Org. Biomol. Chem. 2019, 17, 5239 - 5243.  /    , DOI: 10.1039/C9OB00807A ,

Post-genomic approach based discovery of alkylresorcinols from a cricket-associated fungus, Penicillium soppi

Akiho Kanekoa, Yohei Morishitaa, Kento Tsukadaa Tohru Taniguchib, Teigo Asai*a

Polyketide synthase (PKS) gene-guided genome mining in a cricket-associated fungus, Penicillium soppi, revealed a cryptic biosynthetic gene cluster that contained a highly reducing PKS (HR-PKS), a type III PKS, and a P450 genes. Heterologous expression of the cluster in Aspergillus oryzae led to the isolation of novel alkyresorcinols with a unique Z,E,Z-triene motif. This study displays an unusual biosynthetic mechanism of an HR-PKS and a new releasing mechanism via type III PKS in fungi.