2018 ~ in press
Cell surface flip-flop of phosphatidylserine is critical for PIEZO1-mediated myotube formation.
Tsuchiya M, Hara Y, Okuda M, Itoh K, Nishioka R, Shiomi A, Nagao K, Mori M, Mori Y, Ikenouchi J, Suzuki R, Tanaka M, Ohwada T, Aoki J, Kanagawa M, Toda T, Nagata Y, Matsuda R, Takayama Y, Tominaga M, Umeda M.
Nat Commun. 2018 May 24;9(1):2049. doi: 10.1038/s41467-018-04436-w.
Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders.
Thalman C, Horta G, Qiao L, Endle H, Tegeder I, Cheng H, Laube G, Sigrudsson T, Hauser MJ, Tenzer S, Distler U, Aoki J, Morris AJ, Geisslinger G, Röper J, Kirischuk S, Luhmann HJ, Radyushkin K, Nitsch R, Vogt J.
Mol Psychiatry. 2018 May 9. doi: 10.1038/s41380-018-0053-1.
Measurement of plasma choline in acute coronary syndrome: importance of suitable sampling conditions for this assay.
Ohkawa R, Kurano M, Sakai N, Kishimoto T, Nojiri T, Igarashi K, Hosogaya S, Ozaki Y, Dohi T, Miyauchi K, Daida H, Aoki J, Okubo S, Ikeda H, Tozuka M, Yatomi Y.
Sci Rep. 2018 Mar 16;8(1):4725. doi: 10.1038/s41598-018-23009-x.
Genome Editing Provides New Insights into Receptor-Controlled Signalling Pathways.
Milligan G, Inoue A.
Trends Pharmacol Sci. 2018 Mar 13. pii: S0165-6147(18)30043-9. doi: 10.1016/j.tips.2018.02.005.
Mini G protein probes for active G protein-coupled receptors (GPCRs) in live cells.
Wan Q, Okashah N, Inoue A, Nehmé R, Carpenter B, Tate CG, Lambert NA.
J Biol Chem. 2018 Mar 9. pii: jbc.RA118.001975. doi: 10.1074/jbc.RA118.001975.
Association between serum autotaxin or phosphatidylserine-specific phospholipase A1 levels and melanoma.
Kurano M, Miyagaki T, Miyagawa T, Igarashi K, Shimamoto S, Ikeda H, Aoki J, Sato S, Yatomi Y.
J Dermatol. 2018 Mar 3. doi: 10.1111/1346-8138.14278.
Human GIP(3-30)NH2 inhibits G protein-dependent as well as G protein-independent signaling and is selective for the GIP receptor with high-affinity binding to primate but not rodent GIP receptors.
Gabe MBN, Sparre-Ulrich AH, Pedersen MF, Gasbjerg LS, Inoue A, Bräuner-Osborne H, Hartmann B, Rosenkilde MM.
Biochem Pharmacol. 2018 Apr;150:97-107. doi: 10.1016/j.bcp.2018.01.040. Epub 2018 Feb 3.
Autotaxin-Lysophosphatidic Acid Pathway in Intraocular Pressure Regulation and Glaucoma Subtypes.
Honjo M, Igarashi N, Kurano M, Yatomi Y, Igarashi K, Kano K, Aoki J, Weinreb RN, Aihara M.
Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):693-701. doi: 10.1167/iovs.17-23218.
AP2? Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity.
Gorvin CM, Rogers A, Hastoy B, Tarasov AI, Frost M, Sposini S, Inoue A, Whyte MP, Rorsman P, Hanyaloglu AC, Breitwieser GE, Thakker RV.
Cell Rep. 2018 Jan 23;22(4):1054-1066. doi: 10.1016/j.celrep.2017.12.089. Epub 2018 Jan 28.
Lack of beta-arrestin signaling in the absence of active G proteins.
Grundmann M, Merten N, Malfacini D, Inoue A, Preis P, Simon K, Rüttiger N, Ziegler N, Benkel T, Schmitt NK, Ishida S, Müller I, Reher R, Kawakami K, Inoue A, Rick U, Kühl T, Imhof D, Aoki J, König GM, Hoffmann C, Gomeza J, Wess J, Kostenis E.
Nat Commun. 2018 Jan 23;9(1):341. doi: 10.1038/s41467-017-02661-3.
Role of the Autotaxin-LPA Pathway in Dexamethasone-Induced Fibrotic Responses and Extracellular Matrix Production in Human Trabecular Meshwork Cells.
Honjo M, Igarashi N, Nishida J, Kurano M, Yatomi Y, Igarashi K, Kano K, Aoki J, Aihara M.
Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):21-30. doi: 10.1167/iovs.17-22807.
2017
17,18-EpETE-GPR40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques.
Nagatake T, Shiogama Y, Inoue A, Kikuta J, Honda T, Tiwari P, Kishi T, Yanagisawa A, Isobe Y, Matsumoto N, Shimojou M, Morimoto S, Suzuki H, Hirata S, Steneberg P, Edlund H, Aoki J, Arita M, Kiyono H, Yasutomi Y, Ishii M, Kabashima K, Kunisawa J.
J Allergy Clin Immunol. 2017 Dec 26. pii: S0091-6749(17)32949-4. doi: 10.1016/j.jaci.2017.09.053.
Evidence Suggests Sphingosine 1-Phosphate Might Be Actively Generated, Degraded, and Transported to Extracellular Spaces With Increased S1P2 and S1P3 Expression in Colon Cancer.
Uranbileg B, Nishikawa T, Ikeda H, Kurano M, Sato M, Saigusa D, Aoki J, Watanabe T, Yatomi Y.
Clin Colorectal Cancer. 2017 Nov 21. pii: S1533-0028(17)30369-9. doi: 10.1016/j.clcc.2017.11.004.
TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1.
Hirata Y, Katagiri K, Nagaoka K, Morishita T, Kudoh Y, Hatta T, Naguro I, Kano K, Udagawa T, Natsume T, Aoki J, Inada T, Noguchi T, Ichijo H, Matsuzawa A.
Cell Rep. 2017 Nov 28;21(9):2447-2457. doi: 10.1016/j.celrep.2017.11.007.
Performance of autotaxin as a serum marker for liver fibrosis.
Ikeda H, Kobayashi M, Kumada H, Enooku K, Koike K, Kurano M, Sato M, Nojiri T, Kobayashi T, Ohkawa R, Shimamoto S, Igarashi K, Aoki J, Yatomi Y.
Ann Clin Biochem. 2017 Jan 1:4563217741509. doi: 10.1177/0004563217741509.
A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias.
Sergeev E, Hansen AH, Bolognini D, Kawakami K, Kishi T, Aoki J, Ulven T, Inoue A, Hudson BD, Milligan G.
Sci Rep. 2017 Oct 23;7(1):13741. doi: 10.1038/s41598-017-14096-3.
Lysophosphatidylserine suppresses IL-2 production in CD4 T cells through LPS3/GPR174.
Shinjo Y, Makide K, Satoh K, Fukami F, Inoue A, Kano K, Otani Y, Ohwada T, Aoki J.
Biochem Biophys Res Commun. 2017 Dec 9;494(1-2):332-338. doi: 10.1016/j.bbrc.2017.10.028. Epub 2017 Oct 7.
X-ray structures of endothelin ETB receptor bound to clinical antagonist bosentan and its analog.
Shihoya W, Nishizawa T, Yamashita K, Inoue A, Hirata K, Kadji FMN, Okuta A, Tani K, Aoki J, Fujiyoshi Y, Doi T, Nureki O.
Nat Struct Mol Biol. 2017 Sep;24(9):758-764. doi: 10.1038/nsmb.3450. Epub 2017 Aug 14.
Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6.
Taniguchi R, Inoue A, Sayama M, Uwamizu A, Yamashita K, Hirata K, Yoshida M, Tanaka Y, Kato HE, Nakada-Nakura Y, Otani Y, Nishizawa T, Doi T, Ohwada T, Ishitani R, Aoki J, Nureki O.
Nature. 2017 Aug 17;548(7667):356-360. doi: 10.1038/nature23448. Epub 2017 Aug 9.
Probing the Hydrophobic Binding Pocket of G-Protein-Coupled Lysophosphatidylserine Receptor GPR34/LPS1 by Docking-Aided Structure-Activity Analysis.
Sayama M, Inoue A, Nakamura S, Jung S, Ikubo M, Otani Y, Uwamizu A, Kishi T, Makide K, Aoki J, Hirokawa T, Ohwada T.
J Med Chem. 2017 Jul 27;60(14):6384-6399. doi: 10.1021/acs.jmedchem.7b00693. Epub 2017 Jul 17.
Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK.
O'Hayre M, Eichel K, Avino S, Zhao X, Steffen DJ, Feng X, Kawakami K, Aoki J, Messer K, Sunahara R, Inoue A, von Zastrow M, Gutkind JS.
Sci Signal. 2017 Jun 20;10(484). pii: eaal3395. doi: 10.1126/scisignal.aal3395.
Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways.
Aikawa S, Kano K, Inoue A, Wang J, Saigusa D, Nagamatsu T, Hirota Y, Fujii T, Tsuchiya S, Taketomi Y, Sugimoto Y, Murakami M, Arita M, Kurano M, Ikeda H, Yatomi Y, Chun J, Aoki J.
EMBO J. 2017 Jun 6
Conformational biosensors reveal allosteric interactions between heterodimeric AT1 angiotensin and prostaglandin F2α receptors.
Sleno R, Devost D, Pétrin D, Zhang A, Bourque K, Shinjo Y, Aoki J, Inoue A, Hébert TE.
J Biol Chem. 2017 Jun 5
Sphingosine-1-Phosphate (S1P)-Related Response of Human Conjunctival Fibroblasts After Filtration Surgery for Glaucoma.
Aoyama-Araki Y, Honjo M, Uchida T, Yamagishi R, Kano K, Aoki J, Aihara M.
Invest Ophthalmol Vis Sci. 2017 Apr 1
Trans-fatty acids promote proinflammatory signaling and cell death by stimulating the apoptosis signal-regulating kinase 1 (ASK1)-p38 pathway.
Hirata Y, Takahashi M, Kudoh Y, Kano K, Kawana H, Makide K, Shinoda Y, Yabuki Y, Fukunaga K, Aoki J, Noguchi T, Matsuzawa A.
J Biol Chem. 2017 Mar 29
Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes.
Doçi CL, Mikelis CM, Callejas-Valera JL, Hansen KK, Molinolo AA, Inoue A, Offermanns S, Gutkind JS.
PLoS One. 2017 Mar 16
Identification and pharmacological characterization of succinate receptor agonists.
Geubelle P, Gilissen J, Dilly S, Poma L, Dupuis N, Laschet C, Abboud D, Inoue A, Jouret F, Pirotte B, Hanson J.
Br J Pharmacol. 2017
Purinergic Receptor Transactivation by the β2-Adrenergic Receptor Increases Intracellular Ca2+ in Nonexcitable Cells.
Stallaert W, van der Westhuizen ET, Schönegge AM, Plouffe B, Hogue M, Lukashova V, Inoue A, Ishida S, Aoki J, Le Gouill C, Bouvier M.
Mol Pharmacol. 2017
Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis.
Cahill TJ 3rd, Thomsen AR, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, Huang LY, Kahsai AW, Bassoni DL, Gavino BJ, Lamerdin JE, Triest S, Shukla AK, Berger B, Little J 4th, Antar A, Blanc A, Qu CX, Chen X, Kawakami K, Inoue A, Aoki J, Steyaert J, Sun JP, Bouvier M, Skiniotis G, Lefkowitz RJ.
Proc Natl Acad Sci U S A. 2017 Mar 7
Conformational Profiling of the AT1 Angiotensin II Receptor Reflects Biased Agonism, G Protein Coupling, and Cellular Context.
Devost D, Sleno R, Pétrin D, Zhang A, Shinjo Y, Okde R, Aoki J, Inoue A, Hébert TE.
J Biol Chem. 2017 Mar 31
Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors.
Roszko KL, Bi R, Gorvin CM, Bräuner-Osborne H, Xiong XF, Inoue A, Thakker RV, Strømgaard K, Gardella T, Mannstadt M.
JCI Insight. 2017 Feb 9
Phospholipid localization implies microglial morphology and function via Cdc42 in vitro.
Tokizane K, Konishi H, Makide K, Kawana H, Nakamuta S, Kaibuchi K, Ohwada T, Aoki J, Kiyama H.
Glia. 2017
Analysis of glycero-lysophospholipids in gastric cancerous ascites.
Emoto S, Kurano M, Kano K, Matsusaki K, Yamashita H, Nishikawa M, Igarashi K, Ikeda H, Aoki J, Kitayama J, Yatomi Y.
J Lipid Res. 2017 Apr
Proliferation of mouse endometrial stromal cells in culture is highly sensitive to lysophosphatidic acid signaling.
Aikawa S, Kano K, Inoue A, Aoki J.
Biochem Biophys Res Commun. 2017 Feb 26
LPA1 receptor-mediated thromboxane A2 release is responsible for lysophosphatidic acid-induced vascular smooth muscle contraction.
Dancs PT, Ruisanchez É, Balogh A, Panta CR, Miklós Z, Nüsing RM, Aoki J, Chun J, Offermanns S, Tigyi G, Benyó Z.
FASEB J. 2017 Apr
Different origins of lysophospholipid mediators between coronary and peripheral arteries in acute coronary syndrome.
Kurano M, Kano K, Dohi T, Matsumoto H, Igarashi K, Nishikawa M, Ohkawa R, Ikeda H, Miyauchi K, Daida H, Aoki J, Yatomi Y.
J Lipid Res. 2017 Feb
Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function.
Jørgensen S, Have CT, Underwood CR, Johansen LD, Wellendorph P, Gjesing AP, Jørgensen CV, Quan S, Rui G, Inoue A, Linneberg A, Grarup N, Jun W, Pedersen O, Hansen T, Bräuner-Osborne H.
J Biol Chem. 2017 Jan 27
Synaptic Phospholipid Signaling Modulates Axon Outgrowth via Glutamate-dependent Ca2+-mediated Molecular Pathways.
Vogt J, Kirischuk S, Unichenko P, Schlüter L, Pelosi A, Endle H, Yang JW, Schmarowski N, Cheng J, Thalman C, Strauss U, Prokudin A, Bharati BS, Aoki J, Chun J, Lutz B, Luhmann HJ, Nitsch R.
Cereb Cortex. 2017 Jan
1-Fluoro-2,4-dinitrobenzene and its derivatives act as secretagogues on rodent mast cells.
Manabe Y, Yoshimura M, Sakamaki K, Inoue A, Kakinoki A, Hokari S, Sakanaka M, Aoki J, Miyachi H, Furuta K, Tanaka S.
Eur J Immunol. 2017 Jan
2016
Identification of lysophosphatidylthreonine with an aromatic fatty acid surrogate as a potent inducer of mast cell degranulation
Kishi T, Kawana H, Sayama M, Makide K, Inoue A, Otani Y, Ohwada T, Aoki J
Biochem Biophys Reports in press
Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy.
Furness SG, Liang YL, Nowell CJ, Halls ML, Wookey PJ, Dal Maso E, Inoue A, Christopoulos A, Wootten D, Sexton PM.
Cell in press
Sphingosine kinase-1, S1P transporter spinster homolog 2 and S1P2 mRNA expressions are increased in liver with advanced fibrosis in human.
Sato M, Ikeda H, Uranbileg B, Kurano M, Saigusa D, Aoki J, Maki H, Kudo H, Hasegawa K, Kokudo N, Yatomi Y.
Scientific Reports 6:32119 (2016)
The Role of Lysophosphatidic Acid on Airway Epithelial Cell Denudation in a Murine Heterotopic Tracheal Transplant Model.
Tando Y, Ota C, Yamada M, Kamata S, Yamaya M, Kano K, Okudaira S, Aoki J, Kubo H.
Transplant Direct 1:e35 (2016)
Regulation of the lysophosphatidylserine and sphingosine 1-phosphate levels in autologous whole blood by the pre-storage leukocyte reduction.
Nagura Y, Tsuno NH, Kano K, Inoue A, Aoki J, Hirowatari Y, Kaneko M, Kurano M, Matsuhashi M, Ohkawa R, Tozuka M, Yatomi Y, Okazaki H.
Transfus Med in press
Conformational Constraint of the Glycerol Moiety of Lysophosphatidylserine Affords Compounds with Receptor Subtype Selectivity.
Jung S, Inoue A, Nakamura S, Kishi T, Uwamizu A, Sayama M, Ikubo M, Otani Y, Kano K, Makide K, Aoki J, Ohwada T.
J Med Chem 59:3750-3776 (2016)
Structural basis for specific inhibition of Autotaxin by a DNA aptamer.
Kato K, Ikeda H, Miyakawa S, Futakawa S, Nonaka Y, Fujiwara M, Okudaira S, Kano K, Aoki J, Morita J, Ishitani R, Nishimasu H, Nakamura Y, Nureki O.
Nat Struct Mol Biol 23:395-401 (2016)
ATX-LPA1 axis contributes to proliferation of chondrocytes by regulating fibronectin assembly leading to proper cartilage formation.
Nishioka T, Arima N, Kano K, Hama K, Itai E, Yukiura H, Kise R, Inoue A, Kim S-H, Solnica-Krezel L, Moolenaar WH, Chun J and Aoki J.
Scientific Reports 6:23433 (2016)
Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence.
Uranbileg B, Ikeda H, Kurano M, Enooku K, Sato M, Saigusa D, Aoki J, Ishizawa T, Hasegawa K, Kokudo N, Yatomi Y.
PLoS One. 11, e0149462 (2016)
Serum Autotaxin Levels Are Associated with Proteinuria and Kidney Lesions in Japanese Type 2 Diabetic Patients with Biopsy-proven Diabetic Nephropathy.
Shimizu M, Furuichi K, Toyama T, Yamahana J, Ohkawa R, Igarashi K, Aoki J, Kaneko S, Yatomi Y, Wada T.
Intern Med. 55, 215-221 (2016)
Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility.
Takeda A, Kobayashi D, Aoi K, Sasaki N, Sugiura Y, Igarashi H, Tohya K, Inoue A, Hata E, Akahoshi N, Hayasaka H, Kikuta J, Scandella E, Ludewig B, Ishii S, Aoki J, Suematsu M, Ishii M, Takeda K, Jalkanen S, Miyasaka M, Umemoto E.
Elife e10561 (2016)
Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase.
Morita J, Kano K, Kato K, Takita H, Sakagami H, Yamamoto Y, Mihara E, Ueda H, Sato T, Tokuyama H, Arai H, Asou H, Takagi J, Ishitani R, Nishimasu H, Nureki O and Aoki J
Scientific Reports 6:20995 (2016)
Autotaxin Regulates Maintenance of Ovarian Cancer Stem Cells through Lysophosphatidic Acid-Mediated Autocrine Mechanism.
Seo EJ, Kwon YW, Jang IH, Kim DK, Lee SI, Choi EJ, Kim KH, Suh DS, Lee JH, Choi KU, Lee JW, Mok HJ, Kim KP, Matsumoto H, Aoki J, Kim JH.
Stem Cells 34:551-564 (2016)
Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes.
Hata E, Sasaki N, Takeda A, Tohya K, Umemoto E, Akahoshi N, Ishii S, Bando K, Abe T, Kano K, Aoki J, Hayasaka H, Miyasaka M.
Int Immunol 28:283-292 (2016)
Integrative genomic and proteomic analyses identifies glycerol-3-phosphate acyltransferase as a target of low-dose ionizing radiation in EBV infected-B cells.
Tabe Y, Hatanaka Y, Nakashiro M, Sekihara K, Yamamoto S, Matsushita H, Kazuno S, Fujimura T, Ikegami T, Nakanaga K, Matsumoto H, Ueno T, Aoki J, Yokomizo T, Konopleva M, Andreeff M, Miida T, Iwabuchi K, Sasai K.
Int J Radiat Biol. 92, 24-34 (2016)
Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells.
O'Hayre M, Inoue A, Kufareva I, Wang Z, Mikelis CM, Drummond RA, Avino S, Finkel K, Kalim KW, DiPasquale G, Guo F, Aoki J, Zheng Y, Lionakis MS, Molinolo AA, Gutkind JS.
Oncogene 35:3771-3780 (2016)
2015
The experimental power of FR900359 to study Gq-regulated biological processes.
Schrage R, Schmitz AL, Gaffal E, Annala S, Kehraus S, Wenzel D, Büllesbach KM, Bald T, Inoue A, Shinjo Y, Galandrin S, Shridhar N, Hesse M, Grundmann M, Merten N, Charpentier TH, Martz M, Butcher AJ, Slodczyk T, Armando S, Effern M, Namkung Y, Jenkins L, Horn V, Stößel A, Dargatz H, Tietze D, Imhof D, Galés C, Drewke C, Müller CE, Hölzel M, Milligan G, Tobin AB, Gomeza J, Dohlman HG, Sondek J, Harden TK, Bouvier M, Laporte SA, Aoki J, Fleischmann BK, Mohr K, König GM, Tüting T, Kostenis E.
Nat Commun. 6:10156 (2015)
LPP3 localizes LPA6 signalling to non-contact site in endothelial cells.
Yukiura H, Kano K, Kise R, Inoue A, Aoki J
J Cell Science 128:3871-3877 (2015)
Blood levels of serotonin are specifically correlated with plasma lysophosphatidylserine among the glycero-lysophospholipids.
Kurano M, Dohi T, Nojiri T, Kobayashi T, Hirowatari Y, Inoue A, Kano K, Matsumoto H, Igarashi K, Nishikawa M, Miyauchi K, Daida H, Ikeda H, Aoki J, Yatomi Y.
BBA Clinical 4:92-98 (2015)
A G Protein-biased Designer G Protein-coupled Receptor Useful for Studying the Physiological Relevance of Gq/11-dependent Signaling Pathways
Hu J, Stern M, Gimenez LE, Wanka L, Zhu L, Rossi M, Meister J, Inoue A, Beck-Sickinger AG, Gurevich VV, Wess J.
J Biol Chem 291:7809-7820 (2015)
Glycerophospholipid regulation of modality-specific sensory axon guidance in spinal cord.
Guy AT, Nagatsuka Y, Ooashi N, Inoue M, Nakata A, Greimel P,Inoue A, Nabetani T, Murayama A, Ohta K, Ito Y, Aoki J, Hirabayashi Y, Kamiguchi H.
Sciene 349:974-977 (2015)
Placental autotaxin expression is diminished in women with pre-eclampsia.
Ichikawa M, Nagamatsu T, Schust DJ, Kawai-Iwasawa Y, Kawana K, Yamashita T, Osuga Y, Aoki J, Yatomi Y, Fujii T
J Obstet Gynaecol Res 41:1406-1411 (2015)
Comprehensive analysis of sphingosine-1-phosphate receptor mutants during zebrafish embryogenesis.
Hisano Y, Inoue A, Taimatsu K, Ota S, Ohga R, Kotani H, Muraki M, Aoki J, Kawahara A
Genes Cells 20:647-658 (2015)
A New Enzyme Immunoassay for the Quantitative Determination of Classical Autotaxins (ATXα, ATXβ, and ATXγ) and Novel Autotaxins (ATXδ and ATXε)
Tokuhara Y, Kurano M, Shimamoto S, Igarashi K, Nojiri T, Kobayashi T, Masuda A, Ikeda H, Nagamatsu T, Fujii T, Aoki J, Yatomi Y
PLoS One. 10, e0130074 (2015)
Maternal and Zygotic Sphingosine Kinase 2 are Indispensable for Cardiac Development in Zebrafish
Hisano Y, Inoue A, Okudaira M, Taimatsu K, Matsumoto H, Kotani H, Ohga R, Aoki J, Kawahara A
J. Biol. Chem. 290, 14841-14851 (2015)
Structure-Activity Relationships of Lysophosphatidylserine Analogs as Agonists of G-Protein-Coupled Receptors GPR34, P2Y10 and GPR174
Ikubo M, Inoue A, Nakamura S, Jung S, Sayama M, Otani Y, Uwamizu A, Suzuki K, Kishi, T, Shuto A, Ishiguro J, Okudaira M, Kano K, Makide K, Aoki L, Ohwada T
J. Med. Chem. 58, 4204-4219 (2015)
Autotaxin overexpression causes embryonic lethality and vascular defects
Yukiura H, Kano K, Kise R, Inoue A, Aoki J
Plos One 10, e0126734 (2015)
Mitsugumin 56 (hedgehog acyltransferase-like) is a sarcoplasmic reticulum-resident protein essential for postnatal muscle maturation.
Van B, Nishi M, Komazaki S, Ichimura A, Kakizawa S, Nakanaga K, Aoki J, Park KH, Ma J, Ueyama T, Ogata T, Maruyama N, Takeshima H.
FEBS Lett. 589, 1095-1104 (2015)
Analysis of unique mutations in the LPAR6 gene identified in a Japanese family with autosomal recessive woolly hair/hypotrichosis: Establishment of a useful assay system for LPA6.
Hayashi R, Inoue A, Suga Y, Aoki J, Shimomura Y.
J Dermatol Sci. 78, 197-205 (2015)
Non-cell autonomous and non-catalytic activities of ATX in the developing brain
Greenman R, Gorelik A, Sapir T, Baumgart J, Zamor V, Segal-Salto M, Levin-Zaidman S, Aidinis V, Aoki J, Nitsch R, Vogt J, Reiner O.
Front Neurosci. 2015 9, 53 (2015)
Phosphatidylserine-specific Phospholipase A1 (PS-PLA1) Expression in Colorectal Cancer Correlates with Tumor Invasion and Hematogenous Metastasis.
Iida Y, Sunami E, Yamashita H, Hiyoshi M, Ishihara S, Yamaguchi H, Inoue A, Makide K, Tsuno NH, Aoki J, Kitayama J, Watanabe T
Anticancer Res. 35, 1459-1464 (2015)
Detection of physiological activities of G protein-coupled receptor-acting pharmaceuticals in wastewater
Ihara M, Inoue A, Hanamoto S, Zhang H, Aoki J, Tanaka H
Environ Sci Technol. 49, 1903-19011 (2015)
Lysophosphatidylserine has Bilateral Effects on Macrophages in the Pathogenesis of Atherosclerosis
Nishikawa M, Kurano M, Ikeda H, Aoki J, Yatomi Y
J Atheroscler Thromb 35, 463-470 (2015)
Possible Involvement of Minor Lysophospholipids in the Increase in Plasma Lysophosphatidic Acid in Acute Coronary Syndrome
Kurano M, Suzuki A, Inoue A, Tokuhara Y, Kano K, Matsumoto H, Igarashi K, Ohkawa R, Nakamura K, Dohi T, Miyauchi K, Daida H, Tsukamoto K, Ikeda H, Aoki J, Yatomi Y
Arterioscler Thromb Vasc Biol 35, 463-470 (2015)
Lysophosphatidic acid as a lipid mediator with multiple biological actions
Aikawa S, Hashimoto T, Kano K, Aoki J
J Biochemistry 157, 81-89 (2015)
Lysophosphatidylserine analogs differentially activate three LysoPS receptors
Uwamizu A, Inoue A, Suzuki K, Okudaira M, Shuto A, Shinjo Y, Ishiguro J, Makide K, Ikubo M, Nakamura S, Jung S, Sayama M, Otani Y, Ohwada T and Aoki J.
J Biochem 157, 151-160 (2015)
2014
Separation and quantification of 2-acyl-1-lysophospholipids and 1-acyl-2-lysophospholipids in biological samples by LC-MS/MS.
Okudaira M, Inoue A, Shuto A, Nakanaga K, Kano K, Makide K, Saigusa D, Tomioka Y, Aoki J.
J Lipid Res 55, 2178-2192 (2014)
Novel lysophosphoplipid receptors; their structure and function.
Makide K, Uwamizu A, Shinjo Y, Ishiguro J, Okutani M, Inoue A, Aoki J.
J Lipid Res 55, 1986-1995 (2014)
Regulation of Intestinal IgA Responses by Dietary Palmitic Acid and Its Metabolism.
Kunisawa J, Hashimoto E, Inoue A, Nagasawa R, Suzuki Y, Ishikawa I, Shikata S, Arita M, Aoki J, Kiyono H.
J Immunol 193, 1666-1671 (2014)
Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp6.
Morita J, Kato K, Mihara E, Ishitani R, Takagi J, Nishimasu H, Aoki J, Nureki O.
Acta Crystallogr F Struct Biol Commun. 70, 794-799 (2014)
ENPP2 contributes to adipose tissue expansion in diet-induced obesity.
Nishimura S, Nagasaki M, Okudaira S, Aoki J, Ohmori T, Ohkawa R, Nakamura K, Igarashi K, Yamashita H, Eto K, Uno K, Hayashi N, Kadowaki T, Komuro I, Yatomi Y, Nagai R.
Diabetes 63, 4154-4164 (2015)
Potentials of the circulating pruritogenic mediator lysophosphatidic acid in development of allergic skin inflammation in mice: role of blood cell-associated lysophospholipase D activity of autotaxin .
Shimizu Y, Morikawa Y, Okudaira S, Kimoto S, Tanaka T, Aoki J and Tokumura A.
Am J Pathol 184, 1593-1603 (2014)
Autotaxin-lysophosphatidic acid signaling attenuates sphingosine-1-phosphate signaling leading to cardia bifida in zebrafish embryos
Nakanaga K, Hama K, Kano K, Sato T, Yukiura H, Inoue A, Saigusa D, Tokuyama H, Tomioka Y, Nishina H, Kawahara A and Aoki J.
J Biochem. 155, 235-241 (2014)
Simultaneous Quantification of Sphingolipids in Small Quantities of Liver by LC-MS/MS
Saigusa D, Okudaira M, Wang J, Kano K, Kurano M, Uranbileg B, Ikeda H, Yatomi Y, Motohashi H and Aoki J.
Mass Spectrometry S0046 (2014)
2013
Transcription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function.
Nakamura A, Ebina-Shibuya R, Itoh-Nakadai A, Muto A, Shima H, Saigusa D, Aoki J, Ebina M, Nukiwa T, Igarashi K.
J Exp Med. 2013 210, 2191-2204 (2013)
Screening and X-Ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe.
Kawaguchi M, Okabe T, Okudaira S, Nishimasu H, Ishitani R, Kojima H, Nureki O, Aoki J, Nagano T.
ACS Chem Biol. 8, 1713-1721 (2013)
A novel mutation, c.699C>G (p.C233W), in the LIPH gene leads to a loss of the hydrolytic activity and the LPA6 activation ability of PA-PLA1α in autosomal recessive woolly hair/hypotrichosis
Mayuko Yoshizawa, Motonobu Nakamura, Muhammad Farooq, Asuka Inoue, Junken Aoki, Yutaka Shimomura
J. Dermatol. Sci. 72, 61-64 (2013)
Lysophosphatidic acid (LPA), a lipid produced by the mitochondrial glycerolipid synthesis enzyme GPAT, rescues the mitochondrial fragmentation arising from Mt-GPAT depletion, suggesting this precursor for glycerolipid synthesis to be an active regulator of mitochondrial fusion.
Yohsuke Ohba, Takeshi Sakuragi, Eriko Kage-Nakadai, Naoko H Tomioka, Nozomu Kono, Rieko Imae, Asuka Inoue, Junken Aoki, Naotada Ishihara, Takao Inoue, Shohei Mitani and Hiroyuki Arai
EMBO J 32, 1265-1279 (2013)
Lysophosphatidic acid receptor LPA1 is essential for development of arthritis
Yoshishige Miyabe, Chie Miyabe, Yoshiko Iwai, Aiko Takayasu, Shin Fukuda, Waka Yokoyama, Jun Nagai, Masahiro Jona, Yasunori Tokuhara, Ryunosuke Okawa, Huib Ovaa, Junken Aoki, Jerold Chun, Yutaka Yatomi, Hiroshi Ueda, Masayuki Miyasaka, Nobuyuki Miyasaka and Toshihiro Nanki
Arthritis & Rheumatism in press
Sphingosine 1-phosphate release from platelets during clot formation: close correlation between platelet count and serum sphingosine 1-phosphate concentration
Ono Yoshikazu, Kurano Makoto, Ohkawa Ryunosuke, Yokota Hiromitsu, Igarashi Koji, Aoki Junken, Tozuka Minoru, Yatomi Yutaka
Lipids in Health and Disease in press
GPR34 as a lysophosphatidylserine receptor
Kumiko Makide and Junken Aoki
J. Biochem, (commentary) 153, 327-329
Phosphorothioate analogs of sn-2 radyl lysophosphatidic acid (LPA): Metabolically stabilized LPA receptor agonists.
Guowei Jiang, Asuka Inoue, Junken Aoki, Glenn D. Prestwich
Bioorg Med Chem Lett. 23, 1865-1869
The autotaxin/lysophosphatidic acid axis regulates lymphocyte extravasation at high endothelial venules of lymph nodes
Zhongbin Bai, Linjun Cai, Eiji Umemoto, Kazuo Tohya, Yutaka Komai, Punniyakoti Thanikachalam Veeraveedu, Akira Takeda, Erina Hata, Haruko Hayasaka, Shinichi Okudaira, Junken Aoki, Toshiyuki Tanaka, Harald M. H. G. Albers, Huib Ovaa, Wayne R. Hein & Masayuki Miyasaka
J Immunol 190, 2036-2048
2012
Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling
Kazuki Kato, Hiroshi Nishimasu, Shinichi Okudaira, Emiko Mihara, Ryuichiro Ishitani, Junichi Takagi, Junken Aoki, and Osamu Nureki
PNAS 109, 16876-16881 (2012)
Structure and function of Zucchini endoribonuclease in piRNA biogenesis
Hiroshi Nishimasu, Hirotsugu Ishizu, Kuniaki Saito, Satoshi Fukuhara, Miharu K. Kamatani, Luc Bonnefond, Naoki Matsumoto, Tomohiro Nishizawa, Keita Nakanaga, Junken Aoki, Ryuichiro Ishitani, Haruhiko Siomi, Mikiko C. Siomi & Osamu Nureki
Nature 491, 284-287 (2012)
Decrease in circulating autotaxin by oral administration of prednisolone.
Sumida H, Nakamura K, Yanagida K, Ohkawa R, Asano Y, Kadono T, Tamaki K, Igarashi K, Aoki J, Sato S, Ishii S, Shimizu T, Yatomi Y.
Clin Chim Acta. 415, 74-80 (2012)
TGFalpha shedding assay: an accurate and versatile method for detecting GPCR activation
Asuka Inoue, Jun Ishiguro, Hajime Kitamura, Naoaki Arima, Michiyo Okutani, Akira Shuto, Shigeki Higashiyama, Tomohiko Owada, Hiroyuki Arai, Kumiko Makide and Junken Aoki
Nature Methods 9, 1021-1019 (2012)
Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp1.
Kato K, Nishimasu H, Mihara E, Ishitani R, Takagi J, Aoki J, Nureki O.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 68, 778-782 (2012)
Nakamura K, Igarashi K, Ohkawa R, Yokota H, Masuda A, Nakagawa S, Yano T, Ikeda H, Aoki J, Yatomi Y.
Serum Autotaxin is not a Useful Biomarker for Ovarian Cancer.
Lipid. 47, 927-930 (2012)
Sato T, Sugimoto K, Inoue A, Okudaira S, Aoki J, Tokuyama H.
Synthesis and biological evaluation of optically active Ki16425.
Bioorg Med Chem Lett. 22, 4323-6 (2012)
Fujimoto A, Farooq M, Fujikawa H, Inoue A, Ohyama M, Ehama R, Nakanishi J, Hagihara M, Iwabuchi T, Aoki J, Ito M, Shimomura Y.
A Missense Mutation within the Helix Initiation Motif of the Keratin K71 Gene Underlies Autosomal Dominant Woolly Hair/Hypotrichosis.
J Invest Dermatol. in press
Sato A, Aoki J, Ebina K.
Synthetic biotinylated peptide compound, BP21, specifically recognizes lysophosphatidylcholine micelles.
Chem Biol Drug Des. 80, 417-425 (2012)
Sato A, Kumagai T, Aoki J, Ebina K.
Synthetic biotinylated peptide compounds derived from Asp-hemolysin: Novel potent inhibitors of platelet-activating factor.
Eur J Pharmacol. 15, 685, 205-12 (2012)
Saigusa D, Shiba K, Inoue A, Hama K, Okutani M, Iida N, Saito M, Suzuki K, Kaneko T, Suzuki N, Yamaguchi H, Mano N, Goto J, Hishinuma T, Aoki J, Tomioka Y.
Simultaneous quantitation of sphingoid bases and their phosphates in biological samples by liquid chromatography/electrospray ionization tandem mass spectrometry.
Anal Bioanal Chem. 403, 1897-905 (2012)
Fukuhara S, Simmons S, Kawamura S, Inoue A, Orba Y, Tokudome T, Sunden Y, Arai Y, Moriwaki K, Ishida J, Uemura A, Kiyonari H, Abe T, Fukamizu A, Hirashima M, Sawa H, Aoki J, Ishii M, Mochizuki N.
The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice.
J. Clin. Invest. 122, 1416-1426 (2012)
Satoru Shinkuma, Asuka Inoue, Junken Aoki, Wataru Nishie, Ken Natsuga, Hideyuki Ujiie, Toshifumi Nomura, Riichiro Abe, Masashi Akiyama and Hiroshi Shimizu
The b9 Loop Domain of PA-PLA1a has a Crucial Rolein Autosomal Recessive Woolly Hair/Hypotrichosis
J. Invest. Dermatol. 132, 2093-2095 (2012)
Hajime Kitamura, Kumiko Makide, Akira Shuto, Masaya Ikubo, , Asuka Inoue, Kensuke Suzuki, Yusuke Sato, Sho Nakamura, Yuko Otani, Tomohiko Ohwada and Junken Aoki
GPR34 is a Receptor for Lysophosphatidylserine, with a Fatty Acid at the sn-2 Position
J. Biochem. 151, 511-518 (2012)
Hiroshi Nishimasu, Ryuichiro Ishitani, Junken Aoki, Osamu Nureki
A 3D view of autotaxin
Trens Pharm Sci 33, 138-145 (2012)
Naoaki Arima, Asuka Inoue, Kumiko Makide, Masataka Nonaka and Junken Aoki
Surface loops of extracellular phospholipase A1 determine both substrate specificity and preference for lysophospholipids
J. Lipid Res. 53, 513-521 (2012)
Uyama T, Ichi I, Kono N, Inoue A, Tsuboi K, Jin XH, Araki N, Aoki J, Arai H, Ueda N.
Regulation of peroxisomal lipid metabolism by the catalytic activity of the tumor suppressor H-rev107.
J. Biol. Chem. 287, 2706-2718 (2012)
Takafumi Hashimoto, Shinichi Okudaira, Koji Igarashi, Kotaro Hama, Yutaka Yatomi and Junken Aoki
Identification and biochemical characterization of a novel autotaxin isoform, ATXδ, with a four-amino acid deletion
J. Biochem. 151: 89-97 (2012)
2011
Hiroshi Yukiura, Kotaro Hama, Keita Nakanaga, Masayuki Tanaka, Yoichi Asaoka, Shinichi Okudaira, Naoaki Arima, Asuka Inoue, Takafumi Hashimoto, Hiroyuki Arai, Atsuo Kawahara, Hiroshi Nishina and Junken Aoki
Autotaxin regulates vascular development via multiple lysophosphatidic acid (LPA) receptors in zebrafish
J. Biol. Chem. 286: 43972-43983 (2011)
Masuda A, Fujii T, Iwasawa Y, Nakamura K, Ohkawa R, Igarashi K, Okudaira S, Ikeda H, Kozuma S, Aoki J, Yatomi Y.
Serum autotaxin measurements in pregnant women: Application for the differentiation of normal pregnancy and pregnancy-induced hypertension.
Clin Chim Acta. 412:1944-1950 (2011)
Asuka Inoue, Naoaki Arima, Jun Ishiguro, Glenn D. Prestwich, Hiroyuki Arai and Junken Aoki
LPA-producing enzyme PA-PLA1α regulates hair follicle development by modulating EGFR signaling
EMBO J 30: 4248-4260 (2011)
Kawaguchi M, Okabe T, Okudaira S, Hanaoka K, Fujikawa Y, Terai T, Komatsu T, Kojima H, Aoki J, Nagano T.
Fluorescence Probe for Lysophospholipase C/NPP6 Activity and a Potent NPP6 Inhibitor.
J Am Chem Soc. 133: 12021-12030 (2011)
Nakai Y, Ikeda H, Nakamura K, Kume Y, Fujishiro M, Sasahira N, Hirano K, Isayama H, Tada M, Kawabe T, Komatsu Y, Omata M, Aoki J, Koike K, Yatomi Y.
Specific increase in serum autotaxin activity in patients with pancreatic cancer.
Clin. Biochem. 44, 576-581 (2011)
Nakagawa H, Ikeda H, Nakamura K, Ohkawa R, Masuzaki R, Tateishi R, Yoshida H, Watanabe N, Tejima K, Kume Y, Iwai T, Suzuki A, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Omata M, Igarashi K, Aoki J, Koike K, Yatomi Y.
Autotaxin as a novel serum marker of liver fibrosis.
Clin. Chim. Acta. 412, 1201-1206 (2011)
Nishimasu H, Okudaira S, Hama K, Mihara E, Dohmae N, Inoue A, Ishitani R, Takagi J, Aoki J, Nureki O
Crystal structure of autotaxin and insight into GPCR activation by lipid mediators.
Nat Struct Mol Biol. 18, 205-212 (2011)
2010
Kazama S, Kitayama J, Aoki J, Mori K, Nagawa H.
Immunohistochemical Detection of Autotaxin (ATX)/Lysophospholipase D (lysoPLD) in Submucosal Invasive Colorectal Cancer.
J Gastrointest Cancer. in press
Cavalli S, Houben AJ, Albers HM, van Tilburg EW, de Ru A, Aoki J, van Veelen P, Moolenaar WH, Ovaa H.
Development of an activity-based probe for autotaxin.
Chembiochem. 11, 2311-2317 (2010)
Hosono H, Homma M, Ogasawara Y, Makide K, Aoki J, Niwata H, Watanabe M, Inoue K, Ohkohchi N, Kohda Y.
Expression of phosphatidylserine-specific phospholipase A(1) mRNA in human THP-1-derived macrophages.
Cell Transplant. 19, 759-764 (2010)
Ohuchi H, Fukui H, Matsuyo A, Tomonari S, Tanaka M, Arai H, Noji S, Aoki J.
Autotaxin controls caudal diencephalon-mesencephalon development in the chick.
Dev Dyn. 239, 2647-2658 (2010)
Takahashi K, Sasabe N, Ohshima K, Kitazato K, Kato R, Masuda Y, Tsurumaki M, Obama T, Okudaira SI, Aoki J, Arai H, Yamaguchi T, Itabe H.
Glucagon regulates intracellular distribution of adipose differentiation-related protein during triacylglycerol accumulation in the liver.
J Lipid Res. 51, 2571-2580 (2010)
Nakanaga K, Hama K, Aoki J
Autotaxin – an LPA producing enzyme with diverse functions
J. Biochem. 148, 13-24 (2010)
Okudaira S, Yukiura H, Aoki J
Biological roles of lysophosphatidic acid signaling through its production by autotaxin.
Biochimie 92, 698-706 (2010)
Hama K, Aoki J.
LPA(3), a unique G protein-coupled receptor for lysophosphatidic acid.
Prog Lipid Res. 49, 335-342 (2010)
Shinkuma S, Akiyama M, Inoue A, Aoki J, Natsuga K, Nomura T, Arita K, Abe R, Ito K, Nakamura H, Ujiie H, Shibaki A, Suga H, Tsunemi Y, Nishie W, Shimizu H.
Prevalent LIPH founder mutations lead to loss of P2Y5 activation ability of PA-PLA1alpha in autosomal recessive hypotrichosis.
Hum Mutat. i31, 602-610 (2010)
Nakamura K, Igarashi K, Ohkawa R, Saiki N, Nagasaki M, Uno K, Hayashi N, Sawada T, Syukuya K, Yokota H, Arai H, Ikeda H, Aoki J, Yatomi Y
A novel enzyme immunoassay for the determination of phosphatidylserine-specific phospholipase A1 in human serum samples
Clinica Chimica Acta. 411, 1090-1094 (2010)
Ma L, Uchida H, Nagai J, Inoue M, Aoki J, Ueda H.
Evidence for De Novo Synthesis of Lysophosphatidic Acid in the Spinal Cord through Phospholipase A2 and Autotaxin in Nerve Injury-induced Neuropathic Pain.
J Pharmacol Exp Ther. 333, 540-546 (2010)
David M, Wannecq E, Descotes F, Jansen S, Deux B, Ribeiro J, Serre CM, Grès S, Bendriss-Vermare N, Bollen M, Saez S, Aoki J, Saulnier-Blache JS, Clézardin P, Peyruchaud O.
Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts.
PLoS One. 17, e9741 (2010)
2009
Ma L, Uchida H, Nagai J, Inoue M, Chun J, Aoki J, Ueda H.
Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain.
Mol Pain. 13, 64 (2009)
Trimbuch T, Beed P, Vogt J, Schuchmann S, Maier N, Kintscher M, Breustedt J, Schuelke M, Streu N, Kieselmann O, Brunk I, Laube G, Strauss U, Battefeld A, Wende H, Birchmeier C, Wiese S, Sendtner M, Kawabe H, Kishimoto-Suga M, Brose N, Baumgart J, Geist B, Aoki J, Savaskan NE, Bräuer AU, Chun J, Ninnemann O, Schmitz D, Nitsch R.
Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.
Cell. 2009 138, 1222-35 (2009)
Morikawa RK, Aoki J, Kano F, Murata M, Yamamoto A, Tsujimoto M, Arai H.
Intracellular Phospholipase A1 iPLA1gamma is a Novel Factor Involved in COPI- and Rab6-Independent Retrograde Transport between the ER and the Golgi Complex.
J. Biol. Chem. 284, 26620-30 (2009)
Iwashita M, Makide K, Nonomura T, Misumi Y, Otani Y, Ishida M, Taguchi R, Tsujimoto M, Aoki J, Arai H, Ohwada T
Synthesis and Evaluation of Lysophosphatidylserine Analogues as Inducers of Mast Cell Degranulation. Potent Activities of Lysophosphatidylthreonine and Its 2-Deoxy Derivative
J. Med. Chem. 52, 5837-63 (2009)
Otani K, Kitayama J, Yasuda K, Nio Y, Iwabu M, Okudaira S, Aoki J, Yamauchi T, Kadowaki T, Nagawa H.
Adiponectin suppresses tumorigenesis in Apc(Min)(/+) mice.
Cancer Lett. 288, 177-82 (2009)
Makide K, Kitamura H, Sato Y, Okutani M, Aoki J.
Emerging lysophospholipid mediators, lysophosphatidylserine, lysophosphatidylthreonine, lysophosphatidylethanolamine and lysophosphatidylglycerol (review)
Prostaglandins Other Lipid Mediat. 89, 135-139 (2009)
Endo T, Kano K, Motoki R, Hama K, Okudaira S, Ishida M, Ogiso H, Tanaka M, Matsuki N, Taguchi R, Kanai M, Shibasaki M, Arai H, Aoki J.
Lysophosphatidylmethanol is a pan lysophosphatidic acid receptor agonist and is produced by autotaxin in blood.
J. Biochem. 146, 283-293 (2009)
Nakamura K, Igarashi K, Ohkawa R, Okubo S, Yokota H, Kishimoto T, Ide K, Masuda A, Yamamoto T, Saito N, Kurokawa M, Tsuji S, Okudaira S, Ikeda H, Aoki J, Yatomi Y.
Autotaxin enzyme immunoassay in human cerebrospinal fluid samples.
Clin. Chim. Acta. 405, 160-162 (2009)
Makide K, Kano K, Kitamura H, Arima N, Aoki J.
Lysophospholipid mediators
Tanpakushitsu Kakusan Koso. 54, 29-39 (2009)
Iwasawa Y, Fujii T, Nagamatsu T, Kawana K, Okudaira S, Miura S, Matsumoto J, Tomio A, Hyodo H, Yamashita T, Oda K, Kozuma S, Aoki J, Yatomi Y, Taketani Y.
Expression of autotaxin, an ectoenzyme that produces lysophosphatidic acid, in human placenta.
Am J Reprod Immunol. 62, 90-95 (2009)
Nouh MA, Wu XX, Okazoe H, Tsunemori H, Haba R, Abou-Zeid AM, Saleem MD, Inui M, Sugimoto M, Aoki J, Kakehi Y.
Expression of autotaxin and acylglycerol kinase in prostate cancer: association with cancer development and progression.
Cancer Sci. 100, 1631-1638 (2009)
2008
Inoue M, Ma L, Aoki J, Ueda H.
Simultaneous stimulation of spinal NK1 and NMDA receptors produces LPC which undergoes ATX-mediated conversion to LPA, an initiator of neuropathic pain.
J. Neurochem. 107, 1556-1565 (2008)
Ohuchi H, Hamada A, Matsuda H, Takagi A, Tanaka M, Aoki J, Arai H, Noji S.
Expression patterns of the lysophospholipid receptor genes during mouse early development.
Dev Dyn. 237, 3280-3294 (2008)
Nakasaki T, Tanaka T, Okudaira S, Hirosawa M, Umemoto E, Otani K, Jin S, Bai Z, Hayasaka H, Fukui Y, Aozasa K, Fujita N, Tsuruo T, Ozono K, Aoki J, Miyasaka M.
Involvement of the Lysophosphatidic Acid-Generating Enzyme Autotaxin in Lymphocyte-Endothelial Cell Interactions.
Am J Pathol. 173, 1566-1576 (2008)
Kano K, Arima N, Oogami M and Aoki J.
LPA and its analogs -attractive tools for elucidation of LPA biology and drug development-
Curr Med Chem. (review) 15, 2122-2131 (2008)
Aoki J, Inoue A and Okudaira S.
Two pathways for lysophosphatidic acid production
Biochimi. Biochem. Acta. (review) 1781, 513-518 (2008)
Masuda A, Nakamura K, Izutsu K, Igarashi K, Ohkawa R, Jona M, Higashi K, Yokota H, Okudaira S, Kishimoto T, Watanabe K, Koike Y, Ikeda H, Kozai, Y, Kurokwa, M, Aoki, J, and Yatomi, Y
Serum autotaxin measurement in haematological malignancies: a promising marker for follicular lymphoma
British Journal of Haematology 143, 60-70 (2008)
Kanamori T, Inoue T, Sakamoto T, Gengyo-Ando K, Tsujimoto M, Mitani S, Sawa H, Aoki J, Arai H.
Beta-catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions.
EMBO J. 27, 1647-1657 (2008)
Kono N, Inoue T, Yoshida Y, Sato H, Matsusue T, Itabe H, Niki E, Aoki J, Arai H.
Protection against oxidative stress-induced hepatic injury by intracellular type II PAF-acetylhydrolase by metabolism of oxidized phospholipids in vivo.
J. Biol. Chem. 283, 1628-1636 (2008)
Inoue M, Xie W, Matsushita Y, Chun J, Aoki J, Ueda H.
Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid.
Neuroscience. 152, 296-298 (2008)
Inoue M, Ma L, Aoki J, Chun J, Ueda H.
Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain.
Mol Pain. 8;4, 6 (2008)
Nakamura K, Nangaku M, Ohkawa R, Okubo S, Yokota H, Ikeda H, Aoki J, Yatomi Y.
Analysis of serum and urinary lysophospholipase D/autotaxin in nephrotic syndrome.
Clin. Chem. La.b Med. 46, 150-151 (2008)
Nakamura K, Igarashi K, Ide K, Ohkawa R, Okubo S, Yokota H, Masuda A, Oshima N, Takeuchi T, Nangaku M, Okudaira S, Arai H, Ikeda H, Aoki J, Yatomi Y.
Validation of an autotaxin enzyme immunoassay in human serum samples and its application to hypoalbuminemia differentiation.
Clin. Chim. Acta. 388, 51-58 (2008)
2007
Hama K, Aoki J, Inoue A, Endo T, Amano T, Motoki R, Kanai M, Ye X, Chun J, Matsuki N, Suzuki H, Shibasaki M, Arai H.
Embryo Spacing and Implantation Timing Are Differentially Regulated by LPA3-Mediated Lysophosphatidic Acid Signaling in Mice.
Biol. Reprod., 77, 954-959 (2007)
Morikawa R, Tsujimoto M, Arai H, Aoki J.
Phospholipase A(1) assays using a radiolabeled substrate and mass spectrometry.
Methods Enzymol., 434, 1-13 (2007)
Nakamura K, Takeuchi T, Ohkawa R, Okubo S, Yokota H, Tozuka M, Aoki J, Arai H, Ikeda H, Ohshima N, Kitamura T, Yatomi Y.
Serum lysophospholipase D/autotaxin may be a new nutritional assessment marker: study on prostate cancer patients.
Ann. Clin. Biochem., 44, 549-556 (2007)
Yamaguchi N, Koizumi H, Aoki J, Natori Y, Nishikawa K, Natori Y, Takanezawa Y, Arai H.
Type I platelet-activating factor acetylhydrolase catalytic subunits over-expression induces pleiomorphic nuclei and centrosome amplification.
Genes Cells, 12, 1153-1161 (2007)
Watanabe N, Ikeda H, Nakamura K, Ohkawa R, Kume Y, Tomiya T, Tejima K, Nishikawa T, Arai M, Yanase M, Aoki J, Arai H, Omata M, Fujiwara K, Yatomi Y.
Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity.
Life Sci., 81, 1009-1015 (2007)
Mori K, Kitayama J, Aoki J, Kishi Y, Shida D, Yamashita H, Arai H, Nagawa H.
Submucosal connective tissue-type mast cells contribute to the production of lysophosphatidic acid (LPA) in the gastrointestinal tract through the secretion of autotaxin (ATX)/lysophospholipase D (lysoPLD).
Virchows Arch., 451, 47-56 (2007)
Satoh Y, Ohkawa R, Nakamura K, Higashi K, Kaneko M, Yokota H, Aoki J, Arai H, Yuasa Y, Yatomi Y.
Lysophosphatidic acid protection against apoptosis in the human pre-B-cell line Nalm-6.
Eur. J. Haematol., 78, 510-517 (2007)
Diversified expression patterns of autotaxin, a gene for phospholipid-generating enzyme during mouse and chicken development
Hideyo Ohuchi, Yasunori Hayashibara, Hironao Matsuda, Motoyoshi Onoi, Masayuki Mitsumori, Masayuki Tanaka, Junken Aoki, Hiroyuki Arai and Sumihare Noji
Developmental Dynamics 236, 1134-1143 (2007)
Peritoneal fluids from patients with certain gynecologic tumor contain elevated levels of bioactive lysophospholipase D activity
Akira Tokumura, Tetsuya Kume, Kenji Fukuzawa, Masahiro Tahara, Keiichi Tasaka, Junken Aoki, Hiroyuki Arai, Katsuhiko Yasuda and Hideharu Kanzaki
Life Sciences 80, 1641-1649 (2007)
Neuroprotective Role of Transgenic PAF-Acetylhydrolase II in Mouse Models of Focal Cerebral Ischemia.
K. Umemura, I. Kato, Y. Hirashima, Y. Ishii, T. Inoue, J. Aoki, N. Kono, T. Oya, N. Hayashi, H. Hamada, S. Endo, M. Oda, H. Arai, H. Kinouchi and K. Hiraga
Stroke 38, 1063-1068 (2007)
Plasma lysophosphatidic acid is increased in liver fibrosis in rats and human with enhanced serum autotaxin level.
Naoko Watanabe, Hitoshi Ikeda, Kazuhiro Nakamura, Ryunosuke Ohkawa, Yukio Kume, Junken Aoki, Kotaro Hama, Shinichi Okudaira, Masayuki Tanaka, Mikio Yanase, Kayo Nagashima, Tomoaki Tomiya, Masahiro Arai, Yukiko Inoue, Kazuaki Tejima, Takako Nishikawa, Hiroyuki Arai, Masao Omata, Kenji Fujiwara and Yutaka Yatomi
J. Clin. Gastroenterol. 41, 616-623 (2007)
Structure and function of extracellular phospholipase A1 belonging to the pancreatic lipase gene family (review).
Junken Aoki, Asuka Inoue, Kumiko Makide, Naoya Saiki and Hiroyuki Arai
Biochimie 89, 197-204 (2007)
Measurement of lysophospholipase D/autotaxin activity in human serum samples
Kazuhiro Nakamura, Ryunosuke Ohkawa, Shigeo Okubo, Minoru Tozuka, Mitsumasa Okada, Shinya Aoki, Junken Aoki, Hiroyuki Arai, Hitoshi Ikeda and Yutaka Yatomi
Clinical Biochemistry 40, 274-277 (2007)
Autotaxin (NPP-2) in the brain: Cell type-specific expression and regulation during development and after neurotrauma
Nicolai E. Savaskan, Linda Rocha, Mark R. Kotter, Gert Lubec, Alexandra Baer, Laurens van Meeteren, Yasuhiro Kishi, Junken Aoki, Wouter H. Moolenaar, Robert Nitsch and Anja U. Brauer
Cell. Mol. Life Sci. 64, 230-243 (2007)
2006
Transgenic Expression of Group V, but not Group X, Secreted Phospholipase A2 in Mice Leads to Neonatal Lethality due to Lung Dysfunction
M. Ohtsuki, Y. Taketomi, S. Arata, S. Masuda, Y. Ishikawa, T. Ishii, Y. Takanezawa, J. Aoki, H. Arai,
K. Yamamoto, I. Kudo, M. Murakami
J. Biol. Chem. 281, 36420-36433 (2006)
Asuka Inoue and Junken Aoki
Phospholipase A1s - Structure, distribution and function- (review)
Future Lipidology 1, 687-700 (2006)
Cyclic phosphatidic acid is produced by autotaxin in blood
Satomi Tsuda, Shinichi Okudaira, Keiko Moriya-Ito, Chie Shimamoto, Masayuki Tanaka, Junken Aoki, Hiroyuki Arai, Kimiko Murakami-Murofushi and Tetsuyuki Kobayashi
J. Biol. Chem. 281, 26081-26088 (2006)
Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid
Masayuki Tanaka, Shinichi Okudaira, Yasuhiro Kishi, Ryunosuke Ohkawa, Sachiko Iseki, Masato Ota, Sumihare Noji, Yutaka Yatomi, Junken Aoki, and Hiroyuki Arai
J. Biol. Chem. 281, 25822-25830 (2006)
Lysophosphatidic receptor, LPA3, is positively and negatively regulated by progesterone and estrogen in the mouse uterus
Kotaro Hama, Junken Aoki, Koji Bandoh, Asuka Inoue, Tomoko Endo, Tomokazu, Amano, Hiroshi Suzuki and Hiroyuki Arai
Life Sciences 79, 1736-1740 (2006)
Triglyceride hydrolase-2, a novel paralogue of triglyceride hydrolase, is regulated by nutritional conditions in adipose tissue
Hiroaki Okazaki, Junichi Osuga, Masaki Igarashi, Makiko Tajima, Makiko Nishi, Motohiro Sekiya, Sachiko Okazaki, Naoya Yahagi, Kazuhisa Tsukamoto, Michiyo Amemiya-Kudo, Takashi Matsuzaka, Hitoshi Shimano, Nobuhiro Yamada, Junken Aoki, Rei Morikawa, Yasukazu Takanezawa, Hiroyuki Arai, Ryozo Nagai, Takashi Kadowaki and Shun Ishibashi
DIABETES 55, 2091-2097 (2006)
Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcoholine to lysophosphatidic acid.
Kishi Y, Okudaira S, Tanaka M, Hama K, Shida D, Kitayama J, Yamori T, Aoki J, Fujimaki T and Arai H.
J. Biol. Chem. 281, 17492-17500 (2006)
Phosphorothioate Analogues of Alkyl Lysophosphatidic Acid as LPA3 Receptor-Selective Agonists
Lian Qian, Yong Xu, Ted Simper, Guowei Jiang, Junken Aoki, Makiko Umezu-Goto, Hiroyuki Arai, Shuangxing Yu, Gordon B. Mills, Ryoko Tsukahara, Natalia Makarova, Yuko Fujiwara, Gabor Tigyi and Glenn D. Prestwich
ChemMedChem. 1, 376-383 (2006)
Adipose differentiation-related protein is degraded through the proteasome-dependent pathway during regression of lipid-storing cells
Masuda Y, Itabe H, Odaki M, Hama K, Fujimoto Y, Mori M, Sasabe N, Aoki J, Arai H, Takano T
J. Lipid Res. 47, 87-98 (2006)
Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells.
Watanabe N, Zmijewski JW, Takabe W, Umezu-Goto M, Le Goffe C, Sekine A, Landar A, Watanabe A, Aoki J, Arai H, Kodama T, Murphy MP, Kalyanaraman R, Darley-Usmar VM, Noguchi N.
Am. J. Pathol. 168, 1737-1748 (2006)
Differential expression of lysophosphatidic acid receptor-2 in intestinal and diffuse type gastric cancer.
Yamashita H, Kitayama J, Shida D, Ishikawa M, Hama K, Aoki J, Arai H and Nagawa H.
J. Surg. Oncol. 93, 30-35 (2006)
2005
Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin's lymphoma cells.
Baumforth KR, Flavell JR, Reynolds GM, Davies G, Pettitt TR, Wei W, Morgan S, Stankovic T, Kishi Y, Arai H, Nowakova M, Pratt G, Aoki J, Wakelam MJ, Young LS, Murray PG.
Blood 106, 2138-2146 (2005)
Biochemical and Molecular Characterization of a Novel Choline-specific Glycerophosphodiester Phosphodiesterase Belonging to the Nucleotide Pyrophosphatase/Phosphodiesterase (NPP) family
Hideki Sakagami, Junken Aoki, Yumiko Natori, Kiyotaka Nishikawa, Yoshiyuki Kakehi, Yasuhiro Natori and Hiroyuki Arai
J. Biol. Chem. 280, 23084-23093 (2005)
Neuronal Expression and Neuritogenic Action of Group X SecretedPhospholipase A2
Seiko Masuda, Makoto Murakami, Yasukazu Takanezawa, Junken Aoki, Hiroyuki Arai, Yukio Ishikawa, Toshiharu Ishii, Manabu Arioka and Ichiro Kudo
J. Biol. Chem. 280, 23203-23214 (2005)
Xiaoqin Ye, Kotaro Hama, James J.A. Contos, Brigitte Anliker, Aska Inoue, Michael K. Skinner, Hiroshi Suzuki, Tomokazu Amano, Grace Kennedy, Hiroyuki Arai, Junken Aoki, and Jerold Chun
LPA3-mediated lysophosphatidic acid signalling in implantation and embryo spacing
Nature 435, 104-108 (2005)
Yong Xu, Junken Aoki, Kumiko Shimizu, Makiko Umezu-Goto, Kotaro Hama, Yasukazu Takanezawa, Shuangxing Yu, Gordon B. Mills, Hiroyuki Arai, Lian Qian and Glenn D. Prestwich
Structure-Activity Relationships of Fluorinated Lysophosphatidic Acid Analogues
J. Med. Chem. 48, 3319-3327 (2005)
Makoto Murakami, Seiko Masuda, Kaori Ueda-Semmyo, Emiko Yoda, Hiroshi Kuwata, Yasukazu Takanezawa, Junken Aoki, Hiroyuki Arai, Hideki Sumimoto, Yukio Ishikawa, Toshiharu Ishii, Yoshihito Nakatani adn Ichiro Kudo
Group VIB Ca2+-independent phospholipase A2 (iPLA2) promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipase A2s
J. Biol. Chem. 280, 14028-14041 (2005)
2004年以前の代表的な論文
Takao Inoue, Asako Sugimoto, Yuka Suzuki, Masayuki Yamamoto, Masafumi Tsujimoto, Junken Aoki and Hiroyuki Arai
Type II platelet-activating factor-acetylhydrolase is essential for epithelial morphogenesis in C. elegans
Proc. Natl. Acad. Sci., 101, 13233-13238 (2004)
Junken Aoki
Mechanisms of lysophosphatidic acid production (review).
Semin. Cell Dev. Biol. 15, 477-489 (2004)
Hama K, Aoki J, Fukaya M, Kishi Y, Sakai T, Suzuki R, Ohta H, Yamori T, Watanabe M, Chun J, Arai H.
Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1.
J. Biol. Chem. 279, 17634-17639 (2004)
Keizo Inoue, Hiroyuki Arai and Junken Aoki
Phospholipase A1 -structures, physiological and patho-physiological roles in mammals-
Lipases and Phospholipases in Drug Development: From biochemistry to molecular pharmacology. 23-39, Wiley-VCH Verlag GmbH (2004)
Yoshida K, Nishida W, Hayashi K, Ohkawa Y, Ogawa A, Aoki J, Arai H and Sobue K
Vascular remodeling induced by naturally occurring unsaturated lysophosphatidic acid in vivo.
Circulation. 108, 1746-52 (2003)
T. Hiramatsu, H. Sonoda, Y. Takanezawa, R. Morikawa, M. Ishida, K. Kasahara, Y. Sanai, R. Taguchi, J. Aoki, and H. Arai H
Biochemical and molecular characterization of two phosphatidic acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta.
J. Biol. Chem., 278, 49438-49447 (2003)
LIS1 missense mutations: Variable Phenotypes Result from Unpredictable Alterations in Biochemical and Cellular Properties.
Caspi M, Coquelle FM, Koifman C, Levy T, Arai H, Aoki J, De Mey JR, snf Reiner O.
J. Biol. Chem., 278, 38740-38748 (2003)
Targeted Disruption of Intracellular Type I PAF-Acetylhydrolase Catalytic Subunits Causes Severe Impairment in Spermatogenesis
H. Koizumi, N. Yamaguchi, M. Hattori, T.O. Ishikawa, J. Aoki, M.M. Taketo, K. Inoue and H. Arai
J. Biol. Chem., 278, 12489-12494 (2003)
Identification of an intracellular receptor forlysophosphatidic acid (LPA): LPA is a transcellular PPAR gamma agonist
T. M. McIntyre, A. V. Pontsler, A. R. Silva, A. Hilaire, Y. Xu, J. C. Hinshaw, G. A. Zimmerman, K. Hama, J. Aoki, H. Arai, and G. D. Prestwich
Proc. Natl. Acad. Sci., 100, 131-136 (2003)
Autotaxin Hydrolyzes Sphingosylphosphorylcholine to Produce the Regulator of Migration, Sphingosine-1-Phosphate
Timothy Clair, Junken Aoki, Eunjin Koh, Russell W. Bandle, Suk Woo Nam, Malgorzata M. Ptaszynska, Gordon B. Mills, Elliott Schiffmann, Lance A. Liotta, and Mary L. Stracke
Cancer Res. 63, 5446-5453 (2003)
Identification of a Phosphothionate Analogue of Lysophosphatidic Acid (LPA) as a Selective Agonist of the LPA3 receptor
Yutaka Hasegawa, James R. Erickson, Graham J. Goddard, Shuangxing Yu, Shuying Liu, Kwai Wa Cheng, Astrid Eder, Koji Bandoh, Junken Aoki, Renata Jarosz, Andrew D. Schrier, Kevin R. Lynch, Gordon B. Mills and Xianjun Fang
J. Biol. Chem., 278, 11962-11969 (2003)
Enantioselective Responses to OMPT, a Phosphorothioate Analogue of Lysophosphatidic Acid with LPA3 Receptor-Selective Agonist Activity
Lian Qian, Yong Xu, Yutaka Hasegawa, Junken Aoki, Gordon B. Mills and Glenn D. Prestwich
J. Med. Chem., 46, 5575-5578 (2003)
Serum lysophosphatidic acid is produced through diverse phospholipase pathways.
J. Aoki, A. Taira, Y. Takanezawa, Y. Kishi, K. Hama, T. Kishimoto, K. Mizuno, K. Saku, R. Taguchi, and H. Arai.
J. Biol. Chem. 277, 39696-702 (2002)
SREC-II, a new member of the scavenger receptor type F family, trans-interacts with SREC-I through its extracellular domain.
J. Ishii, H. Adachi, J. Aoki, H. Koizumi, S. Tomita, T. Suzuki, M. Tsujimoto, K. Inoue, and H. Arai
J. Biol. Chem. 277, 39696-39702 (2002)
Autotaxin has lysophospholipase D activity leading to tumor cell growth and motiity by lysophosphatidic acid production
M. Umezu, Y. Kishi, A. Taira, K. Hama, N. Dohmae, K. Takio, T. Yamori, G. B. Mills, K. Inoue, J. Aoki and H. Arai
J. Cell Biol. 158, 227-233 (2002)
A novel phosphatdic acid-selective phospholipase A1 that produces lysophosphatidic acid.
H. Sonoda, J. Aoki, T. Hiramatsu, M. Ishida, K. Bandoh, Y. Nagai, R. Taguchi, K. Inoue and H. Arai
J. Biol. Chem. 277, 34254-34263 (2002)
K. Kawamoto, J. Aoki, H. A. Tanaka, A. Itakura, H. Hosono, Arai, Y. Kiso and H. Matsuda
Nerve Growth Factor Activates Mast Cells Through the Collaborative Interaction with Lysophosphatidylserine Expressed on the Membrane Surface of Activated Platelets.
J. Immunol. 168 6412-6419 (2002)
J. Aoki, Y. Nagai, H. Hosono, K. Inoue and H. Arai
Structure and function of phosphatidylserine-specific phospholipase A1 (review)
Biochimi. Biochem. Acta. (review) 1582, 26-32 (2002)
A novel phospholipase A1 with sequence homology to a mammalian Sec23p-interacting protein, p125.
K. Nakajima, H. Sonoda, T. Mizoguchi, J. Aoki, H. Arai, M. Nagahama, M. Tagaya and K. Tani
J. Biol. Chem. 277, 11329-11335 (2002)
A novel therapeutic agent with oriented carbohydrates for treatment of infections by Shiga toxin-producing Escherichia coli O157:H7.
K. Nishikawa, K. Matsuoka, E. Kita, N. Okabe, M. Mizuguchi, K. Hino, S. Miyazawa, C. Yamasaki, J. Aoki, S. Takashima, Y. Yamakawa, M. Nishijima, D. Terunuma, H. Kuzuhara and Y. Natori
Proc. Natl. Acad. Sci., 99, 7669-7674 (2002)
H. Hosono, J. Aoki, Y. Nagai, K. Bandoh, M. Ishida, R. Taguchi, H. Arai and K. Inoue
Phosphatidylserine-specific Phospholipase A1 Stimulates Histamine Release from Rat Peritoneal Mast Cells through Production of 2-acyl-1-lysophosphatidylserine.
J. Biol. Chem., 276, 29664-29670, (2001)
Phenotypic modulation of vascular smooth muscle cells induced by unsaturated lysophosphatidic acids.
K. Hayashi, M. Takahashi, W. Nishida, K. Yoshida, Y. Ohkawa, A. Kitabatake, J. Aoki, H. Arai and K. Sobue
Circ. Res. 89, 251-258 (2001)
Functional hemizygosity of PAFAH1B3 due to a PAFAH1B3-CLK2 fusion gene in a female with mental retardation, ataxia and atrophy of the brain.
H. G. Nothwang, H. G. Kim, J. Aoki, H. Arai, K. Inoue and J. Wirth
Hum. Mol. Gen., 10, 797-806 (2001)
Identification of a PDZ-domain-conataining protein that interacts with the scavenger receptor class B type I.
M. Ikemoto, H. Arai, D. Fen, K. Tanaka, J. Aoki, N. Dohmae, K. Takio, H. Adachi, M. Tsujimoto and K. Inoue
Proc. Natl. Acad. Sci. USA, 97, 6538-6543 (2000)
Platelet-activating factor (PAF)-dependent transacetylase and its relationship with PAF accetylhydrolases.
K. Bae, L. Longobardi, K. Karasawa, B.. Malone, T. Inoue, J. Aoki, H. Arai, K. Inoue and T.-c. Lee
J. Biol. Chem., 275, 26704-26709 (2000)
Nectin/PRR: An Immunoglobulin-like Cell Adhesion Molecule Recruited to Cadherin-based Adherens Junctions through Interaction with Afadin, a PDZ Domain-containing Protein
K. Takahashi, H. Nakanishi, M. Miyahara, K. Mandai, K. Satoh, A. Satoh, H. Nishioka, J. Aoki, A. Nomoto, A, Mizoguchi and Y. Takai
J. Cell Biol., 145, 539-549, (1999)
An alternative splicing form of phosphatidtlserine-specific phospholipase A1 that exhibits lysophosphatidylserine-specific
lysophospholipase activity in humans.
Y. Nagai, J. Aoki, T. Sato, K. Amano, Y. Matsuda, H. Arai and K. Inoue
J. Biol. Chem., 274, 11053-11059 (1999)
Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid.
K. Bandoh, J. Aoki, H. Hosono, S. Kobayashi, K. Murakami-Murifushi, M. Tsujimoto, H. Arai and K.Inoue
J. Biol. Chem., 274, 27776-27785 (1999)
Biochemical characterization of various catalytic complexes of the brain platelet-activating factor acetylhydrolase.
H. Manya, J. Aoki, H. Kato, J. Ishii, S. Hino, H. Arai and K. Inoue
J. Biol. Chem., 274, 31827-31832 (1999)
Purification, cDNA cloning, and expression of UDP-Gal:glucosylceramide b-1, 4-Galactosyltransferase from rat brain.
T. Nomura, M. Takizawa, J. Aoki, H. Arai, K. Inoue, E. Wakisaka, N. Yoshizuka, G. Imokawa, N. Dohmae, K. Takio, M. Hattori and N. Matsuo
J. Biol. Chem., 273, 13570-13577 (1998)
Switching of platelet-activating factor acetylhydrolase catalytic subunits developing rat brain.
H. Manya, J. Aoki, M. Watanabe, T. Adachi, H. Asou,Y. Inoue, H. Arai and K. Inoue
J. Biol. Chem., 273, 18567-18572 (1998)
Protection against oxidative stress-induced cell death by intracellular platelet-activating factor acetylhydrolase II.
A. Matsuzawa, K. Hattori, J. Aoki, H. Arai and K. Inoue
J. Biol. Chem., 272, 32315-32320 (1997)
Serine phospholipid-specific phospholipase A that is secreted from activated platelets.
T. Sato, J. Aoki, Y. Nagai, N. Dohmae, K. Takio, T. Doi, H. Arai and K. Inoue
J. Biol. Chem., 272, 2192-2198 (1997)
Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer.
Y. S. Ho, L. Swenson, U. Derewenda, L. Serre, Y. Wei, Z. Dauter, M. Hattori, T. Adachi, J. Aoki, H. Arai, K. Inoue and Z. S. Derewenda
Nature, 385, 89-93 (1997)
Efficient delivery of circulating poliovirus to the central nervous system independently of poliovirus receptor
W. X. Yang, T. Terasaki, K. Shiroki, S. Ohka, J. Aoki, S. Tanabe, T. Nomura, E. Terada, Y. Sugiyama and A. Nomoto
Virology, 229, 421-428, (1997)
Mouse homologue of poliovirus receptor-related protein 2, mPRR2, mediates homophilic cell aggregation.
J. Aoki, S. Koike, I. Ise, H. Asou, H. Suwa, T. Tanaka, M. Miyasaka and A. Nomoto
Exp. Cell Res. 235, 374-384, (1997)
Aoki J, Koike S, Ise I, Sato-Yoshida Y, Nomoto A.
Amino acid residues on human poliovirus receptor involved in interaction with poliovirus.
J. Biol. Chem. 269, 8431-8438 (1994)
Aoki J, Umeda M, Takio K, Titani K, Utsumi H, Sasaki M, Inoue K.
Neural cell adhesion molecule mediates contact-dependent inhibition of growth of near-diploid mouse fibroblast cell line m5S/1M.
J. Cell Biol. 115, 1751-1761 (1992)