研究業績 Publication
太字は当研究室メンバー Bold represents our lab members+equal contribution, *corresponding author
2024
特集記事 Topics
- How the brain senses the body
Nature, Nature Index: Neuroscience 2024, Link
原著論文 Original Papers
- Dewa K, Arimura N*, Kakegawa W, Itoh M, Adachi T, Miyashita S, Inoue YU, Hizawa K, Hori K, Honjoya N, Yagishita H, Taya S, Miyazaki T, Usui C, Tatsumoto S, Tsuzuki A, Uetake H, Sakai K, Yamakawa K, Sasaki T, Nagai J, Kawaguchi Y, Sone M, Inoue T, Go Y, Ichinohe N, Kaibuchi K, Watanabe M, Koizumi S, Yuzaki M, Hoshino M*
Neuronal DSCAM regulates the peri-synaptic localization of GLAST in Bergmann Glia for the functional synapse formation
Nature Communications, (2024) 15: 458 - Okonogi T, Kuga N, Yamakawa M, Kayama T, Ikegaya Y, Sasaki T*
Stress-induced vagal activity influences anxiety-relevant prefrontal and amygdala neuronal oscillations in male mice
Nature Communications, (2024) 15: 183 - Ahmadi S, Sasaki T, Sabariego M, Leibold C , Leutgeb S*, Leutgeb JK*
Distinct roles of dentate gyrus and medial entorhinal cortex inputs for phase precession and temporal correlations in hippocampal CA3 place cells
Nature Communications, in press - Yagishita H, Go Y, Okamoto K, Arimura N, Ikegaya Y, Sasaki T*
A method to analyze gene expression profiles from hippocampal neurons electrophysiologically recorded in vivo
Frontiers in Neuroscience, (2024) 18: 1360432 - Shiratori R, Yokoi T, Kinoshita K, Xue W, Sasaki T*, Kuga N*
The posterior insular cortex is necessary for feeding-induced jejunal myoelectrical activity in male rats
Neuroscience, (2024) 553: 40-47 - Kayama T+, Tamura A+, Xiaoying T+, Tsutsui K, Kitajo K, Sasaki T*
Transformer-based classification of visceral pain-related local field potential patterns in the brain
Scientific Reports, (2024) 14(1):24372 - Bénac N, Saraceno GE, Butler C, Kuga N, Nishimura Y, Yokoi T, Su P, Sasaki T, Petit-PedrolM, GallandR, Studer V, Liu F, Ikegaya Y, Sibarita J, Groc L*
Non-canonical interplay between glutamatergic NMDA and dopamine receptors shapes synaptogenesis
Nature Communications, (2024) 15: 27 - Maeda K, Ogawa T, Kayama T, Sasaki T, Tainaka K, Murakami M, Haseyama M*
Trial analysis of brain activity information for presymptomatic disease detection of rheumatoid arthritis
Bioengineering, (2024) 11: 523 - Yokoi T, Sasaki T*
Closed-loop stimulation to suppress sharp wave ripples in the hippocampus
Springer Protocols in press. - Kashima T*, Sasaki T, Ikegaya Y
Optogenetic estimation of synaptic connections in brain slices
Journal of Neuroscience Methods, (2024) 412:110298 - Maeda K, Tanimura M, Masago Y, Horiyama T, Takemoto H, Sasaki T, Koyama R, Ikegaya Y, Ogawa K*
Development of an in vitro compound screening system that replicate the in vivo spine phenotype of idiopathic ASD model mice
Frontiers in Pharmacology, (2024) 15: 1455812 - Sekimori T, Fukunaga K, Oizumi H, Baba T, Totsune T, Takeda A, Sasaki T*, Kawahata I*
FABP2 is involved in intestinal α-Synuclein pathologies
Journal of Integrative Neuroscience, (2024) 23(2): 44 - Araki T, Hiragi T, Kuga N, Luo C, Andoh M, Sugao K, Nagata H, Sasaki T, Ikegaya Y, Koyama R*
Microglia induce auditory dysfunction after status epilepticus in mice
Glia, (2024) 72: 274-288 - Cheng A*, Jia W, Finkelstein D, Stefanova N, Wang H, Sasaki T, Kawahata I, Fukunaga K*
Pharmacological inhibition of FABP7 by MF 6 counteracts cerebellum dysfunction in an experimental multiple system atrophy mouse model
Acta Pharmacologica Sinica, (2024) 45: 66-75 - Fukushima F, Tamura A, Kuga N, Sasaki T*
Heart rate changes related to risky selections and outcomes in a rat gambling task
bioRxiv, (2024) 2024.04.21.590481
総説 Review
- Yagishita H, Sasaki T*
Integrating physiological and transcriptomic analyses at the single-neuron level
Neuroscience Research (2024) S0168-0102(24)00065-8
和文 Japanese
- 佐々木拓哉、内受容感覚を伝達する経路と脳情報処理、実験医学2024年.
2023
原著論文 Original Papers
- Kuga N+, Nakayama R+, Morikawa S, Yagishita H, Konno D, Shiozaki H, Honjoya N, Ikegaya Y, Sasaki T*
Hippocampal sharp wave ripples underlie stress susceptibility in male mice
Nature Communications (2023) 14: 2105 - Yagi S, Igata H, Ikegaya Y, Sasaki T*
Awake hippocampal synchronous events are incorporated into offline neuronal reactivation
Cell Reports (2023) 42: 112871 - Aoki Y, Yokoi T, Morikawa S, Kuga N, Ikegaya Y, Sasaki T*
Effects of theta phase precessing optogenetic intervention on neuronal reactivation and spatial maps in the hippocampus
iScience (2023) 26: 107233 - Cheng A*, Kawahata I, Wang Y, Jia W, Wang H, Sekimori T, Chen Y, Suzuki H, Takeda A, Stefanova N, Finkelstein D, Ma W, Chen M, Sasaki T*, Fukunaga K*
Epsin2, a novel target for multiple system atrophy therapy via α-synuclein/FABP7 propagation
Brain (2023) 146: 3172-3280 - Shiozaki H, Kuga N, Kayama T, Ikegaya Y, Sasaki T*
Selective serotonin reuptake inhibitors suppress sharp wave ripples in the ventral hippocampus
Journal of Pharmacological Sciences (2023) 152: 136-143 - Kudara M, Kuga N, Yamashiro K, Yoshimoto A, Matsumoto N*, Ikegaya Y*, Sasaki T*
An open-source application to identify the three-dimensional locations of electrodes implanted into the rat brain from computed tomography images
Neurosciense Research (2023) 193: 20-27 - Cheng A*, Fukunaga K, Sasaki T, Lakkaraju A
Feasibility and considerations of Epsin2 as a candidate target for multiple system atrophy treatment
Expert Opinion on Therapeutic Targets (2023) 27: 1031-1034 - Tong C+, Min PX+, Zhang Q, Gu RX, Wen YH, Shi Y, Bao YH, Chen X, Zhang YX, Mao XF, Yuan HY, Liu XX, Sasaki T, Zhang L*, Han F*, Lu YM*
Striatal CDK5 regulates cholinergic neuron activation and dyskinesia-like behaviors through BK channels
Research (2023) 6: 0121 - Jia W, Kawahata I, Cheng A, Sasaki T, Sasaoka T, Fukunaga K*
Amelioration of nicotine-induced conditioned place preference behaviors by FABP3 inhibitor in mice
International Journal of Molecular Sciences (2023) 24: 6644 - Wang H, Fukunaga K, Cheng A, Wang Y, Arimura N, Yoshino H, Sasaki T, Kawahata I*
Novel FABP3 ligand, HY-11-9, ameliorates neuropathological deficits in MPTP-induced Parkinsonism in mice
Journal of Pharmacological Sciences (2023) 152: 30-38 - Lu Y, Chen X, Liu X, Shi Y, Wei Z, Feng L, Jiang Q, Ye W, Sasaki T, Fukunaga K, Ji Y, Han F, Lu Y*
Endothelial TFEB signaling-mediated autophagic disturbance initiates microglial activation and cognitive dysfunction
Autophagy (2023) 1-18 - Yokoi T, Shikano Y, Yagishita H Ikegaya Y, Sasaki T*
Effects of novelty and temporal distance on post-experience reactivation of hippocampal place cells encoding multiple environments
bioRxiv (2023) 2023.12.17.572075
総説 Review
- Hizawa K, Sasaki T, Arimura N*
A comparative overview of DSCAM and its multifunctional roles in Drosophila and vertebrates
Neuroscience Research (2023) Dec 21: S0168-0102(23) 00222-5
和文 Japanese
- 久我奈穂子、佐々木拓哉、学習時の個性、『生体の科学』第75巻1号, 2023年.
- 鹿山将、海馬は末梢組織の慢性炎症に伴う疼痛反応を制御する、ファルマシア, トピックス, 2023年.
- 佐々木拓哉、内臓信号が神経回路演算に及ぼす影響の考察、神経回路学会誌, 2023年.
- 佐々木拓哉、求心性迷走神経を介した脳末梢連環の意義、ファルマシア, 最前線 2023年.
- 佐々木拓哉、最新脳科学と応用(5) ~学習・記憶・意思決定~、Yano E plus, 2023年４月号.
- 鹿野悠、佐々木拓哉、池谷裕二、齧歯目における分オーダーの時間認知、CLINICAL NEUROSCIENCE, 41:1055-1058, 2023.
2022
原著論文 Original Papers
- Kuga N, Abe R, Takano K, Ikegaya Y, Sasaki T*
Prefrontal-amygdalar oscillations related to social behavior in mice
eLife (2022) 11: e78428 - Sugisawa E, Kondo T, Kumagai Y, Kato H, Takayama Y, Isohashi K, Shimosegawa E, Takemura N, Hayashi Y, Sasaki T, Martino M, Tominaga M, Maruyama K*
Nociceptor-derived Reg3g prevents endotoxic death by targeting kynurenine pathway in microglia
Cell Reports (2022) 38: 110462 - Konno T, Ikegaya Y, Sasaki T*
Weak representation of awake/sleep states by local field potentials in aged mice
Scientific Reports (2022) 12: 7766 - Kayama T, Ikegaya Y, Sasaki T*
Phasic firing of dopaminergic neurons in the ventral tegmental area triggers peripheral immune responses
Scientific Reports (2022) 12: 1447 - Li Z, Liu X, Li C, Wei Z, Shi Y, Song H, Chen X, Zhang Y, Li J, Zhu R, HU B, Ye W, Huo D, Jiang G, Sasaki T, Zhang L, Lu Y, Han F*
Decreased synapse-associated proteins are associated with the onset of epileptic memory impairment in endothelial CDK5-deficient mice
MedComm (2022) 3: e128 - Sato DX, Inoue YU, Kuga N, Hattori S, Nomoto K, Morimoto Y, Sala G, Hagihara H, Kikusui T, Sasaki T, Ikegaya Y, Miyakawa T, Inoue T, Kawata M*
Humanized substitutions of Vmat1 in mice alter amygdala-dependent behaviors associated with the evolution of anxiety.
iScience (2022) 25: 104800 - Liu XX, Chen XH, Zheng ZW, Jiang Q, Li C, Yang L, Chen X, Mao XF, Yuan HY, Feng LL, Jiang Q, Shi WX, Sasaki T, Fukunaga K, Chen Z, Han F, Lu YM*
BOD1 regulates the cerebellar IV/V lobe-fastigial nucleus circuit associated with motor coordination
Signal Transduction and Targeted Therapy (2022) 7: 170. - Ahmadi S, Sasaki T, Sabariego M, Leibold C, Leutgeb S, Leutgeb JK*
Distinct roles of dentate gyrus and medial entorhinal cortex inputs for phase precession and temporal correlations in the hippocampal CA3 area
bioArxiv (2022) https://doi.org/10.1101/2022.06.07.491859
総説 Review
- Dewa K, Arimura N*
Neuronal and Astrocytic Protein Connections and Associated Adhesion Molecules
Neuroscience Research (2022) 187: 14-20 - Kuga N, Sasaki T*
Memory-related neurophysiological mechanisms in the hippocampus underlying stress susceptibility
Neuroscience Research (2022) S0168-0102(22)00213-9
和文 Japanese
- 佐々木拓哉、研究室紹介：薬学の学生と神経科学を楽しむ 神経科学ニュース 2022年1月号.
2021
原著論文 Original Papers
- Nishimura Y, Ikegaya Y, Sasaki T*
Prefrontal synaptic activation during hippocampal memory reactivation
Cell Reports (2021) 34:108885 - Shikano Y, Ikegaya Y, Sasaki T*
Minute-encoding neurons in hippocampal-striatal circuits
Current Biology (2021) 31: 1438-1449 - Igata H, Ikegaya Y, Sasaki T*
Prioritized experience replays on a hippocampal predictive map for learning
Proceedings of the National Academy of Sciences of the United States of America (2021) 118: e2011266118 - Okonogi T, Sasaki T*
Theta-range oscillations in stress-induced mental disorders as an oscillotherapeutic target
Frontiers in Behavioral Neuroscience (2021) 15: 698753 - Nishimura Y, Ikegaya Y, Sasaki T*
Concurrent recordings of hippocampal neuronal spikes and prefrontal synaptic inputs from an awake rat
STAR Protocols (2021) 2: 100572 - Iwasaki S, Sasaki T, Ikegaya Y*
Hippocampal beta oscillations predict mouse object-location associative memory performance
Hippocampus (2021) 31: 503-511. doi:10.1073/pnas.2011266118 - Cheng A, Jia W, Kawahata I, Fukunaga K*
A novel fatty acid-binding protein 5 and 7 inhibitor ameliorates oligodendrocyte injury in multiple sclerosis mouse mode
EBioMedicine (2021) 72: 103582 - Ma W*, Tan Y, Wang Y, Li Z, Li Z, Gu L, Mei R, Cheng A
Hydroxyl-Directed Ruthenium-Catalyzed peri-Selective C-H Acylmethylation and Annulation of Naphthols with Sulfoxonium Ylides
Org Lett (2021) 1c01684 - Cheng A, Kawahata I, Jia W, Fukunaga K*
Impact of Fatty Acid-Binding Proteins in alpha-Synuclein-Induced Mitochondrial Injury in Synucleinopathy
Biomedicines (2021) 9(5):560 - Cheng A, Wang Y, Shinoda Y, Kawahata I, Yamamoto T, Jia W, Yamamoto H, Mizobata T, Kawata Y, Fukunaga K*
Fatty acid-binding protein 7 triggers α-synuclein oligomerization in glial cells and oligodendrocytes associated with oxidative stress
Acta Pharmacologica Sinica (2021) 0:1-11 - Wang Y, Shinoda Y, Cheng A, Kawahata I, Fukunaga K*
Epidermal Fatty Acid-Binding Protein 5 (FABP5) Involvement in Alpha-Synuclein-Induced Mitochondrial Injury under Oxidative Stress
Biomedicines (2021) 9(2):110. doi: 10.3390/biomedicines9020110 - Yuan D, Cheng A, Kawahata I, Izumi H, Xu J, Fukunaga K*
Single Administration of the T-Type Calcium Channel Enhancer SAK3 Reduces Oxidative Stress and Improves Cognition in Olfactory Bulbectomized Mice
Int J Mol Sci (2021) 22(2):741. doi: 10.3390/ijms22020741 - Degawa T, Kawahata I, Izumi H, Shinoda Y, Fukunaga K*
T-type Ca2+ channel enhancer SAK3 administration improves the BPSD-like behaviors in App NL-G-F/NL-G-F knock-in mice
J Pharmacol Sci (2021) 146(1):1-9. doi: 10.1016/j.jphs.2021.02.006 - Kawahata I, Sekimori T, Wang H, Wang Y, Sasaoka T, Bousset L, Melki R, Mizobata T, Kawata Y, Fukunaga K*
Dopamine D2 Long Receptors Are Critical for Caveolae-Mediated α-Synuclein Uptake in Cultured Dopaminergic Neurons
Biomedicines (2021) 9(1):49. doi: 10.3390/biomedicines9010049 - Jia W, Wilar G, Kawahata I, Cheng A, Fukunaga K*
Impaired Acquisition of Nicotine-Induced Conditioned Place Preference in Fatty Acid-Binding Protein 3 Null Mice
Mol Neurobiol (2021) 58(5):2030-2045. doi: 10.1007/s12035-020-02228-2 - Umaru BA, Kagawa Y, Shil SK, Arakawa N, Pan Y, Miyazaki H, Kobayashi S, Yang S, Cheng A, Wang Y, Shinoda Y, Kiniwa Y, Okuyama R, Fukunaga K, Yuji Owada*
Ligand Bound Fatty Acid Binding Protein 7 (FABP7) Drives Melanoma Cell Proliferation Via Modulation of Wnt/β-Catenin Signaling
Pharm Res (2021) 38(3):479-490
総説 Review
- Jia W, Kawahata I, Cheng A, Fukunaga K*
The Role of CaMKII and ERK Signaling in Addiction
International Journal of Molecular Science (2021) 22(6):3189 - Okonogi T, Sasaki T*
Optogenetic manipulation of the vagus nerve
Optogenetics (Springer Nature) (2021) 1293: 459-470
和文 Japanese
- 郭青云、川畑伊知郎、佐々木拓哉、福永浩司、脳虚血性細胞死における脂肪酸結合タンパク質(FABP)の役割、脳循環代謝 33, 2021年1月号.