English

2023年度

• Design, Synthesis, and Biological Evaluation of Water-Soluble Prodrugs of C5-Curcuminoid GO-Y030 Based on Reversible Thia-Michael Reaction

  Hiroyuki Yamakoshi*, Michihiro Fukuda, Hiro Ikeda, Shogo Fujiki, Aki Kohyama, Shota Nagasawa, Hanae Shinozaki, Hiroyuki Shibata, Yoshiharu Iwabuchi*

  Chem. Phrm. Bull. 2024, 72, 127-134

  
  

• C–H Alkylation of Cubanes via Catalytic Generation of Cubyl Radicals

  Masaki Hosaka, Shota Nagasawa*,and Yoshiharu Iwabuchi*

  Org. Lett. 2024, 26, 658–663

  
  

• Ratiometric analysis of reversible thia-Michael reactions using nitrile-tagged molecules by Raman microscopy

  Hiroyuki Yamakoshi*, Daiki Shibata, Kazuki Bando, Shinji Kajimoto, Aki Kohyama, Syusuke Egoshi, Kosuke Dodo, Yoshiharu Iwabuchi, Mikiko Sodeoka, Katsumasa Fujita and Takakazu Nakabayashi

  Chem. Commun. 2023, 59, 14563

  (プレスリリース)
  

• Biological Evaluation of Isosteric Applicability of 1,3-Substituted Cuneanes as m-Substituted Benzenes Enabled by Selective Isomerization of 1,4-Substituted Cubanes

  Kan Fujiwara, Shota Nagasawa*, Ryusei Maeyama, Ryosuke Segawa, Noriyasu Hirasawa, Takatsugu Hirokawa, Yoshiharu Iwabuchi*

  Chem. Eur. J. 2024, e202303548

  (プレスリリース)
  

• Azetidine synthesis by La(OTf)3-catalyzed intramolecular regioselective aminolysis of cis-3,4-epoxy amines

  Yuse Kuriyama, Yusuke Sasano, Yoshiharu Iwabuchi*

  Front. Chem. 2023, 11, 1251299

  
  

• Mono-Carbonyl Curcumin Analogs for Cancer Therapy

  Takashi MaruYama, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi, Hiroyuki Shibata*

  Biol. Pharm. Bull. 2023, 46, 756–763

  
  

• Asymmetric Total Synthesis of Cytotrienin A: Late-stage Installation of C11 Side Chain onto the Macrolactam Scaffold

  Yuki Tateishi, Ryo Sato, Shingo Komatsu, Masatsugu Noguchi, Shota Nagasawa, Yusuke Sasano, Naoki Kanoh, Yoshiharu Iwabuchi*

  Angew. Chem. Int. Ed. 2023, e202303140

  
  

• 4-Chloro-2-azaadamantane N-Oxyl (4-Cl-AZADO): A Readily Preparable Organocatalyst for NOx Co-catalyzed Aerobic Alcohol Oxidation

  Shota Nagasawa, Yusuke Sasano, and Yoshiharu Iwabuchi*

  Asian J. Org. Chem. 2023, e202300031

  
  

• Sequential click modification of a lithium-ion endohedral fullerene connecting small molecules through a dieneazide linker

  Shogo Fujiki, Takumi Takada, Shota Nagasawa, Hiroshi Okada, Yusuke Sasano, Eusang Kwon, Yutaka Matsuo*, and Yoshiharu Iwabuchi*

  Chem. Commun. 2023, 59, 1237

  
  

• Identification of the Optimal Framework for Nitroxyl Radical/Hydroxylamine in Copper-Cocatalyzed Aerobic Alcohol Oxidation

  Masaki Toda, Yusuke Sasano, Masaya Takahashi, Shogo Fujiki, Koki Kasabata, Tetsuya Ono, Katsuhiko Sato, Yoshitomo Kashiharu, and Yoshiharu Iwabuchi*

  J. Org. Chem. 2023, 88, 1434

  
  

2022年度

• Enantiocontrolled Access to an Intermediate for Highly Functionalized Clovane-Type Terpenoids: Formal Synthesis of Rumphellclovane E

  Daigo Ninomiya, Shota Nagasawa,* and Yoshiharu Iwabuchi*

  Org.Lett. 2022, 24, 7572.

  
  

• 窒素原子を削除して分子骨格を「編集」する

  長澤 翔太

  ファルマシア 2022, 58, 168.

  
  

• Late-stage functionalizationを志向した芳香族C-H結合の直接的酸素化

  長澤 翔太

  有機合成化学協会誌 2022, 80, 377-378.

  
  

• The Utility of Oxoammonium Species in Organic Synthesis: Beyond Alcohol Oxidation

  Shota Nagasawa, Yusuke Sasano, and Yoshiharu Iwabuchi*

  Heterocycles, 2022, 105, advanced article

  
  

2021年度

• Toward the Creation of Induced Pluripotent Small (iPS) Molecules: Establishment of a Modular Synthetic Strategy for the Heronamide C-type Polyene Macrolactams and Their Conformational and Reactivity Analysis

  Naoki Kanoh, Yuta Terajima, Suguru Tanaka, Ryusei Terashima, Hiromichi Nishiyama, Shota Nagasawa, Yusuke Sasano, Yoshiharu Iwabuchi, Shinichi Nishimura, and Hideaki Kakeya

  J. Org. Chem. 2021, 86, 16231-16248

  
  

• Design, Synthesis and Antifungal Activity of 16,17-Dihydroheronamide C and ent-Heronamide

  Naoki Kanoh, Ryusei Terashima, Hiromichi Nishiyama, Yuta Terajima, Shota Nagasawa, Yusuke Sasano, Yoshiharu Iwabuchi, Hiroaki Saito, Syusuke Egoshi, Kosuke Dodo, Mikiko Sodeoka, Chengqian Pan, Yoshinobu Ikeuchi, Shinichi Nishimura, and Hideaki Kakeya

  J. Org. Chem., 2021, 86, 16249-16258

  
  

• ortho-C-H Acetoxylation of Cubane Enabling Access to Cubane Analogues of Pharmaceutically Relevant Scaffolds

  Shota Nagasawa, Masaki Hosaka, and Yoshiharu Iwabuchi

  Org. Lett., 2021, 23, 8717-8721

  
  

• Chromium-Salen Complex/Nitroxyl Radical Cooperative Catalysis: A Combination for Aerobic Intramolecular Dearomative Coupling of Phenols

  Shota Nagasawa, Shogo Fujiki, Yusuke Sasano, Yoshiharu Iwabuchi

  J. Org. Chem., 2021, 86, 6952-6968

  
  

• Expansion of Substrate Scope for Nitroxyl Radical/Copper-Catalyzed Aerobic Oxidation of Primary Alcohols: A Guideline for Catalyst Selection

  Yusuke Sasano, Aoto Yamaichi, Ryota Sasaki, Shota Nagasawa, Yoshiharu Iwabuchi
  selected as Front Cover Picture

  Chem. Pharm. Bull., 2021, 69, 488-497

  
  

• Synthetic Access to gem-Difluoropropargyl Vinyl Ethers and Their Application to Propargyl Claisen Rearrangement

  Toshitaka Okamura, Kenta Koyamada, Junichiro Kanazawa, Kazunori Miyamoto, Yoshiharu Iwabuchi, Masanobu Uchiyama, and Naoki Kanoh

  J. Org. Chem., 2021, 86, 1911-1914.

  
  

• Highly Regioselective 5‐endo‐tet Cyclization of 3,4‐Epoxy Amines into 3‐Hydroxypyrrolidines Catalyzed by La(OTf)3

  Yuse Kuriyama, Yusuke Sasano, Yoshihiko Hoshino, Shun-ichiro Uesugi, Aoto Yamaichi, Yoshiharu Iwabuchi

  Chem. Eur. J., 2021, 27, 1961-1965.

  
  

2020年度

• The Synthetic Curcumin Analogue GO-Y030 Effectively Suppresses the Development of Pressure Overload-induced Heart Failure in Mice

  Kana Shimizu, Yoichi Sunagawa, Masafumi Funamoto, Hiroki Wakabayashi, Mai Genpei, Yusuke Miyazaki, Yasufumi Katanasaka, Nurmila Sari, Satoshi Shimizu, Ayumi Katayama, Hiroyuki Shibata, Yoshiharu Iwabuchi, Hideaki Kakeya, Hiromichi Wada, Koji Hasegawa, Tatsuya Morimoto

  Sci. Rep., 2020, 10, Article Number: 7172

  
  

2019年度

• An integrated screening system for the selection of exemplary substrates for natural and engineered cytochrome P450s

  Naoki Kanoh, Ayano Kawamata-Asano, Kana Suzuki, Yusuke Takahashi, Takeshi Miyazawa, Takemichi Nakamura, Takashi Moriya, Hiroyuki Hirano, Hiroyuki Osada, Yoshiharu Iwabuchi, Shunji Takahashi

  Sci. Rep., 2019, 9, Article Number: 18023

  
  

• Highly Chemoselective gem‐Difluoropropargylation of Aliphatic Alcohols

  Toshitaka Okamura, Syusuke Egoshi, Kosuke Dodo, Mikiko Sodeoka, Yoshiharu Iwabuchi, Naoki Kanoh

  Chem. Eur. J., 2019, 25, 16002-16006

  
  

• Methyl‐Selective α‐Oxygenation of Tertiary Amines to Formamides by Employing Copper/Moderately Hindered Nitroxyl Radical (DMN‐AZADO or 1‐Me‐AZADO)

  Satoru Nakai, Takafumi Yatabe,Kosuke Suzuki, Yusuke Sasano,Yoshiharu Iwabuchi, Jun-ya Hasegawa, Noritaka Mizuno,and Kazuya Yamaguchi*

  Angew. Chem. Int. Ed., 2019, 58, 16651-16559

  
  

• Gold(I)-catalyzed Nicholas Reaction with Aromatic Molecules Utilizing a Bifunctional Propargyl Dicobalt Hexacarbonyl Complex

  Toshitaka Okamura, Shogo Fujiki, Yoshiharu Iwabuchi and Naoki Kanoh
  selected as Front Cover Picture

  Org. Biomol. Chem., 2019, 17, 8522-8526

  
  

• Ln(OTf)3-catalysed highly regioselective alcoholysis of 2,3-epoxy alcohols

  Daichi Nakamura, Yusuke Sasano, and Yoshiharu Iwabuchi

  Org. Biomol. Chem., 2019, 17, 3581-3589

  
  

• Safe and Scalable Aerobic Oxidation by 2-Azaadamantan-2-ol (AZADOL)/NOx Catalysis: Large-Scale Preparation of Shi’s Catalyst

  Yusuke Sasano, Hikaru Sato, Shinsuke Tadokoro, Masami Kozawa, and Yoshiharu Iwabuchi

  10.1021/acs.oprd.8b00456

  
  

2018年度

• 2-Azaadamantane N-oxyl (AZADO)/Cu Catalysis Enables Chemoselective Aerobic Oxidation of Alcohols Containing Electron-Rich Divalent Sulfur Functionalities

  Yusuke Sasano, Naoki Kogure, Shota Nagasawa, Koki Kasabata, and Yoshiharu Iwabuchi

  Org. Lett., 2018, 20, 6104-6107

  
  

• CuCl/TMEDA/nor-AZADO-catalyzed aerobic oxidative acylation of amides with alcohols to produce imides

  Kengo Kataoka, Keiju Wachi, Xiongjie Jin, Kosuke Suzuki, Yusuke Sasano, Yoshiharu Iwabuchi, Jun-ya Hasegawa, Noritaka Mizuno and Kazuya Yamaguchi

  Chem. Sci., 2018, 9, 4756-4768

  
  

• Curcumin analog, GO-Y078, overcomes resistance to tumor angiogenesis inhibitors

  Kazuhiro Shimazu, Masahiro Inoue, Shunsuke Sugiyama, Koji Fukuda, Taichi Yoshida, Daiki Taguchi, Yoshihiko Uehara, Sei Kuriyama, Masamitsu Tanaka, Masatomo Miura, Hiroshi Nanjyo, Yoshiharu Iwabuchi, Hiroyuki Shibata

  Cancer Science., 2018, 109, 3285-3293

  
  

• Dietary intake of pyrolyzed deketene curcumin inhibits gastric carcinogenesis

  Taichi Yoshida, Takashi Maruyama, Masatomo Miura, Masahiro Inoue, Koji Fukuda, Kazuhiro Shimazu, Daiki Taguchi, Hiroaki Kanda, Masanobu Oshima, Yoshiharu Iwabuchi, Hiroyuki Shibata

  Journal of Functional Foods , 2018, 50, 192-200

  
  

• Stereocontrolled Construction of ABCD Tetracyclic Ring System with Vicinal All-Carbon Quaternary Stereogenic Centers of Calyciphylline A Type Alkaloids

  Yusuke Sasano, Junpei Koyama, Kaori Yoshikawa, Naoki Kanoh, Eunsang Kwon, Yoshiharu Iwabuchi

  Org. Lett., 2018, 20, 3053-3056

  
  

• Expedient Entry to 1-Aminoadamantane Derivatives via Aza-Prins Cyclization of 7-Methylenebicyclo[3.3.1]nonan-3-one Oximes

  Tetsuya Kuga, Yusuke Sasano, Masaki Tomizawa, Masatoshi Shibuya, Yoshiharu Iwabuchi

  Synthesis, 2018, 50, 1820-1826.

  
  

• IBX as a Catalyst for Dehydration of Hydroperoxides: Green Entry to α,β-Unsaturated Ketones via Oxygenative Allylic Transposition

  Tetsuya Kuga, Yusuke Sasano, Yoshiharu Iwabuchi

  Chem. Commun. 2018, 54, 798-801

  
  

2017年度

• Nazarov Cyclization Entry to Chiral Bicyclo[5.3.0]decanoid Building Blocks and Its Application to Formal Synthesis of (-)-Englerin A

  Keisuke Morisaki, Yusuke Sasano, Takahiro Koseki, Takuro Shibuta, Naoki Kanoh, Wen-Hua Chiou, Yoshiharu Iwabuchi

  Org. Lett. 2017, 19, 5142-5145

  
  

• Substrate Ｒecognition by a Dual Functional P450 Monooxygenase GfsF Involved in FD-891 Biosynthesis

  Akimasa Miyanaga, Ryuichi Takayanagi, Takashi Furuya, Ayano Kawamata, Tomohiro Itagaki, Yoshiharu Iwabuchi, Naoki Kanoh, Fumitaka Kudo, Tadashi Eguchi

  ChemBioChem. 2017, 18, 2179-2187

  
  

• A Mild Two-Step Propargylation of Aromatic Bioactive Small Molecules

  Naoki Kanoh, Toshitaka Okamura, Takahiro Suzuki, Yoshiharu Iwabuchi

  Org. Biomol. Chem. 2017, 15, 7190-7195.

  
  

• Catalytic Oxygenative Allylic Transposition of Alkenes into Enones with an Azaadamantane-Type Oxoammonium Salt Catalyst

  Shota Nagasawa, Yusuke Sasano, Yoshiharu Iwabuchi*
  selected as Hot Paper

  Chem. Eur.J. 2017, 23, 10276-10279.

  
  

• Synthetic Analogs of Curcumin Modulate the Function of Multidrug Resistance?Linked ATP-Binding Cassette Transporter ABCG2

  Megumi Murakami, Shinobu Ohnuma, Michihiro Fukuda, Eduardo E. Chufan, Katsuyoshi Kudoh, Keigo Kanehara, Norihiko Sugisawa, Masaharu Ishida, Takeshi Naitoh, Hiroyuki Shibata, Yoshiharu Iwabuchi, Suresh V. Ambudkar, Michiaki Unno

  Drug Metab. Dispos 2017, 45, 1166-1177.

  
  

• Concise, Protecting-Group-Free Synthesis of (+)-Nemonapride via Eu(OTf)3-Catalyzed Aminolysis of 3,4-Epoxy Alcohol

  Shun-ichiro Uesugi, Yusuke Sasano, Shogo Matsui, Naoki Kanoh, Yoshiharu Iwabuchi

  Chem. Pharm. Bull. 2017, 65, 22-24.

  
  

2016年度

• Reversibility of thia-Michael reaction of the cytotoxic C5-curcuminoid and structure-activity relationship of the bis-thiol- adducts thereof

  Aki Kohyama, Michihiro Fukuda, Shunsuke Sugiyama, Hiroyuki Yamakoshi, Naoki Kanoh, Chikashi Ishioka, Hiroyuki Sh ibata and Yoshiharu Iwabuchi

  Org. Biomol. Chem. 2016, 14, 10683-10687.

  
  

• Design and synthesis of the penta(acetoxymethyl) ester of dioctanoyl phosphatidylinositol-3,5-bisphosphate

  Naoki Kanoh, Kosuke Mano, Daisuke Saigusa, Takeo Usui, Yoshiharu Iwabuchi

  Bioorg. Med. Chem. Lett. 2016, 26, 5770-5772.

  
  

• Synthesis of 1,3-Cycloalkadienes from Cycloalkenes: Unprecedented reactivity of Oxoammonium Salts

  Shota Nagasawa, Yusuke Sasano, Yoshiharu Iwabuchi
  highlighted in SYNFORM"

  Angew. Chem. Int. Ed. 2016, 55, 13189-13194.

  
  

• Asymmetric Total Synthesis of Heronamides A-C: Stereochemical Confirmation and Impact of Long-range Stereochemical Communication on the Biological Activity

  Naoki Kanoh, Shunya Itoh, Kohei Fujita, Kohei Sakanishi, Ryosuke Sugiyama, Yuta Terajima, Yoshiharu Iwabuchi, Shinichi Nishimura, and Hideaki Kakeya

  Chem. Eur. J. 2016, 22, 8586-8595

  
  

• Photo-Cross-Linked Small-Molecule Affinity Matrix as a Tool for Target Identification of Bioactive Small Molecules（From themed collection "Strategies for Cellular Target Identification of Natural Products")

  Naoki Kanoh

  Nat. Prod. Rep. 2016, 33, 709-718.

  
  

• Synthesis and structure-activity relationship study of FD-891: importance of the side chain and C8-C9 epoxide for cytotoxic activity against cancer cells

  Tomohiro Itagaki, Ayano Kawamata, Miho Takeuchi, Keisuke Hamada, Yoshiharu Iwabuchi, Tadashi Eguchi, Fumitaka Kudo, Takeo Usui and Naoki Kanoh

  J. Antibiot. 2016, 69, 287-293.

  
  

• Vicenistatin induces early endosome-derived vacuole formation in mammalian cells

  Yuko Nishiyama, Tomohiro Ohmichi, Sayaka Kazami, Sayaka Iwasaki, Kousuke Mano, Yoko Nagumo, Fumitaka Kudo, Sosaku Ichikawa, Yoshiharu Iwabuchi, Naoki Kanoh, Tadashi Eguchi, Hiroyuki Osada, and Takeo Usui

  Biosci. Biotech. Biochem., 2016, 80, 902-910.

  
  

• An enantiocontrolled entry to the tricyclic polar segment of (+)-fusarisetin A

  Aki Kohyama, Naoki Kanoh, Eunsang Kwon, Yoshiharu Iwabuchi

  Tetrahedron Lett, 2016, 57, 517-519

  
  

• Identification of anti-cancer chemical compounds using Xenopus embryos

  Masamitsu Tanaka, Sei Kuriyama, Go Itoh, Aki Kohyama, Yoshiharu Iwabuchi, Hiroyuki Shibata, Masakazu Yashiro, Namiko Aiba

  Cancer Sci, 2016, 107, 803-811

  
  

• A diarylpentanoid curcumin analog exhibits improved radioprotective potential in the intestinal mucosa

  Koji Fukuda, Yoshihiko Uehara, Eiko Nakata, Masahiro Inoue, Kazuhiro Shimazu, Taichi Yoshida, Hiroaki Kanda, Hiroshi Nanjo, Yoshio Hosoi, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi, Hiroyuki Shibata

  International Journal of Radiation Biology, 2016, 92, 388-394

  
  

• A diarylpentanoid curcumin analog exhibits improved radioprotective potential in the intestinal mucosa

  Koji Fukuda, Yoshihiko Uehara, Eiko Nakata, Masahiro Inoue, Kazuhiro Shimazu, Taichi Yoshida, Hiroaki Kanda, Hiroshi Nanjo, Yoshio Hosoi, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi, Hiroyuki Shibata

  Anti-Cancer Agents in Medicinal Chemistry, 2016, 16, 633-647

  
  

• Total Synthesis of the Proposed Structure of Turkiyenine

  Hisataka Kobayashi, Yusuke Sasano, Naoki Kanoh, Eunsang Kwon, Yoshiharu Iwabuchi

  Eur. J. Org. Chem, 2016, 270-273

  
  

2015年度

• Total Synthesis and Biological Evaluation of Irciniastatin A (a.k.a. Psymberin) and Irciniastatin B

  Shun-ichiro Uesugi, Tsubasa Watanabe, Takamichi Imaizumi, Yu Ota, Keisuke Yoshida, Haruna Ebisu, Takumi Chinen, Yoko Nagumo, Masatoshi Shibuya, Naoki Kanoh, Takeo Usui, Yoshiharu Iwabuchi

  J. Org. Chem, 2015, 80, 12333-12350

  
  

• Structure-Activity Relationships of the Antitumor C5-Curcuminoid GO-Y030

  Aki Kohyama, Hiroyuki Yamakoshi, Shoko Hongo, Naoki Kanoh, Hiroyuki Shibata, Yoshiharu Iwabuchi

  Molecules, 2015, 20,15374-15391

  
  

• Irciniastatin A Induces a Potent and Sustained Activation of Extracellular Signal-regulated Kinase and Thereby Promotes Ectodomain Shedding of TNF Receptor 1 in Human Lung Carcinoma A549 Cells

  Hue Tu Quach, Seiya Hirano, Tsubasa Watahabe, Naoki Kanoh, Yoshiharu Iwabuchi, Takeo Usui, Takao Kataoka

  Biol. Pharm. Bull., 2015, 38, 941-946

  
  

• 化合物の標的タンパク質を検出するための技術

  叶　直樹, 生体の科学

  Bioconjugate Chem., 2015, 66, 156-162

  
  

• 標的同定の迅速化を目指した生物活性リガンドの非古典的修飾・固相 担持法

  叶　直樹, CSJ カレントレビュー 19 「生物活性分子の標的同定と機能 解明―生命科学の基盤技術としてのアプローチ」

  化学同人 2015,48-56

  
  

• Irciniastatin A, a pederin-type translation inhibitor, promotes ectodomain shedding of cell-surface tumor necrosis factor receptor 1

  Seiya Hirano, Hue Tu Quach, Tsubasa Watanabe, Naoki Kanoh, Yoshiharu Iwabuchi, Takeo Usui, Takao Kataoka

  J Antibiot, 2015, 68, 417-420.

  
  

• Third Generation Photo-Cross-Linked Small-Molecule Affinity Matrix: A Photoactivatable and Photocleavable System Enabling Quantitative Analysis of the Photo-Cross-Linked Small Molecules and Their Target Purification

  Takahiro Suzuki, Toshitaka Okamura, Takenori Tomohiro, Yoshiharu Iwabuchi, Naoki Kanoh

  Bioconjugate Chem, 2015, 26, 389-395

  
  

• Highly Efficient Aerobic Oxidation of Alcohols by Using Less-Hindered Nitroxyl-Radical/Copper Catalysis: Optimum Catalyst Combinations and Their Substrate Scope

  Yusuke Sasano, Naoki Kogure, Tomohiro Nishiyama, Shota Nagasawa, Yoshiharu Iwabuchi

  Chem, Asian J, 2015, 10, 1004-1009

  
  

• Inhibition of β-catenin and STAT3 with a curcumin analog suppresses gastric carcinogenesis in vivo

  Yoshihiko Uehara, Masahiro Inoue, Koji Fukuda, Hiroyuki Yamakoshi, Yoshio Hosoi, Hiroaki Kanda, Masanobu Oshima, Yoshiharu Iwabuchi, Hiroyuki Shibata

  Gastric Cancer, 2015, 18, 774-783

  
  

• Development of an Azanoradamantane-Type Nitroxyl Radical Catalyst for Class-Selective Oxidation of Alcohols

  Ryusuke Doi, Masatoshi Shibuya, Tsukasa Murayama, Yoshihiko Yamamoto, Yoshiharu Iwabuchi

  J. Org. Chem, 2015, 80, 401−413

  
  

2014年度

• Highly Enantioselective Organocatalytic Oxidative Kinetic Resolution of Secondary Alcohols Using Chiral Alkoxyamines as Precatalysts: Catalyst Structure, Active Species, and Substrate Scope

  Keiichi Murakami, Yusuke Sasano, Masaki Tomizawa, Masatoshi Shibuya, Eunsang Kwon, Yoshiharu Iwabuchi

  J. Am. Chem. Soc., 2014, 136, 17591-17600

  
  

• Mechanistic Insight into Aerobic Alcohol Oxidation Using NOx-Nitroxide Catalysis Based on Catalyst Structure-Activity Relationships

  Masatoshi Shibuya, Shota Nagasawa, Yuji Osada, Yoshiharu Iwabuchi

  J. Org. Chem, 2014, 79, 10256-10268

  
  

• Structure-function analyses of cytochrome P450revI involved in reveromycin A biosynthesis and evaluation of the biological activity of its substrate, reveromycin T

  Shunji Takahashi, Shingo Nagano, Toshihiko Nogawa, Naoki Kanoh, Masakazu Uramoto, Makoto Kawatani, Yoshitsugu Shiro, Hiroyuki Osada

  J. Biol. Chem. , 2014, 289, 32446-32458

  
  

• A Concise and Unified Strategy for Synthesis of the C1-C18 Macrolactone Fragments of FD-891, FD-892 and Their Analogues: Formal Total Synthesis of FD-891

  Naoki Kanoh, Ayano Kawamata, Tomohiro Itagaki, Yuta Miyazaki, Kenzo Yahata, Eunsang Kwon, Yoshiharu Iwabuchi

  Org, Lett, 2014, 16, 5216-5219

  
  

• Eu(OTf)3-Catalyzed Highly Regioselective Nucleophilic Ring Opening of 2,3-Epoxy Alcohols: An Efficient Entry to 3-Substituted 1,2-Diol Derivatives

  Shun-ichiro Uesugi, Tsubasa Watanabe, Takamichi Imaizumi, Masatoshi Shibuya, Naoki Kanoh, Yoshiharu Iwabuchi

  Org, Lett, 2014, 16, 4408-4411.

  
  

• Strong inhibitory effects of curcumin and its demethoxy analog on Escherichia coli ATP synthase F1 sector

  Mizuki Sekiya, Eiko Chiba, Momoe Satoh, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi, Masamitsu Futai, Mayumi Nakanishi-Matsui

  International Journal of Biological Macromolecules, 2014, 40, 241-245.

  
  

• Highly Chemoselective Aerobic Oxidation of Amino Alcohols into Amino Carbonyl Compounds

  Yusuke Sasano, Shota Nagasawa, Mai Yamazaki, Masatoshi Shibuya, Jaiwook Park, Yoshiharu Iwabuchi

  Angew. Chem. Int. Ed., 2014, 53, 3236-3240.

  
  

• Enantioselective Intramolecular Aza-Spiroannulation onto Benzofurans Using Chiral Rhodium Catalysis

  Takuro Shibuta, Shigeki Sato, Masatoshi Shibuya, Naoki Kanoh, Tohru Taniguchi, Kenji Monde, Yoshiharu Iwabuchi

  Heterocycles, 2014, 89, 631-639.

  
  

• Total Synthesis of the Proposed Structure of Heronamide C

  Kohei Sakanishi, Shunya Itoh, Ryosuke Sugiyama, Shinichi Nishimura, Hideaki Kakeya, Yoshiharu Iwabuchi, Naoki Kanoh

  Eur. J. Org. Chem., 2014, 1376-1380.

  
  

2013年度

• Discovery and Exploitation of AZADO: The Highly Active Catalyst for Alcohol Oxidation (Review)

  Yoshiharu Iwabuchi

  Chem. Pharm. Bull., 2013, 61, 1197-1213.

  
  

• An Improved Fluorogenic NAD(P)+ Detection Method Using 2-Acetylbenzofuran: Its Origin and Application

  Takashi Moriya, Ayano Kawamata, Yusuke Takahashi, Yoshiharu Iwabuchi, Naoki Kanoh

  Chem. Commun., 2013, 49, 11500-11502.

  
  

• 3-Methyl-4-Oxa-5-Azahomoadamantane: Alkoxyamine-Type Organocatalyst for Alcohol Oxidation

  Yusuke Sasano, Keiichi Murakami, Tomohiro Nishiyama, Eunsang Kwon, Yoshiharu Iwabuchi

  Angew. Chem. Int. Ed., 2013, 52, 12624-12627.

  
  

• On the Origin of cine-Substitution in the Stille Coupling of Trisubstituted Iodoalkene and trans-Vinylstannane

  Naoki Kanoh, Yutaro Ohno, Tomohiro Itagaki, Hayato Fukuda, Yoshiharu Iwabuchi

  Synlett, 2013, 24, 2660-2664.

  
  

• TEG scanning を用いた破骨細胞分化阻害剤メチルゲルフェリンの多次元的構造活性相関

  鈴木貴大、高山　浩、川谷　誠、長田裕之、岩渕好治、叶　直樹

  Chemical Biology (日本ケミカルバイオロジー学会機関紙）, 2013, 6(1), 3-7

  
  

• C-H MODIFICATION OF 2-AZAADAMANTANE: SYNTHESIS OF C5-FUNCTIONALIZED AZADOS FOR ADVANCED USE

  Yusuke Sasano, Tomohiro Nishiyama, Masaki Tomizawa, Masatoshi Shibuya, Yoshiharu Iwabuchi

  Heterocycles, 2013, 87,2109-2118.

  
  

• 有機ニトロキシルラジカルの反応性制御に基づく効率的アルコール空気酸化反応の開発

  澁谷　正俊、岩渕　好治

  有機合成化学協会誌 2013, 71,515-525.

  
  

• Concise Entry to Chiral 5-(4-Hydroxybutyl)-2(5H)-furanone via HTIB-Mediated Novel Oxidative Fragmentation: Formal Total Synthesis of (+)-Dubiusamine A

  Muneo Kawasumi and Yoshiharu Iwabuchi

  Org. Lett. 2013, 15,1788-1790.

  
  

• Dual structure-activity relationship of osteoclastogenesis inhibitor methyl gerfelin based on TEG scanning

  Naoki Kanoh, Takahiro Suzuki, Makoto Kawatani, Yasuhiro Kato, Hiroyuki Osada, Yoshiharu Iwabuchi

  Bioconjugate Chem. 2013, 24, 44-52.

  
  

2012年度

• Nitroxyl Radical/PhI(OAc)2: One-Pot Oxidative Cleavage of Vicinal Diols to (Di)Carboxylic Acids

  Masatoshi Shibuya, Takuro Shibuta, Hayato Fukuda, and Yoshiharu Iwabuchi

  Org. Lett. 2012, 14, 5010-5013.

  
  

• Organocatalytic One-Pot Oxidative Cleavage of Terminal Diols to Dehomologated Carboxylic Acids

  Masatoshi Shibuya, Ryūsuke Doi, Takuro Shibuta, Shun-ichiro Uesugi, and Yoshiharu Iwabuchi

  Org. Lett. 2012, 14, 5006-5009.

  
  

• Synthesis and Structure-Activity Relationship of Vicenistatin, a Cytotoxic 20-Membered Macrolactam Glycoside

  Hayato Fukuda, Yuko Nishiyama, Shiina Nakamura, Yutaro Ohno, Tadashi Eguchi, Yoshiharu Iwabuchi, Takeo Usui, Naoki Kanoh

  Chem. Asian. J. 2012, 7, 2872-2881.

  
  

• Catalytic Oxidation of Silyl Enol Ethers to 1,2-Diketones Employing Nitroxyl Radicals

  Masaki Hayashi, Masatoshi Shibuya, Yoshiharu Iwabuchi

  Synlett 2012, 1025-1031.

  
  

• Oxidation of Alcohols to Carbonyl Compounds with Diisopropyl Azodicarboxylate Catalyzed by Nitroxyl Radicals

  Masaki Hayashi, Masatoshi Shibuya, Yoshiharu Iwabuchi

  J. Org. Chem. 2012, 77, 3005-3009

  
  

• Oxidation of Nitroxyl Radicals: Electrochemical and Computational Studies

  Masatoshi Shibuya, Fabio Pichierri, Masaki Tomizawa, Shota Nagasawa, Iwao Suzuki, Yoshiharu Iwabuchi

  Tetrahedron Lett. 2012, 53,2070-2073.

  
  

• Oxidative Conversion of Silyl Enol Ethers to α,β-Unsaturated Ketones Employing Oxoammonium Salts

  Masaki Hayashi, Masatoshi Shibuya, Yoshiharu Iwabuchi

  Org. Lett. 2012, 14,154-157.

  
  

2011年度

• 9-Azanoradamantane N-Oxyl (Nor-AZADO): A Highly Active Organocatalyst for Alcohol Oxidation

  Masaki Hayashi, Yusuke Sasano, Shota Nagasawa, Masatoshi Shibuya, Yoshiharu Iwabuchi

  Chemical & Pharmaceutical Bulletin 2011, 59, 1570-1573.

  
  

• Practical preparation methods for highly active azaadamantane-nitroxyl-radical-type oxidation catalysts

  Masatoshi Shibuya, Yusuke Sasano, Masaki Tomizawa, Toshimasa Hamada, Masami Kozawa, Noriaki Nagahama, Yoshiharu Iwabuchi

  Synthesis 2011, 3418-3425.

  
  

• Novel Curcumin Analogs, GO-Y030 and GO-Y078, Are Multi-targeted Agents with Enhanced Abilities for Multiple Myeloma

  Chieko Kudo, Hiroyuki Yamakoshi, Atsuko Sato, Hisatsugu Ohori, Chikashi Ishioka , Yoshiharu Iwabuchi, Hiroyuki Shibata

  Cancer Science 2011, 102, 1045-1051.

  
  

• Detection of cytochrome P450 substrates using a small-molecule droplet array on an NADH-immobilized solid surface

  Hiroshi Takayama, Shunji Takahashi, Takashi Moriya, Hiroyuki Osada, Yoshiharu Iwabuchi, Naoki Kanoh

  ChemBioChem 2011, 12, 2748-2752.

  
  

• High-Performance Liquid Chromatography with Photodiode Array Detection for Determination of Nobiletin Content in the Brain and Serum of Mice Administrated the Natural Compound

  Daisuke Saigusa, Masatoshi Shibuya, Daisuke Jinno, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi, Akihito Yokosuka, Yoshihiro Mimaki, Akira Nganuma, Yasushi Ohizumi, Yoshihisa Tomioka, Tohru Yamakuni

  Anal. Bioanal. Chem. 2011, 400, 3635-3641.

  
  

• Targeting Colon Cancer Stem Cells Using a New Curcumin Analogue, GO-Y030

  L. Lin, Y Liu, P-K. Li, J. Fuchs, H. Shibata, Y. Iwabuchi, and J. Lin

  British J. Cancer 2011, 105, 212-220.

  
  

• Synthesis of 86 Species of 1,5-Diaryl-3-oxo-1,4-pentadienes Analogs of Curcumin can Yield a Good Lead in Vivo

  Chieko Kudo, Hiroyuki Yamakoshi, Atsuko Sato, Hiroshi Nanjo, Hisatsugu Ohori, Chikashi Ishioka, Yoshiharu Iwabuchi, Hiyoyuki Shibata

  BMC Phamacology 2011, 11, 4.

  
  

• Highly Efficient, Organocatalytic Aerobic Alcohol Oxidation

  Masatoshi Shibuya, Yuji Osada, Yusuke Sasano, Masaki Tomizawa, Yoshiharu Iwabuchi

  J. Am. Chem. Soc. 2011, 133, 6497-6500.

  
  

• Concise Entry to Both Enantiomers of 8-Oxabicyclo[3.2.1]oct-3-en-2-one Based on Novel Oxidative Etherification: Formal Synthesis of (+)Sundiversiforide

  Muneo Kawasumi, Naoki Kanoh, and Yoshiharu Iwabuchi

  Org. Lett. 2011, 13,3620-3623.

  
  

• Asymmetric Total Syhthesis of (-)-Scabronine G via Intramolecular Double Michael Reaction and Prins Cyclization

  Naoki Kanoh, Kohei Sakanishi, Emiko Iimori, Ken'ichi Nishimura, and Yoshiharu Iwabuchi

  Org. Lett. 2011, 13,2864-2867.

  
  

• Curcumin analog GO-Y030 is a novel inhibitor of IKKβ that suppresses NF-κB signaling and induces apoptosis

  Atsuko Sato, Chieko Kudo, Hiroyuki Yamakoshi, Yoshihiko Uehara, Hisatsugu Ohori, Chikashi Ishioka, Yoshiharu Iwabuchi, Hiroyuki Shibata

  Cancer Science 2011, 102,1045-1051.

  
  

• Preparation of Photo-Cross-Linked Small Molecule Affinity Matrices for Affinity Selection of Protein Targets for Biologically Active Small Molecules

  Hiroshi Takayama, Takashi Moriya, Naoki Kanoh

  in Chemical Genomics and Proteomics: Reviews and Protocols (Ed.: E. D. Zanders), Humana Press, Totowa, 2011,102, pp. 75-84.

  
  

• 化合物アレイを起点としたケミカルバイオロジー ～化合物アレイの基盤技術開発から機能未知タンパク質の機能解析まで～

  Naoki Kanoh, Siro Simizu

  化学と工業, 2011, 64(1), 37-39.

  
  

2010年度

• An Enantio- and Diastereocontrolled Synthesis of (-)-Salinosporamide A

  Yosuke Sato, Hayato Fukuda, Masaki Tomizawa, Tomohito Masaki, Masatoshi, Shibuya, Naoki Kanoh, and Yoshiharu Iwabuchi

  Heterocycles 2010, 81, 2239-2245.

  
  

• KSRP/FUBP2 Is a Binding Protein of GO-Y086, a Cytotoxic Curcumin Analogue

  Hiroyuki Yamakoshi, Naoki Kanoh, Chieko Kudo, Atsuko Sato, Kazunori Ueda, Makoto Muroi, Shunsuke Kon, Masanobu Satake, Hisatsugu Ohori, Chikashi Ishioka, Yoshiteru Oshima, Hiroyuki Osada, Natsuko Chiba, Hiroyuki Shibata, Yoshiharu Iwabuchi

  ACS Med. Chem. Lett. 2010, 1 273-276.

  
  

• Irciniastatin A induces JNK activation that is involved in caspase-8-dependent apoptosis via the mitochondrial pathway

  Takumi Chinen, Yoko Nagumo, Tsubasa Watanabe, Takamichi Imaizumi, Masatoshi Shibuya, Takao Kataoka, Naoki Kanoh, Yoshiharu Iwabuchi, Takeo Usui

  Toxicol. Lett. 2010, 199, 341-346.

  
  

• Concise Total Synthesis of Vicenistatin

  Hayato Fukuda, Shiina Nakamura, Tadashi Eguchi, Yoshiharu Iwabuchi, Naoki Kanoh

  Synlett 2010, 2589-2592.

  
  

• Syntheses and Biological Evaluation of Irciniastatin A and the C1-C2 Alkyne Analogus

  Tsubasa Watanabe, Takamichi Imaizumi, Takumi Chinen, Yoko Nagumo, Masatoshi Shibuya, Takeo Usui, Naoki Kanoh, and Yoshiharu Iwabuchi

  Org. Lett. 2010, 12, 1040-1043.

  
  

• Total Synthesis and Determination of the Absolute Configuration of (-)-Idesolide

  Hiroyuki Yamakoshi, Masatoshi Shibuya, Masaki Tomizawa, Yuji Osada, Naoki Kanoh, and Yoshiharu Iwabuchi

  Org. Lett. 2010, 12, 980-983.

  
  

• Structure-Activity Relationship of C5-Curcuminoids and Synthesis of their Molecular Probes Thereof

  Hiroyuki Yamakoshi, Hisatsugu Ohori, Chieko Kudo, Atsuko Sato, Naoki Kanoh, Chikashi Ishioka, Hiroyuki Shibata, and Yoshiharu Iwabuchi

  Bioorg. Med. Chem. 2010, 18, 1083-1092.

  
  

• Cleavable Linker for Photo-Cross-Linked Small-Molecule Affinity Matrix

  Naoki Kanoh, Hiroshi Takayama, Kaori Honda, Takashi Moriya, Takayuki Teruya, Siro Simizu, Hiroyuki Osada, Yoshiharu Iwabuchi

  Bioconjugate Chem 2010, 21, 182.

  
  

• 光親和型小分子固定化を利用した小分子ー蛋白質間相互作用スクリーニングプラットフォーム

  Naoki Kanoh

  in 生命現象を理解する分子ツール　～イメージングから生体機能解析まで～ (Eds.: I. Hamachi, S. Futaki), 化学同人, Kyoto, 2010,pp. 88-94.

  
  

• 有機合成化学を基盤とした天然有機化合物のケミカルバイオロジー

  Naoki Kanoh

  J. Syn. Org. Chem., Jpn. 2010, 68, 939.

  
  

• 第７章　各種バイオチップ　第４節　化合物チップ

  Naoki Kanoh

  in バイオチップ実用化ハンドブック (Eds.: 金子周一, 堀池靖浩, 監修), NTS Inc., Tokyo, 2010, pp. 203-209.

  
  

• Construction of Photo-Cross-Linked Microarrays of Small Molecules

  Naoki Kanoh

  in Small Molecule Microarrays: Methods and Protocols Eds.: S. Q. Yao, M. Uttamchandani), Humana Press, Totowa, 2010, pp. 17-22.

  
  

2009年度

• Syntheses of Naturally Occurring Cytotoxic[7.7]paracyclophanes, (-)-Cylindrocyclophane A and its Enantiomer, and Implications for Biological Activity

  Hiroyuki Yamakoshi, Fumiya Ikarashi, Masataka Minami, Masatoshi Shibuya, Tsutomu Sugahara, Naoki Kanoh, Hisatsugu Ohori, Hiroyuki Shibata and Yoshiharu Iwabuchi

  Org. Biomol. Chem. 2009, 7 3772-3781.

  
  

• Highly Enantioselective Intramolecular Aza-Spiroannulation onto Indoles Using Chiral Rhodium Catalysis: Asymmetric Entry to the Spiro-β-lactam Core of Chartellines

  Shigeki Sato, Masatoshi Shibuya, Naoki Kanoh, and Yoshiharu Iwabuchi

  Chem. Commun. 2009, 6264-6266.

  
  

• An Expedient Route to a Potent Gastrin/CCK-B Receptor Antagonist (+)-AG-041R

  Shigeki Sato, Masatoshi Shibuya, Naoki Kanoh, and Yoshiharu Iwabuchi

  J. Org. Chem. 2009, 74 7522-7524.

  
  

• 4'-Demethylnobiletin, a Bioactive Metabolite of Nobiletin Enhancing PKA/ERK/CREB Signaling, Rescues Learning Impairment Associated with NMDA Receptor Antagonism via Stimulation of the ERK Cascade

  Md. Al Rahim, Akira Nakajima, Daisuke Saigusa, Naomi Tetsu, Yuji Maruyama, Masatoshi Shibuya, Hiroyuki Yamakoshi, Yoshihisa Tomioka, Yoshiharu Iwabuchi, Yasushi Ohizumi, and Tohru Yamakuni

  Biochemistry. 2009, 48 7713-7721.

  
  

• Activation of Endothlial Nitric Oxide Synthase by a Vanadium Compound Ameliorates Pressure Overload-Induced Cardiac Injury in Ovariectomized Rats

  Md. Shenuarin Bhulyan, Norifumi Shioda, Masatoshi Shibuya, Yoshiahru Iwabuchi, and Kohji Fukunaga

  Hypertension 2009, 53, 57-63.

  
  

• An Expeditious Entry to 9-Azabicyclo[3.3.1]nonane N-Oxyl (ABNO): Another Highly Active Organocatalysts for Oxidation of Alcohols

  Masatoshi Shibuya, Masaki Tomizawa, Yusuke Sasano, and Yoshiharu Iwabuchi

  J. Org. Chem. 2009, 74, 4619-4622.

  
  

• Synthetic Studies on Daphnicyclidin A: Enantiocontrolled Construction of the BCD Ring System

  Shuhei Ikeda, Masatoshi Shibuya, Naoki Kanoh, and Yoshiharu Iwabuchi

  Org. Lett. 2009, 11, 1833-1836.

  
  

• Highly Enantioselective Organocatalytic Oxidative Kinetic Resolution of Secondary Alcohols Using Chirally Modified AZADOs

  Masaki Tomizawa, Masatoshi Shibuya and Yoshiharu Iwabuchi

  Org. Lett. 2009, 11 1829-1831.

  
  

• Curcumin analogue GO-Y030 inhibits STAT3 activity and cell growth in breast and pancreatic carcinomas

  Brian Hutzen, Lauren Friedman, Matthew Sobo, Li Lin, Ling Cen, Stephanie De Angelis, Hiroyuki Yamakoshi, Hiroyuki Shibata, Yoshiharu Iwabuchi, Jiayuh Lin

  Journal of Oncology 2009, 35, 867-872.

  
  

• Newly Synthesized Curcumin Analog Has Improved Potential to Prevent Colorectal Carcinogenesis In Vivo

  Hiroyuki Shibata, Hiroyuki Yamakoshi, Atsuko Sato, Hisatsugu Ohori, Yuichi Kakudo, Chieko Kudo, Yayoi Takahashi, Mika Watanabe, Hiroshi Takano, Chikashi Ishioka, Tetsuo Noda, Yoshiharu Iwabuchi

  Cancer Science 2009, 100, 956-960.

  
  

• Oxoammonium Salt/NaClO2: an Expedient, Catalytic System for One-Pot Oxidation of Primary Alcohols to Carboxylic Acids with Broad Substrate Applicability

  Masatoshi Shibuya, Takahisa Sato, Masaki Tomizawa, and Yoshiharu Iwabuchi

  Chem. Commun. 2009, 1739-1741.

  
  

• Structure-Affinity Relationship Study of Bleomycins and Shble Protein by Use of a Chemical Array

  Isao Miyazaki, Hideo Okumura, Siro Simizu, Yoshikazu Takahashi, Naoki Kanoh, Yasuhiko Muraoka, Yoshiaki Nonomura, Hiroyuki Osada

  ChemBioChem 2009, 10 845-852.

  
  

• Recent Advances and Developments of Small Molecule Microarrays

  Naoki Kanoh, Hiroyuki Osada

  in Protein Targeting with Small Molecules: Chemical BIology Techniques and Applications (Ed.: H. Osada), Wiley, Hoboken, 2009, pp. 57-80.

  
  

2008年度

• Distribution of Photo-Cross-Linked Products from 3-Aryl-3-trifluoromethy ldiazirines and Alcohols

  Naoki Kanoh, Takemichi Nakamura, Kaori Honda, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi, Hiroyuki Osada

  Tetrahedron 2008, 64, 5692-5698.

  
  

• TEMPO/NaIO4-SiO2: A Catalytic Oxidative Reattangement of Tertiary Allylic Alcohols to β-Substituted α,β-Unsaturated Ketones

  Masatoshi Shibuya, Masaki Tomizawa, and Yoshiharu Iwabuchi

  Org. Lett. 2008, 10, 4751-4718.

  
  

• Oxidative Rearrangement of Tertiary Allylic Alcohols Employing Oxoammnonium Salts

  Masatoshi Shibuya, Masaki Tomizawa, and Yoshiharu Iwabuchi

  J. Org. Chem. 2008, 73, 4750-4752.

  
  

• Flexible Access to Monoterpenoid Indole Alkaloids Using a Cyclopentanoid Chiral Building Block

  Masato Hayashi, Keiichi Motosawa, Atsushi Satoh, Masatoshi Shibuya, Kunio Ogasawara, and Yoshiharu Iwabuchi

  Heterocycles 2008, 77, 855-863.

  
  

• Efficient Entry to the Pyrroloquinoline Core of Martinella Alkaloids via Novel Base-catalyzed Mukaiyama-Mannich Reaction

  Shuhei Ikeda, Masatoshi Shibuya, Naoki Kanoh, Yoshiharu Iwabuchi

  Chem. Lett. 2008, 37, 962-963.

  
  

• Chemoenzymatic Preparation of Functionalized bicyclo[3.2.1]octenone and Practical Utilization

  Shinichiro Ito, Ayako Tosaka, Keisuke Hanada, Masatoshi Shibuya, Kunio Ogasawara, and Yoshiharu Iwabuchi

  Tetrahedron: Asymmetry 2008, 19, 176-185.

  
  

• The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I

  Makoto Kawatani, Hideo Okumura, Kaori Honda, Naoki Kanoh, Makoto Muroi, Naoshi Dohmae, Masamichi Takami, Mitsuhiro Kitagawa, Yushi Futamura, Masaya Imoto, Hiroyuki Osada

  Proc. Natl. Acad. Sci. USA 2008, 105 11691.

  
  

2007年度

• Cytoprotective effect of bis(1-oxy-2-pyridinethiolato)oxovanadiun(IV) on myocardial ischemia/reperfusion injury elicits inhibition of Fas ligand and Bim expression and elevation of FLIP expression

  Md. Shenuarin Bhuiyan, Masatoshi Shibuya, Norifumi Shioda, Shigeki Moriguchi, Jiro Kasahara, Yosiharu Iwabuchi, Kohji Fukunaga

  Europian Journal of Pharmacology 2007, 571, 180-188.

  
  

• Asymmetric Total Synthesis of Martinelline and Martinellic Acid

  Shuhei Ikeda, Masatoshi Shibuya, and Yoshiharu Iwabuchi

  Chem. Commun. 2007, 504-506.

  
  

• Synthesis of an Enantiomeric DNA oligomer and its T-Hg(II)-T Base-pair Formation

  Kaichiro Haruta, Yoshiyuki Tanaka, Takuya Kawamura, Yoshinori Kondo, Akira Ono, Hiroyuki Yamakoshi, Naoki Kanoh, Yoshiharu Iwabuchi

  Nucleic Acids Symposium Siries. 2007, 51, 187-188.

  
  

• Enantio- and Diastereocontrolled Synthesis of (+)-Juvabione employing Organocatalytic Desymmetrisation and Photoinduced Fragmentation

  Noriaki Itagaki, Yoshiharu Iwabuchi

  Chem. Commun. 2007, 1175-1176.

  
  

• 第10章　低分子アレイ

  Siro Simizu, Isao Miyazaki, Yasumitsu Kondoh, Naoki Kanoh, Hiroyuki Osada

  in マイクロアレイ・バイオチップの最新技術 (Ed.: Y. Ito), CMC press, Tokyo, 2007, pp. 229-239.

  
  

• 化合物アレイを用いた低分子-タンパク質相互作用の検出

  Akiko Saito, Naoki Kanoh, Hiroyuki Osada

  in 実験医学別冊　分子間相互作用解析ハンドブック(Ed.: 磯辺俊明、中山敬一、伊藤隆司), Yodosha, Tokyo, 2007, pp. 225-229.

  
  

• 第6章　小分子チップ

  N. Kanoh

  in ナノバイオ計測の実際(Eds.: K. Mihara, E. Obata, Y. Baba), Kodansya Scientific, Tokyo, 2007, pp. 52-62.

  
  

2006年度

• Synthesis and Biological Analysis of New Curcumin Analogues Bearing and Enhanced Petential for the Medicinal Treatment of Cancer

  Hisatsugu Ohori, Hiroyuki Yamakoshi, Masaki Tomizawa, Masatoshi Shibuya, Yuikchi Kakudo, Atsuko Takahashi, Shin Takahashi, Satoshi Kato, Takao Suzuki, Chikashi Ishioka, Yoshiharu Iwabuchi, and Hiroyuki Shibata

  Mol. Cancer Ther. 2006, 5, 153-159.

  
  

• Total Synthesis of (-)-Dihydrocorynantheol Using Bicyclo[3.2.1]octenone Chiral Building Block

  Ayako Tosaka, Shinichiro Ito, Norio Miyazawa, Masatoshi Shibuya, Kunio Ogasawra, and Yoshiharu Iwabuchi

  Heterocycles 2006, 70, 2563-2571.

  
  

• 2-Azaadamantane N-Oxyl (AZADO) and 1-Me-AZADO: Highly Efficient Organocatalysts for Oxidation of Alcohols

  Masatoshi Shibuya, Masaki Tomizawa, Iwao Suzuki, Yoshiharu Iwabuchi

  J. Am. Chem. Soc. 2006, 128, 8412-8413.

  
  

2005年度

• Expedient Synthesis of PotentCannabinoid Receptor Agonist (-)-CP55,940

  Noriaki Itagaki,Tsutomu Sugahara, Yoshiharu Iwabuchi

  Org. Lett. 2005, 7, 4181-4183.

  
  

• Oganocatalytic Entry to Chiral Bicyclo [3.n.1] alkanones via Direct Asymmetric Intramolecular Aldolization

  Noriaki Itagaki, Mari Kimura, Tsutomu Sugahara, Yoshiharu Iwabuchi

  Org. Lett. 2005, 7, 4185-4188.

  
  

2004年度

• Oxidative Rearrangement of Cyclic Tertiary Allylic Alcohols with IBX in DMSO

  Masatoshi Shibuya, Shinichiro Ito, Machiyasu Takahashi, and Yoshiharu Iwabuchi

  Org. Lett. 2004, 6, 4303-4306.

  
  

• Total Synthesis and Absolute Stereochemistry of Pentenocin B, a Novel Interleukin-1β Converting Enzyme Inhibitor

  Tsutomu Sugahara, Hayato Fukuda, and Yoshiharu Iwabuchi

  J. Org. Chem. 2004, 69, 1744-1747.