2022.10.15-16：第9回食品薬学シンポジウム (富山) (石、佐藤、松井)

2022.10.14：BINDSシンポジウム 北大
合成生物学を基盤とする天然物の構造展開研究で講演 (浅井)

2022.9.9：第64回天然有機化合物討論会 (口頭-古村)

2022.8.26：生合成若手シンポジウム (東京) (口頭-古村)

2022.6.17：第42回糸状菌遺伝子研究会で講演 (浅井)

2022.3.17：日本農芸化学会2022年度京都大会シンポジウムで講演 (浅井)

2022.3.16：日本農芸化学会2022年度京都大会 (本間、廣川)

2022.3.27：第142回日本薬学会年会 (古村、佐藤、倉澤、小此木)

（最下行）

*Bradley S. Moore
Ancient plant-like terpene biosynthesis in corals.
Nat. Chem. Biol. 2022, 18, 664-669

*Tiangang Liu
Efficient exploration of terpenoid biosynthetic gene clusters in filamentous fungi.
Nat.Catal. 2022, 5, 277-287

*Roland Kersten
Discovery and biosynthesis of cyclic plant peptides via outcatalytic cyclase.
Nat. Chem. Biol. 2022, 18, 18–28

*Yizhou Li
Reversible Covalent Headpiece Enables Interconversion between Double- and Single-Stranded DNA-Encoded Chemical Libraries.
Angew. Chem. Int. Ed. 2022, 61, e202115157

*Xudong Qu
A Pair of Atypical KAS III Homologues with Initiation and Elongation Functions Program the Polyketide Biosynthesis in Asukamycin.
Angew Chem Int Ed Engl. 2022, 61(19), e202200879

*J. Phillip Benz
The F-box protein exo-1 is a target for reverce engeneering enzyme hypersecretion in filamentous fungi.
PNAS. 2021, 118, e2025689118

*Jason Micklefield
Discovery, characterization and engineering of ligases for amide synthesis.
Nature. 2021, 593, 391-398

*HANS RENATA
Divergent synthesis of complex diterpenes through a hybrid oxidative approach.
Science 2020, 369, 799–806

*Patrick Riley
Machine Learning on DNA-Encoded Libraries: A New Paradigm for Hit Finding.
J. Med. hem., 2020, 63, 885

*Changsheng Wu
Myxadazoles, Myxobacterium-Derived Isoxazole-Benzimidazole Hybrids with Cardiovascular Activities.
Angew. Chem. 2021, 133, 21847-21852

*Yudai Matsuda
Molecular and Computational Bases for Spirofuranone Formation in Setosusin Biosynthesis.
J. Am. Chem. Soc. 2021, 143, 17708-17715.

*Christian Hertwecka,
Bacterial endosymbionts protect beneficial soil fungus from nematode attack.
PNAS. 2021, 118, 1-8.

*Wenjun Zhang
Mutanofactin promotes adhesion and biofilm formation of cariogenic Streptococcus mutans.
Nat. Chem. Biol. 2021, 17(5), 576–584

*Robin Teufel
Catalytic Control of Spiroketal Formation in Rubromycin Polyketide Biosynthesis.
Angew. Chem. Int. Ed. 2021, 60, 2-13.

*Xiaoyu Li
Selection of DNA-encoded chemical libraries against endogenous membrane proteins on live cells.
Nat. Chem., 2021, 2021, 13, 77

*Yi Tang
Prospecting for natural products by genome mining and microcrystal electron diffraction.
Nat Chem Biol. 2021, 17, 872–877

*Nils J. V. Hansen
Screening of DNA-Encoded Small Molecule Libraries inside a Living Cell.
J. Am. Chem. Soc., 2021, 143, 2751-275

*Jef D. Boeke
Pathway engineering in yeast for synthesizing the complex polyketide bikaverin.
Nat Commun. 2020, 11(1), 6197.

*Patrick M. Shih
Design of orthogonal regulatory systems for modulating gene expression in plants.
Nat Chem Biol. 2020, 16, 857–865

*Yi Tang
A monodomain class II terpene cyclase assembles complex isoprenoid scaffolds.
J. Am. Chem. Soc. 2021, 143, 6043–6047.

*Youcai Hu
Enzymatic Intermolecular Hetero-Diels–Alder Reaction in the Biosynthesis of Tropolonic Sesquiterpenes.
J. Am. Chem. Soc. 2019, 141,14052–14056 .

*Xiaoyu Li
Selection of DNA-Encoded Dynamic Chemical Libraries for Direct Inhibitor Discovery.
Angew. Chem. Int Ed., 2020, 59, 14965-1497

*Jörn Piel
Modification and de novo design of non-ribosomal peptide synthetases using specific assembly points within condensation domains.
Nat. Chem. 2019, 10,653–661 .

*Jörn Piel
A monodomain class II terpene cyclase assembles complex isoprenoid scaffolds.
Nat. Chem. 2020, 12, 968-972.

*Ikuro Abe
One Polyketide Synthase, Two Distinct Products: Trans-Acting Enzyme-Controlled Product Divergence in Calbistrin Biosynthesis.
Angew. Chem. Int. Ed. 2021, 60, 2–10.

*James U. Bowie
A cell-free platform for the prenylation of natural products and application to cannabinoid production.
Nat Commun. 2019, 10(1), 1-9.

*Hiroyasu Onaka
Minimal lactazole scaffold for in vitro thiopeptide bioengineering.
Nat. Commun. 2020, 11, 2272.

*Bradley S. Moore
Discovery and Biosynthesis of Tetrachlorizine Reveals Enzymatic Benzylic Dehydrogenation via an ortho-Quinone Methide.
J. Am. Chem. Soc. 2021, 143, 3682-3686.

*Hui Ming Ge
Redox Modifications in the Biosynthesis of Alchivemycin A Enable the Formation of Its Key Pharmacophore.
J. Am. Chem. Soc. 2021, 143, 4751-4757.

*Yi Tang
A Polyketide Cyclase That Forms Medium-Ring Lactones.
J. Am. Chem. Soc. 2021, 143, 80–84.

*Yi Tang
Iterative Catalysis in the Biosynthesis of Mitochondrial Complex II Inhibitors Harzianopyridone and Atpenin B.
J. Am. Chem. Soc. 2020, 142, 8550−8554.

*Frank C. Schroeder
Diketopiperazine Formation in Fungi Requires Dedicated Cyclization and Thiolation Domains.
Angew. Chem. Int. Ed. 2019, 58, 14589 –14593.

*Kendall N. Houk, Tobias A. M. Gulder
Fungal Dioxygenase AsqJ Is Promiscuous and Bimodal: Substrate-
Directed Formation of Quinolones versus Quinazolinones
Angew. Chem. Int. Ed. 2021, 60, 8297–8302.

*Bian Wu
Recent advances in biocatalysis of nitrogen-containing heterocycles
Biotechnol Adv. 2021, 24, 107813.

*Christian Hertweck
On-Line Polyketide Cyclization into Diverse Medium-Sized Lactones by a Specialized Ketosynthase Domain.
Angew. Chem. Int. Ed. 2018, 57, 11223-11227.

*Sarah O’Connor
Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle.
Science 2018, 360, 1235-1239.

*William M. Wuest
Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase.
J. Am. Chem. Soc. 2018, 140, 1774-1782.

*Seth B. Herzon
Molecular Basis of Gut Microbiome-Associated Colorectal Cancer: A Synthetic Perspective,
J. Am. Chem. Soc. 2017, 139, 14817–14824.

*Mohammad R. Seyedsayamdost
Discovery of scmR as a global regulator of secondary metabolism and virulence in Burkholderia thailandensis E264,
Proc. Natl. Acad. Sci. 2017, 114, 2920 –2928.

*Matthias Brock
A Non-canonical Melanin Biosynthesis Pathway Protects Aspergillus terreus Conidia from Environmental Stress,
Cell Chem. Biol. 2017, 23, 587 –597.

*Dirk Hoffmeister
Induced Chemical Defense of a Mushroom by a Double-Bond-Shifting Polyene Synthase,
Angew. Chem. Int. Ed. 2017, 56, 5937 –5941.

*Mohammad R. Seyedsayamdost
Discovery of a Cryptic Antifungal Compound from Streptomyces albusJ1074 Using High-Throughput Elicitor Screens,
J. Am. Chem. Soc. 2017, 139, 9203−9212.

*Chengshu Wang
Fungal Cordycepin Biosynthesis Is Coupled with the Production of the Safeguard Molecule Pentostatin,
Cell Chem. Biol. 2017, 24, 1–11.

*Paul D. Straight
A Link between Linearmycin Biosynthesis and Extracellular Vesicle Genesis Connects Specialized Metabolism and BacterialMembrane Physiology,
Cell Chem. Biol. 2017, 24, 1238–1249.

*Elizabeth S. Sattely
Biosynthesis of cabbage phytoalexins from indole glucosinolate,
Proc. Natl. Acad. Sci. 2017, 114, 1910-1915.

*Xinyu Liu
Discovery of a Calcium-Dependent Enzymatic Cascade for the Selective Assembly of Hapalindole-Type Alkaloids: On the Biosynthetic Origin of Hapalindole U,
Angew. Chem. Int. Ed. 2017, 56, 9062 –9066.

*Gong-Li Tang
Catalysis of Extracellular Deamination by a FAD-Linked Oxidoreductase after Prodrug Maturation in the Biosynthesis of Saframycin A,
Angew. Chem. Int. Ed. 2017, 56, 9116 –9120.

*Toshifumi Inada
Ubiquitination of stalled ribosome triggers ribosome-associated quality control,
Nature Communications 2017, 8

*Ming Jiang, Shuangjun Lin and Meifeng Tao
Formation of an Angular Aromatic Polyketide from a Linear Anthrene Precursor via Oxidative Rearrangement,
Cell Chem. Biol. 2017, 24, 881-891.

*Markus Künzler
Autocatalytic backbone N-methylation in a family of ribosomal peptide natural products,
Nature Chem. Biol. 2017, 13, 833–835.

*Gavin J. Williams
Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering,
ACS Chem. Biol. 2017, 12, 114–123.

*Jason M. Crawford
Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis,
J. Am. Chem. Soc. 2017, 139, 4195–4201.

*Michael A. Fischbach
Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases,
Cell 2017, 168, 517–526.

*Craig A. Townsend
Functional and Structural Analysis of Programmed C-Methylation in the Biosynthesis of the Fungal Polyketide Citrinin,
Cell Chem. Biol. 2017, 24, 316-325.

*Makoto Nishiyama
Genome Mining of Amino Group Carrier Protein-Mediated Machinery: Discovery and Biosynthetic Characterization of a Natural Product with Unique Hydrazone Unit,
ACS Chem. Biol. 2017, 12, 124–131.

*Yi Tang
Collaborative Biosynthesis of Maleimide- and Succinimide-Containing Natural Products by Fungal Polyketide Megasynthases,
J. Am. Chem. Soc. 2017, 139, 5317–5320.