2017.12.19:特別講義 (東京理科大学 基礎工学部 生物工学科)

2017.12.16:生合成リデザインー第3回公開シンポジウム (東工大)

2017.12.13駒場サイエンス倶楽部 “自然からの贈り物”-生物がつくり出す多様な二次代謝物


2017.11.20:特別講演会 13:00- 3-116, Prof. Xavier Franc (Rouen-Normandy University, France)

2017.11.16:第17回糸状菌分子生物学コンファレンス  (佐賀)

2017.10.31:特別講義 (熊本大学大学院生命科学研究部)

2017.10.02:1st China-Japan Joint Symposium on Natural Product Biosynthesis

2017.09.20:第59回天然有機化合物討論会 (札幌)

2017.08.25:生合成若手勉強会 (草津)


 Paper for lab. seminar

*Christian Hertweck
On-Line Polyketide Cyclization into Diverse Medium-Sized Lactones by a Specialized Ketosynthase Domain.
Angew. Chem. Int. Ed. 2018, 57, 11223-11227.

*Sarah O’Connor
Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle.
Science 2018, 360, 1235-1239.

*William M. Wuest
Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase.
J. Am. Chem. Soc. 2018, 140, 1774-1782.

*Seth B. Herzon
Molecular Basis of Gut Microbiome-Associated Colorectal Cancer: A Synthetic Perspective,
J. Am. Chem. Soc. 2017, 139, 14817–14824.

*Mohammad R. Seyedsayamdost
Discovery of scmR as a global regulator of secondary metabolism and virulence in Burkholderia thailandensis E264,
Proc. Natl. Acad. Sci. 2017, 114, 2920 –2928.

*Matthias Brock
A Non-canonical Melanin Biosynthesis Pathway Protects Aspergillus terreus Conidia from Environmental Stress,
Cell Chem. Biol. 2017, 23, 587 –597.

*Dirk Hoffmeister
Induced Chemical Defense of a Mushroom by a Double-Bond-Shifting Polyene Synthase,
Angew. Chem. Int. Ed. 2017, 56, 5937 –5941.

*Mohammad R. Seyedsayamdost
Discovery of a Cryptic Antifungal Compound from Streptomyces albusJ1074 Using High-Throughput Elicitor Screens,
J. Am. Chem. Soc. 2017139, 9203−9212.

*Chengshu Wang
Fungal Cordycepin Biosynthesis Is Coupled with the Production of the Safeguard Molecule Pentostatin,
Cell Chem. Biol. 201724, 1–11.

*Paul D. Straight
A Link between Linearmycin Biosynthesis and Extracellular Vesicle Genesis Connects Specialized Metabolism and BacterialMembrane Physiology,
Cell Chem. Biol. 201724, 1238–1249.

*Elizabeth S. Sattely
Biosynthesis of cabbage phytoalexins from indole glucosinolate,
Proc. Natl. Acad. Sci. 2017114, 1910-1915.

*Xinyu Liu
Discovery of a Calcium-Dependent Enzymatic Cascade for the Selective Assembly of Hapalindole-Type Alkaloids: On the Biosynthetic Origin of Hapalindole U,
Angew. Chem. Int. Ed. 201756, 9062 –9066.

*Gong-Li Tang
Catalysis of Extracellular Deamination by a FAD-Linked Oxidoreductase after Prodrug Maturation in the Biosynthesis of Saframycin A,
Angew. Chem. Int. Ed. 201756, 9116 –9120.

*Toshifumi Inada
Ubiquitination of stalled ribosome triggers ribosome-associated quality control,
Nature Communications 20178

*Ming JiangShuangjun Lin and Meifeng Tao
Formation of an Angular Aromatic Polyketide from a Linear Anthrene Precursor via Oxidative Rearrangement,
Cell Chem. Biol. 201724, 881-891.

*Markus Künzler
Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products,
Nature Chem. Biol. 201713, 833–835.

*Gavin J. Williams
Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering,
ACS Chem. Biol. 201712, 114–123.

*Jason M. Crawford
Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis,
J. Am. Chem. Soc. 2017139, 4195–4201.

*Michael A. Fischbach
Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases,
Cell 2017168, 517–526.

*Craig A. Townsend
Functional and Structural Analysis of Programmed C-Methylation in the Biosynthesis of the Fungal Polyketide Citrinin,
Cell Chem. Biol. 201724, 316-325.

*Makoto Nishiyama
Genome Mining of Amino Group Carrier Protein-Mediated Machinery: Discovery and Biosynthetic Characterization of a Natural Product with Unique Hydrazone Unit,
ACS Chem. Biol. 201712, 124–131.

*Yi Tang
Collaborative Biosynthesis of Maleimide- and Succinimide-Containing Natural Products by Fungal Polyketide Megasynthases,
J. Am. Chem. Soc. 2017139, 5317–5320.


Representative Publications

The Discovery of Fungal Polyene Macrol […]

Post-genomic approach based discovery […]

Use of plant hormones to activate sile […]

Use of a biosynthetic intermediate to […]

Structures of Spiroindicumides A and B […]

Chemically Mediated Epigenetic Manipul […]