MB&M 代謝制御薬学分野 東北大学大学院薬学研究科 生命薬学専攻

主な研究業績


Original paper

* Corresponding author

2020:

Takeshi Niki, Jinro Endo, Kazuko Takahashi-Niki, Tatsuki Yasuda, Asami Okamoto, Yoshiro Saito, Hiroyoshi Ariga, Sanae M.M. Iguchi-Ariga (2020) DJ-1-binding compound B enhances Nrf2 activity through the PI3-kinase-Akt pathway by DJ-1-dependent inactivation of PTEN. Brain Research, 1729, 146641

2019:

Nobuhiro Kikuchi, Kimio Satoh, Taijyu Satoh, Nobuhiro Yaoita, Mohammad Abdul Hai Siddique, Junichi Omura, Ryo Kurosawa, Masamichi Nogi, Shinichiro Sunamura, Satoshi Miyata, Hirofumi Misu, Yoshiro Saito, Hiroaki Shimokawa (2019) Diagnostic and Prognostic Significance of Serum Levels of Selenoprotein P in Patients with Pulmonary Hypertension. Arteriosclerosis, Thrombosis, and Vascular Biology, 39, 2553-2562

Mayuka Kobayashi, Kana Muramatsu, Takamitsu Haruyama, Haruka Uesugi, Ai Kikuchi, Hiroki Konno, Noriko Noguchi, and Yoshiro Saito* (2019) Polymerization of oxidized DJ-1 via noncovalent and covalent binding: Significance of disulfide bond formation. ACS Omega, 4, 9603-14

Nobuhiro Kikuchi, Kimio Satoh, Yoshiro Saito, Hiroaki Shimokawa (2019) Response by Kikuchi et al Regarding Article, “Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension: A Possible Novel Therapeutic Target” Circulation, 139, 724-725

Kensuke Mohri, Hirofumi Misu, Hiroaki Takayama, Kiyo-aki Ishii, Akihiro Kikuchi, Fei Lan, Yasufumi Enyama, Yumie Takeshita, Yoshiro Saito, Shuichi Kaneko, and Toshinari Takamura (2019) Circulating concentrations of insulin resistance-associated hepatokines, selenoprotein P and leukocyte cell-derived chemotaxin 2, during an oral glucose tolerance test in humans. Biological and Pharmaceutical Bulletin, 42, 373-378

2018:

Swe Mar Oo, Hirofumi Misu, Yoshiro Saito, Mutsumi Tanaka, Seiji Kato, Yuki Kita, Hiroaki Takayama, Yumie Takeshita, Takehiro Kanamori, Toru Nagano, Masatoshi Nakagen, Takeshi Urabe, Naoto Matsuyama, Shuichi Kaneko, and Toshinari Takamura (2018) Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population. Scientific Reports, 8, 16727

Yuichiro Mita, Yuto Kataoka, Yoshiro Saito,* Takuma Kashi, Kojiro Hayashi, Asa Iwasaki, Takanori Imanishi, Tomohiro Miyasaka, and Noriko Noguchi (2018) Distribution of oxidized DJ-1 in Parkinson’s disease-related sites in the brain and in the peripheral tissues: effects of aging and a neurotoxin. Scientific Reports, 8, 12056

Yuki Kimura, Minori Asa, Yasuomi Urano, Yoshiro Saito, Kiyotaka Nishikawa, and Noriko Noguchi (2018) Tocopherol suppresses 24(S)-hydroxycholesterol-induced cell death via inhibition of CaMKII phosphorylation. Biochimie, 153, 203-209

Nobuhiro Kikuchi, Kimio Satoh, Ryo Kurosawa, Nobuhiro Yaoita, Md. Elias Al-Mamun, Mohammad Abdul Hai Siddique, Junichi Omura, Taijyu Satoh, Masamichi Nogi, Shinichiro Sunamura, Satoshi Miyata, Yoshiro Saito, Yasushi Hoshikawa, Yoshinori Okada, and Hiroaki Shimokawa (2018) Selenoprotein P Promotes the Development of Pulmonary Arterial Hypertension –A Possible Novel Therapeutic Target. Circulation, 138, 600-623

Dae-Hee Lee, Daeho Kim, Sung Tae Kim, Soyeon Jeong, Jung Lim Kim, Sang Mi Shim, Ah Jung Heo, Xinxin Song, Zong Sheng Guo, David L. Bartlett, Sang Cheul Oh, Junho Lee, Yoshiro Saito, Bo Yeon Kim, Yong Tae Kwon, and Yong J. Lee (2018) PARK7 modulates autophagic proteolysis through binding to the N-terminally arginylated form of the molecular chaperone HSPA5. Autophagy, 14, 1870-1885

Yasuomi Urano, Chinatsu Mori, Ayano Fuji, Keito Konno, Takayuki Yamamoto, Shohei Yashirogi, Mayu Ando, Yoshiro Saito, and Noriko Noguchi (2018) 6-Hydroxydopamine induces secretion of PARK7/DJ-1 via autophagy-based unconventional secretory pathway. Autophagy, 14, 1943-1958

Asami Muraishi, Emi Haneta, Yoshiro Saito,* Yutaka Hitomi, Mamoru Sano, and Noriko Noguchi (2018) Hydrogen peroxide-reducing factor released by PC12D cells increases cell tolerance against oxidative stress. Biological and Pharmaceutical Bulletin, 41, 777-785

Yoshiro Saito,* Hirofumi Misu, Hiroaki Takayama, Shin-ichiro Takashima, Soichiro Usui, Masayuki Takamura, Shuichi Kaneko, Toshinari Takamura, and Noriko Noguchi (2018) Comparison of human selenoprotein P determinants in serum between our original methods and commercially available kits. Biological and Pharmaceutical Bulletin, Note, 41, 828-832

Yuko Yamagishi, Kazumasa Saigoh, Yoshiro Saito, Ikuko Ogawa, Yoshiyuki Mitsui, Yoshiyuki Hamada, Makoto Samukawa, Hidekazu Suzuki, Motoi Kuwahara, Makito Hirano, Noriko Noguchi, Susumu Kusunoki (2018) Diagnosis of Parkinson's disease and the level of oxidized DJ-1 protein. Neuroscience Research, 128, 58-62

2017:

Kentaro Shimasaki, Miho Watanabe-Takahashi, Masato Umeda, Satoru Funamoto, Yoshiro Saito, Noriko Noguchi, Keigo Kumagai, Kentaro Hanada, Fujiko Tsukahara, Yoshiro Maru, Norihito Shibata, Mikihiko Naito, and Kiyotaka Nishikawa (2017) The pleckstrin homology domain of p210 BCR-ABL interacts with cardiolipin to regulate its mitochondrial translocation and subsequent mitophagy. Gene to Cells, 23, 22-34 DOI: 10.1111/gtc.12544

Yuichiro Mita, Kaho Nakayama, Shogo Inari, Yukina Nishito, Yuya Yoshioka, Naoko Sakai, Kanade Sotani, Takahiro Nagamura, Yuki Kuzuhara, Kumi Inagaki, Miki Iwasaki, Hirofumi Misu, Masaya Ikegawa, Toshinari Takamura, Noriko Noguchi, and Yoshiro Saito* (2017) Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models. Nature Communications, 8, 1658 doi: 10.1038/s41467-017-01863-z

Natsumi Tajima-Shirasaki, Kiyo-aki Ishii, Hiroaki Takayama, Takayoshi Shirasaki, Hisakazu Iwama, Keita Chikamoto, Yoshiro Saito, Yasumasa Iwasaki, Atsushi Teraguchi, Fei Lan, Akihiro Kikuchi, Yumie Takeshita, Koji Murao, Seiichi Matsugo, Shuichi Kaneko, Hirofumi Misu, and Toshinari Takamura (2017) Eicosapentaenoic Acid Downregulates Expression of the Selenoprotein P Gene by Inhibiting Sterol regulatory element-binding protein-1c Independently of the AMP-activated protein kinase Pathway in H4IIEC3 Hepatocytes. Journal of Biological Chemistry, 292, 10791-800 doi: 10.1074/jbc.M116.747006

Hirofumi Misu, Hiroaki Takayama,Yoshiro Saito, Yuichiro Mita, Akihiro Kikuchi, Kiyo-aki Ishii, Keita Chikamoto, Takehiro Kanamori, Natsumi Tajima, Fei LanLan, Yumie Takeshita, Masao Honda, Mutsumi Tanaka, Seiji Kato, Naoto Matsuyama, Yuya Yoshioka, Kaito Iwayama, Kumpei Tokuyama, Nobuhiko Akazawa, Seiji Maeda, Kazuhiro Takekoshi, Seiichi Matsugo, Noriko Noguchi, Shuichi Kaneko, and Toshinari Takamura (2017) Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of ROS and AMPK in muscle. Nature Medicine, 23, 508-516 doi: 10.1038/nm.4295

Bharatwaj Sowrirajan*, Yoshiro Saito* (contributed equally), Deepak Poudyal*, Qian Chen, Hongyan Sui, Suk See DeRavin, Hiromi Imamichi, Toyotaka Sato, Douglas B. Kuhns, Noriko Noguchi, Harry L. Malech, H. Clifford Lane and Tomozumi Imamichi (2017) Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47phox. Scientific Reports, 7, 43441 doi:10.1038/srep43441.

Takaya Nakazawa, Yuta Miyanoki, Yasuomi Urano, Madoka Uehara, Yoshiro Saito, and Noriko Noguchi (2017) Effects of vitamin E on 24(S)-hydroxycholesterol-induced apoptosis and necroptosis. Journal of Steroid Biochemistry and Molecular Biology, 169, 69-76.

2016:

Yoshiro Saito*, and Noriko Noguchi (2016) Oxidized Lipoprotein as a Major Vessel Cell Proliferator in Oxidized Human Serum. PLoS ONE, 11, e0160530 doi: 10.1371/journal.pone.0160530.

Yoshiro Saito*, Yoko Akazawa-Ogawa, Akihiro Matsumura, Kazumasa Saigoh, Sayoko Itoh, Kenta Sutou, Mayuka Kobayashi, Yuichiro Mita, Mototada Shichiri, Shin Hisahara, Yasuo Hara, Harutoshi Fujimura, Hiroyuki Takamatsu, Yoshihisa Hagihara, Yasukazu Yoshida, Takao Hamakubo, Susumu Kusunoki, Shun Shimohama, and Noriko Noguchi (2016) Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson’s disease patients. Scientific Reports, 6, 30793 doi: 10.1038/srep30793.

Mutsumi Tanaka, Yoshiro Saito, Hirofumi Misu, Seiji Kato, Yuki Kita, Yumie Takeshita, Takehiro Kanamori, Toru Nagano, Masatoshi Nakagen, Takeshi Urabe, Toshinari Takamura, Shuichi Kaneko, Kazuhiko Takahashi, and Naoto Matsuyama (2016) Development of a sol particle homogeneous immunoassay for measuring full-length selenoprotein P in human serum. Journal of Clinical Laboratory Analysis, 30, 114-122.

2015:

Shioji Ishiwatari, Minako Takahashi, Chie Yasuda, Maho Nakagawa, Tatsuya Kon, Yoshiro Saito, Noriko Noguchi, and Shoko Matsukuma (2015) The protective role of DJ-1 in ultraviolet-induced damage of human skin: DJ-1 levels in the stratum corneum as an indicator of antioxidative defense. Archives of Dermatological Research, 307, 925-935.

Yoshiro Saito*, Mototada Shichiri, Takashi Hamajima, Noriko Ishida, Yuichiro Mita, Shohei Nakao, Yoshihisa Hagihara, Yasukazu Yoshida, Kazuhiko Takahashi, Etsuo Niki, and Noriko Noguchi (2015) Enhancement of lipid peroxidation and its amelioration by vitamin E in a subject with mutations in the SBP2 gene. Journal of Lipid Research, 56, 2172-2182.

Diep-Khanh Ho Vo, Yasuomi Urano, Wakako Takabe, Yoshiro Saito, and Noriko Noguchi (2015) 24(S)-Hydroxycholesterol induces RIPK1-dependent but MLKL-independent cell death in the absence of caspase-8. Steloids, 99, 230-237.

2014:

Kazuhide Ishikura, Hirofumi Misu, Masafumi Kumazaki, Hiroaki Takayama, Naoto Matsuzawa-Nagata, Natsumi Tajima, Keita Chikamoto, Fei Lan, Hitoshi Ando, Tsuguhito Ota, Masaru Sakurai, Yumie Takeshita, Kenichiro Kato, Akio Fujimura, Ken-ichi Miyamoto, Yoshiro Saito, Satomi Kameo, Yasuo Okamoto, Yoh Takuwa, Kazuhiko Takahashi, Hiroyasu Kidoya, Nobuyuki Takakura, Shuichi Kaneko, and Toshinari Takamura (2014) Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells. Diabetologia, 57, 1968-1976.

Yoshiro Saito*, Tomohiro Miyasaka, Hiroyuki Hatsuta, Kazuko Takahashi-Niki, Kojiro Hayashi, Yuichiro Mita, Osamu Kusano-Arai, Hiroko Iwanari, Hiroyoshi Ariga, Takao Hamakubo, Yasukazu Yoshida, Etsuo Niki, Shigeo Murayama, Yasuo Ihara, and Noriko Noguchi (2014) Immunostaining of oxidized DJ-1 in human and mouse brain. Journal of Neuropathology and Experimental Neurology, 73, 714-728.

Ikuko Ogawa, Yoshiro Saito, Kazumasa Saigoh, Yoshie Hosoi, Yoshiyuki Mitsui, Noriko Noguchi, and Susumu Kusunoki (2014) The significance of oxidized DJ-1 protein (oxDJ-1) as a biomarker for Parkinson’s disease. Brain and Nerve, 66, 471-477.

Fei Lan, Hirofumi Misu, Keita Chikamoto, Hiroaki Takayama, Akihiro Kikuchi, Kensuke Mohri, Noboru Takata, Hiroto Hayashi, Naoto Matsuzawa-Nagata, Yumie Takeshita, Hiroyo Noda, Yukako Matsumoto, Tsuguhito Ota, Toru Nagano, Masatoshi Nakagen, Ken-ichi Miyamoto, Kanako Takatsuki, Toru Seo, Kaito Iwayama, Kunpei Tokuyama, Seiichi Matsugo, Hong Tang, Yoshiro Saito, Satoshi Yamagoe, Shuichi Kaneko, and Toshinari Takamura (2014) LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance. Diabetes, 63, 1649-64.

Kazunori Yamanaka, Yasuomi Urano, Wakako Takabe, Yoshiro Saito, and Noriko Noguchi (2014) Induction of apoptosis and necroptosis by 24(S)-hydroxycholesterol is dependent on activity of acyl-CoA:cholesterol acyltransferase 1. Cell Death and Disease, 5, e990.

Hiroaki Takayama, Hirofumi Misu, Hisakazu Iwama, Keita Chikamoto, Yoshiro Saito, Koji Murao, Atsushi Teraguchi, Fei Lan, Akihiro Kikuchi, Reina Saito, Natsumi Tajima, Takayoshi Shirasaki, Seiichi Matsugo, Ken-ichi Miyamoto, Shuichi Kaneko, and Toshinari Takamura (2014) Metformin Suppresses Expression of the Selenoprotein P gene via an AMPK-FoxO3a Pathway in H4IIEC3 Hepatocytes. Journal of Biological Chemistry, 289, 335-45.

Akishi Okabe, Yasuomi Urano, Sayoko Itoh, Naoto Suda, Rina Kotani, Yuki Nishimura, Yoshiro Saito, and Noriko Noguchi (2014) Adaptive responses induced by 24S-hydroxycholesterol through liver X receptor pathway reduce 7-ketocholesterol-caused neuronal cell death. Redox Biology, 2, 28-35.

2013:

Basilua Andre Muzembo, Narongpon Dumavibhat, N’landu Roger Ngatu, Masamitsu Eitoku, Ryoji Hirota, Shinichi Kondo, Yoji Deguchi, Yoshiro Saito, Kazuhiko Takahashi, and Narufumi Suganuma (2013) Serum selenium and selenoprotein P in patients with silicosis. Journal of Trace Elements in Medicine and Biology, 27, 40-44.

2012:

Izumi Kato, Hiroshi Maita, Kazuko Takahashi-Niki, Yoshiro Saito, Noriko Noguchi, Sanae M.M. Iguchi-Ariga, and Hiroyoshi Ariga (2012) Oxidized DJ-1 inhibits p53 by sequestering p53 from promoters in a DNA-binding affinity-dependent manner. Molecular and Cellular Biology, 33, 340-359.

Hirotaka Sawada, Yoshiro Saito, and Noriko Noguchi (2012) Enhanced CD36 expression changes the role of Nrf2 activation from anti-atherogenic to pro-atherogenic in apoE-deficient mice. Atherosclerosis, 225, 83-90.

Kazunori Yamanaka, Yoshiro Saito, Junji Sakiyama, Yuya Ohuchi, Fumio Oseto, and Noriko Noguchi (2012) A novel fluorescent probe with high sensitivity and selective detection of lipid hydroperoxides in cells. RSC Advances, 2, 7894-7900.

Hirofumi Misu, Kazuhide Ishikura, Seiichiro Kurita, Yumie Takeshita, Tsuguhito Ota, Yoshiro Saito, Kazuhiko Takahashi, Shuichi Kaneko, and Toshinari Takamura (2012) Inverse Correlation between Serum Levels of Selenoprotein P and Adiponectin in Patients with Type 2 Diabetes. PLoS ONE, 7, e34952.

Takashi Hamajima, Yuichi Mushimoto, Hironori Kobayashi, Yoshiro Saito, and Kazumichi Onigata (2012) Novel compound heterozygous mutations in the SBP2 gene: characteristic clinical manifestations and the implications of GH and triiodothyronine in longitudinal bone growth and maturation. European Journal of Endocrinology, 166, 757-764.

Lai Teng Ling, Yoshiro Saito*, Uma Devi Palanisamy, Hwee Ming Cheng, and Noriko Noguchi (2012) Cytoprotective effects of geraniin against peroxynitrite- and peroxyl radical-induced cell death via free radical scavenging activity. Food Chemistry, 132, 1899-1907.

2011:

Akiko Miyama, Yoshiro Saito*, Kazunori Yamanaka, Kojiro Hayashi, Takao Hamakubo, and Noriko Noguchi (2011) Oxidation of DJ-1 induced by 6-hydroxydopamine decreasing intracellular glutathione. PLoS ONE, 6, e27883.

Kazunori Yamanaka, Yoshiro Saito*, Tohru Yamamori, Yasuomi Urano, and Noriko Noguchi (2011) 24(S)-Hydroxycholesterol induces neuronal cell death through necroptosis, a form of programmed necrosis. Journal of Biological Chemistry, 286, 24666-24673.

Keiko Nishio, Noriko Ishida, Yoshiro Saito, Yoko Ogawa-Akazawa, Mototada Shichiri, Yasukazu Yoshida, Yoshihisa Hagihara, Noriko Noguchi, John Chirico, Jeffrey Atkinson, and Etsuo Niki (2011) -Tocopheryl Phosphate: Uptake, Hydrolysis, and Antioxidant Action in Cultured Cells and Mouse. Free Radical Biology and Medicine, 50, 1794-800.

Akira Kobayashi, Takako Tsukide, Tomohiro Miyasaka, Tomoko Morita, Tatsuya Mizoroki, Yoshiro Saito, Yasuo Ihara, Akihiko Takashima, Noriko Noguchi, Akiyoshi Fukamizu, Yousuke Hirotsu, Makiko Ohtsuji, Fumiki Katsuoka, and Masayuki Yamamoto (2011) Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction. Gene to Cells, 16, 692-703.

Kohzoh Yoshino, Yoshiro Saito, Mamiko Jitousyo, and Yasukazu Yoshida (2011) Correlation between saliva cortisol concentration and sympathovagal balance before sleep in young male subjects. Stress Science Research, 26, 48-52.

Oscar Gonzalez-Moreno, Noemi Boque, Fermin Milagro, Javier Campion, Tobias Endermann, Kazuhiko Takahashi, Yoshiro Saito, Lutz Schomburg, and Alfonso Calvo (2011) Selenoprotein-P is down-regulated in prostate cancer, which results in lack of protection against oxidative damage. The Prostate, 71, 824-834.

2010:

Tohru Yamamori, Ayano Mizobata, Yoshiro Saito, Yasuomi Urano, Irani Kaikobad, and Noriko Noguchi (2010) Phosphorylation of p66shc mediates 6-hydroxydopamine cytotoxicity. Free Radical Research, 45, 342-350.

Yasukazu Yoshida, Nanako Itoh, Mieko Hayakawa, Yoko Habuchi, Yoshiro Saito, Yoshitane Tsukamoto, Osamu Cynshi, Kou-ichi Jishage, Hiroyuki Arai, and Etsuo Niki (2010) The role of alpha-tocopherol in hypofunction of activity with aging in alpha-tocopherol transfer protein knockout mice as assessed by oxidative stress biomarkers. Journal of Nutritional Biochemistry, 21, 66-76

Hirofumi Misu, Toshinari Takamura, Hiroaki Takayama, Hiroto Hayashi, Naoto Matsuzawa-Nagata, Seiichiro Kurita, Kazuhide Ishikura, Hitoshi Ando, Yumie Takeshita, Tsuguhito Ota, Masaru Sakurai, Tatsuya Yamashita, Eishiro Mizukoshi, Taro Yamashita, Masao Honda, Ken-ichi Miyamoto, Tetsuya Kubota, Naoto Kubota, Takashi Kadowaki, Han-Jong Kim, In-kyu Lee, Yasuhiko Minokoshi, Yoshiro Saito, Kazuhiko Takahashi, Yoshihiro Yamada, Nobuyuki Takakura, and Shuichi Kaneko (2010) A Liver-Derived Secretory Protein, Selenoprotein P, Causes Insulin Resistance. Cell Metabolism, 12, 483-495.

Yoshiro Saito*, Keiko Nishio, Yoko Ogawa Akazawa, Kazunori Yamanaka, Akiko Miyama, Yasukazu Yoshida, Noriko Noguchi, and Etsuo Niki (2010) Cytoprotective effect of vitamin E homologues against glutamate-induced cell death in immature primary cortical neuron cultures: Tocopherols and tocotrienols exert similar effects by antioxidant function. Free Radical Biology and Medicine, 49, 1542-1549.

Yoko O Akazawa, Yoshiro Saito*, Takao Hamakubo, Yoshinori Masuo, Yasukazu Yoshida, Keiko Nishio, Mototada Shichiri, Tomohiro, Miyasaka, Hiroko Iwanari, Yasuhiro Mochizuki, Tatsuhiko Kodama, Noriko Noguchi, and Etsuo Niki (2010) Elevation of oxidized DJ-1 in the brain and erythrocytes of Parkinson disease model animals. Neuroscience Letters, 483, 201-205

Yo Omata, Yoshiro Saito*, Yasukazu Yoshida, Byeong-Seon Jeong, Remigiusz Serwa, Tae-gyu Nam, Ned A Porter and Etsuo Niki (2010) Action of 6-amino-3-pyridinols as novel antioxidants against free radicals and oxidative stress in solution, plasma, and cultured cells. Free Radical Biology and Medicine, 48, 1358-1365

Yoko Ogawa Akazawa, Yoshiro Saito*, Keiko Nishio, Masanori Horie, Tomoya Kinumi, Yoshinori Masuo, Yasukazu Yoshida, Hitoshi Ashida and Etsuo Niki (2010) Proteomic characterization of the striatum and midbrain treated with 6-hydroxydopamine: Alteration of 58-kDa glucose-regulated protein and C/EBP homologous protein. Free Radical Research, 44, 410-421

Yasukazu Yoshida, Yasuharu Imai, Yoshiyuki Sawai, Yoshiro Saito, Jiaofei Cao, Kazuto Fukuda, Etsuo Niki (2010) Hydroxyoctadecadienoic acid as a potential biomarker for oxidative stress in patients with chronic hepatitis C. Journal of Gastroenterology and Hepatology, 25, 107-115.

2009:

Masanori Horie, Akiko Fukuhara, Yoshiro Saito, Yasukazu Yoshida , Hiroe Sato, Hiromi Ohi, Makoto Obata, Yuji Mikata, Shigenobu Yano, Etsuo Niki (2009) Antioxidant action of sugar-pendant C(60) fullerenes. Bioorganic & Medicinal Chemistry Letters, 19, 5902-5904

Yoshiro Saito*, Takao Hamakubo, Yasukazu Yoshida, Yoko Ogawa, Yasuo Hara, Harutoshi Fujimura, Yasuharu Imai, Hiroko Iwanari, Yasuhiro Mochizuki, Mototada Shichiri, Keiko Nishio, Tomoya Kinumi, Noriko Noguchi, Tatsuhiko Kodama, Etsuo Niki (2009) Preparation and application of monoclonal antibodies against oxidized DJ-1. Significant elevation of oxidized DJ-1 in erythrocytes of early-stage Parkinson disease patients. Neuroscience Letters, 465, 1-5

Masanori Horie, Keiko Nishio, Katsuhide Fujita, Shigehisa Endoh, Arisa Miyauchi, Yoshiro Saito, Hitoshi Iwahashi, Kazuhiro Yamamoto, Hideki Murayama, Hajime Nakano, Naoki Nanashima, Etsuo Niki and Yasukazu Yoshida (2009) Protein Adsorption of Ultrafine Metal Oxide and Its Influence on Cytotoxicity toward Cultured Cells. Chemical Research in Toxicology, 22, 543-553.

Tatsunobu Matsui, Yukie Yamada, Hideki Mitsuya, Yasushi Shigeri, Yasukazu Yoshida, Yoshiro Saito, Hiroshi Matsui and Kunihiko Watanabe (2009) Sustainable and practical degradation of intact chicken feathers by cultivating a newly isolated thermophilic Meiothermus ruber H328. Applied Microbiology and Biotechnology, 82, 941-950

Yo Omata, Yoko Ogawa, Yoshiro Saito, Yasukazu Yoshida, and Etsuo Niki (2009) Assessment of antioxidant capacity of fermented grain food product, Antioxidant Biofactor (AOB), by ORAC method and inhibition of lipid peroxidation. Food Chemistry, 114, 429-433

Yasukazu Yoshida, Atsushi Yoshikawa, Tomoya Kinumi, Yoko Ogawa, Yoshiro Saito, Kazuyuki Ohara, Hirokazu Yamamoto, Yasuharu Imai and Etsuo Niki (2009) Hydroxyoctadecadienoic acid and oxidatively modified peroxiredoxins in the blood of Alzheimer's disease patients and their potential as biomarkers. Neurobiology of Aging, 30, 174-185.

2008:

Keiko Nishio, Akiko Fukuhara, Yo Omata, Yoshiro Saito*, Shuuhei Yamaguchi, Hisatoyo Kato, Yasukazu Yoshida, and Etsuo Niki (2008) Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults. Bioorganic & Medicinal Chemistry, 16, 10332-10337

Yo Omata, Yoshiro Saito*, Katsuhide Fujita, Yoko Ogawa, Keiko Nishio, Yasukazu Yoshida, and Etsuo Niki (2008) Induction of adaptive response and enhancement of PC12 cell tolerance by lipopolysaccharide primarily through the upregulation of glutathione S-transferase A3 via Nrf2 activation. Free Radical Biology and Medicine, 45, 1437-1445

Etsuo Niki, Yo Omata, Akiko Fukuhara, Yoshiro Saito, and Yasukazu Yoshida (2008) Assessment of Radical Scavenging Capacity and Lipid Peroxidation Inhibiting Capacity of Antioxidant. Journal of Agricultural Food Chemistry, 56, 8255-8260

Yoko Ogawa, Yoshiro Saito*, Keiko Nishio, Yasukazu Yoshida, Hitoshi Ashida, and Etsuo Niki (2008) Gamma-Tocopheryl quinone, not alpha-tocopheryl quinone, induces adaptive response through up-regulation of cellular glutathione and cysteine availability via activation of ATF4. Free Radical Research, 42, 674-687

Zhi-Hua Chen, Yoshiro Saito*, Yasukazu Yoshida, Noriko Noguchi, and Etsuo Niki (2008) Regulation of GCL Activity and Cellular Glutathione through Inhibition of ERK Phosphorylation. BioFactors, 33, 1-11

Zhi-Hua Chen, Yoshiro Saito, Yasukazu Yoshida, and Etsuo Niki. (2008) Effect of Oxygen Concentration on Free Radical-Induced Cytotoxicity. Bioscience Biotechnology and Biochemistry, 72, 1491-1497

Yoshiro Saito*, Akiko Fukuhara, Keiko Nishio, Mieko Hayakawa, Yoko Ogawa, Hirokazu Sakamoto, Kenji Fujii, Yasukazu Yoshida, and Etsuo Niki (2008) Characterization of cellular uptake and distribution of coenzyme Q10 and vitamin E in PC12 cells. Journal of Nutritional Biochemistry, 20, 350-357

Yo Omata, Yoshiro Saito, Yasukazu Yoshida, and Etsuo Niki (2008) Simple Assessment of Radical Scavenging Capacity of Beverages. Journal of Agricultural Food Chemistry, 56, 3386-3390

Etsuo Niki, Akiko Fukuhara, Yo Omata, Yoshiro Saito, and Yasukazu Yoshida (2008) Antioxidant capacity of BO-653, 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran, and uric acid as evaluated by ORAC method and inhibition of lipid peroxidation. Bioorganic & Medicinal Chemistry Letters, 18, 2464-2466.

2007:

Yoko Ogawa, Yo Omata, Keiko Nishio, Yoshiro Saito*, Yasukazu Yoshida, and Etsuo Niki (2007) Assessment of antioxidative activity of extract from fermented grain food mixture using chemical and cellular systems. BioFactors, 31, 237-248

Yoshiro Saito*, Yasukazu Yoshida, and Etsuo Niki (2007) Cholesterol is more susceptible to oxidation than linoleates in cultured cells under oxidative stress induced by selenium deficiency and free radicals. FEBS Letters, 581, 4349-4354.

Yoshiro Saito*, Keiko Nishio, Yumiko Numakawa, Yoko Ogawa, Yasukazu Yoshida, Noriko Noguchi, and Etsuo Niki (2007) Protective effects of 15-deoxy-delta12,14-prostaglandin J2 against glutamate-induced cell death in primary cortical neuron cultures: Induction of adaptive response and enhancement of cell tolerance primarily through up-regulation of cellular glutathione. Journal of Neurochemistry, 102, 1625-1634.

Yasukazu Yoshida, Yoshiro Saito, Mieko Hayakawa, Yoko Habuchi, Yasuharu Imai, Yoshiyuki Sawai, and Etsuo Niki (2007) Levels of Lipid Peroxidation in Human Plasma and Erythrocytes: Comparison between Fatty Acids and Cholesterol. Lipids, 42, 439-449.

Yoshiro Saito*, Keiko Nishio, Yoko Ogawa, Tomoya Kinumi, Yasukazu Yoshida, Yoshinori Masuo, and Etsuo Niki (2007) Molecular mechanisms of 6-hydroxydopamine-induced cytotoxicity in PC12 cells- INVOLVEMENT OF HYDROGEN PEROXIDE-DEPENDENT AND -INDEPENDENT ACTION. Free Radical Biology and Medicine, 42, 675-685.

Rosaria Piga, Yoshiro Saito*, Yasukazu Yoshida and Etsuo Niki (2007) Cytotoxic effects of various stressors on PC12 cells: Involvement of oxidative stress and effect of antioxidants. NeuroToxicology, 28, 67-75.

2006:

Yoshiro Saito*, Keiko Nishio, Yoko Ogawa, Junko Kimata, Tomoya Kinumi, Yasukazu Yoshida, Noriko Noguchi and Etsuo Niki (2006) Turning point in apoptosis/necrosis induced by hydrogen peroxide. Free Radical Research, 40, 619-630.

Zhi-Hua Chen, Yasukazu Yoshida, Yoshiro Saito, Azusa Sekine, Noriko Noguchi, and Etsuo Niki. (2006) Induction of adaptive response and enhancement of PC12 cell tolerance by 7-hydroxycholesterol and 15-deoxy-delta12,14-prostaglandin J2 through up-regulation of cellular glutathione via different mechanisms. Journal of Biological Chemistry, 281, 14440-14445.

Zhi-Hua Chen, Yasukazu Yoshida, Yoshiro Saito, Noriko Noguchi, and Etsuo Niki. (2006) Adaptive response induced by lipid peroxidation products in cell cultures. FEBS Letters, 580, 479-483.

2005:

Zhi-Hua Chen, Yoshiro Saito, Yasukazu Yoshida, Azusa Sekine, Noriko Noguchi, and Etsuo Niki. (2005) 4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2. Journal of Biological Chemistry, 280, 41921-41927.

Tomoya Kinumi, Yoko Ogawa, Junko Kimata, Yoshiro Saito, Yasukazu Yoshida, Etsuo Niki (2005) Proteomic characterization of oxidative dysfunction in human umbilical vein endothelial cells (HUVEC) induced by exposure to oxidized LDL. Free Radical Research, 39, 1335-1344.

Zhi-Hua Chen, Yasukazu Yoshida, Yoshiro Saito, and Etsuo Niki (2005) Adaptation to hydrogen peroxide enhances PC12 cell tolerance against oxidative damage. Neuroscience Letters, 383, 256-259.

Yoshiro Saito*, Keiko Nishio, Yasukazu Yoshida, and Etsuo Niki (2005) Cytotoxic effect of formaldehyde with free radicals via increment of cellular reactive oxygen species. Toxicology, 210, 235-245.

Rosaria Piga, Yoshiro Saito*, Zhi-Hua Chen, Yasukazu Yoshida and Etsuo Niki (2005) Characterization of monochloramine toxicity on PC12 cells and protective effect of tocopherol via antioxidative function. Archives of Biochemistry and Biophysics, 436, 101-109

2004:

Yoshiro Saito*, Yasukazu Yoshida, Keiko Nishio, Mieko Hayakawa and Etsuo Niki (2004) Characterization of Cellular Uptake and Distribution of Vitamin E. Annals of the New York Academy of Sciences, 1031, 368-375

Shin-ichiro Maehara, Shinji Tanaka, Mitsuo Shimada, Ken Shirabe, Yoshiro Saito, Kazuhiko Takahashi and Yoshihiko Maehara (2004) Selenoprotein P, as a Predictor for Evaluating Gemcitabine Resistance in Human Pancreatic Cancer Cells. International Journal of Cancer, 112, 184-189

Yoshiro Saito, Noriko Sato, Masaki Hirashima, Gen Takebe, Shigeharu Nagasawa and Kazuhiko Takahashi (2004) Domain structure of bi-functional selenoprotein P. Biochemical Journal, 381, 841-846

Yoshiro Saito, Akira Shiga, Yasukazu Yoshida, Takuya Furuhashi, Yoji Fujita and Etsuo Niki (2004) Effects of Volatile Constituents of the Rosemary Extract on the Oxidation Caused by Ultraviolet Radiation and Nitrogen Dioxide. Aroma Research, 18, 118-122

Yoshiro Saito, Akira Shiga, Yasukazu Yoshida, Takuya Furuhashi, Yoji Fujita and Etsuo Niki (2004) Effects of a Novel Gaseous Antioxidative System Containing a Rosemary Extract on the Oxidation Induced by Nitrogen Dioxide and Ultraviolet Radiation. Bioscience, Biotechnology, and Biochemistry, 68, 781-786

Yasukazu Yoshida, Nanako Itoh, Yoshiro Saito, Mieko Hayakawa and Etsuo Niki (2004) Application of Water-Soluble Radical Initiator, 2,2’-Azobis[2-(2-imidazolin-2-yl)propane] Dihydrochloride, to a Study of Oxidative Stress. Free Radical Research, 38, 375-384

Takahiro Taira, Yoshiro Saito, Takeshi Niki, Sanae M.M. Iguchi-Ariga, Kazuhiko Takahashi and Hiroyoshi Ariga (2004) DJ-1 Has a Role in Antioxidative Stress to Prevent Cell Death. EMBO Report, 5, 213-218

2003:

Yoshiro Saito*, Yasukazu Yoshida, Takashi Akazawa, Kazuhiko Takahashi and Etsuo Niki (2003) Cell Death Caused by Selenium Deficiency and Protective Effect of Antioxidants. Journal of Biological Chemistry, 278, 39428-39434

Masaki Hirashima, Takeshi Naruse, Hiroaki Maeda, Chikateru Nozaki, Yoshiro Saito and Kazuhiko Takahashi (2003) Identification of Selenoprotein P as a Cell-Death Inhibitory Factor. Biological and Pharmaceutical Bulletin, 26, 794-798

2002:

Yoshiro Saito and Kazuhiko Takahashi (2002) Characterization of Selenoprotein P as a Selenium Supply Protein. European Journal of Biochemistry, 269, 5746-5751

Gen Takebe, Junko Yarimizu, Yoshiro Saito, Takaaki Hayashi, Hajime Nakamura, Junji Yodoi, Shigeharu Nagasawa, and Kazuhiko Takahashi (2002) A Comparative Study on the Hydroperoxide and Thiol Specificity of the Glutathione Peroxidase Family and Selenoprotein P. Journal of Biological Chemistry, 277, 41254-41258

2001:

Yoshiro Saito, Yasuko Watanabe, Eiji Saito, Tsutomu Honjoh and Kazuhiko Takahashi (2001) Production and Application of Monoclonal Antibodies to Human Selenoprotein P. Journal of Health Science, 47, 346-352

1999:

Yoshiro Saito, Takaaki Hayashi, Ayako Tanaka, Yasuko Watanabe, Masayo Suzuki, Eiji Saito and Kazuhiko Takahashi (1999) Selenoprotein P in Human Plasma as an Extracellular Phospholipid Hydroperoxide Glutathione Peroxidase. Isolation and Enzymatic Characterization of Human Selenoprotein P. Journal of Biological Chemistry, 274, 2866-2871

Review and book

* Corresponding author

2020:

Ryouhei Tsutsumi and Yoshiro Saito (2020) Selenoprotein P; P for Plasma, Prognosis, Prophylaxis, and More. Biological and Pharmaceutical Bulletin, 43, 366-374

斎藤芳郎(2020)ビタミン E 類の多様な抗酸化作用 ―アイソフォームによる細胞保護メカニズムの違い― ビタミン、94、59-70

Yoshiro Saito* (2020) Selenoprotein P as a significant regulator of pancreatic β cell function. Jounal of Biochemistry, 167, 119-124

Yoshiro Saito* (2020) Selenoprotein P as an in vivo redox regulator: disorders related to its deficiency and excess. Journal of Clinical Biochemistry and Nutrition, 66, 1-7

2019:

斎藤芳郎(2019)セレノプロテインPの機能と疾患—疾患バイオマーカーとしての可能性 生化学 みにれびゅう、第91巻、5号、686-691

斎藤芳郎(2019)感謝報恩:東北大学大学院薬学研究科代謝制御薬学分野 生化学 北から南から、第91巻、3号、429-430

2018:

Yoshiro Saito* (2018) Selenoprotein P and glucose metabolism: The involvement of redox signaling. Glycative Stress Research, 5, 171-176

Yoshiro Saito* and Yasukazu Yoshida (2018) Chemical Reactivity and Cellular Uptake of Tocopherols and Tocotrienols. In: Etsuo Niki (eds) Vitamin E: Chemistry and Nutritional Benefits. Royal Society of Chemistry, Food Chemistry, Function and Analysis, 11, 51-63.

斎藤芳郎(2018)酸化DJ-1のバイオマーカーとしての可能性 Frontiers in Parkinson Disease 座談会「パーキンソン病のバイオマーカーへの期待」、第11巻、2号、63-75

斎藤芳郎*、野口範子、御簾博文、篁俊成 (2018)セレノプロテインPによるレドックス制御と2型糖尿病 レドックス疾患学、実験医学増刊、第36巻、5号、121-127

2017:

斎藤芳郎*、野口範子 (2017)抗酸化タンパク質DJ-1の分子機能および皮膚における役割 日本美容皮膚科学会雑誌、第27巻、4号、315-322 [Yoshiro Saito* and Noriko Noguchi (2017) Molecular function of the antioxidative protein DJ-1 and its role in the skin, Aesthetic Dermatology, 27, 315-322]

Yoshiro Saito* (2017) DJ-1 as a Biomarker of Parkinson’s Disease. In: Ariga H., Iguchi-Ariga S. (eds) DJ-1/PARK7 Protein. Springer, Singapore, Advances in Experimental Medicine and Biology, 1037, 149-171. doi: 10.1007/978-981-10-6583-5_10.

2016:

斎藤芳郎*(2016)セレンの生物学—セレノプロテインの機能と疾患 細胞工学、35、240-246

2015:

斎藤芳郎、野口範子 (2015)神経変性とレドックスーパーキンソン病関連分子DJ-1のレドックス制御機能 レドックスUPDATE、第4章、224-228

Noriko Noguchi, Yasuomi Urano, Wakako Takabe, Yoshiro Saito (2015) New aspects of 24S-hydroxycholesterol in modulating neuronal cell death. Free Radical Biology & Medicine, 87, 366-72

2014:

斎藤芳郎、野口範子 (2014)パーキンソン病と酸化ストレス 酸化ストレスの医学、第2版、264-271

Noriko Noguchi, Yoshiro Saito, Yasuomi Urano (2014) Diverse functions of 24(S)-hydroxycholesterol in the brain. Biochemical and Biophysical Research Communications, 446, 692-696

Yoshiro Saito* (2014) Oxidized DJ-1 as a possible biomarker of Parkinson’s disease. Journal of Clinical Biochemistry and Nutrition, 54, 138-44

Yoshiro Saito* and Noriko Noguchi (2014) 7-Hydroxycholestrol as a possible biomarker of cellular lipid peroxidation: Difference between cellular and plasma lipid peroxidation. Biochemical and Biophysical Research Communications, 446, 741-744

2013:

斎藤芳郎*(2013)パーキンソン病におけるバイオマーカーの現状—マイケルJフォックス財団の取り組み ファルマシア、49、870-872

斎藤芳郎(2013)ネクロトーシス、セレノプロテインP(ことば) 生化学、85、46

2012:

斎藤芳郎、二木鋭雄、野口範子 (2012)トコフェロール・トコトリエノールによる抗酸化作用を介した神経保護効果 ビタミンE研究の進歩、15、73-79

2011:

斎藤芳郎 (2011) 酸化ストレスの謎に迫りパーキンソン病の克服を目指す(知の胎動) Heart & Hand, 5, 16

Yoshiro Saito and Kazuhiko Takahashi (2011) Selenoprotein P. Selenoproteins and Mimics, 77-88

2010:

斎藤芳郎、西尾敬子、赤澤(小川)陽子、吉田康一、野口範子、二木鋭雄 (2010) グルタミン酸誘導性の神経細胞死に対するビタミンE類の抑制効果 ビタミンE研究の進歩、14、27-32

斎藤芳郎、野口範子 (2010) 脂質酸化物により誘導される適応反応のメカニズム 放射線生物研究、45、160-169

2009:

斎藤芳郎 (2009) 血漿セレン含有蛋白質セレノプロテインPに関する最近の話題 ビタミン、83、662-665

Katsuhide Fujita, Yasuo Morimoto, Akira Ogami, Isamu Tanaka, Shigehisa Endoh, Kunio Uchida, Hiroaki Tao, Mikio Akasaka, Masaharu Inada, Kazuhiro Yamamoto, Hiroko Fukui, Mieko Hayakawa, Masanori Horie, Yoshiro Saito, Yasukazu Yoshida, Hitoshi Iwahashi, Etsuo Niki and Junko Nakanishi (2009) A Gene Expression Profiling Approach to Study the Influence of Ultrafine Particles on Rat Lungs. Atmospheric and Biological Environmental Monitoring, 219-227

2008:

Yoshiro Saito, Yasukazu Yoshida, and Etsuo Niki (2008) Novel finding regarding cholesterol oxidation: Cholesterol is more susceptible to oxidation than linoleates in cultured cells under oxidative stress. International Arteriosclerosis Society (IAS) commentaries

Noriko Noguchi, Yoshiro Saito and Etsuo Niki (2008) Uptake, Distribution and Protective Action of Tocotrienols in Cultured Cells. Tocotrienols : Vitamin E Beyond Tocopherols, 159-170

2007:

斎藤芳郎 (2007) ストレスに対する生体の応答 蛋白質 ストレスの科学と健康、52-59

Yasukazu Yoshida, Yoshiro Saito, Leslie Sargent Jones, and Yasushi Shigeri (2007) Chemical Reactivities and Physical Effects in Comparison between Tocopherols and Tocotrienols. Journal of Bioscience and Bioengineering, 104, 439-445

2006:

斎藤芳郎、絹見朋也、二木鋭雄 (2006) 抗酸化蛋白質DJ-1の酸化修飾による機能制御 蛋白質の翻訳後修飾と疾患プロテオミクス、34-40

斎藤芳郎 (2006) 酸化ストレスから体を守るミネラル“セレン” バイオサイエンスとインダストリー、64、159-160

2005:

Yoshiro Saito, Noriko Sato, Masaki Hirashima, Gen Takebe, Shigeharu Nagasawa, Etsuo Niki and Kazuhiko Takahashi. (2005) Domain Structure of Bi-functional Selenoprotein P. Natural Antioxidants and Micronutrients, 105-108

Etsuo Niki, Yasukazu Yoshida, Yoshiro Saito, and Noriko Noguchi (2005) Lipid peroxidation: Mechanisms, inhibition, and biological effects. Biochemical and Biophysical Research Communications, 338, 668-676

斎藤芳郎、西尾敬子、吉田康一、二木鋭雄 (2005) 必須微量元素セレン及び酸化ストレスに伴う細胞死に対するAOBの添加効果、AOB研究会、4、42-46

2004:

斎藤芳郎、吉田康一、二木鋭雄 (2004) トコトリエノールのストレス抑制作用と細胞内取り込みについて ビタミンE研究の進歩、11、108-114

2001:

斎藤芳郎、高橋和彦 (2001) 血漿セレン含有蛋白質Selenoprotein Pのユニークな構造とその機能 放射線生物研究、36、291-301

高橋和彦、斎藤芳郎 (2001) Selenoprotein P (SeP) の構造上のユニークな特徴とその機能 生化学、73、261-264

2000:

Yoshiro Saito and Kazuhiko Takahashi (2000) Selenoprotein P: Its Structure and Functions. Journal of Health Science, 46, 409-413

斎藤芳郎 (2000) 全く異なる2つの顔を持つ蛋白質 ファルマシア、36、513-514