スタッフ

助教
山越　博幸Hiroyuki Yamakoshi

履歴

受賞

リンク先

原著論文

1. Design, synthesis, and biological evaluation of water-soluble prodrugs of C5-curcuminoid GO-Y030 based on reversible thia-Michael reaction H. Yamakoshi,* Michihiro Fukuda, Hiro Ikeda, Shogo Fujiki, Aki Kohyama, Shota Nagasawa, Hanae Shinozaki, Hiroyuki Shibata, Yoshiharu Iwabuchi* Chem. Pharm. Bull. accepted.(査読有)
2. Ratiometric analysis of reversible thia-Michael reactions using nitrile-tagged molecules by Raman microscopy H. Yamakoshi,* D. Shibata, K. Bando, S. Kajimoto, A. Kohyama, S. Egoshi, K. Dodo, Y. Iwabuchi, M. Sodeoka, K. Fujita, T. Nakabayashi Chem. Commun. 2023, 59, 14563-14566 (査読有)
3. Multiple deuteration of triphenylphosphine and live-cell Raman imaging of deuterium-incorporated Mito-Q S. Moriyama, M. Mae, D. Shibata, H. Yamakoshi, S. Kajimoto, T. Nakabayashi, T. Ishimoto, K. Mogi, H. Sajiki, S. Akai, Y. Sawama Chem. Commun. 2023, 59, 12100-12103 (査読有)
4. LiHMDS-mediated deprotonative coupling of toluenes with ketone.
   M. Shigeno, A. Kajima, E. Toyama, T. Korenaga, H. Yamakoshi, K. Nozawa-Kumada, Y. Kondo,
   Chem. Eur. J. 2023, e202203549(査読有)
5. Stereoselective synthesis of the DE ring portion of kadcoccilactone A by a radical addition/cyclization approach
   K. Noguchi, S. Saito, H. Yamakoshi, S. Nakamura
   Eur. J. Org. Chem. 2022, e202201201(査読有)
6. Direct C-H carboxylation forming polyfunctionalized aromatic carboxylic acids by combined Bronsted bases.
   M. Shigeno, K. Hanasaka, I. Tohara, K. Izumi, H. Yamakoshi, E. Kwon, K. Nozawa- Kumada, Y. Kondo,
   Org. Lett. 2022, 24, 809-814 (査読有)
7. Stereoselective 1,4-addition of primary alcohols to γ-alkoxy-α,β-unsaturated esters.
   S. Inatomi, Y. Takayanagi, K. Watanabe, A. Toita, H. Yamakoshi, S. Nakamura,
   Synthesis 2021, 53, 161-174 (査読有)
8. Quantitative drug dynamics visualized by alkyne-tagged plasmonic-enhanced Raman microscopy.
   K. Koike, K. Bando, J. Ando, H. Yamakoshi, N. Terayama, K. Dodo, N. I. Smith, M. Sodeoka, K. Fujita,
   ACS Nano 2020, 14, 15032-15041 (査読有)
9. Total syntheses of marrubiin and related labdane diterpene lactones.
   Y. Sakagami, N. Kondo, Y. Sawayama, H. Yamakoshi, S. Nakamura,
   Molecules 2020, 25, 1610 (査読有)
10. Second-generation synthesis of a chiral building block for oxygenated terpenoids via a ring-contractive coupling with a secondary alcohol.
    S. Saito, H. Yamakoshi, S. Nakamura,
    Heterocycles 2019, 99, 1086-1094 (査読有)
11. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model.
    N. Tsuburaya, K. Homma, T. Higuchi, A. Balia, H. Yamakoshi, N. Shibata, S. Nakamura, H. Nakagawa, S. Ikeda, N. Umezawa, N. Kato, S. Yokoshima, M. Shibuya, M. Shimonishi, H. Kojima, T. Okabe, T. Nagano, I. Naguro, K. Imamura, H. Inoue, T. Fujisawa, H. Ichijo,
    Nat. Commun. 2018, 9, 2668 (査読有)
12. Tandem oxidation/cyclization reaction of 4-(arylmethyl)oxy-2-diazobutyrate derivatives.
    H. Kondo, S. Nagano, H. Yamakoshi, S. Nakamura,
    Heterocycles 2018, 97, 894-915 (査読有)
13. The alkyne-tag Raman imaging of coronatine, a plant pathogen virulence factor, in Commelina communis and the possible mode of action.
    M. Ueda, K. Hayashi, S. Egoshi, Y. Ishimaru, Y. Takaoka, H. Yamakoshi, K. Dodo, M. Sodeoka,
    Org. Biomol. Chem. 2018, 16, 3348-3352 (査読有)
14. Cyclization of α-diazo esters triggered by oxidation: A facile preparation of 5-aryl-2,3-dihydrofuran-4-carboxylates.
    H. Kondo, H. Yamakoshi, A. Kimura, S. Nakamura,
    ChemistrySelect 2017, 2, 5646-5649 (査読有)
15. Non-canonical function of a small-molecular virulence factor coronatine against plant immunity: An In vivo Raman imaging approach.
    M. Ueda, S. Egoshi, K. Dodo, Y. Ishimaru, H. Yamakoshi, T. Nakano, Y. Takaoka, S. Tsukiji, M. Sodeoka,
    ACS Cent. Sci. 2017, 3, 462-472 (査読有)
16. A double hemiketal formation/hetero-Michael addition approach to the [6,5,5]-dispiroketal system of spirolides.
    H. Yamakoshi, A. Toita, T. Igari, K. Takeda, S. Hashimoto, S. Nakamura,
    Heterocycles 2017, 95, 934-949 (査読有)
17. Reversibility of thia-Michael reaction of the cytotoxic C5-curcuminoid and structure-activity relationship of the bis-thiol-adducts thereof.
    A. Kohyama, M. Fukuda, S. Sugiyama, H. Yamakoshi, N. Kanoh, C. Ishioka, H. Shibata, Y. Iwabuchi,
    Org. Biomol. Chem. 2016, 14, 10683-10687 (査読有)
18. Alkyne-tag SERS screening and identification of small-molecule-binding sites in protein.
    J. Ando, M. Asanuma, K. Dodo, H. Yamakoshi, S. Kawata, K. Fujita, M. Sodeoka,
    J. Am. Chem. Soc. 2016, 138, 13901-13910 (査読有)
19. Total Syntheses of (+)-Marrubiin and (?)-Marrulibacetal.
    H. Yamakoshi, Y. Sawayama, Y. Akahori, M. Kato, S. Nakamura,
    Org. Lett. 2016, 18, 3430-3433 (査読有)
20. A diarylpentanoid curcumin analog exhibits improved radioprotective potential in the intestinal mucosa.
    K. Fukuda, Y. Uehara, E. Nakata, M. Inoue, K. Shimazu, T. Yoshida, H. Kanda, H. Nanjo, Y. Hosoi, H. Yamakoshi, Y. Iwabuchi, H. Shibata,
    Int. J. Radiat. Biol. 2016, 92, 388-394 (査読有)
21. Dual function of coronatine as a bacterial virulence factor against plant: possible COI1-JAZ-independent role.
    S. Egoshi, Y. Takaoka, H. Saito, Y. Nukadzuka, K. Hayashi, Y. Ishimaru, H. Yamakoshi, K. Dodo, M. Sodeoka, M. Ueda,
    RSC Advances 2016, 6, 19404-19412 (査読有)
22. A curcumin analog, GO-Y078, effectively inhibits angiogenesis through actin disorganization.
    S. Sugiyama, Y. Yoshino, S. Kuriyama, M. Inoue, K. Komine, K. Otsuka, A. Kohyama, H. Yamakoshi, C. Ishioka, M. Tanaka, Y. Iwabuchi, H. Shibata,
    Anti-Cancer Agents Med. Chem. 2016, 16, 633-647 (査読有)
23. Construction of bridged polycyclic systems by polyene cyclization.
    K. Suzuki, H. Yamakoshi, S. Nakamura,
    Chem. Eur. J. 2015, 21, 17605-17609 (査読有)
24. Structure-activity relationship of antitumor C5-curcuminoid GO-Y030.
    A. Kohyama, H. Yamakoshi, S. Hongo, N. Kanoh, H. Shibata, Y. Iwabuchi,
    Molecules 2015, 20, 15374-15391 (査読有)
25. Novel Raman-tagged sphingomyelin that closely mimics original raft-forming behavior.
    J. Cui, S. Matsuoka, M. Kinoshita, N. Matsumori, F. Sato, M. Murata, J. Ando, H. Yamakoshi, K. Dodo, M. Sodeoka,
    Bioorg. Med. Chem. 2015, 23, 2989-2994 (査読有)
26. Sphingomyelin distribution in lipid rafts of artificial monolayer membranes visualized by Raman microscopy.
    J. Ando, M. Kinoshita, J. Cui, H. Yamakoshi, K. Dodo, K. Fujita, M. Murata, M. Sodeoka,
    Proc. Natl. Acad. Sci. USA, 2015, 112, 4558-4563 (査読有)
27. A sensitive and specific Raman probe based on bisarylbutadiyne for live cell imaging of mitochondria.
    H. Yamakoshi, A. Palonpon, K. Dodo, J. Ando, S. Kawata, K. Fujita, M. Sodeoka,
    Bioorg. Med. Chem. Lett. 2015, 25, 664-667 (査読有)
28. Inhibition of β-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivo.
    Y. Uehara, M. Inoue, K. Fukuda, H. Yamakoshi, Y. Hosoi, H. Kanda, M. Oshima, Y. Iwabuchi, H. Shibata,
    Gastric Cancer, 2015, 18, 774-783 (査読有)
29. Strong inhibitory effects of curcumin and its demethoxy analog on Escherichia coli ATP synthase F1 sector.
    M. Sekiya, E. Chiba, M. Satoh, H. Yamakoshi, Y. Iwabuchi, M. Futai, M. Nakanishi-Matsui,
    Int. J. Biol. Macromol. 2014, 70, 241-245 (査読有)
30. Stereoselective synthesis of the CDE ring system of antitumor saponin scillascilloside E-1.
    Y. Akahori, H. Yamakoshi, S. Hashimoto, S. Nakamura,
    Org. Lett. 2014, 16, 2054-2057 (査読有)
31. Synthesis of chiral building blocks for oxygenated terpenoids through a simultaneous and stereocontrolled construction of contiguous quaternary stereocenters by an Ireland-Claisen rearrangement.
    Y. Akahori, H. Yamakoshi, Y. Sawayama, S. Hashimoto, S. Nakamura,
    J. Org. Chem. 2014, 79, 720-735 (査読有)
32. Simultaneous imaging of protonated and deprotonated carbonylcyanide p-trifluoromethoxyphenylhydrazone in live cells by Raman microscopy.
    H. Yamakoshi, A. F. Palonpon, K. Dodo, J. Ando, S. Kawata, K. Fujita, M. Sodeoka,
    Chem. Commun. 2014, 50, 1341-1343 (査読有)
33. Raman/SERS microscopy for molecular imaging of live cells.
    A. F. Palonpon, J. Ando, H. Yamakoshi, K. Dodo, M. Sodeoka, S. Kawata, K. Fujita,
    Nat. Protoc. 2013, 8, 677-692 (査読有)
34. Alkyne-tag Raman imaging for visualization of mobile small molecules in live cells.
    H. Yamakoshi, K. Dodo, A. Palonpon, J. Ando, K. Fujita, S. Kawata, M. Sodeoka,
    J. Am. Chem. Soc. 2012, 134, 20681-20689 (査読有)
35. Imaging of EdU, an alkyne-tagged cell proliferation probe, by Raman microscopy.
    H. Yamakoshi, K. Dodo, M. Okada, J. Ando, A. Palonpon, K. Fujita, S. Kawata, M. Sodeoka,
    J. Am. Chem. Soc. 2011, 133, 6102-6105 (査読有)
36. Synthesis of 86 species of 1,5-diaryl-3-oxo-1,4-pentadienes analogs of curcumin can yield a good lead in vivo.
    C. Kudo, H. Yamakoshi, A. Sato, H. Nanjo, H. Ohori, C. Ishioka, Y. Iwabuchi, H. Shibata,
    BMC Pharmacol. 2011, 11, 4 (査読有)
37. Novel curcumin analogs, GO-Y030 and GO-Y078, are multi-targeted agents with enhanced abilities for multiple myeloma.
    C. Kudo, H. Yamakoshi, A. Sato, H. Ohori, C. Ishioka, Y. Iwabuchi, H. Shibata,
    Anticancer Res. 2011, 31, 3719-3726 (査読有)
38. Curcumin analog GO-Y030 is a novel inhibitor of IKKβ that suppresses NF-κB signaling and induces apoptosis.
    A. Sato, C. Kudo, H. Yamakoshi, Y. Uehara, H. Ohori, C. Ishioka, Y. Iwabuchi, H. Shibata,
    Cancer Sci. 2011, 102, 1045-1051 (査読有)
39. High-performance liquid chromatography with photodiode array detection for determi-nation of nobiletin content in the brain and serum of mice administrated the natural compound.
    D. Saigusa, M. Shibuya, D. Jinno, H. Yamakoshi, Y. Iwabuchi, A. Yokosuka, Y. Mimaki, A. Naganuma, Y. Ohizumi, Y. Tomioka, T. Yamakuni,
    Anal. Bioanal. Chem. 2011, 400, 3635-3641 (査読有)
40. KSRP/FUBP2 is a binding protein of GO-Y086, a cytotoxic curcumin analogue.
    H. Yamakoshi, N. Kanoh, C. Kudo, A. Sato, K. Ueda, M. Muroi, S. Kon, M. Satake, H. Ohori, C. Ishioka, Y. Oshima, H. Osada, N. Chiba, H. Shibata, Y. Iwabuchi,
    ACS Med. Chem. Lett. 2010, 1, 273-276 (査読有)
41. Total synthesis and determination of the absolute configuration of (-)-idesolide.
    H. Yamakoshi, M. Shibuya, M. Tomizawa, Y. Osada, N. Kanoh, Y. Iwabuchi,
    Org. Lett. 2010, 12, 980-983 (査読有)
42. Structure?activity relationship of C5-curcuminoids and synthesis of their molecular probes thereof.
    H. Yamakoshi, H. Ohori, C. Kudo, A. Sato, N. Kanoh, C. Ishioka, H. Shibata, Y. Iwabuchi,
    Bioorg. Med. Chem. 2010, 18, 1083-1092 (査読有)
43. Syntheses of naturally occurring cytotoxic [7.7]paracyclophanes, (-)-cylindrocyclophane A and its enantiomer, and implications for biological activity.
    H. Yamakoshi, F. Ikarashi, M. Minami, M. Shibuya, T. Sugahara, N. Kanoh, H. Ohori, H. Shibata, Y. Iwabuchi,
    Org. Biomol. Chem. 2009, 7, 3772-3781 (査読有)
44. Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas.
    B. Hutzen, L. Friedman, M. Sobo, L. Lin, L. Cen, S. De Angelis, H. Yamakoshi, H. Shibata, Y. Iwabuchi, J. Lin,
    Int. J. Oncol. 2009, 35, 867-872 (査読有)
45. (40) 4’-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade. M. Al Rahim, A. Nakajima, D. Saigusa, N. Tetsu, Y. Maruyama, M. Shibuya, H. Yamakoshi, Y. Tomioka, Y. Iwabuchi, Y. Ohizumi, T. Yamakuni, Biochemistry 2009, 48, 7713-7721 (査読有)
46. Newly synthesized curcumin analog has improved potential to prevent colorectal carcinogenesis in vivo.
    H. Shibata, H. Yamakoshi, A. Sato, H. Ohori, Y. Kakudo, C. Kudo, Y. Takahashi, M. Watanabe, H. Takano, C. Ishioka, T. Noda, Y. Iwabuchi,
    Cancer Sci. 2009, 100, 956-960 (査読有)
47. Distribution of photo-cross-linked products from 3-aryl-3-trifluoromethyldiazirines and alcohols.
    N. Kanoh, T. Nakamura, K. Honda, H. Yamakoshi, Y. Iwabuchi, H. Osada,
    Tetrahedron 2008, 64, 5692-5698 (査読有)
48. Synthesis and biological analysis new curcumin analogues bearing an enhanced potential for the medicinal treatment of cancer.
    H. Ohori, H. Yamakoshi, M. Tomizawa, M. Shibuya, Y. Kakudo, A. Takahashi, S. Takahashi, S. Kato, T. Suzuki, C. Ishioka, Y. Iwabuchi, H. Shibata,
    Mol. Cancer Ther. 2006, 5, 2563?-2571 (査読有)

会議発表論文

1. Surface-enhanced Raman scattering (SERS) imaging of alkyne-tagged small molecule drug in live cells with endocytosed gold nanoparticles.
   J. Ando, T. Sekiya, D. Ka, H. Yamakoshi, K. Dodo, M. Sodeoka, S. Kawata, K. Fujita,
   Proceedings of SPIE 2017, 10046-4.
2. Alkyne-tag Raman imaging of bio-active small molecules in live cells.
   J. Ando, Almar F. Palonpon, H. Yamakoshi, K. Dodo, S. Kawata, M. Sodeoka, K. Fujita,
   Proceedings of SPIE, Biophotonics Japan 2015, 9792, 979207.
3. Raman spectroscopic detection of bio-active small molecules using alkyne tag.
   J. Ando, A. F. Palonpon, H. Yamakoshi, K. Dodo, S. Kawata, M. Sodeoka, K. Fujita,
   IEEE Proceedings (CPMT Symposium Japan 2015), 2015, 7357369, 93-96.
4. Watching bioactive small molecules in live cells by alkyne-tag Raman imaging.
   A. Palonpon, H. Yamakoshi, K. Dodo, J. Ando, S. Kawata. K. Fujita, M. Sodeoka,
   JSAP-OSA Joint Symposia 2013, 19p_D4_5.
5. Raman imaging of alkyne as a small tag for biological molecules.
   K. Fujita, H. Yamakoshi, K. Dodo, A. Palonpon, M. Okada, J. Ando, S. Kawata, M. Sodeoka,
   Proceedings of SPIE 2012, 8225, 822515-822515-4.
6. Slit-scanning Confocal Raman Microscopy: Practical Applications in Live Cell Imaging.
   A. Palonpon, M. Okada, J. Ando, H. Yamakoshi, K. Dodo, M. Sodeoka, S. Kawata, K. Fujita,
   Conference on Laser and Electro-Optics/Pacific Rim 2011, 86-88.
7. Synthesis of an enantiomeric DNA oligomer and its T-HgII-T base-pair formation.
   K. Haruta, Y. Tanaka, T. Kawamura, Y. Kondo, A. Ono, H. Yamakoshi, N. Kanoh, Y. Iwabuchi,
   Nucleic Acids Symp. Ser. 2007, 51, 187-188.

著書、総説など

1. Raman imaging and screening of bioactive small molecules H. Yamakoshi, J. Ando, S. Egoshi, K. Dodo, M. Sodeoka, K. Fujita Raman Spectroscopy in Human Health and Biomedicine 1st Edition; H. Sato, J. Popp, B. R. Wood, Y. Ozeki; World Scientific; 2023; pp 271-298.
2. Mono-carbonyl curcumin analogs for cancer therapy T. Maruyama, H. Yamakoshi, Y. Iwabuchi, H. Shibata Biol. Pharm. Bull. 2023, 46, 756-763.
3. スペクトル解析によるバイオ・ラマンデータ化学種の成分分離に向けて 何 建海、山越 博幸、盛田 伸一 細胞 2022, 54, 774-777.
4. ラマン顕微鏡を用いた低分子化合物の生細胞解析
   山越 博幸、江越 脩祐、闐闐 孝介、袖岡 幹子、藤田 克昌
   技術情報協会 ラマン分光スペクトルデータ解析事例集 第11章 第4節 2022, 366-372.
5. Spontaneous Raman and SERS microscopy for Raman tag imaging.
   H. Yamakoshi, K. Fujita,
   Stimulated Raman Scattering Microscopy Techniques and Applications 1st Edition; J.-X. Cheng, W. Min, Y. Ozeki, D. Polli; Elsevier; 2021; pp 275-287.
6. 新規骨格構築法を基盤とする縮環生物活性天然物の合成研究、
   山越 博幸
   薬学雑誌, 2021, 141, 1087?1094.
7. 新規キラル合成ブロックの創製を基盤とする生物活性テルペノイドの合成研究、
   山越 博幸、中村 精一、
   シーエムシー出版 月刊ファインケミカル 2020, 49, 5?11.
8. アルキンが拓く低分子化合物の生細胞イメージング、
   山越 博幸、
   共立出版 化学の要点シリーズ18 基礎から学ぶケミカルバイオロジー コラム9 2016, 130-131.
9. マスターキーでアクセス　アクアミリンアルカロイドの不斉全合成、
   山越 博幸、
   化学同人 化学 2016, 71, 62-63.
10. アルキンタグラマンイメージングを利用した低分子化合物の生細胞観察、
    山越 博幸、
    日本化学会生体機能関連科学部会ニュースレター 2015, 30, 10?13.
11. アルキン標識を用いた低分子化合物のラマンイメージング、
    山越 博幸、闐闐 孝介、安藤 潤、藤田 克昌、袖岡 幹子、
    実験医学 増刊号 2012, 30, 1220-1226.
12. Live cell imaging of EdU, a DNA synthesis probe, by Raman microscopy,
    H. Yamakoshi, K. Dodo, A. Palonpon, M. Okada, J. Ando, K. Fujita, S. Kawata, M. Sodeoka,
    日本ケミカルバイオロジー学会機関誌 Chemical Biology 2011, 4, 2-5.
13. Construction of Fluorinated Chiral Center,
    H. Yamakoshi,
    Journal of Synthetic Organic Chemistry, Japan (Yuki Gosei Kagaku Kyoukaishi), 2010, 68, 962-963.
14. 超効率的な不斉メタセシス触媒の開発、
    H. Yamakoshi,
    The Pharmaceutical Society of Japan (FARUMASHIA) 2009, 45, 812-813.

特許

1. 発明の名称: PROTAC化合物
   発明者: 岩渕 好治、平澤 典保、山越 博幸、瀬川 良佑
   出願番号（出願日）: 特願2023-140474（2023.08.30）
2. 発明の名称: 医薬化合物及びこれを用いたウイルス感染症治療薬、緩和用、又は予防用医薬組成物
   発明者: 柴田 浩行、島津和弘、林豪士、丸山貴司、岩渕 好治、山越 博幸
   出願番号（出願日）: 特願2023-032880（2023.03.03）
3. 発明の名称: Antiprotozoal agents containing curcumin analogs （寄生虫症の治療または予防効果を有するクルクミン誘導体）
   発明者: 柴田 浩行、岩渕 好治、山越 博幸、天野 優子、佐藤 謙一、
   公開番号（出願日）: JP2010248119/A（日本国出願日2010.11.04）
4. 発明の名称:Bis(arylmethylidene)acetone compound, anti-cancer agent,
   carcinogenesis-preventive agent, inhibitor of expression of ki-ras, erbb2, c-myc and cycline d1, β-catenin-degrading agent, and p53 expression enhancer （ビス（アリールメチリデン）アセトン化合物、Ki-Ras、ErbB2、c-Myc、及びCyclinD1の発現抑制剤、β-カテニン分解剤並びにp53の発現増強剤）、
   発明者: 柴田 浩行、岩渕 好治、大堀 久詔、山越 博幸、角道 祐一、
   公開番号（出願日）: WO2007000998（国際出願日2006.06.27）、
   特許番号（登録日）:特許第5050206号（2012.08.03）

招待講演、受賞講演など

1. 抗腫瘍活性クルクミンアナログの標的探索を出発点とする創薬化学研究
   山越 博幸
   袖岡有機合成化学研究室シンポジウム第15回有機合成化学のフロンティア
   2023.11.25（理化学研究所和光地区）
   
2. クルクミンを起点とする創薬化学研究ならびに生細胞解析手法の開発
   山越 博幸
   日本薬学会東北支部第21回化学系若手研究者セミナー
   2023.9.2（東北大学青葉山北キャンパス）
3. Live cell analysis of the intracellular distribution of bioactive small molecules with Raman-tags
   Hiroyuki Yamakoshi
   Asian Symposium on Pharmaceutical Sciences for the Next Generation
   2023.3.28（Hokkaido Univ, Japan）
4. 新規骨格構築法を基盤とする縮環生物活性天然物の合成研究、
   山越 博幸、
   日本薬学会東海支部特別講演会 2020年度東海支部学術奨励賞受賞講演
   2020.9.26（名城大学八事キャンパス）
5. 縮環骨格を持つ薬理活性天然物の合成研究、
   山越 博幸、
   東北大学大学院薬学研究科　第544回薬学研究科セミナー、
   2018.12.10（東北大学青葉山キャンパス）
6. 小さな標識が拓く低分子化合物のラマンイメージング、
   山越 博幸、
   第13回若手イブニングセミナー、
   2018.7.25（名古屋市立大学桜山キャンパス）
7. ラマンタグを用いた低分子化合物の生細胞イメージング、
   山越 博幸、
   理研シンポジウム：最先端光計測とライフサイエンスの近未来?バイオラマン2017-[4]、
   2014.5.1（東北大学片平キャンパス）
8. 生きた細胞中で低分子化合物を観察する手法：アルキンタグラマンイメージングの開発、
   山越 博幸、
   第140回薬学談話会、
   2013.10.30（名古屋市立大学田辺通キャンパス）
9. 低分子化合物のアルキンタグラマンイメージング、
   山越 博幸、-- 孝介、Palonpon Almar、安藤 潤、岡田 昌也、藤田 克昌、河田聡、袖岡 幹子、
   理研シンポジウム：最先端光計測とライフサイエンスの近未来-バイオラマン2017-[2]、
   2012.10.27（理化学研究所 和光）
10. あるがままの生物活性化合物を理解するために、
    山越 博幸、
    有機合成化学を基盤とする未来型創薬を考えるシンポジウム、
    2012.7.13（ラフォーレ蔵王）