Publications

Representative publications

学位記伝達式。

本日、卒業式ならびに学位記伝達式が行われました。みなさんおめでとうございます […]

送別会。

M2の小此木くんの送別会を行いました。3年半お疲れ様でした。研究では、なかな […]

卒論発表会。

本日卒論発表会が実施されました。皆、立派な成果発表でした。修士でも引き続き頑 […]

修論発表会。

天井くん、小此木くん、佐藤くんの3名が修論発表しました。2年前の卒論発表はオ […]

菅原さんご栄転。

医薬資源化学分野助教の菅原先生が、北里大学大村智記念研究所の講師として、ご栄 […]

石さん、D論発表

D3の石さんがD論発表しました。ゲノムマイニングに関する研究課題で、面白い化 […]

Research articles

2024

A new 3,6-dialkyl-α-pyrone produced by the heterologous expression of a PKS-NRPS hybrid enzyme derived from a Pestalotiopsis endophyte
Shi, Y., Ozaki, T., Sugawara, A., Morishita, Y., Tang, Y. P., Shivas, R. G., Davis, R. A., Asai, T.*
Tetrahedron Lett. 2024, 134, 154865–154867. doi.org/10.1016/j.tetlet.2023.154865

2023

Identification and Functional Characterization of Fungal Chalcone Synthase and Chalcone Isomerase
Furumura, S., Ozaki, T., Sugawara, A., Morishita, Y., Tsukada, K., Ikuta, T., Inoue, A., Asai, T.* (Furumura and Ozaki contributed equally.)
J. Nat. Prod. 2023, 86, 398-405. doi.org/10.1021/acs.jnatprod.2c01027

2022

Discovery of a Cyclic Depsipeptide from Chaetomium mollipilium by the Genome Mining Approach
Homma, Y., Sugawara, A., Morishita, Y., Tsukada, K., Ozaki, T., Asai, T.*
Org. Lett. 2022, 24, 3504–3509. doi.org/10.1021/acs.orglett.2c01172

 

Synthetic Biology-Based Discovery of Diterpenoid Pyrones from the Genome of Eupenicillium shearii
Morishita, Y., Tsukada, K., Murakami. K., Irie, K., Asai, T.* (Morishita and Tsukada contributed equally.)
J. Nat. Prod. 2022, 85, 384-390. doi.org/10.1021/acs.jnatprod.1c00973

 

2020

Genome Mining-Based Discovery of Fungal Macrolides Modified by Glycosylphosphatidylinositol (GPI)-Ethanolamine Phosphate Transferase Homologues
Morishita, Y., Aoki, Y., Ito, M., Hagiwara, D., Torimaru, K., Morita, D., Kuroda, T., Fukano, H., Hoshino, Y., Suzuki, M., Taniguchi, T., Mori, Keiji., Asai, T.*
Org. Lett. 2020 22, 5876-5879.  doi.org/10.1021/acs.orglett.0c01975

 

Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones
Tsukada, K., Shinki, S., Kaneko, A., Murakami, K., Irie, K., Murai, M., Miyoshi, H., Dan, S., Kawaji, K., Hayashi, H., Kodama, E. N., Hori, A., Salim, E., Kuraishi, T., Hirata, N., Kanda, Y., Asai, T.*
Nature Commun. 11, Article number: 1830 (2020), doi: 10.1038/s41467-020-15664-4.

 

Synthetic-biology-based discovery of fungal macrolide from Macrophomina phaseolina
Morishita, Y., Sonohara, T., Taniguchi, T., Adachi, K., Fujita, M., Asai, T.*
Org. Biomol. Chem. 2020, 18, doi: 10.1039/D0OB00519C

 

Chemical Activation of Natural Product Biosynthesis in Filamentous Fungi
Teigo Asai
Comprehensive Natural Products III: Chemistry and Biology, Vol. 7, Elsevier, 475-486 (2020).

2019

The Discovery of Fungal Polyene Macrolides via a Postgenomic Approach Reveals a Polyketide Macrocyclization by trans-Acting Thioesterase in Fungi
Yohei Morishita, Huiping Zhang, Tohru Taniguchi, Keiji Mori, Teigo Asai*
Org. Lett. 2019, 21, 4788−4792.

 

Post-genomic approach based discovery of alkylresorcinols from a cricket-associated fungus, Penicillium soppi
Akiho Kaneko, Yohei Morishita, Kento Tsukada, Tohru Taniguchi, Teigo Asai*
Org. Biomol. Chem. 2019, 17, 5239 – 5243.

 

Use of plant hormones to activate silent polyketide biosynthetic pathways in Arthrinium sacchari, a fungus isolated from a spider
Y. Morishita, Y. Okazaki, Y. Y. Luo., J. Nunoki, T. Taniguchi, Y. Oshima, T Asai*
Org. Biomol. Chem. 2019, 17, 780-784.

2018

Pazopanib-induced crystal deposition in intestinal mucosa in a patient with retroperitoneal liposarcoma.
Shigemitsu Horie, Hayato Nishida*, Toshihiko Sakurai, Osamu Ichiyanagi, Tomoyuki Kato, Makoto Yagi, Takanobu Kabasawa, Teigo Asai and Norihiko Tsuchiya.
International Journal of Urology 2018, doi: 10.1111/iju.13567.

2016

A lanthipeptide-like N-terminal leader region guides peptide epimerization by radical SAM epimerases – implications for RiPP evolution.
S. W. Fuchs, G. Lackner, B. I. Morinaka, Y. Morishita, T. Asai, S. Riniker, J. Piel*.
Angew. Chem. Int. Ed.
2016, 55, 12330-12333
.

Epigenetic stimulation of polyketide production in Chaetomium cancroideum by an NAD+-dependent HDAC inhibitor.
T. Asai*, S. Morita, T. Taniguchi, K. Monde, Y. Oshima*.
Org. Biomol. Chem. 2016, 14, 646-651.

2015

Use of a biosynthetic intermediate to explore the chemical diversity of pseudo-natural fungal polyketides.
T. Asai*, K. Tsukada, S. Ise, N. Shirata, M. Hashimoto, I. Fujii, K. Gomi, K. Nakagawara, E. N. Kodama, Y, Oshima*.
Nature Chem. 2015, 7, 737-743.

 

2013

Structures of Spiroindicumides A and B, Unprecedented Carbon Skeletal Spirolactones, and Determination of the Absolute Configuration by Vibrational Circular Dichroism Exciton Approach.
T. Asai*, T. Taniguchi, T, Yamamoto, K. Monde, Y. Oshima*.
Org. Lett. 2013, 15, 4320–4323.

Suberoylanilide Hydroxamic Acid, a Histone Deacetylase Inhibitor, Induces the Production of Anti-inflammatory Cyclodepsipeptides from Beauveria felina. Y. M. Chung, M. E. Shazly, D. W. Chuang, T. L. Hwang, T. Asai, Y. Oshima, M. L. Ashour, Y. C. Wu, F. R. Chang*.
J. Nat. Prod. 2013, 76, 1260–1266.

Structurally Diverse Chaetophenol Productions Induced by Chemically Mediated Epigenetic Manipulation of Fungal Gene Expression.
T. Asai*, T. Yamamoto, N. Shirata, T. Taniguchi, K. Monde, I. Fujii, K. Gomi, Y. Oshima*.
Org. Lett. 2013, 15, 3346-3349.

An epigenetic modifier enhances the production of anti-diabetic and anti-inflammatory sesquiterpenoids from Aspergillus sydowii.
Y. M. Chung, C. K. Wei, D. W. Chuang, M. E. Shazly, C. T. Hsieh, T. Asai, Y. Oshima, T. J. Hsieh, T. L. Hwang, Y. C. Wu, F. R. Chang*.
Bioorg. Med. Chem. 2013, 21, 3866-3872.

Benzophenones from an Endophytic Fungus, Graphiopsis chlorocephala, from Paeonia lactiflora Cultivated in the Presence of an NAD+-Dependent HDAC Inhibitor.
T. Asai*, S. Otsuki, H. Sakurai, K. Yamashita, T. Ozeki, Y. Oshima*.
Org. Lett. 2013, 15, 2058-2061.

Structures and absolute configurations of short-branched fatty acid dimers from an endophytic fungus of Aloe arborescens.
T. Asai*, S. Otsuki, T. Taniguchi, K. Monde, K. Yamashita, H. Sakurai, T. Ozekid, Y. Oshima*.
Tetrahedron Lett. 2013, 54, 3402-3405.

Structures and Biomimetic Synthesis of Novel a-Pyrone Polyketides of an Endophytic Penicillium sp. in Catharanthus roseus.
T. Asai*, D. Luo, K. Yamashita, Y. Oshima*.
Org. Lett. 2013, 15, 1020-1023.

2012

Structural Diversity of New C13-Polyketides Produced by Chaetomium mollipilium Cultivated in the Presence of a NAD+-Dependent Histone Deacetylase Inhibitor
T. Asai*, S. Morita, N. Shirata, T. Taniguchi, K. Monde, H. Sakurai, T. Ozeki, Y. Oshima*.
Org. Lett. 2012, 14, 5456-5459.

Cyclic glycolipids from glandular trichome exudates of Cerastium glomeratum.
T. Asai, Y. Nakamura, Y. Hirayama, K. Ohyama, Y. Fujimoto*.
Phytochemistry 2012, 82, 149-157.

Highly oxidized ergosterols and isariotin analogs from an entomopathogenic fungus, Gibellula formosana, cultivated in the presence of epigenetic modifying agents.
T. Asai*, Y. M. Chung, H. Sakurai, T. Ozeki, F. R. Chang, Y. C. Wu, K. Yamashita, Y. Oshima*.
Tetrahedron 2012, 68, 5817-5823.

Epi-a-bisabolol 6-deoxy-b-D-gulopyranoside from the glandular trichome exudate of Brillantaisia owariensis.
T. Asai, Y. Hirayama, Y. Fujimoto*.
Phytochemistry Lett. 2012, 5, 376-378.

Aromatic Polyketide Production in Cordyceps indigotica, an Entomopathogenic Fungus, Induced by Exposure to a Histone Deacetylase Inhibitor.
T. Asai*, T. Yamamoto, Y. Oshima*.
Org. Lett. 2012, 14, 2006-2009.

Dihydrobenzofurans as cannabinoid receptor ligands from Cordyceps annullata, an entomopathogenic fungus cultivated in the presence of an HDAC inhibitor.
T. Asai*, D. Luo, Y. Obara, T. Taniguchi, K. Monde, K. Yamashita, Y. Oshima*.
Tetrahedron Lett. 2012, 53, 2239-2243.

Tenuipyrone, a Novel Skeletal Polyketide from the Entomopathogenic Fungus, Isaria tenuipes, Cultivated in the Presence of Epigenetic Modifiers.
T. Asai*, Y. M. Chung, H. Sakurai, T. Ozeki, F. R.Chang, K. Yamashita, Y, Oshima*.
Org. Lett. 2012, 14, 513-515.

Aromatic polyketide glycosides from an entomopathogenic fungus, Cordyceps indigotica.
T. Asai*, T. Yamamoto, Y. M. Chung, F. R. Chang, Y. C. Wu, K. Yamashita, Y. Oshima*.
Tetrahedron Lett. 2012, 53, 277-280.

2011

Histone deacetylase inhibitor induced the production of three novel prenylated tryptophan analogs in the entomopathogenic fungus, Torrubiella luteorostrata.
T. Asai*, T. Yamamoto, Y. Oshima*.
Tetrahedron Lett. 2011, 52, 7042-7045.

2-Acety-1-(3-glycosyloxyoctadecanoyl)glycerol and dammarane triterpenes in the exudates from secretary organs on the stipules and leaves of Cerasus yedoensis,
T. Asai, Y. Fujimoto*.
Phytochemistry Lett. 2011, 15, 38-42.

n-Octyl a-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside derivatives from the glandular trichome exudate of Geranium carolinianum,
T. Asai, T. Sakai, K. Ohyama, Y. Fujimoto*.
Chem. Pharm. Bull. 2011, 59, 747-752.

~2010

Cyclic fatty acyl glycosides in the glandular trichome exudate of Silene gallica.
T. Asai, Y. Fujimoto*.
Phytochemistry, 2010, 71, 1410-1417.

Fatty acid derivatives and dammarane triterpenes from the glandular trichome exduates of Ibicella lutea and Proboscidea louisiana.
T. Asai, N. Hara, Y. Fujimoto*
Phytochemistry, 2010, 71, 877-894.

Artabotryols A-E, new lanostane triterpenes from the seeds of Artabotrys odoratissimus
C. Gupta, S. Prasad, M. Sahai, T. Asai, N. Hara, Y. Fujimoto.
Helv. Chim. Acta, 2010, 93, 1925-1932.

Acylglycerols (=glycerides) from the glandular trichome exudate on the leaves of Paulownia tomentosa.
T. Asai, N. Hara, S. Kobayashi, S. Kohshima, Y. Fujimoto*.
Helv. Chim. Acta, 2009, 92, 1473-1492.

Geranylated flavanones from the secretion on the surface of the immature fruits of Paulownia tomentosa.
T. Asai, N. Hara, S. Kobayashi, S. Kohshima, Y. Fujimoto*.
Phytochemistry. 2008, 69, 1234-1241.

Radermachol and naphthoquinone derivatives from Tecomella undulata: complete 1H and 13C NMR assignments of radermachol with the aid of computational 13C shift prediction.
P. Singh, P. Khandelwal, N. Hara, T. Asai, Y. Fujimoto*.
Ind. J. Chem. Sec B, 2008, 47B, 1865-1870.

Anti-herbivore structures of Paulownia tomentosa: morphology, distribution, chemical constituents, and changes during shoot and leaf development.
S. Kobayashi, T. Asai, Y. Fujimoto, S. Kohshima*.
Ann. Botany, 2008, 101, 1035-1047.

Further studies on the constituents of the gorgonian octocoral Pseudopterogorgia elisabethae collected in San Andres and Providencia islands, Colombian Caribbean: isolation of a putative biosynthetic intermediate leading to erogorgiaene.
C. Duque, M. Puyana, L. Castellanos, A. 5. Arias, H. Correa, O. Osorno, T. Asai, N. Hara, Y. Fujimoto*.
Tetrahedron, 2006, 62, 4205-4213.

Hyosmin, a new lignan from Hyocyamus niger L.
A. S. Begum, S. Verma, M. Sahai, T. Asai, N. Hara, Y Fujimoto*.
J. Chem. Res., 2006, 675-677.

Apollineanin: a new flavanone from Tephrosia apollinea.
A. Hisham, S. John, W. Shuaily, T. Asai, Y. Fujimoto.
Nat. Prod. Res., 2006, 20, 1046-1052.

A new kaempferol diglycoside from Datura suaveolens Humb. & Bonpl. ex. Willd.
A. S. Begum, M. Sahai, Y. Fujimoto, T. Asai, K. Schneider, G. Nicholson, R. Suessmuth*.
Nat. Prod. Res., 20, 2006, 1231-1236.

Hyosgerin, a new optically active coumarinolignan, from the seeds of Hyosymus niger.
S. Begum, M. Sahai, R. Suessmuth, T. Asai, N. Hara, Y. Fujimoto*.
Chem. Pharm. Bull., 2006, 54, 538-541.

Books & Reviews

 

•糸状菌の遺伝子情報を活用する天然物ケミカルスペースの開拓
浅井禎吾.
月間ファインケミカル 特集 ポストゲノム時代の天然物化学ーゲノム情報に基づいた天然物の探索と合成ー Vol 50, No. 4 (2021)

•微生物に「天然にはない天然物」をつくらせる
現代化学 FLASH 2020年 8月号

•Chemical Activation of Natural Product Biosynthesis in Filamentous Fungi
Teigo Asai
Comprehensive Natural Products III: Chemistry and Biology, Vol. 7, Elsevier, 475-486 (2020).

•単離•構造決定に立脚する天然物化学研究
浅井禎吾.
有機合成化学協会誌, 天然物化学特集号, 2018, 76 406-409.

•エピジェネティック制御を利用する新規医薬資源の開拓
浅井禎吾,大島吉輝.
生化学 「みにれびゅー」, 2016, 88, 643-648.

•微生物の可能性を開拓する−多様な新奇化合物合成のための新しいアプローチ−
浅井禎吾,大島吉輝.
現代化学 「解説」, 2016, 9, 21-26.

•ケミカルエピジェネティクスによる未利用生合成遺伝子の活用と多様な天然物の創出.
浅井禎吾,大島吉輝.
ファルマシア「最前線」2014, 50, 112-116.

•糸状菌二次代謝のエピジェネティック制御と天然物探索.
浅井禎吾, 大島吉輝.
化学と生物, 2013, 1, 13-21.