycles, 2015, 90(1), 482－501.[Professor Isao Kuwajima Special Issue]
• Total Synthesis of Telomestatin and its Analogues, Takayuki Doi,* Masahito Yoshida, Kazuaki Shibata, J. Synth. Org. Chem. Jpn., 2015,73(1), 3－13.

• Total Synthesis and Biological Evaluation of PF1171A, C, F, and G, Cyclic hexapeptides with Insecticidal Activity, Yuichi Masuda, Ren Tanaka, Kenji Kai, A. Ganesan, and Takayuki Doi,* J. Org. Chem. 2014, 79(17), 7844－7853.

• Alternate Mode of Palladium-Catalyzed Alkynyliminium Ion Cyclizations Affording Stereodefined N-Alkyl-2-alkylidenepyrrolidines, Hirokazu Tsukamoto*, Mitsugu Shiraishi, and Takayuki Doi, Org. Lett. 2013, 15(23), 5932－5935.

• A Concise Synthesis of 3-Aroylflavones via Lewis Base 9-Azajulolidine－catalyzed Tandem Acyl Transfer－Cyclization, Masahito Yoshida, Koya Saito, Yuta Fujino, and Takayuki Doi,* Chem. Commun. 2012, 48, 11796-11798.

• Regioselective Synthesis of Flavone Derivatives via DMAP-catalyzed Cyclization of o-Alkynoylphenols, Masahito Yoshida, Yuta Fujino, Koya Saito, and Takayuki Doi, Tetrahedron, 2011, 67(51), 9993－9997. [Organic Synthesis -2011: Perspective, Journeys and Accounts, Part I, Edited by Gilbert Stork]

• Continuous-Flow Synthesis of Vitamin D3, Shinichiro Fuse, Nobutake Tanabe, Masahito Yoshida, Takayuki Doi, and Takashi Takahashi, Chem. Commun. 2010, 46(46), 8722－8724. inside front cover はhere

• An Efficient Synthesis of a Cyclic Ether Key Intermediate for 9-Membered Masked Enediyne Using an Automated Synthesizer, Yoshikazu Tanaka, Shinichiro Fuse, Hiroshi Tanaka, Takayuki Doi, and Takashi Takahashi, Org. Proc. Res. Devel. 2009, 13, 1111–1121.

• Palladium-Catalyzed Synthesis of 2-Substituted Benzothiazoles via a C-H Functionalization/Intramolecular C-S Bond Formation Process, Kiyofumi Inamoto, Chisa Hasegawa, Kou Hiroya, and Takayuki Doi, Org. Lett. 2008, 10(22), 5147–5150.