最先端の合成テクノロジーに立脚した自在な構造展開を可能にする創薬拠点

研究成果

Enantioselective total synthesis of sacrolide A
T. Mohri, Y. Ogura, R. Towada, S. Kuwahara
Tetrahedron Lett., 58, 4011-4013 (2017)

Stereoselective synthesis of beta-amino acid derivatives by asymmetric Mannich reaction in flow
M. Yoshida, K. Umeda, T. Doi
Bull. Chem. Soc. Jpn., 90, 1157-1163 (2017)

Conformation-based design and synthesis of apratoxin A mimetics modified at the alfa,beta-unsaturated thiazoline moiety
Y. Onda, Y. Masuda, M. Yoshida, T. Doi
J. Med. Chem., 60, 6751-6765 (2017)

Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6
R. Taniguchi, A. Inoue, M. Sayama, A. Uwamizu, K. Yamashita, K. Hirata, M. Yoshida,
Y. Tanaka, H. Kato, Y. Nakada-Nakura, Y. Otani, T. Nishizawa, T. Doi, T. Ohwada, R. Ishitani, J. Aoki, O. Nureki
Nature, 548, 356-360 (2017)

NaOPh Mediated Hydroxymethylation of Alkynylsilanes with N-((Trimethylsilyloxy)methyl)phthalimide
N. Asano, K. Sasaki, I. Chataigner, M. Shigeno, Y. Kondo
Eur. J. Org. Chem., Just Accepted.

Deprotonative Silylation of Aromatic C−H Bonds Mediated by a Combination of Tßrifluoromethyltrialkylsilane and Fluoride
K. Nozawa-Kumada, S. Osawa, M. Sasaki, I. Chataigner, M. Shigeno, Y. Kondo
J. Org. Chem., 82, 9487–9496 (2017)

Nazarov Cyclization Entry to Chiral Bicyclo[5.3.0]decanoid Building Blocks and Its Application to Formal Synthesis of (–)-Englerin A
K. Morisaki, Y. Sasano, T. Koseki, T. Shibuta, N. Kanoh, W.H. Chiou, Y. Iwabuchi
Org. Lett., 19 (19), 5142–5145 (2017)

A Mild Two-Step Propargylation of Aromatic Bioactive Small Molecules
N. Kanoh, T. Okamura, T. Suzuki, Y. Iwabuchi
Org. Biomol. Chem., 15, 7190-7195 (2017)

AgNTf2-Mediated Allylation with Allylsilanes at C3a-Position of Hexahydropyrroloindoles: Application to Total Syntheses of Amauromine Alkaloids
H. Hakamata, S. Sato, H. Ueda, H. Tokuyama
Org. Lett., 19, 5308–5311 (2017)

AgNTf2-Mediated Arylation of Bromopyrroloindolines
S. Sato, A. Hirayama, T. Adachi, D. Kawauchi, H. Ueda, H. Tokuyama
Heterocycles, 94, 1940-1957 (2017)

Isolation, Synthsis, and Biological Activity of Chlorinated Alkylresorcinols from Dictyostelium Cellular Slime Molds
H. Kikuchi, I. Ito, K. Takahashi, H. Ishigaki, K. Iizumi, Y. Kubohara, Y. Oshima,
J. Nat. Prod., 80, 2716-2722 (2017)

Production of Novel Bispyrone Metabolites in the Cellular Slime Mold Dictyostelium giganteum Induced by Zinc(II) Ion
V. H. Nguyen, H.Kikuchi, H. Sasaki, K. Iizumi, Y. Kubohara, Y. Oshima
Tetrahedron, 73, 583-588 (2017)

Synthesis of Unsymmetric HetAr–X–HetAr’ Compounds by Rhodium-Catalyzed Heteroaryl Exchange Reactions
M. Arisawa, S. Tanii, T. Tazawa, M. Yamaguchi
Heterocycles, in press (2017)

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