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Original Papers
(183) Semisynthetic Studies Establish a Role for Conjugate Halide Exchange in the Formation of
Chlorinated Pyrroloiminoquinones and Related Alkaloids
S. Sala, M. Shimomura, L. Tham, J. Sakata, A. N. Sobolev, S. A. Moggach, J. Fromont, O. Gomez,
M. J. Piggott, H. Tokuyama, S. G. Stewart, G. R. Flematti
J. Nat. Prod., published as ASAP article (DOI: doi.org/10.1021/acs.jnatprod.4c00549).
(182) Antibody-mimetic drug conjugate with efficient internalization activity using anti-Her2 VHH and duocarmycin
J. Sakata, T. Tatsumi, A. Sugiyama, A. Shimizu, Y. Inagaki, H. Katoh, T. Yamashita, K. Takahashi,
S. Aki, Y. Kaneko, T. Kawamura, M. Miura, M. Ishii, T. Osawa, T. Tanaka, S. Ishikawa, M. Tsukagoshi,
M. Chansler, T. Kodama, M. Kanai, H. Tokuyama, A. Sugiyama
Protein Expression and Purification, 214, 106375 (2024). (DOI: 10.1016/j.pep.2023.106375).
(181) Unified Divergent Total Synthesis of Discorhabdin B, H, K, and Aleutianamine via the Late-Stage Oxidative N,S-Acetal Formation
M. Shimomura, K. Ide, J. Sakata, H. Tokuyama
J. Am. Chem. Soc., 145, 18233-18239 (2023) (DOI: 10.1021/jacs.3c06578).
(180) Concise Total Synthesis of (+)-Pleiocarpamine and Convergent Total Syntheses of (+)-Voacalgine A and (+)-Bipleiophylline via an
Aerobic Oxidative Coupling
K. Okada, K. Ojima, H. Ueda, H. Tokuyama
J. Am. Chem. Soc., 145(30), 16337-16343 (2023) (DOI: 10.1021/jacs.3c05811).
(179) Synthetic Studies on Cimiciduphytine
K. Ojima, H. Ueda, H. Tokuyama
Bull. Chem. Soc. Jpn., 96(5), 484-495 (2023) (DOI: 10.1246/bcsj.20230054).
(178) Iron-Catalyzed Biomimetic Dimerization of Tryptophan-Containing Peptides
H. Ueda, S. Sato, K. Noda, H. Hakamata, E. Kwon, N. Kobayashi, H. Tokuyama
Angew. Chem. Int. Ed., 62(22), e202302404 (2023) (DOI: 10.1002/anie.202302404). Open Access
(177) Efficient and Scalable Asymmetric Total Synthesis of (−)-Emetine with Pharmaceutical Grade Quality; First Multigram Scale Synthesis
M.Yamada, K. Azuma, I. Takizawa, Y. Ejima, M. Yamano, K. Satoh, T. Doi, H. Ueda, H. Tokuyama
Org. Process Res. Dev. 27, 343-357 (2023) (DOI: 10.1021/acs.oprd.2c00355). selected as ACS Editors Choice
(176) Catalytic Enantioselective 5-endo-Bromocycloetherification of Unactivated Cyclic Alkenes
H. Xiong, K. Okada, K. Yoshida, H. Ueda, H. Tokuyama
Tetrahedron Lett., 101, 153906 (2022) (DOI: 10.1016/j.tetlet.2022.153906).
(175) Construction of Tetrahydroquinolines with Spirocyclic Structures at the 4-Position
Y. Wakahara, T. Noro, J. Sakata, H. Ueda, H. Tokuyama
Heterocycles, 105, 438-460 (2022) (DOI:10.3987/COM-22-S(R)16) (Prof. Somsak Ruchirawat's Special Issues).
(174) Total synthesis of (±)-vinoxine: construction of the bridged pyrido[1,2-a]indole skeleton
via Tf2O-mediated Bischler–Napieralski reaction and stereoselective radical cyclization
K. Okada, H. Ueda, H. Tokuyama
Org. Biomol. Chem., 20, 5943-5947 (2022) (DOI:10.1039/D2OB00274D).
(173) Photoredox-Catalyzed Intramolecular Cyclopropanation of Alkenes with α-Bromo-β-keto Esters
K. Ide, M. Furuta, H. Tokuyama
Org. Biomol. Chem.,19, 9172-9176 (2021) (DOI:10.1039/D1OB01733K).
(172) Synthetic Studies on Discorhabdin V: Construction of the A–F Hexacyclic Framework
T. Noro, J. Sakata, H. Tokuyama
Tetrahedron Lett., 81, 153333 (2021) (DOI: 10.1016/j.tetlet.2021.153333).
(171) Synthesis of leuconoxine, leuconodine B, and rhazinilam by transformation of melodinine E via 6-hydro-21-dehydroxyleuconolam
A. Umehara, H. Ueda, H. Tokuyama
Tetrahedron, 79, 131809 (2021) (DOI: 10.1016/j.tet.2020.131809).
(170) Synthesis of substituted anilines via a gold-catalyzed three-component reaction
H. Ueda, R. Yamamoto, M. Yamaguchi, H. Tokuyama
Org. Biomol. Chem., 19, 765-769 (2021) (DOI: 10.1039/D0OB02018D). selected as inside fort cover
(169) Total syntheses of (-)-emestrin H and (-)-asteroxepin
K. Umeki, Y. Ueda, J. Sakata, H. Tokuyama
Tetrahedron, 76, 131630 (2020) (DOI: 10.1016/j.tet.2020.131630) selected as 2020 editors choice collection
(168) A Concise Enantioselective Total Synthesis of (–)-Deoxoapodine
K. Yoshida, K. Okada, H. Ueda, H. Tokuyama
Angew. Chem. Int. Ed., 59, 23089-23093 (2020) (DOI: 10.1002/anie.202010759).
(167) Cyclic Sulfamidite as Simultaneous Protecting Group for Amino Alcohols: Development of a Mild
Deprotection Protocol Using Thiophenol
J. Sakata, K. Akita, M. Sato, M. Shimomura, H. Tokuyama
Chem. Pharm. Bull., 68, 996-1000 (2020) (DOI: 10.1248/cpb.c20-00531).
(166) Nitrile Synthesis by Aerobic Oxidation of Primary Amines and in situ Generated Imines from Aldehydes and Ammonium Salt
with Grubbs Catalyst
T. Utsumi, K. Noda, D. Kawauchi, H. Ueda, H. Tokuyama
Adv. Synth. Catal., 362, 3583-3588 (2020) (DOI: 10.1002/adsc.202000663).
(165) Divergent Total Syntheses of Isobatzellines A/B and Batzelline A
Y. Yamashita, L. Poignant, J. Sakata, H. Tokuyama
Org. Lett., 22, 6239-6243 (2020) (DOI:10.1021/acs.orglett.0c01894). selected as cover picture
(164) Aerobic Dehydrogenation of N-Heterocycles with Grubbs Catalyst: Its Application to
Assisted-Tandem Catalysis to Construct N-Containing Fused Heteroarenes
D. Kawauchi, K. Noda, Y. Komatsu, K. Yoshida, H. Ueda, H. Tokuyama
Chem. Eur. J., 26, 15793-15798 (2020) (DOI:10.1002/chem.202001961). selected as Hot Paper and Frontispiece
(163) Total Synthesis of (–)-Lepadiformine A via Radical Translocation–Cyclization Reaction
M. Shimomura, M. Sato, H. Azuma, J. Sakata, H. Tokuyama
Org. Lett., 22, 3313-3317 (2020) (DOI:10.1021/acs.orglett.0c00474). selected as cover picture
(162) Fluorescent labeling method re-evaluates the intriguing thermoresponsive behavior of poly(acrylamide-co-acrylonitrile)s
with upper critical solution temperatures
C. Otsuka, Y. Wakahara, K. Okabe, J. Sakata, M. Okuyama, A. Hayashi, H. Tokuyama, S; Uchiyama
Macromolecules, 52, 7646-7660 (2019) (DOI: 10.1021/acs.macromol.9b00880).
(161) Identification of Emetine as a Therapeutic Agent for PulmonaryAarterial Hypertension -A Novel Eeffect of an Old Drug-
MAH Siddique, K. Satoh, R. Kurosawa, N. Kikuchi, M. Elias-Al-Mamun, J. Omura, T. Satoh, M. Nogi, S. Sunamura, S. Miyata,
H. Ueda, H. Tokuyama, H. Shimokawa
Arterioscler. Thromb. Vasc. Biol. 39, 2367–2385 (2019) (Doi: 10.1161/ATVBAHA.119.313309.).
(160) Total Synthesis of (+)-CC-1065 Utilizing Ring Expansion Reaction of Benzocyclobutenone Oxime Sulfonate
T. Imaizumi, Y. Yamashita, Y. Nakazawa, K. Okano, J. Sakata, H. Tokuyama
Org. Lett., 21, 6185-6189 (2019) (DOI: 10.1021/acs.orglett.9b01690). selected as cover picture
(159) Rapid Assembly of Protoilludane Skeleton through Tandem Catalysis: Total Synthesis of Paesslerin A and Its Structural Revision
Y. Mogi, K. Inanaga, H. Tokuyama, M. Ihara, Y. Yamaoka, K. Yamada, K. Takasu
Org. Lett., 21, 3954-3958 (2019) (DOI: 10.1021/acs.orglett.9b01089).
(158) Construction of Indole Structure on Pyrroloindolines via AgNTf2-Mediated Amination/Cyclization Cascade:
Application to Total Synthesis of (+)-Pestalazine B
H. Hakamata, H. Ueda, H. Tokuyama
Org. Lett.,21, 4205-4209 (2019) (DOI:10.1021/acs.orglett.9b01399).
(157) Synthesis of Propargylic Ethers by Gold-Mediated Reaction of Terminal Alkynes with Acetals
M. Furuta, K. Sugiyama, M. Yamaguchi, H. Ueda, H. Tokuyama
Chem. Pharm. Bull.,67, 872-876 (2019) (DOI: 10.1248/cpb.c19-00322). selected as highlighted paper and cover picture
(156) Double Functionalization of Styrenes by Cu-mediated Assisted Tandem Catalysis
D. Kawauchi, H. Ueda, H. Tokuyama
Eur. J. Org. Chem., 15, 2056-2060 (2019) (DOI: 10.1002/ejoc.201900088).
(155) Synthetic Studies on Plakinidines
T. Satoh, T. Adachi, K. Okano, J. Sakata, H. Tokuyama
Heterocycles, 99, 310-323 (2019) (DOI: 10.3987/COM-18-S(F)26).
(154) Novel Potent ABCB1 Modulator, Phenethylisoquinoline Alkaloid, Reverses Multidrug Resistance in Cancer Cell
N. Sugisawa, S. Ohnuma, H. Ueda, M. Murakami, K. Sugiyama, K. Ohsawa, K. Kano, H. Tokuyama, T. Doi,
J. Aoki, M. Ishida, K. Kudoh, T. Naitoh, S. V. Ambudkar, M. Unno
Mol. Pharmaceutics,15, 4021–4030 (2018) (DOI: 10.1021/acs.molpharmaceut.8b00457)
(153) One-pot Reductive Allylation of Amides Using a Combination of Titanium Hydride and Allylzinc Reagents: Application
to a Total Synthesis of (–)-Castoramine
S. Itabashi, M. Shimomura, M. Sato, H. Azuma, K. Okano, J. Sakata, H. Tokuyama
Synlett, 29, 1786-1790 (2018) (DOI: 10.1055/s-0037-1610435)
(152) Synthetic Studies Toward Isoschizogamine: Construction of Pentacyclic Core Structure
K. Sugimoto, H. Fujiwara, A. Takada, D.-G. Kim, H. Ueda, H. Tokuyama
Heterocycles, 97, 1028-1049 (2018) (DOI: 10.3987/COM-18-S(T)85).
(151) A Cell‐Targeted Non‐Cytotoxic Fluorescent Nanogel Thermometer Created with an Imidazolium‐Containing Cationic Radical Initiator
S. Uchiyama, T. Tsuji, K. Kawamoto, K. Okano, E. Fukatsu, T. Noro, K. Ikado, S. Yamada, Y. Shibata, T. Hayashi, N. Inada, M. Kato,
H. Koizumi, H. Tokuyama
Angew. Chem. Int. Ed., 57, 5413-5417 (2018) (DOI: 10.1002/anie.201801495)
(150) Cordybislactone, a Stereoisomer of the 14-Membered Bislactone Clonostachydiol, from the Hopper Pathogenic
Fungus Cordyceps sp. BCC 49294: Revision of the Absolute Configuration of Clonostachydiol
K. Ojima, A. Yangchum, P. Laksanacharoen, K. Tasanathai, D. Thanakitpipattana, H. Tokuyama, M. Isaka
J. Antibiot.,71, 351–358 (2018) (DOI:10.1038/s41429-017-0008-9)
(149) Synthesis of 9,10-Diarylanthracenes via Mg(TMP)2·2LiCl-Mediated Benzyne Generation/[4+2] Cycloaddition and
Deoxygenation of 9,10-Epoxyanthracene Intermediates
N. Miyamoto, Y. Nakazawa, T. Nakamura, K. Okano, S. Sato, Z. Sun, H. Isobe, H. Tokuyama
Synlett, 29, 513–518 (2018) (DOI: 10.1055/s-0036-1591510)
(148) AgNTf2-Mediated Allylation with Allylsilanes at C3a-Position of Hexahydropyrroloindoles:
Application to Total Syntheses of Amauromine Alkaloids
H. Hakamata, S. Sato, H. Ueda, H. Tokuyama
Org. Lett., 19, 5308–5311 (2017) (DOI: 10.1021/acs.orglett.7b02602)
(147) Total Synthesis of Actinophyllic Acid
Y. Yoshii, H. Tokuyama, D. Y.-K. Chen
Angew. Chem. Int. Ed., 56, 12277-12281 (2017) (DOI: 10.1002/anie.201706312)
(146) AgNTf2-Mediated Arylation of Bromopyrroloindolines
S. Sato, A. Hirayama, T. Adachi, D. Kawauchi, H. Ueda, H. Tokuyama
Heterocycles, 94, 1940-1957 (2017) (DOI: 10.3987/COM-17-13777)
(145) Total Synthesis of (−)-Histrionicotoxin through a Stereoselective Radical Translocation–Cyclization Reaction
M. Sato, H. Azuma, A. Daigaku, S. Sato, K. Takasu, K. Okano, H. Tokuyama
Angew. Chem. Int. Ed., 56, 1087-1091 (2017) (DOI: 10.1002/anie.201609941)
(144) Structural determination of (–)-SCH 64874 and hirsutellomycin by semi-synthesis
H. Tokuyama, K. Yamada, H. Fujiwara, J. Sakata, K. Okano, M. Sappan, M. Isaka
J. Org. Chem., 82, 353-371 (2017) (DOI: 10.1021/acs.joc.6b02452)
(143) An obtuse-angled corner unit for fluctuating carbon nanohoops
Z. Sun, N. Miyamoto, S. Sato, H. Tokuyama, H. Isobe
Chem. Asian J.,12, 271-275 (2017) (DOI: 10.1002/asia.201601551)
(142) Total Syntheses of (+)-T988 B and C via AgNTf2-Mediated Coupling of Bromopyrroloindoline with Indole
S. Sato, A. Hirayama, H. Ueda, H. Tokuyama
Asian J. Org. Chem., 6, 54-58 (2017) (DOI: 10.1002/1joc.201600474)
(141) Bioinspired Total Synthesis of the Dimeric Indole Alkaloid (+)-Haplophytine by Direct Coupling
and Late-Stage Oxidative Rearrangement
H. Satoh, K. Ojima, H. Ueda, H. Tokuyama
Angew. Chem. Int. Ed., 55, 15157-15161 (2016) (DOI: 10.1002/anie.201609285)
(140) Condensation of Carboxylic Acids with Non-Nucleophilic N-Heterocycles and Anilides Using Boc2O
A. Umehara, H. Ueda, H. Tokuyama
J. Org. Chem., 81, 11444-11453 (2016) (DOI: 10.1021/acs.joc.6b02097)
(139) Convergent Synthesis of 2-Aryl-Substituted Quinolines by Gold-Catalyzed Cascade Reaction
H. Ueda, M. Yamaguchi, H. Tokuyama
Chem. Pharm. Bull.,64, 824-829 (2016) (DOI: 10.1248/cpb.c16-00193)
(138) Coversion of Vindoline into 11-Mesyloxytabersonine
Y. Han-ya, T. Inui, S. Yokoshima, H. Tokuyama, T. Fukuyama
Chem. Pharm. Bull., 64, 800-804 (2016) (DOI: 10.1248/cpb.c16-00175)
(137) Trichloroboron-Promoted Deprotection of Phenolic Benzyl Ether using Pentamethylbenzene as a Non Lewis-Basic Cation Scavenger
S. Okaya, K. Okuyama, K. Okano, H. Tokuyama
Org. Synth., 93, 63-74 (2016) (DOI: 10.15227/orgsyn.093.0063)
(136) Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase
J. Morita, K. Kano, K. Kato, H. Takita, H. Sakagami, Y. Yamamoto, E. Mihara, H. Ueda, T. Sato, H. Tokuyama, H. Arai,
H. Asou, J. Takagi, R. Ishitani, H. Nishimasu, O. Nureki, J. Aoki
Scientific Reports, 6, 20995 (2016) (DOI: 10.1038/srep20995)
(135) Total syntheses of codonopsinine and 4-epi-codonopsinine via gold-mediated tandem catalyzed pyrrole synthesis
M. Yamaguchi, D. Itagaki, H. Ueda, H. Tokuyama
J. Antibiot.,69, 253-258 (2016)
(DOI: 10.1038/ja.2016.13)
(134) DIBALH-Mediated Reductive Ring-Expansion Reaction of Cyclic Ketoxime
T. Imaizumi, K. Okano, H. Tokuyama
Org. Synth., 93, 1-13 (2016) (DOI: 10.1002/0471264229.os093.01)
(133) Synthesis of Substituted Quinolizidines via a Gold-Catalyzed Double Cyclization Cascade
S. Nonaka, K. Sugimoto, H. Ueda, H. Tokuyama
Adv. Synth. Catal., 358, 380-385 (2016) (DOI: 10.1002/adsc.201500907) selected as cover picture
(132) Synthetic Studies on Acochlearine: Construction of A/B/C/E/F Ring System
K. Fujioka, N. Miyamoto, H. Toya, K. Okano, H. Tokuyama
Synlett, 27, 621-625 (2016) (DOI: 10.1055/s-0035-1560384)
(131) Total Synthesis of (+)-MPC1001B
T. Kurogi, S. Okaya, H. Fujiwara, K. Okano, H. Tokuyama
Angew. Chem. Int. Ed., 55, 283-287 (2016) (DOI: 10.1002/anie.201609941)
(130) Total Synthesis of (–)-Isoschizogamine
A. Takada, H. Fujiwara, K. Sugimoto, H. Ueda, H. Tokuyama
Chem. Eur. J., 21, 16400-16403 (2015) (DOI: 10.1002/chem.201503606)
(129) A Concise Total Synthesis of (–)-Indolactam V
T. Noji, K. Okano, H. Tokuyama
Tetrahedron, 71, 3833-3837 (2015) (DOI: 10.1016/j.tet.2015.04.015)
(128) Total Synthesis of (–)-Rhazinilam Using 1,3-Dipolar Cycloaddition of Optically Active Münchnone Intermediate
K. Sugimoto, Y. Miyakawa, H. Tokuyama
Tetrahedron, 71, 3619-3624 (2015) (DOI: 10.1016/j.tet.2014.12.018)
(Symposium-in-Print on Synthesis of Indole/Pyrrole-Containing Natural Products)
(127) Synthetic Studies toward Penitrem E: Enantiocontrolled Construction of B-E Rings
Y. Yoshii, T. Otsu, N. Hosokawa, K. Takasu, K. Okano, H. Tokuyama
Chem. Commun., 51, 1070-1073 (2015) (DOI: 10.1039/c4cc08505a)
(126) Stereochemistry of Vinylogous Rubottom Oxidation of Proline-fused Cyclohexadienol Silyl Ether
K. Okano, S. Okaya, T. Kurogi, H. Fujiwara, H. Tokuyama
Heterocycles, 90, 1299-1308 (2015) (DOI: 10.3987/COM-14-S(K)62)
(125) Synthetic studies on lycopodine: construction of hexahydrojulolidine core by intramolecular Mannich reaction
T. Sato, H. Ueda, H. Tokuyama
Tetrahedron Lett., 55, 7177-7180 (2014) (DOI: 10.1016/j.tetlet.2014.10.150)
(124) Total Synthesis of (-)-Haouamine B Pentaacetate and Structural Revision of Haouamine B
Y. Momoi, K. Okuyama, H. Toya, K. Sugimoto, K. Okano, H. Tokuyama
Angew. Chem. Int. Ed., 53, 13215-13219 (2014) (DOI: 10.1002/ange.201407686)
(123) Generation of Aryl Grignard Reagent from Arene Chromium Tricarbonyl Complex by Mg(TMP)2·2LiCl and Its Application to Murahashi Coupling
Y. Momoi, K. Okano, H. Tokuyama
Synlett, 25, 2503-2507 (2014) (DOI: 10.1055/s-0034-1379205)
(122) Auto tandem Catalysis: Synthesis of Pyrroles by Gold-Catalyzed Cascade Reaction
H. Ueda, M. Yamaguchi, H. Kameya, K. Sugimoto, H. Tokuyama
Org. Lett., 16, 4948-4951 (2014) (DOI: 10.1021/ol5024695)
(121) Stereocontrolled Total Synthesis and Biological Evaluation of (–)- and (+)-Petrosin, and Its Derivatives
H. Toya, T. Satoh, K. Okano, K. Takasu, M. Ihara, A. Takahashi, H. Tanaka, H. Tokuyama
Tetrahedron, 70, 8129-8141 (2014) (DOI: 10.1016/j.tet.2014.08.009)
(120) Acetic Acid-Promoted Metal-Free Aerobic Carbon-Carbon Bond Forming Reactions at α-Position of Tertiary Amines
H. Ueda, K. Yoshida, H. Tokuyama
Org. Lett., 16, 4194-4197 (2014) (DOI: 10.1021/ol5018883)
(119) Total Syntheses of Leuconoxine, Leuconodine B, and Melodinine E by Oxidative Cyclic Aminal Formation
and Diastereoselective Ring-Closing Metathesis
A. Umehara, H. Ueda, H. Tokuyama
Org. Lett., 16, 2526-2529 (2014) (DOI: 10.1021/ol500903e)
(118) Synthesis of a Human Urate Transporter-1 Inhibitor, an Arginine Vasopressin Antagonist, and a 17β-Hydroxysteroid Dehydrogenase
Type 3 Inhibitor, Using Ring-Expansion of Cyclic Ketoximes with DIBALH
H. Cho, Y. Iwama, K. Okano, H. Tokuyama
Chem. Pharm. Bull., 62, 354-363 (2014) (DOI: 10.1248/cpb.c13-00961)
(117) Overexprssion of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by
hypo-sphingosine-1-phosphate signaling in zebrafish embryo
K. Nakanaga, K. Hama, K. Kano, T. Sato, H. Yukiura, A. Inoue, D. Saigusa, H. Tokuyama, Y. Tomioka, H. Nishina, A. Kawahara, J. Aoki
J. Biochem., 155, 235-241 (2014) (DOI: 10.1093/jb/mvt114)
(116) Formation of Xanthone Oxime and Related Compounds Using a Combination of tert-Butyl Nitrite and Potassium Hexamethyldisilazide
Y. Iwama, T. Noro, K. Okano, H. Cho, H. Tokuyama
Heterocycles, 88, 1433-1444 (2014) (DOI: 10.3987/COM-13-S(S)110)
(115) Synthetic Studies on Isoschizogamine: Construction of [3.3.1] Bicyclic Aminal Core by Using Oxidative Skeletal Rearrangement
H. Ueda, A. Takada, H. Tokuyama
Tetrahedron Lett., 54, 7115-7118 (2013)
(114) Total Synthesis of PDE-I and -II by Copper-Mediated Double Aryl Amination
K. Okano, N. Mitsuhashi, H. Tokuyama
Tetrahedron, 69, 10946-10954 (2013)
(113) Formal Synthesis of Hepatitis C Virus NS5B Polymerase Inhibitor
T. Noro, K. Okano, H. Tokuyama
Synlett, 2143-2147 (2013)
(112) Protecting-Group-Free Total Synthesis of (–)-Rhazinilam and (–)-Rhazinicine using a Gold-Catalyzed Cascade Cyclization
K. Sugimoto, K. Toyoshima, S. Nonaka, K. Kotaki, H. Ueda, H. Tokuyama
Angew. Chem. Int. Ed., 52, 7168-7171 (2013)
(111) Enantiocontrolled Total Synthesis of (–)-Mersicarpine
Y. Iwama, K. Okano, K. Sugimoto, H. Tokuyama
Chem. Eur. J., 19, 9325-9334 (2013)
(110) Synthesis of Substituted Indoline and Carbazole by Benzyne-Mediated Cyclization-Functionalization
T. Noji, H. Fujiwara, K. Okano, H. Tokuyama
Org. Lett., 15, 1946-1949 (2013)
(109) Construction of Dibenzazocine Skeleton by Regiocontrolled Ring-expansion Reaction of Cyclic Oxime with DIBALH:
Facile Synthesis of 17β-Hydroxysteroid Dehydrogenase Type 3 Inhibitor
H. Cho, Y. Iwama, K. Okano, H. Tokuyama
Synlett, 813-816 (2013)
(108) Divergent Total Synthesis of (–)-Aspidophytine and its Congeners via Fischer Indole Synthesis
H. Satoh, H. Ueda, H. Tokuyama
Tetrahedron, 69, 89-95 (2013)
(107) Synthetic Studies on Strictamine: Unexpected Oxidation of Tertiary Amine in Ru-Catalyzed Ring-Closing Olefin Metathesis
Y. Komatsu, K. Yoshida, H. Ueda, H. Tokuyama
Tetrahedron Lett., 54, 377-380 (2013)
(106) Toward the Total Synthesis of (±)-Andrastin C
R. Okamoto, K. Takeda, H. Tokuyama, M. Ihara, M. Toyota
J. Org. Chem., 78, 93-103 (2013)
(105) Total Synthesis of (–)-Acetylaranotin
H. Fujiwara, T. Kurogi, S. Okaya, K. Okano, H. Tokuyama
Angew. Chem. Int. Ed., 51, 13062-13065 (2012)
(104) Total Synthesis of Makaluvamine A/D, Damirone B, Batzelline C, Makaluvone, and Isobatzelline C
Featuring One-Pot Benzyne-Mediated Cyclization-Functionalization
T. Oshiyama, T. Satoh, K. Okano, H. Tokuyama
Tetrahedron, 68, 9376-9383 (2012)
(103) Ring-Expansion Reaction of Oximes with Aluminum Reductants
H. Cho, Y. Iwama, N. Mitsuhashi, K. Sugimoto, K. Okano, H. Tokuyama
Molecules, 17, 7348-7355 (2012)
(102) Facile Isomerization of Silyl Enol Ethers Catalyzed by Triflic Imide and Its Application to One-Pot
Isomerization–(2+2) Cycloaddition
K. Inanaga, Y. Ogawa, Y. Nagamoto, A. Daigaku, H. Tokuyama, Y. Takemoto, K. Takasu
Beilstein J. Org. Chem., 8, 658-661 (2012)
(101) Synthesis and biological evaluation of optically active Ki16425
T. Sato, K. Sugimoto, A. Inoue, S. Okudaira, J. Aoki, H. Tokuyama
Bioorg. Med. Chem. Lett., 22, 4323-4326 (2012)
(100) Total Synthesis of Batzelline C and Isobatzelline C
T. Oshiyama, T. Satoh, K. Okano, H. Tokuyama
RSC Adv., 2, 5147-5149 (2012)
(99) Concise Total Synthesis of (–)-Mersicarpine
Y. Iwama, K. Okano, K. Sugimoto, H. Tokuyama
Org. Lett., 14, 2320-2322 (2012)
(98) Synthetic Studies on Paspaline: Lewis Acid-Mediated Sequential Construction of A-E Ring Skeleton
K. Okano, Y. Yoshii, H. Tokuyama
Heterocycles, 84, 1325-1334 (2012)
(97) Synthesis of Acylsilanes by Palladium-catalyzed Cross-coupling Reaction of Thiol Esters and Silylzinc Chlorides
H. Azuma, K. Okano, H. Tokuyama
Chem. Lett., 40, 959-961 (2011)
(96) Total Synthesis of Tryprostatins A and B
T. Yamakawa, E. Ideue, Y. Iwaki, A. Sato, H. Tokuyama, J. Shimokawa, T. Fukuyama
Tetrahedron, 67, 6547-6560 (2011)
(95) An Intramolecular Amination of Aryl Halides with a Combination of Copper(I) Iodide and Cesium Acetate:
Preparation of 5,6-Dimethoxyindole-1,2-dicarboxylic Acid 1-Benzyl Ester 2-Methyl Ester
T. Noji, K. Okano, T. Fukuyama, H. Tokuyama
Org. Synth., 88, 388-397 (2011)
(94) Total Synthesis of (–)-Conophylline and (–)-Conophyllidine
Y. Han-ya, H. Tokuyama, T. Fukuyama
Angew. Chem. Int. Ed., 50, 4884-4887 (2011)
(93) Preparation of Horner-Wadsworth-Emmons Reagent:
Methyl 2-Benzyloxycarbonylamino-2-(dimethoxyphosphinyl)acetate
H. Azuma, K. Okano, T. Fukuyama, H. Tokuyama
Org. Synth., 88, 152-161 (2011)
(92) Synthetic Studies toward Haouamine B: Construction of Indenotetrahydropyridone Skeleton
K. Okuyama, Y. Momoi, K. Sugimoto, K. Okano, H. Tokuyama
Synlett, 73-76 (2011)
(91) Regiospecific Rearrangement of Hydroxylamines to Secondary Amines using Diisobutylaluminum Hydride
H. Cho, K. Sugimoto, Y. Iwama, N. Mitsuhashi, K. Okano, H. Tokuyama
Heterocycles, 82, 1633-1644 (2011)
(90) Total Synthesis of Dictyodendrins A–E
H. Tokuyama, K. Okano, H. Fujiwara, T. Noji, T. Fukuyama
Chem. Asian J., 6, 560-572 (2011)
(89) Enantioselective Total Synthesis of (–)- and (+)-Petrosin
H. Toya, K. Okano, K. Takasu, M. Ihara, A. Takahashi, H. Tanaka, H. Tokuyama
Org. Lett., 12, 5196-5199 (2010)
(88) Total Synthesis of Dictyodendrin A and B
K. Okano, H. Fujiwara, T. Noji, T. Fukuyama, H. Tokuyama
Angew. Chem. Int. Ed., 49, 5925-5929 (2010)
(87) Selective Accumulation of Rhodacyanine in Plasmodial Mitochondria is Related to the Growth Inhibition of Malaria Parasites
D. Morisaki, H.-S. Kim, H. Inoue, H. Terauchi, S. Kuge, A. Naganuma, Y. Wataya, H. Tokuyama, M. Ihara, K. Takasu
Chem. Sci., 1, 206-209 (2010)
(86) Total Synthesis of PDE-II by Copper-Mediated Double Amination
K. Okano, N. Mitsuhashi, H. Tokuyama
Chem. Commun., 46, 2641-2643 (2010)
(85) Total Synthesis of (±)-Lepadiformine A via Radical Translocation/Cyclization Reaction
M. Fujitani, M. Tsuchiya, K. Okano, K. Takasu, M. Ihara, H. Tokuyama
Synlett, 822-826 (2010)
(84) Regioselective Synthesis of Heterocycles containing Nitrogen Neighboring an Aromatic Ring
by the Reductive Ring Expansion using Diisobutylaluminum Hydride (DIBALH) and Studies on the Reaction Mechanism
H. Cho, Y. Iwama, K. Sugimoto, S. Mori, H. Tokuyama
J. Org. Chem., 75, 627-636 (2010)
(83) Total Synthesis of (+)-Haplophytine
H. Ueda, H. Satoh, K. Matsumoto, K. Sugimoto, T. Fukuyama, H. Tokuyama
Angew. Chem. Int. Ed., 48, 7600-7603 (2009) selected as cover picture
(82) Regiospecific Synthesis of Unsubstituted Basic Skeletons of Heterocycles Containing Nitrogen
Neighboring an Aromatic Ring by the Reductive Ring Expansion Reaction using Diisobutylaluminum Hydride
H. Cho, Y. Iwama, K. Sugimoto, E. Kwon, H. Tokuyama
Heterocycles, 78, 1183-1190 (2009)
(81) Synthesis of Lysergic Acid Methyl Ester via the Double Cyclization Strategy
T. Kurokawa, M. Isomura, H. Tokuyama, T. Fukuyama
Synlett, 775-778 (2009)
(80) Protection of Diols with p-(tert-Butyldimethylsilyloxy)benzylidene Acetal and Its Deprotection:
(4-((4R,5R)-4,5-Diphenyl-1,3-dioxolan-2-yl)phenoxy)(tert-butyl)dimethylsilane
H. Osajima, H. Fujiwara, K. Okano, H. Tokuyama, T. Fukuyama
Org. Synth., 86, 130-140 (2009)
(79) Palladium-Catalyzed Coupling of N-Heteroaryl Sulfides with Organozinc Reagents
T. Koshiba, T. Miyazaki, H. Tokuyama, T. Fukuyama
Heterocycles, 77, 233-239 (2009)
(78) Triflic Imide Catalyzed (3+2) Cycloaddition of Aldimines with α-,α-Dimethylallylsilane
N. Shindoh, H. Tokuyama, Y. Takemoto, K. Takasu
Heterocycles, 77, 187-192 (2009)
(77) A Mild Inter- and Intramolecular Amination of Aryl Halides with a Combination of CuI and CsOAc
T. Kubo, C. Katoh, K. Yamada, K. Okano, H. Tokuyama, T. Fukuyama
Tetrahedron, 64, 11230-11236 (2008)
(76) Auto-Tandem Catalysis in Synthesis of Substituted Quinolines from Aldimines and Electron-rich Olefins:
Cascade Povarov-Hydrogen Transfer Reaction
N. Shindoh, H. Tokuyama, Y. Takemoto, K. Takasu
J. Org. Chem., 73, 7451-7456 (2008)
(75) Mild Debenzylation of Aryl Benzyl Ether with BCl3 in the Presence of Pentamethylbenzene
as a Non-Lewis-Basic Cation Scavenger
K. Okano, K. Okuyama, T. Fukuyama, H. Tokuyama
Synlett, 1977-1980 (2008)
(74) (2 + 2) Cycloaddition Reaction of Alkyl Enol Ethers with Acrylates by in situ Generated Silyl Trifric Imide Catalyst
K. Takasu, Y. Miyakawa, M. Ihara, H. Tokuyama
Chem. Pharm. Bull., 56, 1205-1206 (2008)
(73) Synthesis of Eudistomin C and E: Improved Preparation of the Indole Unit
H. Yamagishi, K. Matsumoto, K. Iwasaki, T. Miyazaki, S. Yokoshima, H. Tokuyama, T. Fukuyama
Org. Lett., 10, 2369-2372 (2008)
(72) Total Synthesis of (–)-Kainic Acid via Intramolecular Michael Addition: A Second-Generation Route
H. Sakaguchi, H. Tokuyama, T. Fukuyama
Org. Lett., 10, 1711-1714 (2008)
(71) Total Synthesis of (+)-Yatakemycin
K. Okano, H. Tokuyama, T. Fukuyama
Chem. Asian J., 3, 296-309 (2008)
(70) Synthetic Studies on Haplophytine: Protective Group Controlled Rearrangement
K. Matsumoto, H. Tokuyama, T. Fukuyama
Synlett, 3137-3140 (2007)
(69) Synthesis of Vinyloxazolidinones by Palladium-Catalyzed CO2-Recycling Reaction of 4-(Benzylamino)-2-butenyl Carbonates
M. Yoshida, Y. Ohsawa, K. Sugimoto, H. Tokuyama, M. Ihara
Tetrahedron Lett., 48, 8678-8682 (2007)
(68) Synthesis of (+)-Vinblastine and Its Analogs
T. Miyazaki, S. Yokoshima, S. Shimizu, H. Osada, H. Tokuyama, T. Fukuyama
Org. Lett., 9, 4737-4740 (2007)
(67) Design and Synthesis of Thiazoline-Thiazole Hybrid Macrocycles Possessing Strong Binding Affinity to Pb2+ and Cd2+
F. S. Han, H. Tokuyama, T. Fukuyama
Chem. Commun., 3444-3446 (2007)
(66) Cascade and One-pot Processes Providing Substituted Quinolines from Aldimines and Allylsilanes:
Auto-tandem Catalysis of Triflic Imide
N. Shindoh, H. Tokuyama, K. Takasu
Tetrahedron Lett., 48, 4749-4753 (2007)
(65) Stereocontrolled Total Synthesis of (–)-Kainic Acid
H. Sakaguchi, H. Tokuyama, T. Fukuyama
Org. Lett., 9, 1635-1638 (2007)
(64) Novel Structural Motifs Consisting of Chiral Thiazolines: Synthesis, Molecular Recognition, and Anticancer Activity
F. S. Han, H. Osajima, M. Cheung, H. Tokuyama, T. Fukuyama
Chem. Eur. J., 13, 3026-3036 (2007)
(63) A Novel Indole Synthesis via Conjugate Addition of Pyrrolidine to o-Nitrophenylacetylenes
H. Tokuyama, T. Makido, Y. Han-ya, T. Fukuyama
Heterocycles, 72, 191-197 (2007)
(62) Catalytic Imino Diels-Alder Reaction by Triflic Imide and Its Application to One-pot Synthesis from Three Components
K. Takasu, N. Shindoh, H. Tokuyama, M. Ihara
Tetrahedron, 62, 11900-11907 (2006)
(61) Total Synthesis of (+)-Yatakemycin
K. Okano, H. Tokuyama, T. Fukuyama
J. Am. Chem. Soc., 128, 7136-7137 (2006)
(60) Synthesis of Chiral Cyclic Oligothiazolines: A Novel Structural Motif of Macrocyclic Molecule
F. S. Han, H. Osajima, M. Cheung, H. Tokuyama, T. Fukuyama
Chem. Commun., 1757-1758 (2006)
(59) Stereocontrolled Total Synthesis of (–)-Eudistomin C
T. Yamashita, N. Kawai, H. Tokuyama, T. Fukuyama
J. Am. Chem. Soc., 127, 15038-15039 (2005)
(58) Synthesis of Tetrahydro-β -carbolines via Radical Cyclization of 2-Alkenylthioanilides
M. Iwadate, T. Yamashita, H. Tokuyama, T. Fukuyama
Heterocycles, 66, 241-249 (2005)
(57) Stereocontrolled Total Synthesis of (–)-Kainic Acid. Regio- and Stereoselective Lithiation of Pyrrolidine Ring
with the (+)-Sparteine Surrogate
Y. Morita, H. Tokuyama, T. Fukuyama
Org. Lett., 7, 4337-4340 (2005)
(56) Synthesis of 2,3-Dialkylindoles from 2-Alkenylphenylisocyanides and Imines by Silyltelluride- and Tin Hydride-Mediated
Sequential Radical Reactions
M. Kotani, S. Yamago, A. Satoh, H. Tokuyama, T. Fukuyama
Synlett, 1893-1896 (2005)
(55) Fluorescence Enhancement by Hydroperoxides Based on the Change in Intramolecular Charge Transfer Character of Benzofurazan
M. Onoda, H. Tokuyama, S. Uchiyama, K. Mawatari, T. Santa, K. Kaneko, K. Imai, K. Nakagomi
Chem. Commun., 1848-1850 (2005)
(54) Thermal and Palladium-Catalyzed [3 + 2] Synthesis of Cyclopentadienone Acetals from Cyclopropenone Acetals and Acetylenes
H. Isobe, S. Sato, T. Tanaka, H. Tokuyama, E. Nakamura
Org. Lett., 6, 3569-3571 (2004)
(53) Stereocontrolled Total Synthesis of (+)-Vincristine
T. Kuboyama, S. Yokoshima, H. Tokuyama, T. Fukuyama
Proc. Natl. Acad. Sci. USA, 101, 11966-11970 (2004)
(52) Total Synthesis of (–)-Stychnine
Y. Kaburagi, H. Tokuyama, T. Fukuyama
J. Am. Chem. Soc., 126, 10246-10247 (2004)
(51) 4-(t-Butyldimethylsilyloxy)benzylidene Acetal: A Novel Benzylidene-type Protecting Group for 1,2-Diols
Y. Kaburagi, H. Osajima, K. Shimada, H. Tokuyama, T. Fukuyama
Tetrahedron Lett., 45, 3817-3821 (2004)
(50) Enanthioselective Total Synthesis of FR900482
M. Suzuki, M. Kambe, H. Tokuyama, T. Fukuyama
J. Org. Chem., 69, 2831-3843 (2004)
(49) New Odorless Protocols for the Synthesis of Aldehydes and Ketones from Thiol Esters
T. Miyazaki, Y. Han-ya, H. Tokuyama, T. Fukuyama
Synlett, 477-480 (2004)
(48) Synthesis of Secondary Arylamines through Copper-Mediated Intermolecular Aryl Amination
K. Okano, H. Tokuyama, T. Fukuyama
Org. Lett., 5, 4987-4990 (2003)
(47) Stereocontrolled Total Synthesis of (–)-Aspidophytine
S. Sumi, K. Matsumoto, H. Tokuyama, T. Fukuyama
Tetrahedron, 59, 8571-8587 (2003)
(46) A Novel Palladium-Catalyzed Coupling of Thiol Esters with 1-Alkynes
H. Tokuyama, T. Miyazaki, S. Yokoshima, T. Fukuyama
Synlett, 1512-1514 (2003)
(45) Total Synthesis of Duocarmycins
K. Yamada, T. Kurokawa, H. Tokuyama, T. Fukuyama
J. Am. Chem. Soc., 125, 6630-6631 (2003)
(44) Enantioselective Total Synthesis of Aspidophytine
S. Sumi, K. Matsumoto, H. Tokuyama, T. Fukuyama
Org. Lett., 5, 1891-1893 (2003)
(43) First Fluorescent Photoinduced Electron Transfer (PET) Reagent for Hydroperoxides
M. Onoda, S. Uchiyama, A. Endo, H. Tokuyama, T. Santa, K. Imai
Org. Lett., 5, 1459-1461 (2003)
(42) Stereoselective Formation of a β-Lactam Fused Oxathiazepin: A Synthetic Approach to Eudistomins
T. Yamashita, H. Tokuyama, T. Fukuyama
Synlett, 738-741 (2003)
(41) Transformation of Primary Amines to N-Monoalkylhydroxylamines: N-Hydroxy-(S)-phenylethylamine Oxalate
H. Tokuyama, T. Kuboyama, T. Fukuyama
Org. Synth., 80, 207-218 (2003)
(40) Stereocontrolled Total Synthesis of (+)-Vinblastine
S. Yokoshima, T. Ueda, S. Kobayashi, A. Sato, T. Kuboyama, H. Tokuyama, T. Fukuyama
Pure Appl. Chem., 75, 29-38 (2003)
(39) Facile Construction of N-Hydroxybenzazocine: Enantioselective Total Synthesis of (+)-FR900482
M. Suzuki, M. Kambe, H. Tokuyama, T. Fukuyama
Angew. Chem. Int. Ed., 41, 4686-4688 (2002)
(38) A Novel Estrogen Receptor Binding Assay Method for Endocrine Disruptors using Fluorescence Polarization
K. Ohno, T. Santa, T. Fukushima, N. Waizumi, H. Tokuyama, M. Maeda, K. Imai
Anal. Chem., 74, 4391-4396 (2002)
(37) Synthesis of 2,3-Disubstituted Indoles by Radical Cyclization with Hypophosphorous Acid and
Its Application to Total Synthesis of (±)-Catharanthine
M. T. Reding, Y. Kaburagi, H. Tokuyama, T. Fukuyama
Heterocycles, 56, 313-330 (2002)
(36) One-Pot Claisen Rearrangement with n-Butyl Vinyl Ether
H. Tokuyama, T. Makido, T. Ueda, T. Fukuyama
Synth. Commun., 32, 869-873 (2002)
(35) A Mild Copper-Mediated Intramolecular Amination of Aryl Halides
K. Yamada, T. Kubo, H. Tokuyama, T. Fukuyama
Synlett, 231-234 (2002)
(34) A Novel Conversion of alpha-Aminonitrile to Amide
S. Yokoshima, T. Kubo, H. Tokuyama, T. Fukuyama
Chem. Lett., 122-124 (2002)
(33) Stereocontrolled Total Synthesis of Vinblastine
S. Yokoshima, T. Ueda, S. Kobayashi, A. Sato, T. Kuboyama, H. Tokuyama, T. Fukuyama
J. Am. Chem. Soc., 124, 2137-2139 (2002)
(32) Reduction of Ethanethiol Esters to Aldehydes
H. Tokuyama, S. Yokoshima, S.-C. Lin, L. Li, T. Fukuyama
Synthesis, 1121-1123 (2002)
(31) A Practical Route to Quinoline from Anilines
H. Tokuyama, M. Sato, T. Ueda, T. Fukuyama
Heterocycles, 54, 105-108 (2001)
(30) 1,3-Dipolor Cycloaddition Strategy for Enatioselective Total Synthesis of FR-900482 Analogues
M. Kambe, E. Arai, M. Suzuki, H. Tokuyama, T. Fukuyama
Org. Lett., 3, 2575-2578 (2001)
(29) A Novel Protocol for Construction of Indolylmethyl Group at Aldehydes or Ketones
H. Tokuyama, M. Watanabe, Y. Hayashi, T. Kurokawa, G. Peng, T. Fukuyama
Synlett, 1403-1406 (2001)
(28) Synthesis of 2,3-Disubstituted Indoles by Palladium-Mediated Coupling of 2-Iodoindoles
H. Tokuyama, Y. Kaburagi, X. Chen, T. Fukuyama
Synthesis, 429-434 (2000)
(27) A Novel Transformation of Primary Amines to N-Monoalkylhydroxylamines
H. Tokuyama, T. Kuboyama, A. Amano, T. Yamashita, T. Fukuyama
Synthesis, 1299-1304 (2000)
(26) Enatioselective Total Synthesis of (+)-Gelsemine: Determination of Its Absolute Configuration
S. Yokoshima, H. Tokuyama, T. Fukuyama
Angew. Chem. Int. Ed., 39, 4073-4075 (2000)
(25) Radical Cyclization of 2-Alkenylthioanilides: A Novel Synthesis of 2,3-Disubstituted Indoles
H. Tokuyama, T. Yamashita, M. T. Reding, Y. Kaburagi, T. Fukuyama
J. Am. Chem. Soc., 121, 3791-3792 (1999)
(24) Cyclopropenone-Containg Cysteine Proteinase Inhibitors. Synthesis and Enzyme Inhibitory Activites
R. Ando, T. Sakaki, Y. Morinaka, C. Takahashi, Y. Tamao, N. Yoshii, S. Katayama, K. Saito, H. Tokuyama, M. Isaka, E. Nakamura
Bioorg. Med. Chem., 7, 571-579 (1999)
(23) 2-(2-Aminophenyl)-Acetoaldehyde Dimethyl Acetal: A Novel Reagent for the Protection of Carboxylic Acids
E. Arai, H. Tokuyama, M. S. Linsell, T. Fukuyama
Tetrahedron Lett., 39, 71-74 (1998)
(22) A Novel Ketone Synthesis by a Palladium-Catalyzed Reaction of Thiol Esters and Organozinc Reagents
H. Tokuyama, S. Yokoshima, T. Yamashita, T. Fukuyama
Tetrahedron Lett., 39, 3189-3192 (1998)
(21) Facile Palladium-Mediated Conversion of Ethanethiol Esters to Aldehydes and Ketones
H. Tokuyama, S. Yokoshima, T. Yamashita, S.-C. Lin, L. Li, T. Fukuyama
J. Braz. Chem. Soc., 9, 381-387 (1998)
(20) Synthetic and Computational Studies on Symmetry-Defined Double Cycloaddition of a New Tris-Annulating Reagent to C60
H. Isobe, H. Tokuyama, M. Sawamura, E. Nakamura
J. Org. Chem., 62, 5034-5041 (1997)
(19) Nitrene Additions to [60]Fullerene Do Not Generate [6,5] Aziridines
A. B. Smith, III, H. Tokuyama
Tetrahedron, 52, 5257-5262 (1996)
(18) Biological Acitvity of Water-Soluble Fullerenes. Structure Dependence of DNA Cleavage, Cytotoxicity, and
Enzyme Inhibitory Activities Including HIV-Protease Inhibition
E. Nakamura, H. Tokuyama, S. Yamago, T. Shiraki, Y. Sugiura
Bull. Chem. Soc. Jpn., 69, 2143-2151 (1996)
(17) Photocytotoxicity of Water-Soluble Fullerene Derivatives
K. Irie, Y. Nakamura, H. Ohigashi, H. Tokuyama, S. Yamago, E. Nakamura
Biosci. Biotech. Biochem., 60, 1359-1361 (1996)
(16) Regio- and Diastereo-Controlled Double Cycloaddition to [60]Fullerene: One-step Synthesis of Cs and C2 Chiral Organofullerenes
with New Tris Annulating Reagents
E. Nakamura, H. Isobe, H. Tokuyama, M. Sawamura
J. Chem. Soc., Chem. Commun., 1747-1748 (1996)
(15) Structure of Fullerene Anchored by Five-membered-ring
H. Amano, H. Uekusa, Yuji Ohashi, H. Tokuyama, E. Nakamura
Mol. Cryst. Liq. Cryst., 276, 291-294 (1996)
(14) Methano- and Propanofullerenes by [1+2] and [3+2] Cycloaddition of Vinylcarbene Species
H. Tokuyama, H. Isobe, E. Nakamura
Bull. Chem. Soc. Jpn., 68, 935-941 (1995)
(13) In vivo Biological Behavior of a Water-Miscible Fullerene: 14C Labeling, Absorption, Distribution, Excretion and Acute Toxicity
S. Yamago, H. Tokuyama, E. Nakamura, K. Kikuchi, S. Kananishi, K. Sueki, H. Nakahara, S. Enomoto, F. Ambe
Chem. Biol., 2, 385-389 (1995)
(12) Synthesis of Cyclopropenone-Containing Amino Acid Mimic. Addition of Cyclopropenyl Cerium Reagent to -Amino Aldehydes
H. Tokuyama, M. Isaka, E. Nakamura
Synth. Commun., 25, 2005-2012 (1995)
(11) Synthesis of Oxo- and Methylene-Bridged C60 Dimers, the First Well-Characterized Species Containing Fullerene-Fullerene Bonds
A. B. Smith, III, H. Tokuyama, R. M. Strongin, G. T. Furst, W. J. Romanow, B. T. Chait, U. A. Mirza, I. Haller
J. Am. Chem. Soc., 117, 9359-9360 (1995)
(10) Photoaddition of Silyl Ketene Acetal to [60]Fullerene. Synthesis of -Fullerene-substituted Carboxylic Esters
H. Tokuyama, H. Isobe, E. Nakamura
J. Chem. Soc., Chem. Commun., 2753-2754 (1994)
(9) Synthetic Chemistry with Fullerenes. Photooxygenation of Olefins
H. Tokuyama, E. Nakamura
J. Org. Chem., 59, 1135-1138 (1994)
(8) Fullerene-Oligonucleotide Conjudates: Photo-induced Sequence-Specific DNA Cleavage
A. S. Boutorine, H. Tokuyama, M. Takasugi, H. Isobe, E. Nakamura, C. Helene
Angew. Chem. Int. Ed. Engl., 33, 2462-2465 (1994)
(7) A New Class of Proteinase Inhibitor. Cyclopropenone-Containing Inhibitor of Papain
R. Ando, Y. Morinaka, H. Tokuyama, M. Isaka, E. Nakamura
J. Am. Chem. Soc., 115, 1174-1175 (1993)
(6) Regioselective Generation and Stereoselective [1+2] Cycloaddition of Substituted Vinylcarbenes
H. Tokuyama, T. Yamada, E. Nakamura
Synlett, 589-591 (1993)
(5) Photoinduced Biochemical Activity of Fullerene Carboxylic Acid
H. Tokuyama, S. Yamago, E. Nakamura, T. Shiraki Y. Sugiura
J. Am. Chem. Soc., 115, 7918-7919 (1993)
(4) Chemical Derivatization of Organofullerenes through Oxidation, Reduction, and C-O and C-C Bond-Forming Reactions
S. Yamago, H. Tokuyama, E. Nakamura, M. Prato, F. Wudl
J. Org. Chem., 58, 4796-4798 (1993)
(3) [1+2] and [3+2] Cycloaddition Reaction of Vinylcarbenes with C60
H. Tokuyama, M. Nakamura, E. Nakamura
Tetrahedron Lett., 34, 7429-7432 (1993)
(2) Thermal Reactions of Substituted Cyclopropenone Acetals. Regio- and Stereochemistry of Vinylcarbene Formation and
Low-Temperature [3+2] Cycloaddition
H. Tokuyama, M. Isaka, E. Nakamura
J. Am. Chem. Soc., 114, 5523-5530 (1992)
(1) Synthesis and Biological Activities of Cyclopropenone Antibiotic Penitricin and Congeners
H. Tokuyama, M. Isaka, E. Nakamura
J. Antibiot., 45, 1148-1154 (1992)
Reviews and Accounts
(33) トリプトファン残基の選択的な酸化を利用したペプチド二量化法
植田浩史、徳山英利
Biochemistry & Industry、81(6)、522-523 (2023)
(32) インドールアルカロイドハプロファイチンの全合成ーThe last synthesis を目指して
徳山英利
ドラマチック有機合成化学感動の瞬間、有機合成化学協会編、化学同人、28-29 (2023)
(31) ニューモダリティー時代の有機合成化学
徳山英利
有機合成化学協会誌、 80(4) 321-321 (2022) (DOI: 10.5059/yukigoseikyokaishi.80.321)
(30) Construction of N-Heterocycles Fused with a Highly Substituted Benzene Ring by a Benzyne-mediated Cyclization/Functionalization
Cascade Reaction and Its Application to the Total Synthesis of Marine Natural Products
H. Tokuyama
Chem. Pharm. Bull., 69, 707-818 (2021) (DOI: 10.1248/cpb.c21-00389). selected as cover picture
(29) 総論 日本発,温度生物学の成熟を願う
内山聖一、徳山英利
細胞、52(14), 788-789 (2020)
(28) 合成終盤での酸化反応を利用したアルカロイドの全合成
徳山英利
Medchem News, 29(4), 167-172 (2019) (ISSN:2432-8626)
(27) 薬学におけるナノゲル研究の最前線
内山聖一、徳山英利
ファルマシア、55(8), 770-774 (2019) (DOI: 10.14894/faruawpsj.55.8_770)
(26) アゾ系カチオン性ラジカル重合開始剤の開発
内山聖一、徳山英利
化学、73(12), 47-52 (2018)
(25) 制御の難しいアミンの酸化をあえて有機合成に利用する
植田浩史、徳山英利
化学と教育、65, 190-191 (2017).
(24) 化学はどこに行くかー次世代の化学が目指すべきこと
中村栄一、相田卓三、菅 裕明、徳山英利、内山真伸
現代化学、No. 548, 2016年12月、44-48.
(23) The Total Synthesis of Biosynthetically Related Monoterpene Indole Alkaloids
H. Tokuyama
J. Synth. Org. Chem., Jpn, 73, 1120-1129 (2015)
(22) Copper-mediated aromatic amination reaction and its application to the total synthesis of natural products
K. Okano, H. Tokuyama, T. Fukuyama
Chem. Commun., 50, 13650-13663 (2014) Featured as a front cover ! PDF
(21) 不安定な七員環をいかにつくるか?ーアセチルアラノチンの全合成
H. Tokuyama, K. Okano
Kagaku (Kyoto), 69, 68-69 (2014)
(20) Total Syntheses of Mersicarpine
Y. Iwama, K. Okano, H. Tokuyama
J. Synth. Org. Chem., Jpn, 71, 926-934 (2013)
(19) Total Syntheses of Nitrogen-Containing Cyclic Natural Products Based on Aryl Amination
K. Okano, T. Fukuyama, H. Tokuyama
J. Synth. Org. Chem., Jpn, 68, 1036-1046 (2010)
(18) 現在の有機合成化学をもってしても合成困難な天然物とは?
二量体型アルカロイド(+)-Haplophytineの全合成
徳山英利,植田浩史,福山透
化学と生物,48,450-453 (2010)
(17) Total Synthesis of (+)-Vinblastine: Control of the Stereochemistry at C18'
S. Yokoshima, H. Tokuyama, T. Fukuyama
Chem. Rec., 10, 101-118 (2010)
(16) Total Synthesis of Dimeric Alkaloid (+)-Haplophytine
H. Tokuyama
Farumashia, 46, 223-228 (2010)
(15) ついに合成!難攻不落のアザジラクチン
K. Sugimoto, H. Tokuyama
Kagaku (Kyoto), 62, 70-71 (2007)
(14) Total Syntheses of FR900482
H. Tokuyama, M. Suzuki, T. Fukuyama,
J. Synth. Org. Chem., Jpn, 65, 470-480 (2007)
(13) Acceleration of Reaction by Microwave Irradiation
H. Tokuyama, M. Nakamura
J. Synth. Org. Chem., Jpn, 63, 1893-1896 (2005)
(12) 「インドール合成の進展とその応用」
徳山英利
現代化学増刊43「最新有機合成化学ーさまざまな元素の活用」、東京化学同人、2005年
(11) Palladium-Mediated Synthesis of Aldehydes and Ketones from Thiol Esters
T. Fukuyama, H. Tokuyama
Aldrichimica Acta, 37, 87-96 (2004)
(10) 「世界をリードする日本の化学、実用的な有機合成を目指すービンブラスチン全合成の考え方ー」
福山 透、徳山英利
現代化学、2004年7月号、pp38-43
(9) Development of New Synthetic Methods and Their Application to Synthesis of Useful Compounds
H. Tokuyama
Yakugaku Zasshi, 123, 1007-1021 (2003)
(8) Synthesis of 2,3-Disubstituted Indoles by Radical Cyclization of 2-Alkenylphenylisocyanide
H. Tokuyama and T. Fukuyama
Chem. Rec., 2, 37-45 (2002)
(7) Development and Application of A Novel Indole Synthesis and Useful Functional Group Transformations
H. Tokuyama and T. Fukuyama
有機合成 創造の軌跡 126のマイルストーン 有機合成化学協会編、2002年、pp224-225
(6) New Development of Indole Synthesis using Radical Cyclization and Application to Indole Alkaloid Synthesis
H. Tokuyama
J. Synth. Org. Chem., Jpn, 59, 488-489 (2001)
(5) Development of new indole synthesis and application to synthesis of natural products
H. Tokuyama, T. Fukuyama
Kagaku Kogyo, 52, 416-421 (2001)
(4) Total Synthesis of Antibiotic Vancomycin
H. Tokuyama, T. Fukuyama
Kagaku (Kyoto), 55, 68-69 (2000)
(3) 含窒素天然物の効率的合成
徳山英利、福山透
ファルマシア、34(12), 1208-1212 (1998) (DOI: org/10.14894/faruawpsj.34.12_1208)
(2) Pharmacokinetic and Toxicity Studies on Water-Miscible Fullerenes
E. Nakamura, S. Yamago, H. Tokuyama, K. Kuchi, S. Kananishi, K. Sueki, H. Nakahara, S. Enomoto, and F. Ambe
New Horizons in Organic Synthesis, V. Nair and S. Jumar, Eds., New Age International, New Delhi, 1997, pp. 207-212
(1) Synthesis of Organic Derivatives of Fullerenes
S. Yamago, H. Tokuyama, E. Nakamura, M. Prato, and F. Wudl
Trans. Mat. Res. Soc. Jpn, 14B, 1169-1172 (1994)
Books
(20) 「Modern Natural Product Synthesis, Overcoming Difficulties」分担執筆, M. Nakada, K. Tanino, K. Nagasawa, S. Yokoshima, Eds., Springer Singapore, 2024, 520 pages, ISBN 978-981-97-1618-0, 978-981-97-1621-0, 978-981-97-1619-7.
(19) 「ドラマチック有機合成化学感動の瞬間」共編、分担執筆、有機合成化学協会編、化学同人、2023, ISBN978-4-7598-2336-3
(18) 「細胞の温度を測る Cellular thermometry」月刊「細胞」2020年12月号、共編、北隆館、ISBN04127-12
(17) 「Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules」分担執筆, Yuichi Kobayashi Ed., Springer, 2019, ISBN 978-981-13-6243-9
(16) 「CSJ Current Review 27 天然有機化合物の全合成 独創的なものづくりの反応と戦略」分担編集、分担執筆、日本化学会編, 化学同人、2018、 ISBN978-4-7598-1387-6
(15)「アルカロイドの科学 生物活性を生み出す物質の探索から創薬の実際まで」分担執筆、高山廣光編、化学同人、2017
(14) 「ジョーンズ有機化学(下)第5版」分担訳、東京化学同人、2016
(13) 「ジョーンズ有機化学(上)第5版」分担訳、東京化学同人、2016
(12) 「有機合成実験法ハンドブック 第2版」分担執筆、有機合成化学協会編、丸善、2015
(11)「大学院講義有機化学第2版」分担執筆、東京化学同人、2015
(10) 「スタンダード薬学シリーズII 化学系薬学 I. 化学物質の性質と反応」分担執筆、日本薬学会編、東京化学同人、2015
(9) 「トップドラッグから学ぶ創薬化学」分担執筆、有機合成化学協会編、東京化学同人、2012
(8) 「天然物合成で活躍した反応」分担執筆、有機合成化学協会編、化学同人、2011
(7) 「天然物全合成の最新動向」分担執筆、北泰行監修、シーエムシー出版、2009
(6) 「天然物の全合成 2000〜2008(日本)」分担執筆、有機合成化学協会編、化学同人、2009
(5) 「大学院講義有機化学演習編」分担執筆、野依良治ら編、東京化学同人、2007
(4) 「天然物化学ー植物編」分担執筆、山村庄亮、長谷川宏司編、アイピーシー、2007
(3) 「演習で学ぶ 有機反応機構」共著、共編、有機合成化学協会編、化学同人、2005
(2) 「スタンダード薬学シリーズ 化学系薬学 I. 化学物質の性質と反応」分担執筆、日本薬学会編、東京化学同人、2004
(1) 「有機合成 創造の軌跡 126のマイルストーン」共編、有機合成化学協会編、化学同人、2002
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