- 2021-06-29【Press Release】
In various neurodegenerative diseases, agglomerates of degenerative proteins commonly accumulate in nerve cells, causing nerve cell death. Professor Emeritus Koji Fukunaga and Associate Professor Ichiro Kawahata of Tohoku University Graduate School of Pharmaceutical Sciences have developed a low-molecular-weight compound SAK3, which enhances cognitive function by increasing the release of the neurotransmitter acetylcholine (ACh) involved in memory formation. We reported improvements in 2017. We have now discovered that SAK3 activates the proteasome, a device that degrades denatured proteins, to remove denatured proteins in nerve cells. Furthermore, we elucidated the mechanism by which SAK3 activates the proteasome of nerve cells and promotes the degradation of denatured proteins. The results of this research will promote the degradation of denatured proteins such as amyloid beta protein, sinucrane, huntingtin, and tau protein, which cause neurodegenerative diseases, and prevent nerve cell death. Please refer to the following site for details.
For details http://www.pharm.tohoku.ac.jp/file/information/20210629.pdf
For details http://www.qlifepro.com/news/20210630/alz-sak3.html
- 2021-03-24【Press Release】
The involvement of "phase-separating proteins" that separate liquid-liquid phases has become clear in neurodegenerative diseases such as dementia and Alzheimer's disease. Liquid-liquid phase separation is a phenomenon in which a dense liquid phase of proteins is formed in a liquid phase in which proteins are dispersed at a low concentration. Temporary clustering of proteins enables highly efficient chemical reactions, but at the same time risks the formation of insoluble aggregates that cause disease. Associate Professor Kiyoto Kamagata of Tohoku University Institute of Multidisciplinary Materials Science, Associate Professor Ichiro Kawabata of Tohoku University Graduate School of Pharmaceutical Sciences, Professor Koji Fukunaga, Associate Professor Keisuke Ikeda of Pharmaceutical and Japanese-Chinese Studies, Tohoku University, and Industrial Technology Research Institute A research group led by Associate Professor Tomofumi Kameda of the Artificial Intelligence Research Center searched for amino acids that can control liquid-liquid phase separation as an efficient search method for peptides that control phase-separated proteins. We devised a method for designing peptides containing. This method has also succeeded in controlling the liquid-liquid phase separation of the protein FUS, which is involved in neurodegenerative diseases, and the formation of solid aggregates. In the future, it is expected to be applied to drug discovery targeting phase-separated proteins involved in diseases.
- 2021-03-19【Professor Kohji Fukunaga, Final Lecture】
Professor Koji Fukunaga gave a final lecture in honor of his many years of achievements in pharmacology research at Tohoku University. Professor Koji Fukunaga will be an emeritus professor from April. Please see the video from the Graduate School of Pharmaceutical Sciences page.
- 2021-03-09【Professor Kohji Fukunaga, Honorary Member】
At the 94th Annual Meeting of the Japanese Pharmacological Society, Professor Kohji Fukunaga was appointed as an honorary member of the Japanese Pharmacological Society.
- 2021-03-08【Associate Professor Ichiro Kawahata, Japanese Pharmacological Society Academic Encouragement Award】
At the 94th Annual Meeting of the Japanese Pharmacological Society, Associate Professor Ichiro Kawahata received the 36th Annual Meeting of the Japanese Pharmacological Society.
Click here for details https://pharmacol.or.jp/award/bounty
- 2020-11-11【Associate Professor Ichiro Kawahata, Young Excellent Presentation Award】
Associate Professor Ichiro Kawahata received The Young Investigator Award at The 14th International Conference on Protein Phosphatase.
- 2020-10-12【Associate Professor Ichiro Kawahata, Nishinomiya Basic Medical Sciences Research Grant Fund】
At the 71st Annual Meeting of the Japanese Society of Pharmacology, Associate Professor Ichiro Kawahata was awarded the Nishinomiya Basic Medical Sciences Research Grant Fund.
- 2020-07-15【Assistant Professor Ichiro Kawahata, Tohoku University Graduate School of Pharmaceutical Sciences Dean's Award】
Assistant Professor Ichiro Kawahata was awarded the Dean's Award at the Graduate School of Pharmaceutical Sciences, Tohoku University.