PUBLICATIONS

Genome mining-based discovery of an atypical fungal non-reducing polyketide synthase encoding dimeric alkylresorcinol biosynthesis.

Homma, Y.,# Hasegawa, T.,# Morishita, Y.,# Koremura, S., Sugawara, A., Ozaki, T., Asai, T.,*

J. Antibiot 2026,
doi.org/10.1038/s41429-025-00891-y.
Research articles
2026

4-Desmethyl 7-Prenyl Mollicellin Analogue Isolated from Chaetomium brasiliense.

Morita, S.,# Furumura, S.,# Morishita, Y., Ozaki, T., Fukano, H., Hoshino, H., Hirabayashi,A., Suzuki, M., Oshima, Y., Asai, T.,*

Chem. Pharm. Bull.2026, 74, 170-174.
doi.org/10.1248/cpb.c25-00729
Research articles
2026

Discovery of a fungal HR-PKS cluster encoding biosynthetic pathways for macrolides with two distinct ring sizes

Li, Y.,# Morishita, Y.,# Sugawara, A., Moussa, A. Y., Elissawy, A. M., Singab, A. N. B., Ozaki, T., Asai, T.*

Chem. Pharm. Bull. 2026, 74, 64-70.
doi.org/10.1248/cpb.c25-00638
Research articles
2026

Biosynthesis of Circumdatins Employs an Anthranilate Tailoring Pathway for NRPS Substrate Supplies

Sato, Y., Morishita, Y., Homma, Y., Sugawara, A., Moussa, A. Y., Elissawy, A. M., Singab, A. N. B., Ozaki, T., Asai, T.*

Org. Lett. 2025, 27, 7170?7175.
doi.org/10.1021/acs.orglett.5c02131
Research articles
2025

Discovery and Theoretical Studies of Nonenzymatic Polyketide Dimerizations of Chaetophenols

Matsui, H., Morishita, Y., Yamamoto, T., Ozaki, T., Sugawara, A., Masumoto, Y., Watanabe, M., Watanabe, A., Sato, H., Kanazawa, J., Taniguchi, T., Uchiyama, M.,* Asai, T.*

Org. Lett. 2025, 27, 1095-1099.
doi.org/10.1021/acs.orglett.4c04346
Research articles
2025

Overexpression of the RNA-binding protein NrdA affects global gene expression and secondary metabolism in Aspergillus species

Kadooka, C., Izumitsu, K., Asai, T., Hiramatsu, K., Mori, K., Okutsu, K., Yoshizaki, Y., Takamine, K., Goto, M., Tamaki, H., Futagami, T.*

mSphere.2025, Feb 25;10(2):e0084924.
doi: 10.1128/msphere.00849-24
Research articles
2025

Vinigrol Tricyclic Scaffold Biosynthesis Employs an Atypical Terpene Cyclase and a Multipotent Cyclization Cascade

Tsukada, K., Sato, F., Matsuyama, T., Matsuda, R., Ozaki, T.,* Morishita, Y., Furumura, S., Homma, Y., Sekiya, H., Sugawara, A., Kubota, M., Mitsuhashi, T., Yasuno, Y., Shinada, T., Nagata, R., Kuzuyama, T., Taniguchi, T., Fujita, M., Uchiyama, M.,* Asai, T.*

J. Am. Chem. Soc. 2025, 147, 45168-45177.
doi/10.1021/jacs.5c14400
Research articles
2025

A new 3,6-dialkyl-α-pyrone produced by the heterologous expression of a PKS-NRPS hybrid enzyme derived from a?Pestalotiopsis?endophyte

Shi, Y., Ozaki, T., Sugawara, A., Morishita, Y., Tang, Y. P., Shivas, R. G., Davis, R. A., Asai, T.*

Tetrahedron Lett. 2024, 134, 154865?154867.
doi.org/10.1016/j.tetlet.2023.154865
Research articles
2024

Semi-synthesis of a DNA-Tagged Polyketide-Peptide Hybrid Macrocycle Using a Biosynthetically Prepared Fungal Macrolide as a Synthetic Component Arthrinium sacchari

Koremura, S., Sugawara, A., Morishita, Y., Ozaki, T., Asai, T.* (Koremura, Sugawara and Morishita are contributed equally.)

Org. Lett. 2024, 26,?9151-9156.
doi.org/10.1021/acs.orglett.4c03588
Research articles
2024

Genome mining of labdane-related diterpenoids: Discovery of the two-enzyme pathway leading to (-)-sandaracopimaradiene in the fungus Arthrinium sacchari

Sato, F., Sonohara, T., Fujiki, S., Sugawara, A., Morishita, Y., Ozaki, T.,* Asai, T.*

Beilstein J. Org. Chem. 2024, 20, 714-720.
doi.org/10.3762/bjoc.20.65
Research articles
2024

合成生物学を基盤とする天然物の探索研究

浅井禎吾

実験医学 Vol. 41 No. 3 (2月号) 2023 “いま知りたい” 長鎖DNA合成 ─ゲノムは読む時代から書く時代へ
Books and Reviews
2023

Synthetic Biology-Based Natural Product Discovery

Teigo Asai

New Tide of Natural Product Chemistry Springer, 3-16 (2023)
Books and Reviews
2023

合成生物学を基盤とする天然物の探索と創製研究

浅井禎吾

科学と工業 (Science and Industry) 巻: 97 号: 11 ページ: 340-345 発行年: 2023年11月20日
Books and Reviews
2023

糸状菌の遺伝子情報を活用する天然物ケミカルスペースの開拓

浅井禎吾

月間ファインケミカル 特集 ポストゲノム時代の天然物化学ーゲノム情報に基づいた天然物の探索と合成ー Vol 50, No. 4 (2021)
Books and Reviews
2021

Chemical Activation of Natural Product Biosynthesis in Filamentous Fungi

Teigo Asai

Comprehensive Natural Products III: Chemistry and Biology, Vol. 7, Elsevier, 475-486 (2020).
Books and Reviews
2020

微生物に「天然にはない天然物」をつくらせる

現代化学 FLASH 2020年 8月号
Books and Reviews
2020

微生物の可能性を開拓する−多様な新奇化合物合成のための新しいアプローチ−

浅井禎吾,大島吉輝

現代化学 「解説」, 2016, 9, 21-26
Books and Reviews
2016

エピジェネティック制御を利用する新規医薬資源の開拓

浅井禎吾,大島吉輝

生化学 「みにれびゅー」, 2016, 88, 643-648
Books and Reviews
2016

糸状菌二次代謝のエピジェネティック制御と天然物探索

浅井禎吾, 大島吉輝

化学と生物, 2013, 1, 13-21.
Books and Reviews

ケミカルエピジェネティクスによる未利用生合成遺伝子の活用と多様な天然物の創出

浅井禎吾,大島吉輝

ファルマシア「最前線」2014, 50, 112-116
Books and Reviews
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