業績

PUBLICATION LIST

赤字は100回以上引用された論文、青字は50~99回引用された論文、緑字は20～49回引用された論文

(出展 Web of Science、2017年1月31日現在)

2020年

Original Articles

  1. Hoshi Y, Uchida Y, Kuroda T, Tachikawa M, Couraud PO, Suzuki T, Terasaki T, Distinct roles of ezrin, radixin and moesin in maintaining the plasma membrane localizations and functions of human blood-brain barrier transporters. J. Cereb. Blood Flow Metab., 2019 Aug 14:271678X19868880. doi: 10.1177/0271678X19868880. [Epub ahead of print]
  2. Tachikawa M, Kaneko Y, Ohtsuki S, Uchida Y, Watanabe M, Ohtsuka H, Terasaki T, Targeted proteomics-based quantitative protein atlas of pannexin and connexin subtypes in mouse and human tissues and cancer cell lines. J Pharm Sci. 109 (2): 1161-1168 (2020). doi: 10.1016/j.xphs.2019.09.024.
  3. Tachikawa M, Murakami K, Akaogi R, Akanuma S, Terasaki T and Hosoya K, Polarized hemichannel opening of pannexin 1/connexin 43 contributes to dysregulation of transport function in blood-brain barrier endothelial cells, Neurochem. Int., 132: 104600 (2020). doi: 10.1016/j.neuint.2019.104600.
  4. Uchida Y, Goto R, Takeuchi H, Łuczak M, Usui T, Tachikawa M, Terasaki T, Abundant expression of OCT2, MATE1, OAT1, OAT3, PEPT2, BCRP, MDR1 and xCT transporters in blood-arachnoid barrier of pig, and polarized localizations at CSF- and blood-facing plasma membranes, Drug Metab. Dispos., 48 (2) : 135-145 (2020), DOI: https://doi.org/10.1124/dmd.119.089516
  5. Hoshi Y, Uchida Y, Tachikawa M, Ohtsuki S, Couraud PO, Suzuki T, Terasaki T, Oxidative stress-induced activation of Abl and Src kinases rapidly induces P-glycoprotein internalization via phosphorylation of caveolin-1 on tyrosine-14, decreasing cortisol efflux at the blood-brain barrier. J Cereb Blood Flow Metab. 40(2):420-436 (2020). doi: 10.1177/0271678X18822801.
  6. Omori K, Tachikawa M, Hirose S, Taii A, Akanuma S, Hosoya K, Terasaki T, Developmental changes in transporter and receptor protein expression levels at the rat blood-brain barrier based on quantitative targeted absolute proteomics, Drug Metab Pharmacokinet, 35(1):117-123 (2020). doi: 10.1016/j.dmpk.2019.09.003.
  7. Tachikawa M, Akaogi R, Taii A, Akanuma SI, Uchida Y, Terasaki T, Distinct Transport Properties of Human Pannexin 1 and Connexin 32 Hemichannels, J Pharm Sci, 109(3): 1395-1402 (2020). doi: 10.1016/j.xphs.2019.12.008.
  8. Taii, A., Tachikawa, M., Ohta, Y., Hosoya, K.-I., Terasaki, T, Determination of intrinsic creatine transporter (SLC6A8) activity and creatine transport function of leukocytes in rats, Biol. Pharm. Bull., 43(3) 474-479 (2020).
  9. Zhang J, Furuta T, Sabit H, Tamai S, Jiapaer S, Dong Y, Kinoshita M, Uchida Y, Ohtsuki S, Terasaki T, Zhao S, Nakada M., Gelsolin inhibits malignant phenotype of glioblastoma and is regulated by miR-654-5p and miR-450b-5p., Cancer Sci., 2020 Apr 23. doi: 10.1111/cas.14429. [Epub ahead of print]
  10. Uchida Y, Yagi Y, Takao M, Tano M, Umetsu M, Hirano S, Usui T, Tachikawa M, Terasaki T., Comparison of absolute protein abundances of transporters and receptors among blood-brain barriers at different cerebral regions and blood-spinal cord barrier in human and rat. Mol Pharm., 17(6):2006-2020 (2020). doi: 10.1021/acs.molpharmaceut.0c00178.
  11. Uchida Y, Sasaki H, Terasaki T., Establishment and validation of highly accurate formalin-fixed paraffin-embedded quantitative proteomics by heat-compatible pressure cycling technology using phase-transfer surfactant and SWATH-MS. Sci Rep. 10(1):11271 (2020). doi: 10.1038/s41598-020-68245-2.

    12.  

    Book Chapter

    1. Y Uchida, R Goto, T Usui, M Tachikawa and T Terasaki. Blood-arachnoid barrier as a dynamic physiological and pharmacological interface between cerebrospinal fluid and blood. Springer, 2020, in press

     

    総説

    1. Yasuo Uchida、Physiological and Pharmacological Roles of “Blood-Arachnoid Barrier”, a New Interface of Central Nervous System: Importance of Quantitative Proteomics to Open up a New World, Proteome Letters,　5, 2020, in press

     

    その他

    1. 内田康雄：　4つの中枢関門の分子機構の解明に基づくヒトの脳内薬物濃度の予測と中枢疾患の新たな創薬フィールドの開拓、薬事日報、2020年3月18日発行
    2. 寺崎哲也：　紹介：　奨励賞受賞　内田康雄氏の業績、ファルマシア、56(6): 574 (2020)
    3. 寺崎哲也：　紹介：　学術貢献賞受賞　出口芳春氏の業績、ファルマシア、56(5): 447 (2020)

     

    2019年

    Original Articles

    1. Nishimura T, Sano Y, Takahashi Y, Noguchi S, Uchida Y, Takagi1 A, Tanaka T, Katakura S, Nakashima E, Tachikawa M, Maruyama T, Terasaki T, Tomi M, Quantification of ENT1 and ENT2 Proteins at the Placental Barrier and Contribution of These Transporters to Ribavirin Uptake. J. Pharm. Sci., 108(12): 3917-3922 (2019). doi: 10.1016/j.xphs.2019.09.005. Selected for Featured article by the Editor
    2. Hellinen L, Sato K, Reinisalo M, Kidron H, Rilla K, Tachikawa M, Uchida Y, Terasaki T, Urtti A, Quantitative protein expression comparison between apical and basolateral plasma membranes of the human retinal pigment epithelium. Invest. Ophthal. Vis. Sci., 60: 5022-5034 (2019). doi.org/10.1167/iovs.19-27328.
    3. Prasad B, Achour B, Artursson P, Hop CE, Lai Y, Smith PC, Barber J, Wisniewski JR, Spellman D, Uchida Y, Zientek M, Unadkat JD, Rostami-Hodjegan A. Towards a Consensus on Applying Quantitative LC-MS/MS Proteomics in Translational Pharmacology Research: A White Paper. Clin Pharmacol Ther., 2019 Sep;106(3):525-543. doi: 10.1002/cpt.1537.
    4. Ochiai Y, Uchida Y, Tachikawa M, Couraud PO, Terasaki T. Amyloid beta(25-35) impairs docosahexaenoic acid efflux by down-regulating fatty acid transport protein 1 (FATP1/SLC27A1) protein expression in human brain capillary endothelial cells. J Neurochem, 150(4):385-401 (2019). doi: 10.1111/jnc.14722.
    5. Sato K, Tachikawa M, Watanabe M, Uchida Y, Terasaki T, Selective Protein Expression Changes of Leukocyte-Migration-Associated Cluster of Differentiation Antigens at the Blood-Brain Barrier in a Lipopolysaccharide-Induced Systemic Inflammation Mouse Model without Alteration of Transporters, Receptors or Tight Junction-Related Protein, Biol Pharm Bull., 2019;42(6):944-953. doi:10.1248/bpb.b18-00939. Selected for Featured article by the Editor
    6. Yaguchi Y, Tachikawa M, Zhang Z, Terasaki T. Organic Anion Transporting Polypeptide 1a4 (Oatp1a4/Slco1a4) at the Blood-Arachnoid Barrier is the Major Pathway of Sulforhodamine-101 Clearance from Cerebrospinal Fluid of Rats. Mol Pharm., 16(5):2021-2027 (2019). doi: 10.1021/acs.molpharmaceut.9b00005.
    7. Pan Y, Omori K, Ali I, Tachikawa M, Terasaki T, Brouwer KLR, Nicolazzo JA. Increased Expression of Renal Drug Transporters in a Mouse Model of Familial Alzheimer's Disease. J Pharm Sci., 108(7):2484-2489 (2019). doi: 10.1016/j.xphs.2019.02.016.
    8. Sato K, Tachikawa M, Watanabe M, Miyauchi E, Uchida Y, Terasaki T. Identification of blood-brain barrier-permeable proteins derived from peripheral organ: In vivo and in vitro evidence of blood-to-brain transport of creatine kinase. Mol Pharm., 6(1): 247-257（2019）. doi: 10.1021/acs.molpharmaceut.8b00975.
    9. Kuroda H, Tachikawa M, Yagi Y, Umetsu M, Nurdin A, Miyauchi E, Watanabe M, Uchida Y, Terasaki T. Cluster of Differentiation 46 is the Major Receptor in Human Blood-Brain Barrier Endothelial Cells for Uptake of Exosomes Derived from Brain-Metastatic Melanoma Cells (SK-Mel-28). Mol Pharm., 16(1), 292–304 (2019). doi: 10.1021/acs.molpharmaceut.8b00985.
    10. Uchida Y, Sumiya T, Tachikawa M, Yamakawa T, Murata S, Yagi Y, Sato K, Stephan A, Ito K, Ohtsuki S, Couraud PO, Suzuki T, Terasaki T. Involvement of Claudin-11 in Disruption of Blood-Brain, -Spinal Cord, and -Arachnoid Barriers in Multiple Sclerosis. Mol Neurobiol. 2019;56(3):2039-2056 doi: 10.1007/s12035-018-1207-5.

      11.  

      総説

      1. 内田康雄、次世代型定量プロテオミクスに基づく中枢関門の新規密着結合分子の同定および多発性硬化症の中枢関門破綻への関与, ファルマシア, 55巻、4 号、320-324、2019
      2. 内田康雄、Uniprotデータベース, ファルマシア, 55巻、4 号、335_3、2019
      3. 内田康雄、臼井拓也、寺崎哲也、中枢疾患時の血液脳関門P糖タンパク質の機能変動機構の解明と中枢関門創薬への新展開, 医学のあゆみ 271(1), 104-111, 2019年10月号
      4. 内田康雄、輸送分子夾雑系の再構築に基づくヒト血液脳関門の薬物輸送システムの解明, CMCB NEWS LETTER, 2019年

       

      著書

      1. 寺崎哲也、入江徹美：　第二部はじめに、「学術会議叢書２５　IT・ ビッグデータと薬学　-創薬・医薬品適正使用への活用-」、日本学術会議事務局・日本薬学会編、日本学術協力財団、東京、(2019), pp.69-72

       

      その他

      1. 寺崎哲也：　オピニオン：　脳への薬物送達研究の新たな日の出に向けて、Drug Delivery System, 34 (5): 232 (2019)
      2. 寺崎哲也：　オピニオン：　プロテオミクスによる創薬科学の新展開、ファルマシア、55(12): 1097 (2019)

       

      2018年

      Original Articles

      1. Sano Y, Mizuno T, Mochizuki T, Uchida Y, Umetsu M, Terasaki T, Kusuhara H. Evaluation of Organic Anion Transporter 1A2-knock-in Mice as a Model of Human Blood-brain Barrier. Drug Metab Dispos. 2018;46(11):1767-1775. doi:10.1124/dmd.118.081877.
      2. Pan Y, Omori K, Ali I, Tachikawa M, Terasaki T, Brouwer KLR, Nicolazzo JA. Altered Expression of Small Intestinal Drug Transporters and Hepatic Metabolic Enzymes in a Mouse Model of Familial Alzheimer's Disease. Mol Pharm. 2018;15(9):4073-4083. doi: 10.1021/acs.molpharmaceut.8b00500.
      3. Tachikawa M, Akanuma SI, Imai T, Okayasu S, Tomohiro T, Hatanaka Y, Hosoya KI. Multiple Cellular Transport and Binding Processes of Unesterified Docosahexaenoic Acid in Outer Blood-Retinal Barrier Retinal Pigment Epithelial Cells. Biol Pharm Bull. 2018;41(9):1384-1392. doi: 10.1248/bpb.b18-00185.
      4. Tachikawa M, Yokoyama R, Akanuma SI, Hosoya KI. Assembly of Taurine Transporter (Slc6a6) with Na(+)-H(+) Exchanger Regulatory Factor 1 (Slc9a3r1) Improves GABA Transport Activity by Increasing the Maximum Transport Velocity. Biol Pharm Bull. 2018;41(3):338-341. doi: 10.1248/bpb.b17-00664.
      5. Akanuma SI, Higashi H, Maruyama S, Murakami K, Tachikawa M, Kubo Y, Hosoya KI. Expression and function of connexin 43 protein in mouse and human retinal pigment epithelial cells as hemichannels and gap junction proteins. Exp Eye Res. 2018;168:128-137. doi: 10.1016/j.exer.2018.01.016.
      6. Tachikawa M, Hirose S, Akanuma SI, Matsuyama R, Hosoya KI. Developmental changes of l-arginine transport at the blood-brain barrier in rats. Microvasc Res. 2018;117:16-21. doi: 10.1016/j.mvr.2017.12.003.
      7. Akazawa T, Uchida Y, Miyauchi E, Tachikawa M, Ohtsuki S, Terasaki T, High Expression of UGT1A1/1A6 in Monkey Small Intestine: Comparison of Protein Expression Levels of Cytochromes P450, UDP-Glucuronosyltransferases, and Transporters in Small Intestine of Cynomolgus Monkey and Human. Mol Pharm., 15(1):127-140 (2018). doi: 10.1021/acs.molpharmaceut.7b00772.
      8. Tachikawa M, Watanabe M, Fukaya M, Sakai K, Terasaki T, Hosoya KI, Cell-type-specific spatiotemporal expression of creatine biosynthetic enzyme S-adenosylmethionine: guanidinoacetate N-methyltransferase in developing mouse brain, Neurochem Res.,43(2):500-510 (2018). doi: 10.1007/s11064-017-2446-y.
      9. Sasaki K, Tachikawa M, Uchida Y, Hirano S, Kadowaki F, Watanabe M, Ohtsuki S, Terasaki T, ATP-binding cassette transporter A subfamily 8 is a sinusoidal efflux transporter for cholesterol and taurocholate in mouse and human liver, Mol Pharm., 15(2):343-355 (2018). doi: 10.1021/acs.molpharmaceut.7b00679.
      10. Zhang Z, Tachikawa M, Uchida Y, Terasaki T, Drug clearance from cerebrospinal fluid mediated by organic anion transporters 1 (Slc22a6) and 3 (Slc22a8) at arachnoid membrane of rats. Mol Pharm., 15(3):911-922 (2018). doi: 10.1021/acs.molpharmaceut.7b00852.
      11. Miyauchi E, Furuta T, Ohtsuki S, Tachikawa M, Uchida Y, Sabit H, Obuchi W, Baba T, Watanabe M, Terasaki T, Nakada M, Identification of blood biomarkers in glioblastoma by SWATH mass spectrometry and quantitative targeted absolute proteomics. PLOS ONE, 13(3):e0193799 (2018). doi: 10.1371/journal.pone.0193799.
      12. Nakamura S, Muramatsu S, Takino N, Ito M, Jimbo FE, Yamagata T, Shimazaki K, Onaka T, Ohtsuki S, Terasaki T, Osaka H, Gene therapy for Glut1-deficient mouse using an AAV vector with the human intrinsic GLUT1 promoter. J Gene Med, 20(4):e3013 (2018). doi: 10.1002/jgm.3013. Top 20 most downloaded article 2017-2018 in Journal of Gene Medicine
      13. Tachikawa M, Sumiyoshiya U, Saigusa D, Sasaki K, Watanabe M, Uchida Y, Terasaki T, Liver zonation index of drug transporter and metabolizing enzyme protein expressions in mouse liver acinus. Drug Metab Dispos., 46(5):610-618 (2018). doi: 10.1124/dmd.117.079244.
      14. Tachikawa M, Toki H, Watanabe M, Tomi M, Hosoya KI, Terasaki T, Gene expression of A6-like subgroup of ATP-binding cassette transporters in mouse brain parenchyma and microvessels. Anat Sci Int., 2018;93(4):456-463. doi: 10.1007/s12565-018-0435-0.

        15.  

        総説

        1. 寺崎哲也、佐藤和貴、血液脳関門、 神経系のトランスポーター　Up to date, 臨床神経科学(Clinical Neuroscience) 36 (6), 692-697 (2018)
        2. 内田康雄、SWATH-MS法って何？優れた定量精度・感度・網羅性を兼ね備えた次世代型定量プロテオミクス, 薬剤学「最近のトピックス」, 78(5),228-234 (2018)

         

        2017年

        Original Articles

        1. Uemura T, Ito S, Ohta Y, Tachikawa M, Wada T, Terasaki T, Ohtsuki T, Abnormal N-glycosylation of a novel missense creatine transporter mutant, G561R, associated with cerebral creatine deficiency syndromes alters transporter activity and localization, Biol Pharm Bull.,, 40(1):49-55 (2017).
        2. Nakamura S, Osaka H, Muramatsu SI, Takino N, Ito M, Aoki S, Jimbo EF, Shimazaki K, Onaka T, Ohtsuki S, Terasaki T, Yamagata T,　Gene therapy for a mouse model of glucose transporter-1 deficiency syndrome. Mol Genet Metab Rep., 10:67-74 (2017). doi: 10.1016/j.ymgmr.2016.12.008.
        3. Ochiai Y, Uchida Y, Ohtsuki S, Tachikawa M, Aizawa S, Terasaki T, The blood-brain barrier fatty acid transport protein 1 (FATP1/SLC27A1) supplies docosahexaenoic acid to the brain, and insulin facilitates transport, J Neurochem., 141(3):400-412 (2017).doi: 10.1111/jnc.13943.
        4. Inoue K, Ohtsuka H, Tachikawa M, Motoi F, Shijo M, Douchi D, Kawasaki S, Kawaguchi K, Masuda K, Fukase K, Naitoh T, Katayose Y, Egawa S, Unno M, Terasaki T, MK2461, a Multitargeted Kinase Inhibitor, Suppresses the Progression of Pancreatic Cancer by Disrupting the Interaction Between Pancreatic Cancer Cells and Stellate Cells, Pancreas., 46(4):557-566 (2017).
        5. Hoshi Y, Uchida Y, Tachikawa M, Ohtsuki S and Terasaki T, Actin filament-associated protein 1 (AFAP-1) is a key mediator in inflammatory signaling-induced rapid attenuation of intrinsic P-gp function in human brain capillary endothelial cells, J Neurochem., 141(2):247-262 (2017). doi: 10.1111/jnc.13960.
        6. Pelkonen L, Sato K, Reinisalo M, Kidron H, Tachikawa M, Watanabe M, Uchida Y, Urtti A and Terasaki T, LC-MS/MS Based Quantitation of ABC and SLC transporter proteins in plasma membranes of cultured primary human retinal pigment epithelium cells and immortalized ARPE19 cell line, Mol Pharm, 14(3):605-613 (2017).
        7. Kuroda H, Tachikawa M, Uchida Y, Inoue K, Ohtsuka H, Ohtsuki S, Unno M, Terasaki T, All-trans retinoic acid enhances gemcitabine cytotoxicity in human pancreatic cancer cell line AsPC1 by up-regulating protein expression of deoxycytidine kinase, Eur J Pharm Sci., 103: 116-121 (2017). doi: 10.1016/j.ejps.2017.02.021.
        8. Miura T, Tachikawa M, Ohtsuka H, Fukase K, Nakayama S, Sakata N, Motoi F, Naitoh T, Katayose Y, Uchida Y, Ohtsuki S, Terasaki T, Unno M, Application of quantitative targeted absolute proteomics to profile protein expression changes of hepatic transporters and metabolizing enzymes during cholic acid-promoted liver regeneration. J Pharm Sci., 106: 2499-2508 (2017). doi: 10.1016/j.xphs.2017.02.018
        9. Hirayama-Kurogi M, Takizawa Y, Kunii Y, Matsumoto J, Wadad A, Hino M, Akatsu H,Hashizume Y, Yamamoto S, Kondo T, Ito S, Tachikawa M, Niwa S, Yabe H, Terasaki T, Setou M, Ohtsuki S, Downregulation of GNA13-ERK network in prefrontal cortex of schizophrenia brain identified by combined focused and targeted quantitative proteomics, J Proteomics, 158:31-42 (2017). doi: 10.1016/j.jprot.2017.02.009.
        10. Yoneyama T, Ohtsuki S, Tachikawa M, Uchida Y, Terasaki T, Scrambled Internal Standard Method for High-Throughput Protein Quantification by Matrix-Assisted Laser Desorption Ionization Tandem Mass Spectrometry. J Proteome Res., 16(4):1556-1565 (2017). doi: 10.1021/acs.jproteome.6b00941
        11. Braun C, Sakamoto A, Fuchs H, Ishiguro N, Suzuki S, Cui Y, Klinder K, Watanabe M, Terasaki T and Sauer A, Quantification of transporter and receptor proteins in dog brain capillaries and choroid plexus: relevance for the distribution in brain and CSF of selected BCRP and P-gp substrates, Mol Pharm., 14(10):3436-3447 (2017). doi: 10.1021/acs.molpharmaceut.7b00449.
        12. Zhang Z, Uchida Y, Hirano S, Ando D, Kubo Y, Auriola S, Akanuma S, Hosoya K, Urtti A, Terasaki T, Tachikawa M, Inner blood-retinal barrier dominantly expresses breast cancer resistance protein: Comparative quantitative targeted absolute proteomics (QTAP) study of CNS barriers in pig, Mol Pharm., 14(11):3729-3738 (2017). doi: 10.1021/acs.molpharmaceut.7b00493.

         

          Perspective

        1. Ehrhardt C, Bäckman P, Couet W, Edwards C, Forbes B, Fridén M, Gumbleton M, Hosoya K, Kato Y, Nakanishi T, Takano M, Terasaki T, Yumoto R, Current progress toward a better understanding of drug disposition within the lungs: summary proceedings of the 1st Workshop on Drug Transporters in the Lungs　J Pharm Sci., 106(9):2234-2244 (2017). doi: 10.1016/j.xphs.2017.04.011.

         

          Commentary

        1. Kusuhara H, Obach SR, Rostami-Hodjegan A, Pang SK, Hammarlund-Udenaes M, Derendorf H, Artursson P, Huang SM, Suzuki H, Terasaki T, Professor Yuichi Sugiyama: A Brilliant, Creative, Amicable, Charming and Humorous Pharmaceutical Scientist, J Pharm Sci, 106(9): 2188-2194 (2017).

         

        総説

        1. 寺崎哲也、標的絶対定量的プロテオミクスに基づくPharmacoproteomics:国際共同研究の重要性、YAKUGAKU ZASSHI 137(6): 685-689 (2017)
        2. 張正宇、立川正憲、寺崎哲也、脳脊髄液中物質動態における脳脊髄液と接する関門の役割：脈絡叢上皮細胞、クモ膜上皮細胞、脊髄毛細血管内皮細胞における細胞膜輸送、神経内科Neurological Medicine、87 (3): 253-263 (2017)

         

        2016年

        Original Articles

        1. Sakamoto A, Suzuki S, Matsumaru T, Yamamura N, Uchida Y, Tachikawa M and Terasaki T, Correlation of OCTN1 and MRP1 transport activities with protein expression levels in primary cultured human tracheal, bronchial and alveolar epithelial cells, J Pharm Sci., 105: 876-883 (2016).
        2. Lloret-Linares C., Miyauchi E., Luo H., Labat L., Bouillot JL., Poitou C., Oppert JM., Laplanche JL., Mouly S., Scherrmann JM., Uchida Y., Tachikawa M., Terasaki T., Bergmann JF., Declèves X., Oral morphine pharmacokinetic in obesity: the role of P-glycoprotein, MRP2, MRP3, UGT2B7 and CYP3A4 jejunal contents and obesity-associated biomarkers, Mol. Pharm., 13(3):766-773 (2016).
        3. Nakamura K, Hirayama M, Ito S, Yoneyama T, Obuchi W, Terasaki T, Ohtsuki S, Large-scale multiplex absolute protein quantification of drug-metabolizing enzymes and transporters in human intestine, liver and kidney microsomes by SWATH-MS: comparison with MRM/SRM and HR-MRM/PRM, Proteomics, 16(15-16): 2106-2117 (2016). doi: 10.1002/pmic.201500433.
        4. Akazawa T, Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T., Quantitative Targeted Absolute Proteomics of Transporters and Pharmacoproteomics-Based Reconstruction of P-Glycoprotein Function in Mouse Small Intestine. Mol Pharm., 13(7): 2443-2456 (2016). doi: 10.1021/acs.molpharmaceut.6b00196.
        5. Miyauchi E, Tachikawa M, Decleves X, Uchida Y, Bouillot JL, Poitou C, Oppert JM, Mouly S, Bergmann JF, Terasaki T, Scherrmann JM, Lloret-Linares C. Quantitative atlas of cytochrome P450, UDP-glucuronosyltransferase, and transporter proteins in jejunum of morbidly obese subjects. Mol Pharm., 13(8):2631-2640 (2016). doi: 10.1021/acs.molpharmaceut.6b00085.
        6. Yoneyama T, Ohtsuki S, Honda K, Kobayashi M, Iwasaki M, Uchida Y, Okusaka T, Nakamori S, Shimahara M, Ueno T, Tsuchida A, Sata N, Ioka T, Yasunami Y, Kosuge T, Kaneda T, Kato T, Yagihara K, Fujita S, Huang W, Yamada T, Tachikawa M and Terasaki T, Identification of IGFBP2 and IGFBP3 as Compensatory Biomarkers for CA19-9 in Early-Stage Pancreatic Cancer Using a Combination of Antibody-based and LC-MS/MS-based Proteomics. PLoS One, 11(8):e0161009 (2016). doi: 10.1371/journal.pone.0161009.
        7. Armania N, Hoshi Y, Yoneyama T, Miyauchi E, Tachikawa M, Watanabe M and Terasaki T,Global and Targeted Proteomics of Prostate Cancer Cell Secretome: Combination of 2-Dimensional Image-Converted Analysis of Liquid Chromatography and Mass Spectrometry (2DICAL) and In Silico Selection SRM Analysis. J Pharm Sci.,105(11):3440-3452 (2016).

         

        Note

        1. Uchida Y, Toyohara T, Ohtsuki S, Moriyama Y, Abe T and Terasaki T, Quantitative targeted absolute proteomics for 28 transporters in brush-border and basolateral membrane fractions of rat kidney, J Pharm Sci., 105: 1011-1016 (2016).

         

        その他

        1. 寺崎哲也：　エッセー：　世界標準の人材育成を、公益財団法人富山県ひとづくり財団「創造」、56: 2 (2016)

         

        2015年

         

        Original Articles

        1. Gartzke D1, Delzer J, Laplanche L, Uchida Y, Hoshi Y, Tachikawa M, Terasaki T, Sydor J, Fricker G., Genomic Knockout of Endogenous Canine P-Glycoprotein in Wild-Type, Human P-Glycoprotein and Human BCRP Transfected MDCKII Cell Lines by Zinc Finger Nucleases. Pharm Res, 2014 Dec 19. [Epub ahead of print]
        2. Kaneko Y., Tachikawa M., Akaogi R., Fujimoto K., Ishibashi M., Uchida Y., Couraud P.O., Ohtsuki S., Hosoya K., Terasaki T., Contribution of pannexin 1 and connexin 43 hemichannels to extracellular calcium-dependent transport dynamics in human blood–brain barrier endothelial cells. J Pharmacol Exp Ther, 353(1): 192-200 (2015).

        3. Sakamoto A., Matsumaru T., Yamamura N., Suzuki S., Uchida Y., Tachikawa M., and Terasaki T., Drug transporter protein quantification of immortalized human lung cell lines derived from tracheo-bronchial epithelial cells (Calu-3 and BEAS2-B), bronchiolar-alveolar cells (NCI-H292 and NCI-H441) and alveolar type II-like cells (A549) by liquid chromatography-tandem mass spectrometry. J Pharm Sci, 104(9): 3029-3038 (2015).　　

        4. Kubo Y., Ohtsuki S., Uchida Y. and Terasaki T., Quantitative determination of luminal and abluminal membrane distributions of transporters in porcine brain capillaries by plasma membrane fractionation and quantitative targeted proteomics. J Pharm Sci, 104(9): 3060-3068 (2015).
        5. Uchida Y, Ito K, Ohtsuki S, Kubo Y, Suzuki T and Terasaki T, Major involvement of Na+-dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells. J Neurochem, 134(1): 97-112 (2015).
        6. Waqas SM, Uchida Y, Hoshi Y, Tachikawa M, Terasaki T and Udenaes HM, Validation of a P-glycoprotein (P-gp) humanized mouse model by integrating selective absolute quantification of human MDR1, mouse mdr1a and mdr1b protein expressions with in vivo functional analysis for blood-brain barrier transport, PLOS one, 10(5):e0118638 (2015). doi: 10.1371/journal.pone.0118638.
        7. Uchida Y, Zhang Z, Tachikawa M and Terasaki T, Quantitative Targeted Absolute Proteomics of Rat Blood-Cerebrospinal Fluid Barrier Transporters: Comparison with a Human Specimen, J Neurochem, May 7. doi: 10.1111/jnc.13147. [Epub ahead of print] (2015).

        8. Ohmine K, Kawaguchi K, Ohtsuki S, Motoi F, Ohtsuka H, Kamiie J, Abe T, Unno M and Terasaki T, Quantitative targeted proteomics of pancreatic cancer: Deoxycytidine kinase protein level correlates to progression-free survival of patients receiving gemcitabine treatment, Mol Pharm, 12(9): 3282-91 (2015).  doi: 10.1021/acs.molpharmaceut.5b00282

         

        Note

        1. Uchida Y, Ohtsuki S, Kamiie J, Ohmine K, Iwase R, Terasaki T., Quantitative targeted absolute proteomics for 28 human transporters in plasma membrane of Caco-2 cell monolayer cultured for 2, 3, and 4 weeks. Drug Metab Pharmacokin, 30(2): 205-208 (2015).

         

        総説

        1. 米山敏広、内田康雄、立川正憲、大槻純男、寺崎哲也、質量分析法に基づくバイオマーカー研究へのアプローチ、「オミックスで加速するがんバイオマーカー研究の最新動向：　リスク評価，早期診断，治療効果・予後予測を可能にする　新しいバイオマーカー」遺伝子医学MOOK 29号、72-81頁、2015年〔監修：今井浩三／編集：山田哲司・金井弥栄〕

         

        著書

        1. 寺崎哲也：東北大学における薬剤学の歴史―古典的薬剤学から標的絶対定量プロテオミクスに基づいた新展開へ―、「薬剤学概史―私はこう見る120人による俯瞰図―」、公益社団法人 日本薬剤学会、岡田弘晃、渡辺善照 監修、pp147-150 (2015).

         

        その他

        1. 寺崎哲也：　紹介：　奨励賞受賞　立川正憲氏の業績、ファルマシア、51（5）: 476 (2015)

         

        2014年

         

        Original Articles

        1. Ito S, Ohtsuki S, Murata S, Katsukura Y, Suzuki H, Funaki M, Tachikawa M. Terasaki T, Involvement of insulin-degrading enzyme in insulin- and atrial natriuretic peptide-sensitive internalization of amyloid-beta peptide in mouse brain capillary endothelial cells. J Alzheimers Dis 38(1):185-200 (2014).

        2. Uchida Y, Wakayama K, Ohtsuki S, Chiba M, Ohe T, Ishii Y, Terasaki T. Blood-Brain Barrier Pharmacoproteomics-based Reconstruction of the In-Vivo Brain Distribution of P-glycoprotein Substrates in Cynomolgus Monkeys. J Pharmacol Exp Ther 350(3):578-588 (2014).

        3. Uchida Y, Ohtsuki S, Terasaki T, Pharmacoproteomics-based Reconstruction of In Vivo P-Glycoprotein Function at Blood-Brain Barrier and Brain Distribution of Substrate Verapamil in Pentylenetetrazole-kindled Epilepsy, Spontaneous Epilepsy and Phenytoin Treatment Models. Drug Metab Dispos 42: 1719-1726 (2014).

         

        Short Communication

        1. Ohtsuki S, Kawakami H, Inoue T, Nakamura K, Tateno C, Katsukura Y, Obuchi W, Uchida Y, Kamiie J, Horie T, Terasaki T. Validation of uPA/SCID mouse with humanized liver as a human liver model: protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases by LC-MS/MS. Drug Metab Dispos 42(6): 1039-1043 (2014).

         

        Review Articles

        1. Ohtsuki S, Hirayama M, Ito S, Uchida Y, Tachikawa M, Terasaki T. Quantitative targeted proteomics for understanding the blood-brain barrier: towards pharmacoproteomics. Expert Rev Proteomics 11(3):303-313 (2014).

        2. Tachikawa M, Hosoya K, Terasaki T. Pharmacological significance of prostaglandin E2 and D2 transport at the brain barriers. Thematic Issue edited by Thomas P. Davis “The pharmacological implications of the recent discoveries made concerning the structure and function of the blood-brain barrier” Adv Pharmacol 71:337-360 (2014).

         

        Book Chapter

              1. Tachikawa M, Uchida Y, Ohtsuki S, Terasaki T. Recent progress in blood-brain barrier and blood-CSF barrier transport research: Pharmaceutical relevance for drug delivery to the brain. “Drug Delivery to the Brain – Physiological Concepts, Methodologies and Approaches”, ed., by R. Thorne, L. de Lange, M. Hammarlund-Udenaes, springer, pp 23-62 (2014).
              2. Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T. Blood-brain barrier (BBB) pharmacoproteomics: a new research field opened up by quantitative targeted absolute proteomics (QTAP). “Drug Delivery to the Brain – Physiological Concepts, Methodologies and Approaches”, ed., by R. Thorne, L. de Lange, M. Hammarlund-Udenaes, springer,  pp 63-100 (2014).

         

        著書

        1. 内田康雄、立川正憲：第10章ファーマコプロテオミクス、「薬剤学実験法 必携マニュアル - Pharmaceutical Scientistのために（II. 生物薬剤学）」、南江堂、渡辺善照、出口芳春、伊藤清美 編集、pp312-324 (2014).

         

        その他

        1. 寺崎哲也、巻頭言：薬剤学の新地平：タンパク質定量の大切さ、薬剤学、74(3):171 (2014).

        2. 内田康雄：9年間の薬物動態予測研究と、その先の薬効・副作用予測を目指して海外留学、DMPK News Letter, 29(3):14-15 (2014).

        3. 寺崎哲也：定量的プロテオミクスに基づく薬剤学の新地平金沢大学薬学部同窓会誌、61: 4 (2014)

         

        2013年

         

        Original Articles

        1. Hoshi Y., Uchida Y., Tachikawa M., Inoue T., Ohtsuki S., Terasaki T.,Quantitative atlas of blood-brain barrier transporters, receptors and tight junction  proteins in rats and common marmoset. J Pharm Sci 102 (9): 3343-3355 (2013).
        2. Kazuki Y., Kobayashi K., Aueviriyavit S., Oshima T., Kuroiwa Y., Tsukazaki Y., Senda N., Kawakami H., Ohtsuki S., Abe S., Takiguchi M., Hoshiya H., Kajitani N., Takehara S., Kubo K., Terasaki T., Chiba K., Tomizuka K., Oshimura M., Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans. Hum Mol Genet 22(3):578-592 (2013).
        3. Ohtsuki S, Ikeda C, Uchida Y, Sakamoto Y, Miller F, Glacial F, Decleves X, Scherrmann JM, Couraud PO, Kubo Y, Tachikawa M, Terasaki T., Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model. Mol Pharm 10(1): 289-296 (2013).
        4. Obuchi W, Ohtsuki S, Uchida Y, Ohmine K, Yamori T, Terasaki T., Identification of transporters associated with etoposide sensitivity of stomach cancer cell lines and methotrexate sensitivity of breast cancer cell lines by quantitative targeted absolute proteomics. Mol. Pharmacol 83(2):490-500 (2013).
        5. Tega Y, Akanuma SI, Kubo Y, Terasaki T.,Hosoya KI., Blood-to-brain influx transport of nicotine at the rat blood-brain barrier: involvement of a pyrilamine-sensitive organic cation transport process. Neurochem Int 62(2):173-181 (2013).
        6. Yoneyama T, Ohtsuki S, Ono M, Ohmine K, Uchida Y, Yamada T, Tachikawa M, Terasaki T. Quantitative targeted absolute proteomics-based large-scale quantification of proline-hydroxylated α-fibrinogen in plasma for pancreatic cancer diagnosis. J Proteome Res 12(2):753-762 (2013).
        7. Shimomura K, Okura T, Kato S, Couraud PO, Schermann JM, Terasaki T., Deguchi Y., Functional expression of a proton-coupled organic cation (H+/OC) antiporter in human brain capillary endothelial cell line hCMEC/D3, a human blood-brain barrier model. Fluids Barriers CNS 10(1):8 (2013).
        8. Devi T.S., Hosoya K.I., Terasaki T., Singh L.P., Critical role of TXNIP in oxidative stress, DNA damage and retinal pericyte apoptosis under high glucose: Implications for diabeticretinopathy. Exp Cell Res. 19(7):1001-1012 (2013).
        9. Ito S., Matsumiya K., Ohtsuki S., Kamiie J., Terasaki T., Contributions of degradation and elimination across the blood-brain barrier to cerebral clearance of human amyloid-beta peptide(1-40) in mouse brain. J Cereb Blood Flow Metab 33(11):1770-7 (2013).
        10. Sakamoto A., Matsumaru T., Yamamura N., Uchida Y., Tachikawa M., Ohtsuki S. and Terasaki T., Quantitative Expression of Human Drug Transporter Proteins in Lung Tissues: Analysis of Regional, Gender and Inter-individual differences by Liquid Chromatography-Tandem Mass Spectrometry. E-pub ahead of print. J Pharm Sci102(9): 3395-3406 (2013).
        11. Uchida Y., Tachikawa M., Obuchi W., Hoshi Y., Tomioka Y., Ohtsuki S., Terasaki T., A Study Protocol for Quantitative Targeted Absolute Proteomics (QTAP) by LC-MS/MS: Application for Inter-Strain Differences in Protein Expression Levels of Transporters, Receptors, Claudin-5, and Marker Proteins at the Blood-Brain Barrier in ddY, FVB, and C57BL/6J mice.Fluids Barriers CNS 10(1):21 (2013).

         

        総説

        1. 小渕航、寺崎哲也: 定量的標的プロテオミクスに基づく胃癌・乳癌薬剤感受性関連トランスポーターの解明、医学のあゆみ、245（1）: 135-141 (2013).

        2. 立川正憲、内田康雄、寺崎哲也: 動的インターフェースとしての脳関門輸送システムと脳関門生理学・創薬研究 、Brain and Nerve、 65(2):121-136 (2013).

        3. 内田康雄、立川正憲、星裕太朗、寺崎哲也、血液脳関門トランスポートソームの定量的絶対発現プロファイル：動物種間、系統間、野生型-遺伝子欠損マウス間の相違性と類似性、脳21「トランスポートソーム：トランスポーター・チャネル群の相互作用に基づく神経系の機能構築」、16(3): 298-304 (2013).

        4. 内田康雄、佐藤和貴、黒田広樹、星裕太郎、立川正憲、寺崎哲也、血液脳関門におけ る定量的標的絶対プロテオミクス解析、特集号「網羅解析からの血管研究アプロー チ」、血管医学、14(4): 399-409 (2013)

        5. 寺崎哲也、基礎の基礎：特集　血液脳関門：BBBの概念提唱から百年の時を越えてとらえたその実体、細胞工学、32(9): 930-934 (2013).
        6. 内田康雄、立川正憲、寺崎哲也、定量的標的プロテオミクス(QTAP)に基づく血液脳関門機能のin vitro再構築、特集　血液脳関門：BBBの概念提唱から百年の時を越えてとらえたその実体、細胞工学、32(9): 955-961(2013).
        7. 立川正憲、赤沼伸乙、寺崎哲也、脳関門プロスタグランジン輸送の分子病態生理、特集　血液脳関門：BBBの概念提唱から百年の時を越えてとらえたその実体、細胞工学、32(9): 946-949 (2013).
        8. 伊藤慎悟、大槻純男、寺崎哲也、脳内β-アミロイド制御における血液脳関門排出輸送分子機構とその破綻、特集　血液脳関門：BBBの概念提唱から百年の時を越えてとらえたその実体、細胞工学、32(9): 965-970 (2013).

        9. 立川正憲、内田康雄、寺崎哲也、標的絶対定量プロテオミクスが拓くヒト血液脳関門輸送研究、「特集：脳をターゲットとするDDSの基礎と臨床」、Drug Delivery System, 28(4): 270-278 (2013).

               

              Commentary

                          1. Hammarlund-Udenaes M, Brouwer K, Nakashima E and Terasaki T, Perspectives on a Pharmacokinetics Legend: C versus T (Contributions over Time), J. Pharm. Sci., 102(9): 2889-2894 (2013).

                           

        2012年

        Original Articles

        1. Ohtsuki S, Schaefer O, Kawakami H, Inoue T, Liehner S, Sato A, Ishiguro N, Kishimoto W, Ludwig-Schwellinger E, Ebner T, and Terasaki T.,Simultaneous absolute protein quantification of transporters, Cytochrome P450s and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: Comparison with mRNA levels and activities. Drug Metab. Dispos.40:83-92 (2012).
        2. Schaefer O, Ohtsuki S, Kawakami H, Inoue T, Liehner S, Saito A, Sakamoto A, Ishiguro N, Matsumaru T,Terasaki T, Ebner T., Absolute quantitation and differential expression of drug transporters, Cytochrome P450 Enzymes and UDP-Glucuronosyltransferases in cultured primary human hepatocytes. Drug Metab. Dispos. 40:93-103 (2012).
        3. A. Yoshikawa, M. Nakada, S. Ohtsuki, Y. Hayashi, W. Obuchi, Y. Sato, C. Ikeda, T. Watanabe, Y. Kawahara, T. Hasegawa, A. Sabit, D. Kita, Y. Hayashi, T. Teraaki, J. Hamada: Recurrent anaplastic meningioma treated by sunitinib based on the absolute quantitative proteomics: a case report. Neuropathology and Applied Neurobiology. 38:105-110 (2012).
        4. Agarwal S, Uchida Y, Mittapalli RK, Sane R, Terasaki T, Elmquist WF, Quantitative Proteomics of Transporter Expression in Brain Capillary Endothelial Cells Isolated from P-gp, Bcrp, and P-gp/Bcrp Knockout Mice. Drug Metab. Dispos., 40(6):1164-1169 (2012).

        5. Ohmine K, Kawaguchi K, Ohtsuki S, Motoi F, Egawa S, Unno M, Terasaki T, Attenuation of phosphorylation by deoxycytidine kinase is key to acquired gemcitabine resistance in a pancreatic cancer cell line: targeted proteomic and metabolomic analyses in PK9 cells. Pharm. Res., 29(7):2006-2016 (2012).

        6. Abe M, Sano Y, Maeda T, Shimizu F, Kashiwamura Y, Haruki H, Saito K, Tasaki A, Kawai M, Terasaki T, Kanda T., Establishment and characterization of human peripheral nerve microvascular endothelial cell lines: A new in vitro blood-nerve barrier (BNB) model. Cell Struct Funct., 37(2):89-100 (2012).

        総説

        1. 内田康雄、立川正憲、寺崎哲也: 定量的絶対プロテオミクスに基づくトランスポーター研究の新展開、細胞工学、31(5):587-588 (2012).

        著書

        1. 寺崎哲也、立川正憲：分布、「エピソード薬物動態学」、京都廣川書店、寺崎哲也、荻原琢男編集、辻彰総監修、pp169-177 (2012).

        その他

        1. 内田康雄:LC-MS/MSを用いた血液脳関門トランスポーター研究 、Drug Delivery System, 27(4):316-317 (2012).

         

        2011年

        Original Articles

        1. H. Kawakami, S. Ohtsuki, J. Kamiie, T. Suzuki, T. Abe, T. Terasaki: Simultaneous absolute quantification of 11 cytochrome P450 isoforms in human liver microsomes by liquid chromatography tandem mass spectrometry with in silico target peptide selection. J Pharm Sci. 100:341-352 (2011)
        2. S. Ito, S. Ohtsuki, Y. Katsukura, M. Funaki, Y. Koiotabashi, A. Sugino, S. Murata, T. Terasaki: Atrial natriuretic peptide is eliminated from the brain by natriuretic peptide receptor-C-mediated brain-to-blood efflux transport at the blood-brain barrier. J. Cereb. Blood Flow Metab. 31:457-466 (2011) (Selected as highlighted paper by editor)
        3. F. Shimizu, Y. Sano, M.A. Abe, T. Maeda, S. Ohtsuki, T. Terasaki, T. Kanda: Peripheral nerve pericytes modify the blood-nerve barrier function and tight junctional molecules through the secretion of various soluble factors. J Cell Physiol. 226:255-266 (2011)
        4. K. Ito, Y. Uchida, S. Ohtsuki, S. Aizawa, H. Kawakami, Y. Katsukura, J. Kamiie, T. Terasaki: Quantitative membrane protein expression at the blood-brain barrier of adult and younger cynomolgus monkeys. J Pharm Sci.100:3939-3950 (2011)
        5. Y. Uchida, S. Ohtsuki, Y. Katsukura, C Ikeda, T. Suzuki, J. Kamiie, T. Terasaki: Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors. J. Neurochem. 117:333-345 (2011)
        6. T. Okura, S. Kato, Y. Takano, T. Sato, A. Yamashita, R. Morimoto, S. Ohtsuki, T. Terasaki, Y. Deguchi: Functional characterization of rat plasma membrane 1 monoamine transporter (PMAT) in the blood-brain and blood-cerebrospinal fluid barriers. J. Pharm Sci.100:3924-3938 (2011)
        7. A. Sakamoto, T. Matsumaru, N. Ishiguro, O. Schaefer, S. Ohtsuki, T. Inoue, H. Kawakami, T. Terasaki: Reliability and robustness of simultaneous absolute quantification of drug transporters, cytochrome P450 enzymes and UDP-glucuronosyltranferases in human liver tissue by multiplexed MRM/SRM mode tandem mass spectrometry with nano-liquid chromatography (NanoLC-MS/MS). J. Pharm Sci.100:4037-4043 (2011)
        8. N.Y. Lee, Y. Sai, E. Nakashima, S. Ohtsuki, T. Terasaki, Y.S. Kang: 6-Mercaptopurine transport by equilibrative nucleoside transporters in conditionally immortalized rat syncytiotrophoblast cell lines TR-TBTs. J. Pharm Sci.100:3773-3782 (2011)
        9. M. Fujiyoshi, M. Tachikawa, S. Ohtsuki, S. Ito, Y. Uchida, S. Akanuma, J. Kamiie, T. Hashimoto, K. Hosoya, T. Iwatsubo, T. Terasalo: Amyloid-b peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier. J. Neurochem.118:407-415 (2011)
        10. S. Ito, S. Ohtsuki, Y. Nezu, Y. Koitabashi, S. Murata, T. Terasaki: 1a,25-Dihydroxyvitamin D3 enhances cerebral clearance of human amyloid-b peptide(1-40) from mouse brain across the blood-brain barrier. Fluids and Barriers of the CNS. 8:20 (2011).
        11. R. Shawahna, Y. Uchida, X. Decleves, S. Ohtsuki, S. Yosif, S. Dauchy, A. Jacob, F. Chassoux, C. Daumas, P.O. Couraud, T. Terasaki, J.M. Scherrmann: Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels. Mol. Pharm. 8:1332-1341 (2011)
        12. Y. Uchida, S. Ohtsuki, J. Kamiie, T. Terasaki: Blood-brain barrier (bbb) pharmacoproteomics (ppx): reconstruction of in vivo brain distribution of 11 p-glycoprotein substrates based on the bbb transporter protein concentration, in vitro intrinsic transport activity, and unbound fraction in plasma and brain in mice. J. Pharmacol. Exp. Ther. 339: 579-588 (2011).
        13. Gonzalez AM, Leadbeater WE, Burg M, Sims K, Terasaki T, Johanson CE, Stopa EG, Eliceiri BP, Baird A., Targeting choroid plexus epithelia and ventricular ependyma for drug delivery to the central nervous system. BMC Neurosci. 12(1):4 (2011).
        14. Sadiq MW, Borgs A, Okura T, Shimomura K, Kato S, Deguchi Y, Jansson B, Björkman S, Terasaki T, Hammarlund-Udenaes M., Diphenhydramine active uptake at the blood-brain barrier and its interaction with oxycodone in vitro and in vivo. J Pharm Sci.,100 (9): 3939-3950 (2011).
        15. Tachikawa M, Okamoto M, Hirose S, Yoneyama D, Akanuma SI, Terasaki T,Hosoya KI. Inner blood-retinal barrier mediates l-isomer-predominant transport of serine. J Pharm Sci., 100(9): 3892-3903 (2011).
        16. Devi TS, Singh LP, Hosoya KI, Terasakki T. GSK-3β/CREB axis mediates IGF-1-induced ECM/adhesion molecule expression, cell cycle progression and monolayer permeability in retinal capillary endothelial cells: Implication for diabetic retinopathy. Biochim Biophys Acta. 1812: 1080-1088 (2011).
        17. Kaneko H, Kamiie J, Kawakami H, Anada T, Honda Y, Shiraishi N, Kamakura S, Terasaki T,Shimauchi H, Suzuki O., Proteome analysis of rat serum proteins adsorbed onto synthetic octacalcium phosphate crystals. Anal Biochem., 418: 276-285 (2011) .
        18. Akanuma S, Uchida Y, Ohtsuki S, Tachikawa M, Terasaki T, Hosoya K., Attenuation of prostaglandin E2 elimination across the mouse blood-brain barrier in lipopolysaccharide- induced inflammation and additive inhibitory effect of cefmetazole. Fluids Barriers CNS 8: 24 (2011).
        19. Akanuma S, Uchida Y, Ohtsuki S, Kamiie J, Tachikawa M, Terasaki T,Hosoya K., Molecular-weight-dependent, anionic-substrate-preferential transport of β-lactam antibiotics via multidrug resistance-associated protein 4. Drug Metab Pharmacokinet. 26:602-611 (2011).

        Review Articles

        1. S. Ohtsuki, Y. Uchida, Y. Kubo, T. Terasaki: Quantitative targeted absolute proteomics-based ADME research as a new path to drug discovery and development: methodology, advantages, strategy and prospects. J Pharm Sci., 100:3547-3559 (2011)

        Commentary

              1. Terasaki T, Sugiyama Y, Benet L.Z., Professor Akira Tsuji: Scientist, Educator and Leader, J. Pharm. Sci., 100(9): 3541-3546 (2011).

        Editorial

        1. Jones HC, Terasaki T., Fluids and Barriers of the CNS: a new journal encompassing Cerebrospinal Fluid Research. Fluids and Barriers of the CNS, 8:1 (2011).

        総説

        1. 内田康雄、大槻純男、寺崎哲也：Pharmacoproteomics (PPx)に基づく血液脳関門輸送機能の解明、遺伝子医学MOOK19、148-154 (2011)
        2. 内田康雄、大槻純男、大峰健、寺崎哲也：血液脳関門における薬物トランスポーターの役割、トランスポートソームの世界　―膜輸送研究の源流から未来へ―、金井好克、竹島浩、森泰生、久保義弘編、京都廣川書店、東京、282-290 (2011)
        3. 大峰健、久保義行、大槻純男、内田康雄、寺崎哲也：定量的トランスポーター解析のための質量分析による膜タンパク質絶対定量法、トランスポートソームの世界　―膜輸送研究の源流から未来へ―、金井好克、竹島浩、森泰生、久保義弘編、京都廣川書店、東京、405-410 (2011)
        4. 大槻純男：脳関門輸送機構を利用した神経変性疾患に対する新たな治療戦略の構築、インテリジェントコスモス学術振興財団紀要、15:13-16 (2011)
        5. 元井冬彦、川口　桂、大峰　健、大槻純男、大塚英郎、力山敏樹、片寄　友、江川新一、寺崎哲也、海野倫明、膵臓癌の個別化医療：分子生物学的解析を中心に「特集癌個別化医療はどこまですすんだのか」、外科 73: 1073-1078 (2011).
        6. 立川正憲、内田康雄、大槻純男、寺崎哲也、定量的絶対標的プロテオミクスに基づくヒト血液脳関門におけるトランスポーターの発現と生理機能、脳21、5: 201-204, (2011).

         

        2010年

        Original Articles

        1. S. Akanuma, K. Hosoya, S. Ito, M. Tachikawa, T. Terasaki, S. Ohtsuki: Involvement of multidrug resistance-associated protein 4 in efflux transport of prostaglandin E2 across mouse blood-brain barrier and its inhibition by intravenous administration of cephalosporins. J. Pharmacol. Exp. Ther.,99:912-919 (2010)
        2. Nakazawa Y, Okura T, Shimomura K, Terasaki T, Deguchi Y, Drug-drug interaction between oxycodone and adjuvant analgesics in blood-brain barrier transport and antinociceptive effect. J Pharm Sci. 99:467-474 (2010)
        3. J. Niesen, G. Jedlitschky, M. Gube, H. Kawakami, J. Kamiie, S. Ohtsuki, H. Schwertz, S. Bien, K. Starke, C. Ritter, U. Strobel, A. Greinacher, T. Terasaki, HK. Kroemer: Expression of ABC-type transport proteins in human platelets. Pharmacogene. Genomics.20:396-400 (2010)
        4. S. Ito, T. Ueno, S. Ohtsuki, T. Terasaki: Lack of brain-to-blood efflux transport activity of low-density lipoprotein receptor-related protein-1 (LRP-1) for amyloid-b peptide(1-40) in mouse: involvement of an LRP-1-independent pathway. J. Neurochem. 76:1356/1363 (2010)
        5. S. Ohtsuki, H. Yamaguchi, Y.S. Kang, S. Hori, T. Terasaki: Reduction of LAT1 mRNA expression in brain capillaries in a mouse model of Parkinson’s disease. Biol. Pharm. Bull. 77:1250-1252 (2010)
        6. Y. Sano, F. Shimizu, M. Abe, T. Maeda, Y. KAshiwamura, S. Ohtsuki, T. Terasaki, M. Obinata, K. Kajiwara, M. Fujii, M. Suzuki, T. Kanda: Establishment of a new conditionally immortalized human brain microvascular endothelial cell line retaining an in vivo blood-brain barrier function. J. Cell. Physiol. 225:519-528 (2010)

        7. Perrone L, Devi TS, Hosoya KI, Terasaki T, Singh LP. Inhibition of TXNIP expression in vivo blocks early pathologies of diabetic retinopathy. Cell Death Dis. 1(8):e65 (2010)

         

        Perspectives

        1. S. Ohtsuki, S. Ito, T. Terasaki: Is P-glycoprotein involved in amyloid b elimination across the blood-brain barrier in Alzheimer’s disease? Clin. Pharmacol. Ther. 88:443-435 (2010)

        総説

        1. 大槻純男、内田康雄、寺崎哲也：血液脳関門輸送システムの分子機序と中枢疾患、分子脳血管病、9:257-264 (2010)

        著書

        1. 寺崎哲也：第６章 薬物送達異常と細胞膜。「細胞の構造とオルガネラ」大熊勝治、中西義信編、廣川書店、(2010), pp. 251-267.

         

        2009年

        Original Articles

        1. KI. Hosoya, A. Makihara, Y. Tsujikawa, D. Yoneyama, S. Mori, T. Terasaki, S. Akanuma, M. Tomi, M. Tachikawa: Roles of inner blood-retinal barrier organic anion transporter 3 (OAT3) in the vitreous/retina-to-blood efflux transport of p-aminohippuric acid, benzylpenicillin, and 6-mercaptopurine. J Pharmacol Exp Ther., 329:87-93 (2009)
        2. J. Niessen, G. Jedlitschky, M. Grube, S. Bien, H. Schwertz, S. Ohtsuki, H. Kawakami, J. Kamiie, S. Oswald, K. Starke, U. Strobel, W. Siegmund, D. Rosskopf, A. Greinacher, T. Terasaki, HK. Kroemer: Human platelets express OATP2B1, an uptake transporter for atorvastatin. Drug Metab Dispos37:1129-1137 (2009)
        3. Abukawa H, Tomi M, Kiyokawa J, Hori S, Kondo T, Terasaki T, Hosoya K., Modulation of retinal capillary endothelial cells by Muller glial cell-derived factors. Mol Vis., 15: 451-457 (2009)
        4. N. Katamura, R. Araya, M. Kudoh, H. Kimura, M. Murayama, A. Takashima, Y. Sakamaki, T. Hashikawa, S. Ito, S. Ohtsuki, T. Terasaki, J. Wess, M. Yamada: Beneficial Effects of Estrogen in a Mouse Model of Cerebrovascular Insufficiency. PLoS ONE 4:e5159 (2009)
        5. Kador PF, Randazzo J, Blessing K, Makita J, Zhang P, Yu K, Hosoya KI, Terasaki T, Polyol Formation in Cell Lines of Rat Retinal Capillary Pericytes and Endothelial Cells (TR-rPCT and TR-iBRB). J Ocul Pharmacol Ther. 25:299-308 (2009)
        6. Perrone L, Devi TS, Hosoya K, Terasaki T, Singh LP., Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions. J Cell Physiol., 221(1):262-272 (2009)
        7. Y. Nishida, S. Ito, S. Ohtsuki, N. Yamamoto, T. Takahashi, N. Iwata, K. Jishage, H. Yamada, H. Sasaguri, S. Yokota, W. Piao, H. Tomimitsu, TC. Saido, K. Yanagisawa, T. Terasaki, H. Mizusawa, T. Yokota, Depletion of vitamin E increases Ab accumulation by decreaseing its clearances from brain and blood in a mouse model of Alzheimer disease. J. Biol. Chem. 284:33400-33408 (2009)
        8. Tachikawa M, Kasai Y, Yokoyama R, Fujinawa J, Ganapathy V, Terasaki T, Hosoya K., The blood-brain barrier transport and cerebral distribution of guanidinoacetate in rats: involvement of creatine and taurine transporters. J Neurochem. 111:499-509 (2009)
        9. K. Yamada, C. Yabuki, P. Seubert, D. Schenk, Y. Hori, S. Ohtsuki, T. Terasaki, T. Hashimoto, T. Iwatsubo: Ab; immunotherapy: intracerebral sequestration of Ab; by an anti-Ab; monoclonal antibody 266 with high affinity to soluble Ab. J. Neurosci 29:11393-11398 (2009)
        10. Toyohara T, Suzuki T, Morimoto R, Akiyama Y, Souma T, Shiwaku HO, Takeuchi Y, Mishima E, Abe M, Tanemoto M, Masuda S, Kawano H, Maemura K, Nakayama M, Sato H, Mikkaichi T, Yamaguchi H, Fukui S, Fukumoto Y, Shimokawa H, Inui K, Terasaki T, Goto J, Ito S, Hishinuma T, Rubera I, Tauc M, Fujii-Kuriyama Y, Yabuuchi H, Moriyama Y, Soga T, Abe T: SLCO4C1 transporter eliminates uremic toxins and attenuates hypertension and renal inflammation. J Am Soc Nephrol. 20:2546-2555 (2009)

         

        総説

        1. 大峰健、上家潤一、大槻純男、寺崎哲也：質量分析法を用いたタンパク質の複数同時絶対定量法とPharmacoproteomicsへの新展開、薬事新報、2558:45-50 (2009)
        2. 大槻純男、上家潤一、寺崎哲也：Targeted Absolute Proteomicsを用いたトランスポーターの新しい研究展開、遺伝子医学MOOK12、48-54 (2009)
        3. 大槻純男：中枢への薬物分布におけるトランスポーターの機能と役割、日本薬理学雑誌、134:83-86 (2009)

         

        著書

        1. 寺崎哲也：　第19章分布 この章で何を学ぶか、「薬学教科書シリーズ６、薬と疾病, IIB.薬の効くプロセス(2)」、日本薬学会編、東京化学同人、東京、(2009), pp.50-51.
        2. 寺崎哲也、堀　里子：　SBO66、第19章分布、「薬学教科書シリーズ６、薬と疾病, IIB.薬の効くプロセス(2)」、日本薬学会編、東京化学同人、東京、(2009), pp.52-54.
        3. 大槻純男、寺崎哲也：　SBO67、第19章分布、「薬学教科書シリーズ６、薬と疾病, IIB.薬の効くプロセス(2)」、日本薬学会編、東京化学同人、東京, (2009), pp. 55-56.
        4. 崔　吉道、寺崎哲也：　SBO68、第19章分布、「薬学教科書シリーズ６、薬と疾病, IIB.薬の効くプロセス(2)」、日本薬学会編、東京化学同人、東京、(2009), pp. 57-59

         

        2008年

        Original Articles

        1. S. Ohtsuki, H. Yamaguchi, Y. Katsukura, T. Asashima, T.Terasaki: mRNA expression levels of tight junction protein genes in mouse brain capillary endothelial cells highly purified by magnetic cell sorting. J. Neurochem., 104:147-154 (2008)
        2. F. Shimizu, Y. Sano, T. Maeda, MA. Abe, H. Nakayama, R. Takahashi, M. Ueda, S. Ohtsuki, T. Terasaki, M. Obinata, T. Kanda, Peripheral nerve pericytes originating from the blood-nerve barrier expresses tight junctional molecules and transporters as barrier-forming cells. J Cell Physiol., 217(2):388-399 (2008)
        3. S. Akanuma, S. Hori, S. Ohtsuki, M. Fujiyoshi, T. Terasaki: Expression of nuclear receptor mRNA and liver X receptor-mediated regulation of ABC transporter A1 at rat blood-brain barrier. Neurochem. Int., 52: 669-674 (2008)
        4. S. Akanuma, S. Ohtsuki, Y. Doi, M. Tachikawa, S. Ito, S. Hoti, T. Asashima, T. Hashimoto, K. Yamada, K. Ueda, T. Iwatsubo, T. Terasaki: ATP binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-b peptide (1-40) at the blood-brain barrier. Neurochem. Int., 52:956-961 (2008)
        5. R. Araya, M. Kudo, M. Kawano, K. Ishii, T. Hashikawa, T. Iwasato, S. Itohara, T. Terasaki, A. Oohira, Y. Mishina, M. Yamada: BMP signaling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood-brain-barrier. Mol Cell Neurosci. 38(3):417-430 (2008)
        6. J. Kamiie, S. Ohtsuki, R. Iwase, K. Ohmine, Y. Katsukura, K. Yanai, Y. Sekine, Y. Uchida, S. Ito, T. Terasaki: Quantitative atlas of membrane transporter proteins: Development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria. Pharm. Res., 25: 1469-1483 (2008) (AAPS Meritorious Manuscript Award)
        7. Y. Sai, T. Nishimura, S. Shimpo, T. Chishu, K. Sato, N Kose, T. Terasaki, C. Mukai, S. Kitagaki, N. Miyakoshi, Y.S. Kang, E. Nimashima: Characterization of the mechanism of Zidovudine uptake by rat conditionally immortalized syncytiotrophoblast cell line TR-TBT. Pharm Res., 25: 1647-1653 (2008)
        8. N. Giri, G. Pan, N. Shaik, T. Terasaki, C. Mukai, S. Kitagaki, N. Miyakoshi, WF. Elmquist, Investigation of the Role of Abcg2/Bcrp1 on Pharmacokinetics and CNS Penetration of Abacavir (ABC) and Zidovudine (AZT) in the Mouse. Drug Metab Dispos. 36(8): 1476-1484 (2008)
        9. T. Okura, A. Hattori, Y. Takano, T. Sato, M. Hammarlund-Udenaes, T. Terasaki, Y. Deguchi: Involvement of the Pyrilamine Transporter, a Putative Organic Cation Transporter, in Blood-Brain Barrier Transport of Oxycodone. Drug Metab Dispos., 36(10):2005-2013 (2008)
        10. T. Nishimura, Y. Seki, K. Sato, T. Chishu, N. Kose, T. Terasaki, Y.S. Kang, Y. Sai, E. Nakashima: Enhancement of zidovudine uptake by dehydroepiandrosterone sulfate in rat syncytiotrophoblast cell line TR-TBT 18d-1. Drug Metab Dispos., 36(10):2080-2085 (2008)
        11. M. Tachikawa, Y. Kasai, M. Takahashi, J. Fujinawa, K. Kitaichi, T. Terasaki, K. Hosoya: The blood-cerebrospinal fluid barrier is a major pathway of cerebral creatinine clearance: involvement of transporter-mediated process. J. Neurochem., 107(2), 432-442, (2008)
        12. M. Tachikawa, J. Fujinawa, M. Takahashi, Y. Kasai, M. Fukaya, K. Sakai, M. Yamazaki, M. Tomi, M. Watanabe, K. Sakimura, T. Terasaki, KI. Hosoya: Expression and possible role of creatine transporter in the brain and at the blood-cerebrospinal fluid barrier as a transporting protein of guanidinoacetate, an endogenous convulsant. J Neurochem., 107(3), 768-778, (2008)
        13. K. Yamada, T. Hashimoto, C. Yabuki, Y. Nagae, M. Tachikawa, D. K. Strickland, Q. Liu, G. Bu, J. M. Basak, D. M. Holtzman, S. Ohtsuki, T. Terasaki and T. Iwatsubo: The Low Density Lipoprotein Receptor-related Protein 1 Mediates Uptake of Amyloid β Peptides in An In Vitro Model of the Blood-Brain Barrier Cells. J. Biol. Chem.,283(50),34554-34562 (2008)
        14. S. Greenwood, A. Swetloff, AM. Wade, T. Terasaki, P. Ferretti: Fgf2 is expressed in embryonic human and murine choroid plexus and affects choroid plexus epithelial cell behaviour. Cerebrospinal Fluid Res., 5:20 (2008)

         

        総説

        1. 寺崎哲也、血液脳関門機能と薬物の分布、薬剤学、68(2): 88-96 (2008)
        2. 大槻純男、崔吉道：生体膜分子を基盤とする薬剤開発・治療に向けた新展開、薬学雑誌、128:495-496 (2008)
        3. 内田康雄、大槻純男、寺崎哲也：脳関門のABCトランスポーターの薬物療法における役割、Clinical Neuroscience, 26: 1107-1110 (2008).
        4. 大槻純男：血液脳関門におけるモノアミン関連トランスポーターの役割、 26: 1077-1080 (2008).

        著書

        1. 寺崎哲也、血液脳関門研究の楽しみ方, 「トランスポーター科学最前線」, 辻彰編, 京都廣川書店, 95-115　(2008)
        2. 大槻純男、寺崎哲也：血液脳関門、血液脳脊髄液関門、「分子薬物動態学」、杉山雄一、楠原洋之、381-394 (2008)
        3. 寺崎哲也、大槻純男: 体内分布, 「わかりやすい生物薬剤学」, 第4版, 辻 彰 編, 広川書店, 東京、(2008), pp. 63-92.
        4. 寺崎哲也： 生理学的薬物速度論, 「わかりやすい生物薬剤学」, 第4版, 辻 彰 編, 広川書店, 東京,  (2008), pp. 168-193.

         

        2007年

        Original Articles

        1. M. Belanger, T. Asashima, S. Ohtsuki, H. Yamaguchi, S. Ito, T. Terasaki: Hyperammonemia induces transport of taurine and creatine and suppresses claudin-12 gene expression in brain capillary endothelial cells in vitro. Neurochem. Int., 50:95-101 (2007)
        2. S. Ohtsuki, S. Sato, H. Yamaguchi, M. Kamoi, T. Asashima, T. Terasaki: Exogenous expression of claudin-5 induced barrier properties in cultured rat brain capillary endothelial cells. J. Cell. Physiol., 210:81-86 (2007)
        3. K. Ikesugi, ML. Mulhern, CJ. Madson, K. Hosoya, T. Terasaki, PF. Kador, T. Shinohara: Induction of endoplasmic reticulum stress in retinal pericytes by glucose deprivation. Curr. Eye Res., 31: 947-953 (2006).
        4. M. Fujiyoshi, S. Ohtsuki, S. Hori, M. Tachikawa, T. Terasaki: 24S-Hydroxycholesterol induces cholesterol release from choroid plexus epithelial cells in an apical- and apoE isoform-dependent manner concomitantly with the induction of ABCA1 and ABCG1 expression. J. Neurochem. 100:968-978 (2007)
        5. S. Ohtsuki, H. Yamaguchi, T. Asashima, T. Terasaki: Establishing a method to isolate rat brain capillary endothelial cells by magnetic cell sorting and dominant mRNA expression of multidrug resistance-associated protein 1 and 4 in highly purified rat brain capillary endothelial cells. Pharm. Res., 24:688-694 (2007)
        6. M. Tomi, T. Terayama, T. Isobe, F. Egami, A. Morito, M. Kurachi, S. Ohtsuki, YS. Kang, T. Terasaki, K. Hosoya: Function and regulation of taurine transport at the inner blood-retinal barrier. Microvasc. Res. 73:100-106 (2007)
        7. S. Ohtsuki, M. Kamoi, Y. Watanabe, H. Suzuki, S. Hori, T. Terasaki: Correlation of induction of ATP binding cassette transporter A5 (ABCA5) and ABCB1 mRNAs with differentiation state of human colon tumor. Biol. Pharm. Bull., 30:1144-1146 (2007)
        8. N. Perriere, S. Yousif, S. Cazaubon, N. Chaverot, F. Bourasset, S. Cisternino, X. Decleves, S. Hori, T. Terasaki, M. Deli, J.M. Scherrmann, J.Temsamani, F. Roux, P.O. Couraud: A functional in vitro model of rat blood-brain barrier for molecular analysis of efflux transporters. Brain Res., 1150:1-13 (2007)
        9. N.Kose, T. Asashima, M. Muta, H. Iizasa, Y. Sai, T. Terasaki, E. Nakashima: Altered expression of basement membrane-related molecules in rat brain
          pericyte, endothelial, and astrocyte cell lines after transforming growth factor-beta1 treatment. Drug Metab Pharmacokinet. 22:255-266 (2007)
        10. S. Ohtsuki, S. Ito, A. Matsuda, S. Hori, T. Abe, T. Terasaki: Brain-to-blood elimination of 24S-hydroxycholesterol from rat brain is mediated by organic anion transporting polypeptide 2 (oatp2) at the blood-brain barrier. J. Neurochem., 103:1430-1438(2007).
        11. C. Tamaki, S. Ohtsuki, T. Terasaki: Insulin facilitates the hepatic clearance of plasma amyloid β-peptide (1-40) by intracellular translocation of LRP-1 to the plasma membrane in hepatocytes. Mol. Pharmacol., 72:850-855 (2007)
        12. S. Ito, S. Ohtsuki, J. Kamiie, Y. Nezu, T. Terasaki: Cerebral clearance of human amyloid-b peptide (1-40) across the blood-brain barrier is reduced by self-aggregation and formation of low-density lipoprotein receptor-related protein-1 ligand complexes. J. Neurochem., 103:2482-2490 (2007)
        13. Y. Uchida, J. Kamiie, S. Ohtsuki, T. Terasaki: Multichannel liquid chromatography tandem mass spectrometry cocktail method for comprehensive substrate characterization of multidrug resistance-associated protein 4 transporter. Pharm. Res., 24:2281-2296 (2007)
        14. Y. Sano, F. Shimizu, H. Nakayama, M. Abe, T. Maeda, S. Ohtsuki, T. Terasaki, M. Obinata, M. Ueda, R. Takahashi, T. Kanda: Endothelial cells constituting blood-nerve barrier have highly specialized characteristics as barrier-forming cells. Cell Struct. Func., 32：139-147 (2007)
        15. EC. Leal, A. Manivannan, K. Hosoya, T. Terasaki, J. Cunha-Vaz, AF. Ambrosio, JV. Forrester, Inducible nitric oxide synthase isoform is a key mediator of leukostasis and blood-retinal barrier breakdown in diabetic retinopathy. Invest Ophthalmol Vis Sci. 48(11):5257-65 (2007)

        Review Articles & Book Chapters

        1. S. Ohtsuki, T. Terasaki: Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development. Pharm. Res., 24:1745-1758 (2007)
        2. M. Tachikawa, K. Hosoya, S. Ohtsuki, and T. Terasaki: A novel relationship between creatine transport at the blood-brain and blood-retinal barriers, Creatine biosynthesis, and its use for brain and retinal energy homeostasis. "Creatine and Creatine Kinase in Health and Disease", ed., by M. Wyss and G. S. Salomons, Springer, pp83-98 (2007)

         

        総説

        1. 内田康雄、上家潤一、大槻純男、小田切優樹、寺崎哲也：尿毒症物質の血液脳関門と陣輸送、腎と透析、62:327-333 (2007)
        2. 寺崎哲也、大槻純男、上家潤一 : 薬物の薬効、毒性標的への分布：血液脳関門の透過性の評価 「最新創薬学2007 -薬物動態学特性の解析は創薬のキーワード-」遺伝子医学Mook, 8: 170-177 (2007)
        3. 寺崎哲也： ABCタンパク質と個体維持機構：脳関門におけるABCトランスポーターの働きと疾患治療、「ABCタンパク質の基礎と臨床」、最新医学、62(11): 2454-2460 (2007).

         

        著書

        1. 寺崎哲也: 総論, 「生物薬剤学、改定第2版」, 林正弘、谷川原祐介編, 南江堂, 東京, (2007), 第2章,第1節 pp. 63-65.
        2. 寺崎哲也: 脳内移行, 「生物薬剤学」, 林正弘、谷川原祐介編, 南江堂, 東京, (2007), 第2章, 第3節 pp. 73-78.

         

        2006年

        Original Articles

        1. T. Deguchi, K. Isozaki, K. Yousuke, T. Terasaki, M. Otagiri: Involvement of organic anion transporters in the efflux of uremic toxins across the blood-brain barrier. J Neurochem., 96(4):1051-1059 (2006). (ISI-IF: 4.824)
        2. T. Hino, T. Yokota, S. Ito, K. Nishina, YS Kang, S. Mori, S. Hori, T. Kanda, T. Terasaki, Mizusawa H., In vivo delivery of small interfering RNA targeting brain capillary endothelial cells. Biochem Biophys Res Commun., 340(1):263-267 (2006).(ISI-IF: 2.904)
        3. T. Asashima, S. Hori, S. Ohtsuki, M. Tachikawa, M. Watanabe, C. Mukai, S.Kitagaki, N. Miyakoshi, T. Terasaki: ATP-binding cassette transporter G2 mediates the efflux of phototoxins on the luminal membrane of retinalcapillary endothelial cells. Pharm Res., 23:1235-1242 (2006)(ISI-IF: 2.325)
        4. C. Tamaki, S. Ohtsuki, T. Iwatsubo, T. Hashimoto, K. Yamada, C. Yabuki, T. Terasaki: Major involvement of low-density lipoprotein receptor-related protein 1 in the clearance of plasma free amyloid beta-peptide by the liver. Pharm Res., 23:1407-1416 (2006)(ISI-IF: 2.325) (Selected as Featured Article by the journal's Chief Editor)
        5. S. Ohtsuki, T. Kikkawa, S. Hori, T. Terasaki: Modulation and compensation of the mRNA expression of energy related transporters in the brain of glucose transporter 1-deficient mice. Biol. Pharm. Bull., 29:1587-1591 (2006)
        6. M. Matsuo, K. Koizumi, S. Yamada, M. Tomi, R.I. Takahashi, M. Ueda, T. Terasaki, M. Obinata, K. Hosoya, O. Ohtani, I. Saiki: Establishment and characterization of conditionally immortalized endothelial cell lines from the thoracic duct and inferior vena cava of tsA58/EGFP double-transgenic rats. Cell Tissue Res. 326:749-758 (2006)
        7. S. Ito, S. Ohtsuki, T. Terasaki: Functional characterization of the brain-to-blood efflux clearance of human amyloid-beta peptide (1-40) across the rat blood-brain barrier. Neurosci. Res.. 56:246-252 (2006)
        8. K. Ikesugi, M.L. Mulhern, C.J. Madson, K. Hosoya, T. Terasaki , P.F. Kador, T. Shinohara: Induction of endoplasmic reticulum stress in retinal pericytes by glucose deprivation. Curr Eye Res. 31:947-53 (2006)

         

        Review Articles & Book Chapters

        1. Y. Deguchi, T. Terasaki,
          Transport of basic peptides at the blood-brain barrier, in "Handbook of Biologically Active Peptides", ed., by A. Kastin, Elsevier, pp 1443-1448 (2006).

         

        総説

        1. 大槻純男：脳関門輸送の分子機構と脳へのDDS、DDS学会誌、21:102-110 (2006)
        2. 大槻純男、寺崎哲也：血液脳脊髄液関門、Clinical Neuroscience、24:1213-1215 (2006)

         

        2005年 (ISI-IF: Total 54.156) ISI-IF: 2003年度版

        Original Articles

        1. T. Kondo, K. Hosoya, S. Hori, M. Tomi, S. Ohtsuki, T. Terasaki: PKC/MAPK signaling suppression by retinal pericyte conditioned medium prevents retinal endothelial cell proliferation. J. Cell. Physiol. 203:378-386 (2005) (ISI-IF: 5.463)
        2. J. Bhongsatiern, S. Ohtsuki, M. Tachikawa, S. Hori, T. Terasaki: Retinal specific ATP-binding cassette transporter (ABCR/ABCA4) is expressed at the choroid plexus in rat brain. J. Neurochem. 92:1277-1280 (2005) (ISI-IF: 4.825)
        3. S. Hori, S. Ohtsuki, M. Ichinowatari, T. Yokota, T. Kanda, T. Terasaki: Selective gene silencing of rat ATP-binding cassette G2 transporter in an in vitro blood-brain barrier model by short interfering RNA. J. Neurochem. 93:63-71 (2005)(ISI-IF: 4.825)
        4. S. Ohtsuki, M. Tomi, T. Hata, Y. Nagai, S. Hori, S. Mori, K. Hosoya, T. Terasaki: Dominant expression of androgen receptors and their functional regulation of organic anion transporter 3 in rat brain capillary endothelial cells; comparison of gene expression between the blood-brain and -retinal barriers. J. Cell. Physiol. 204:896-900 (2005) (ISI-IF: 5.463)
        5. S. Ohtsuki, N. Kamiya, S. Hori, T. Terasaki: Vascular endothelium-selective gene induction by Tie2 promoter/enhancer in the brain and retina of a transgenic rat. Pharm. Res. 22:852-857 (ISI-IF: 2.609)
        6. P. Garberg, M. Ball, N. Borg, R. Cecchelli, L. Fenart, RD Hurst, T. Lindmark, A. Mabondzo, JE Nilsson, TJ Raub, D Stanimirovic, T. Terasaki, JO Oberg, T. Osterberg : In vitro models for the blood-brain barrier. Toxicol In Vitro. 19: 299-334 (2005) (ISI-IF: 1.642)
        7. T. Nakashima, M. Tomi, M. Tachikawa, M. Watanabe, T. Terasaki and K. Hosoya: Evidence for Creatine Biosynthesis in Muller Glial Cells. Glia 52:47-52 (2005) (ISI-IF: 4.677)
        8. Jie Zhou, Baljit K. Deo, Kenichi Hosoya, Tetsuya Terasaki, Irina G. Obrosova, Frank C. Brosius, III, Arno K. Kumagai: Increased JNK Phosphorylation and Oxidative Stress in Response to Increased Glucose Flux through Increased GLUT1 Expression in Rat Retinal Endothelial Cells, Invest Ophthalmol Vis Sci., Accepted for publication (ISI-IF: 4.148)
        9. T. Miyata, H. Iizasa, Y. Sai, J. Fujii, T. Terasaki, E. Nakashima: Platelet-derived growth factor-BB (PDGF-BB) induces differentiation of bone marrow endothelial progenitor cell-derived cell line TR-BME2 into mural cells, and changes the phenotype. J Cell Physiol. 204: 948-955 (2005) (ISI-IF: 5.463)
        10. YS. Kang, KE. Lee, NY. Lee, T. Terasaki: Donepezil, tacrine and alpha-phenyl-n-tert-butyl nitrone (PBN) inhibit choline transport by conditionally immortalized rat brain capillary endothelial cell lines (TR-BBB). Arch Pharm Res. 28:443-450 (2005) (ISI-OF: 0.555)
        11. T. Deguchi, Y. Kouno, T. Terasaki, A. Takadate, M. Otagiri: Differential contributions of rOat1 (Slc22a6) and rOat3 (Slc22a8) to the in vivo renal uptake of uremic toxins in rats. Pharm. Res. 22:619-627 (2005) (ISI-IF: 2.609)
        12. M. Okabe, M. Unno, H. Harigae, M. Kaku, Y. Okitsu, T. Sasaki, T. Mizoi, K. Shiiba, H. Takanaga, T. Terasaki, S. Matsuno, I. Sasaki, S. Ito, T. Abe: Characterization of the organic cation transporter SLC22A16: A doxorubicin importer. Biochem Biophys Res Commun. 333:754-762 (2005) (ISI-IF: 2.904)
        13. M. Tomi, M. Mori, M. Tachikawa, K. Katayama, T. Terasaki, K. Hosoya: L-type amino Acid transporter 1-mediated L-leucine transport at the inner blood-retinal barrier. Invest Ophthalmol Vis Sci. 46:2522-2530 (2005) (ISI-IF: 4.148)
        14. T. Tachikawa, M. Watanabe, S. Hori, M. Fukaya, S. Ohtsuki, T. Asashima, T. Terasaki: Distinct sapatio-temporal expression of ABCA and ABCG transporters in the developing and adult brain. J. Neurochem. 95:294-304 (2005) (ISI-IF: 4.825)

         

        Review Articles & Book Chapters

        1. T. Terasaki, S. Ohtsuki: Brain-to-blood transporters for endogenous substrates and xenobiotics at the blood-brain barrier: an overview of biology and methodology. NeuroRx, 2:63-72 (2005)

         

        総説

        1. 渡辺雅彦、立川正憲、寺崎哲也：クレアチンを介した脳内エネルギー代謝の調節機構とニューロン・グリア相関, Clinical Neuroscience, 23: 158-160 (2005)
        2. 立川正憲、寺崎哲也：脳内エネルギー代謝における血液脳関門トランスポーターの生理的役割、化学と生物、43:166-171 (2005).

         

        2004年 (ISI-IF: Total 70.764)

        Original Articles

        1. S. Hori, S. Ohtsuki, K. Hosoya, E. Nakashima, T. Terasaki: A Pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie-2 activation in vitro. J. Neurochem., 89: 503-513 (2004) (ISI-IF: 4.825) On-line Article
        2. S. Ohtsuki, T. Kikkawa, S. Mori, S. Hori, H. Takanaga, M. Otagiri, T. Terasaki: Mouse "reduced in osteosclerosis" transporter (Roct) functions as an organic anion transporter 3 (mOAT3) and is localized at abluminal membrane of blood-brain barrier. J. Pharmacol. Exp. Ther., 309: 1273-1281 (2004) (ISI-IF: 4.337) On-line Article
        3. Y. Deguchi, Y. Naito, S. Ohtsuki, Y. Miyakawa, K. Morimoto, K. Hosoya, S. Sakurada, T. Terasaki: Blood-brain barrier permeability of novel [D-Arg2]dermorphin (1-4) analogues: transport property is related to the slow onset of antinociceptive activity in the central nervous system. J. Pharmacol. Exp. Ther., 310: 177-184 (2004) (ISI-IF: 4.337) On-line Article
        4. K. Hosoya, A. Minamizono, K. Katayama, T. Terasaki, M. Tomi: Vitamin C transport in oxidized form across the rat blood-retinal barrier. Invest. Ophathalmol. Vis. Sci. 45:1232-1239 (2004) (ISI-IF: 4.148)
        5. S. Hori, S. Ohtsuki, M. Tachikawa, N. Kimura, T. Kondo, M. Watanabe, E. Nakashima, T. Terasaki: Functional expression of rat ABCG2 on the luminal side of brain capillaries and its enhancement by astrocyte-derived soluble factor(s). J. Neurochem., 90:526-536 (2004) (ISI-IF: 4.825) On-line Article
        6. S. Ohtsuki, T. Takizawa, H. Takanaga, S. Hori, K. Hosoya, T. Terasaki: Localization of organic anion transporting polypeptide 3 (oatp3) in mouse brain parenchymal and capillary endothelial cells. J. Neurochem., 90:743-749 (2004) (ISI-IF: 4.825) On-line Article
        7. T. Nakashima, M. tomi, K. Katayama, M. Tachikawa, M. Watanabe, T. Terasaki, K. Hosoya: Blood-to-retina transport of creatine via creatine transporter (CRT) at the rat inner blood-retinal barrier. J. Neurochem. 89:1454-1461 (2004) (ISI-IF: 4.825) On-line Article
        8. S. Mori, S. Ohtsuki, H. Takanaga, T. Kikkawa, Y.S. Kang, T. Terasaki: Organic anion transporter 3 is involved in the brain-to-blood efflux transport of thiopurine nucleobase analogs. J. Neurochem., 90:931-941 (2004) (ISI-IF: 4.825)
        9. M. Tachikawa, M. Fukaya, T. Terasaki, S. Ohtsuki, M. Watanabe: Distinct cellular expressions of creatine synthetic enzyme GAMT and creatine kinases uCK-Mi and CK-B suggest novel neuron-glial relationship for brain energy homeostasis., Eur. J. Neurosci., 20:144-160 (2004) (ISI-IF: 3.872)
        10. S. Ohtsuki, Y. Watanabe, S. Hori, H. Suzuki, J. Bhongsatiern, M. Fujiyoshi, M. Kamoi, N. Kamiya, H. Takanaga, T. Terasaki: mRNA expression of the ATP-binding cassette transporter subfamily A (ABCA) in rat and human brain capillary endothelial cells. Biol. Pharm. Bull., 27:1437-40 (2004) (ISI-IF: 1.124)
        11. K. Hosoya, M. Tomi, M. Takayama, Y. Komokata, D. Nakai, T. Tokui, K. Nishimura, M. Ueda, M. Obinata, S. Hori, S. Ohtsuki, G. L. Amidon, T. Terasaki: Transporter mRNA Expression in a Conditionally Immortalized Rat Small Intestine Epithelial Cell Line (TR-SIE). Drug Metabol. Pharmacokin., 19:364-269 (2004).
        12. M. Tomi, H. Abukawa, Y. Nagai. T. Hata, H. Takanaga, S. Ohtsuki, T. Terasaki, K. Hosoya: Retinal selectivity of gene expression in rat retinal versus brain capillary endothelial cell lines by differential display analysis. Mol. Vis.., 10:537-543 (2004) (ISI-IF: 2.777)
        13. R. Fernandes, A. L. Carvalho, A. Kumagai, R. Seica, K. Hosoya, T. Terasaki, J. Murta, P. Pereira, C. Faro: Downregulation of retinal GLUT1 in diabetes by ubiquitinylation. Mol. Vis. 10:618-628 (2004) (ISI-IF: 2.777)
        14. T. Shiiki, S. Ohtsuki, A. Kurihara, H. Naganuma, K. Nishimura, M. Tachikawa, K. Hosoya, T. Terasaki: Brain insulin impairs amyloid-beta(1-40) clearance from the brain. J. Neurosci. 24:9632-9637 (2004) (ISI-IF=8.306)
        15. W. Pan, AJ. Kastin, TC Zankel, P. Van Kerkhof, T. Terasaki, G.Bu: Efficient transfer of receptor-associated protein (RAP) across the blood-brain barrier. J Cell Sci. 117:5071-5078. (2004) (ISI-IF=7.250)

        Review Articles & Book Chapters

        1. S. Ohtsuki, S. Hori, T. Terasaki: Modulation of Blood-Brain Barrier Efflux Transporters and the Impact of Treatment on CNS Disorders - Blood-brain barrier clearance as an essential function for CNS detoxification -. IN The Role of Efflux Transporters in a Functional Blood-Brain Barrier, E.M. Taylor (Ed), Nova Science Publishers, in press.
        2. S. Ohtsuki: New aspects of the blood brain barrier transporters; its physiological roles in the central nervous system. Biol. Pharm. Bull., 27：1489-1496 (ISI-IF: 1.124)
        3. K. Hosoya, S. Hori, S. Ohtsuki, T. Terasaki: A new in vitro model for blood?cerebrospinal fluid barrier transport studies: an immortalized choroid plexus epithelial cell line derived from the tsA58 SV40 large T-antigen gene transgenic rat. Adv. Drug Deliv. Rev., 56:1875-1885 (2004) (ISI-IF: 6.588)

        総説

        1. 大槻純男、堀里子、寺崎哲也：ダイナミック輸送システムとしての血液脳関門と中枢創薬研究への応用、月刊薬事、46:1243-1249 (2004)
        2. 大槻純男：中枢支援防御システムとしての血液脳関門輸送の生理機能、薬学雑誌、24:791-802 (2004)
        3. 堀里子：血液脳関門透過型キャリアを用いた脳への遺伝子デリバリーと疾患治療への応用、薬剤学、65:38-42 (2005)

        著書

        1. 寺崎哲也、堀　里子：SBO66、第19章分布、「薬学教科書シリーズ、第６巻、薬と疾病, I薬の効くプロセス」、日本薬学会編、東京化学同人、東京、276-278 (2005)
        2. 大槻純男、寺崎哲也：SBO67、第19章分布、「薬学教科書シリーズ、第６巻、薬と疾病, I薬の効くプロセス」、日本薬学会編、東京化学同人、東京、279-280 (2005)
        3. 崔　吉道、寺崎哲也：SBO68、第19章分布、「薬学教科書シリーズ、第６巻、薬と疾病, I薬の効くプロセス」、日本薬学会編、東京化学同人、東京、281-283 (2005)

         

        その他

        1. 寺崎哲也：　紹介：　薬学会賞受賞　杉山雄一氏の業績、ファルマシア、40(4): 347 (2004)

         

        2003年 (ISI-IF: Total 41.534)

        Original Articles

        1. Y. Deguchi, Y. Miyakawa, S. Sakurada, Y. Naito, K. Morimoto, S. Ohtsuki, K. Hosoya, T. Terasaki: Blood-brain barrier transport of a novel m1-specific opioid peptide, H-Tyr-D-Arg-Phe-b-Ala-OH (TAPA). J. Neurochem.,84:1154-1161 (2003) (ISI-IF: 4.825) On-line Article
        2. S. Ohtsuki, T. Takizawa, H. Takanaga, N. Terasaki, T. Kitazawa, M. Sasaki, T. Abe, K. Hosoya, T. Terasaki: In vitro study of the functional expression of organic anion transporting polypeptide 3 at rat choroid plexus epithelial cells and its involvement in the cerebrospinal fluid-to-blood transport of estrone-3-sulfate. Mol. Pharmacol. 63: 532-537 (2003) (ISI-IF: 5.650) On-line Article
        3. N. Nakagawa, T. Hishinuma, H. Nakamura, T. Yamazaki, H. Tsukamoto, M. Hiratsuka, T. Ido, M. Mizugaki, T. Terasaki, J. Goto: Brain and heart specific alteration of methamphetamine (MAP) distribution in MAP-sensitized rat. Biol. Pharm. Bull. 23:432-440 (2003) (ISI-IF: 1.124) On-line Article
        4. S. Mori, H. Takanaga, S. Ohtsuki, T. Deguchi, Y.S. Kang, K. Hosoya, T. Terasaki. Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells. J Cereb Blood Flow Metab 23:432-440 (2003) (ISI-IF: 5.370) On-line Article
        5. M. Tomi, T. Funaki, H. Abukawa, K. Katayama, T. Kondo, S. Ohtsuki, M. Ueda, M. Obinata, T. Terasaki, K. Hosoya: Expression and regulation of L-cystine transporter, system xc-, in the newly developed rat retinal muller cell line (TR-MUL). Glia 43: 208-217 (2003) (ISI-IF: 4.677) On-line Article
        6. T. Asashima, H. Iizasa, T. Terasaki, E. Nakashima. Rat brain pericyte cell lines expressing b2-adrenergic receptor, angiotensin II receptor type 1A, klotho, and CXCR4 mRNAs despite having endothelial cell markers J Cell Physiol 197:69-76 (2003) (ISI-IF: 5.463) On-line Article
        7. T. Kondo, K. Hosoya, S. Hori, M. Tomi, S. Ohtsuki, H. Takanaga, E. nakashima, H. Iizasa, T. Asashima, M. Ueda, M. Obinata, T. Terasaki: Establishment of conditionally immortalized rat retinal pericyte cell lines (TR-rPCT) and its application for the co-culture system using retinal capillary endothelial cell lines (TR-iBRB). Cell Struct. Func. 28: 145-153 (2003) (ISI-IF: 1.664) On-line Article
        8. L.J. Shen, W.C. Lin, W. Beloussow, K. Hosoya, T. Terasaki, D.K. Ann, W.C. Shen: Recombinant arginine deiminase as a differential modulator of inducible (iNOS) and endothelial (eNOS) nitric oxide synthetase activity in cultured endothelial cells. Biochem. Pharmacol. 66:1945-1952 (2003) (ISI-IF: 2.993) On-line Article
        9. K. Tetsuka, H. Takanaga, S. Ohtsuki, K. Hososya, T. Terasaki: The L-isomer-selective transport of aspartic acid is mediated by ASCT2 at the blood-brain barrier. J. Neurochem., 87:891-901 (2003) (ISI-IF: 4.825) On-line Article

        Review Articles & Book Chapters

        1. T. Terasaki, S. Ohtsuki, S. Hori, H. Takanaga, E. Nakashima, K. Hosoya. New approaches to in vitro models of blood-brain barrier drug transport. Drug Discov Today 8:944-954 (2003) (ISI-IF: 4.943) On-line Article Comment
        2. Terasaki, S. Ohtsuki, S. Hori, K. Hosoya: Blood-brain barrier transport biology and drug delivery to the brain, in Advences in Biomaterials and Drug Delivery System, S. Hsiue, et al., Editors. Princeton International Publishing. pp. 499-516 (2003)
        3. H. Kusuhara, T. Terasaki, Y. Sugiyama: Brain efflux index method: Characterization of efflux transport across the blood-brain barrer, in Method in Molecular Medicine, S. Nag, Editor. Humana Press: New Jersey. pp. 221-234 (2003)

        総説・著書

        1. 寺崎哲也、堀里子、大槻純男：条件的不死化脳関門細胞株を用いた脳へのDDS研究の新展開、DDS学会誌、18: 118-125 (2003)
        2. 大槻純男、寺崎哲也：血液脳関門におけるセロトニントランスポーター、Clinical Neuroscience, 21(6): 641-643, (2003)
        3. 大槻純男、堀里子、寺崎哲也：血液脳関門の薬物透過と排出の分子機構　～中枢支援防御システム～、日本薬理学雑誌、122：55-64, (2003) On-line Article
        4. 大槻純男、立川正憲、堀里子、寺崎哲也：脳を守る脳関門トランスポーター、未来材料　(Review視点-護る)、3, 2-6 (2003)
        5. 寺崎哲也、大槻純男、堀　里子、高長ひとみ：血液脳関門輸送系の分子機構と生理的役割、神経免疫学　（特集IV:血液脳関門、血液神経関門の基礎と臨床：バリアーの生理と破綻・修復のメカニズムを探る）、11、227-235 (2003)
        6. 大槻純男、寺崎哲也：血液脳関門の分子生理学、ファルマシア　39（11月号）、1057-1061（2003）
        7. 大槻純男、寺崎哲也：血液脳関門の輸送機構と脳支援・防御システムとしての生理的役割、「神経科学の基礎と臨床 XI：脳質とその周囲器官」、板倉　徹編、ブレーン出版、東京、(2003)
        8. 寺崎哲也、大槻純男：第３章　体内分布、「わかりやすい生物薬剤学」、辻彰編、廣川書店、東京、(2003)
        9. 寺崎哲也、：第６章　生理学的薬物速度論、「わかりやすい生物薬剤学」、辻彰編、廣川書店、東京、(2003)

         

        2002年 (ISI-IF: Total 62.755)

        Original Articles

        1. T. Asashima, H. Iizasa, T. Terasaki, K. Hosoya, K. Tetsuka, M. Ueda, M. Obinata, E. Nakashima. Newly developed rat brain pericyte cell line, TR-PCT1, responds to transforming growth factor- 1 and -glycerophosphate. Eur J Cell Biol 81:145-152 (2002) (ISI-IF: 2.185)
        2. A. Kakee, H. Takanaga, K. Hosoya, Y. Sugiyama and T. Terasaki: In vivo evidence for brain-to-blood efflux transport of valproic acid across the blood-brain barrier. Microv. Res., 63: 233-238 (2002). (ISI-IF: 1.858)
        3. M. Tomi, K. Hosoya, H. Takanaga, S. Ohtsuki, T. Terasaki. Induction of xCT gene expression and L-cystine transport activity by diethyl maleate at the inner blood-retinal barrier. Invest Ophthalmol Vis Sci 43:774-779 (2002) (ISI-IF: 4.148)
        4. T. Deguchi, S. Ohtsuki, M. Otagiri, H. Takanaga, H. Asaba, S. Mori, T. Terasaki. Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney. Kidney Int 61:1760-1768 (2002) (ISI-IF: 5.302)
        5. H. Takanaga, N. Tokuda, S. Ohtsuki, K. Hosoya, T. Terasaki. ATA2 is predominantly expressed as system A at the blood-brain barrier and acts as brain-to-blood efflux transport for L-proline. Mol Pharmacol 61:1289-1296 (2002) (ISI-IF: 5.650)
        6. K. Hosoya, M. Tomi, S. Ohtsuki, H. Takanaga, S. Saeki, Y. Kanai, H. Endou, M. Naito, T. Tsuruo, T. Terasaki. Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment. J Pharmacol Exp Ther 302:225-231 (2002) (ISI-IF: 4.337) On-line Article
        7. S. Ohtsuki, H. Asaba, H. Takanaga, T. Deguchi, K. Hosoya, M. Otagiri, T. Terasaki. Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain. J Neurochem 83:57-66 (2002) (ISI-IF: 4.825) On line Article
        8. K. Wakayama, S. Ohtsuki, H. Takanaga, K. Hosoya, T. Terasaki. Localization of norepinephrine and serotonin transporter in mouse brain capillary endothelial cells. Neurosci Res 44:173-180 (2002) (ISI-IF: 2.200)
          (Selected as highlighted paper by the journal's Chief Editor)
        9. T. Kitano, H. Iizasa, T. Terasaki, T. Asashima, N. Matsunaga, N. Utoguchi, Y. Watanabe, M. Obinata, M. Ueda, E. Nakashima. Polarized glucose transporters and mRNA expression properties in newly developed rat syncytiotrophoblast cell lines, TR-TBTs. J Cell Physiol 193:208-218 (2002) (ISI-IF: 5.463)
        10. Y. Deguchi, H. Okutsu, T. Okura, S. Yamada, R. Kimura, T. Yuge, A. Furukawa, K. Morimoto, M. Tachikawa, S. Ohtsuki, K. Hosoya, T. Terasaki. Internalization of basic fibroblast growth factor at the mouse blood-brain barrier involves perlecan, a heparan sulfate proteoglycan. J Neurochem 83:381-389 (2002) (ISI-IF: 4.825) On-line Article
        11. H. Iizasa, S.H. Bae, T. Asashima, T. Kitano, N. Matsunaga, T. Terasaki, Y.S. Kang, E. Nakashima. Augmented expression of the tight junction protein occludin in brain endothelial cell line TR-BBB by rat angiopoietin-1 expressed in baculovirus-infected Sf plus insect cells. Pharm Res 19:1757-1760 (2002) (ISI-IF: 2.609)
        12. K. Hosoya, T. Takashima, K. Matsuda, T. Terasaki: Spleen lymphocyte kinetics in mice under normal and inflammatory conditions: An application of the transgenic mouse expressing b-galactosidase (ROSA 26).Biol. Pharm. Bull.,25: 1378-1380 (2002). (ISI-IF: 1.124)
        13. S. Ohtsuki, M. Tachikawa, H. Takanaga, H. Shimizu, M. Watanabe, K. Hosoya, T. Terasaki. The blood-brain barrier creatine transporter is a major pathway for supplying creatine to the brain. J Cereb Blood Flow Metab 22:1327-1335 (2002) (ISI-IF: 5.370)
        14. C.H. Chau, K.Y. Chen, H.T. Deng, K.J. Kim, K. Hosoya, T. Terasaki, H.M. Shih, D.K. Ann. Coordinating Etk/Bmx activation and VEGF upregulation to promote cell survival and proliferation. Oncogene 21:8817-8829 (2002) (ISI-IF: 6.495)
        15. N. Umeki, Y. Fukasawa, S. Ohtsuki, S. Hori, Y. Watanabe, Y. Kohno, T. Terasaki. mRNA expression and amino acid transport characteristics of cultured human brain microvascular endothelial cells (hBME). Drug Metab Pharmacokin 17:367-373 (2002)
        16. Y.S. Kang, S. Ohtsuki, H. Takanaga, M. Tomi, K. Hosoya, T. Terasaki. Regulation of taurine transport at the blood-brain barrier by tumor necrosis factor- , taurine and hypertonicity. J Neurochem 83:1188-1195 (2002) (ISI-IF: 4.825) On-line Article

        Review Articles & Book Chapters

        1. K. Hosoya, S. Ohtsuki, T. Terasaki. Recent advances in the brain-to-blood efflux transport across the blood-brain barrier. Int J Pharm 248:15-29 (2002) (ISI-IF: 1.539)
        2. K. Hosoya, S. Ohtsuki, T. Terasaki: Blood-brain barrier transport and drug targeting to the brain, in Biomedical Aspect of Drug Targeting, V.R. Muzykantov and V.P. Torchilin, Editors. Kluwer Academic Press. pp. 313-326 (2002)

        総説・著書

        1. 寺崎哲也：中枢疾患治療薬開発における血液脳関門排出輸送研究の重要性、脳21、15: 201-204 (2002)

         

        2001年

        Original Articles

        1. T. Kitazawa, K. Hosoya, M. Watanabe, T. Takashima, S. Ohtsuki, H. Takanaga, M. Ueda, N. Yanai, M. Obinata and T. Terasaki: Characterization of the amino acid transport of new immortalized choroids plexus epithelial cell lines: A novel in vitro system for investigating transport functions at the blood-cerebrospinal fluid barrier., Pharm. Res.,18: 16-22 (2001)
        2. K. Hosoya, M. Tomi, S. Ohtsuki, H. Takanaga, N. Ueda, N. Yanai, M. Obinata and T. Terasaki: Conditionally immortalized retinal capillary endothelial cell lines (TR-iBRB) expressing differentiated endothelial cell functions derived from a transgenic rat harboring the temperature-sensitive SV40 large T-antigen., Exp. Eye Res., 72:163-72 (2001)
        3. K. Hattori, M. Muta, M. Toi, H. Iizasa, M. Shinsei, T. Terasaki, M. Obinata, M. Ueda, and E. Nakashima: Establishment of bone marrow-derived endothelial cell lines from ts-SV40 T-antigen gene transgenic rats. Pharm. Res., 18: 9-15 (2001)
        4. K. Hosoya, S. Saeki and T. Terasaki: Activation of carrier-mediated transport of L-cystine at the blood-brain and blood-retinal barriers In vivo. Microvasc. Res., 62: 136-142 (2001)
        5. K. Tetsuka, K. Hosoya, S. Ohtsuki, H. Takanaga, Y. Yanai, M. Ueda, M. Obinata and T. Terasaki: Acidic amino acid transport characterization of a newly developed conditionally immortalized crat Type 2 astrocyte cell line (TR-AST). Cell Struct. Func., 26: 197-203 (2001)
        6. H. Takanaga, S. Ohtsuki, K. Hosoya and T. Terasaki: GAT2/BGT-1 as a system responsible for the transport of y-aminobutylic acid at the mouse blood-brain barrier. J. Cereb. Blood Flow Metab., 21: 1232-1239 (2001)
        7. A. Kakee, H. Takanaga, T. Terasaki, M. Naito, T. Tsuruo and Y. Sugiyama: Efflux of a suppressive neurotransmitter, GABA, across the blood-brain barrier. J. Neurochem., 79: 110-118 (2001).
        8. K. Hosoya, T. Kondo, M. Tomi, H. Takanag, S. Ohtsuki, T. Terasaki: MCT1-mediated transport of L-lactic acid at the inner blood-retinal barrier: a possible route for delivery of monocarboxylic acid drugs to the retina. Pharm. Res., 18:1669-76 (2001)

        Review Articles & Book Chapters

        1. T. Terasaki and K. Hosoya: Conditionally immortalized cell lines as a new in vitro model for the study of barrier functions. Biol. Pharm. Bull., 24: 111-118 (2001).

        総説・著書

        1. 大槻純男、高長ひとみ、細谷健一、寺崎哲也：概説-血液脳関門研究の最近の進歩、生体の科学、52(6): 532-540 (2001)
        2. 細谷健一、高長ひとみ、大槻純男、寺崎哲也：血液脳関門輸送系の分子機構と生理的役割、生体の科学、52(6): 552-562 (2001)
        3. 出口　芳春、森本一洋、寺崎哲也：脳微小透析法の血液脳関門輸送研究への応用、生体の科学、52: 563-570 (2001)
        4. 寺崎哲也：関門組織のin vitroモデル開発と細胞膜輸送機能に基づいたドラッグ・デリバリー、翠らん、15, 48-52 (2001)
        5. 出口芳春、奥津広士、内藤隆文、黄倉崇、山田静雄、弓削卓郎、古川明彦、大槻純男、細谷健一、寺崎哲也、森本一洋、木村良平：Basic Fibroblast Growth Factorの血液脳関門透過機構、薬物動態、16: 140-144 (2001)
        6. 細谷健一、寺崎哲也：血液網膜関門及び血液脳関門の再構築とドラッグデリバリー研究への応用、Drug Delivery System, 16, 29-38 (2001)
        7. 寺崎哲也： 脳内移行, 「生物薬剤学」, 林正弘、谷川原祐介編, 南江堂, 東京, 第2章,第2節 83-88 (2001)

         

        2000年

        Original Articles

        1. T. Kitazawa, K. Hosoya, T. Takahashi, Y. Sugiyama, T. Terasaki: In vivo and in vitro evidence of a carrier-mediated efflux transport system for estrone-3-sulfate across the blood-cerebrospinal fluid barrier. J. Pharm. Pharmacol., 52: 281-288 (2000)
        2. H. Asaba, K. Hosoya, H. Takanaga, S. Ohtsuki, E. Tamura, T. Takizawa, T. Terasaki: Blood-brain barrier is involved in the efflux transport of a neuroactive steroid, dehydroepiandrosterone sulfate, via organic anion transporting polypeptide 2, J. Neurochem., 75:1907-16 (2000)
        3. K. Hosoya, H. Asaba, T. Terasaki:Brain-to-blood efflux transport of estrone-3-sulfate at the blood-brain barrier in rats.Life Sci., 67: 2669-2711 (2000)
        4. K. Hosoya, K. Tetsuka, K. Nagase, M. Tomi, S. Saeki, S. Ohtsuki, H. Takanaga, N. Yanai, M. Obinata, A. Kikuchi, T. Okano, T. Terasaki: Conditionally immortalized brain capillary endothelial cell lines established from transgenic mouse harboring temperature-sensitive SV 40 large T-Antigen gene, AAPS PharmSci, 2: article 27 (http://www.pharmsci.org/scientificjournals/pharmsci/journal/27.html) (2000)
        5. K. Hosoya, T. Takashima, K. Tetsuka, T. Nagura, S. Ohtsuki, H. Takanaga, M. Ueda, N. Yanai, M. Obinata, T. Terasaki: mRNA expression and transport characterization of conditionally immortalized rat brain capillary endothelial cell lines: A new in vitro BBB model for drug targeting, J. Drug Targeting, 8: 357-370 (2000)

        Review Articles & Book Chapters

        1. T. Terasaki, S. Ohtsuki, H. Takanaga, K. Tetsuka, K. Nagase, K. Wakayama, I. Osawa, N. Ynai, M. Obinata, A. Kikuchi, T. Okano and K. Hosoya: Brain Barrier Function: Its Analysis and reconstitution, IN Tissue Engineering for Therapeutic Use 4, Y. Ikada(Ed), Y. Shimizu, Elsevier Science B.V., pp. 95-104 (2000).
        2. T. Terasaki and W. M. Pardridge: Preface: Targeted drug delivery to the brain. J. Drug Target., 8: 353-355 (2000)

        総説・著書

        1. 高長ひとみ、森しのぶ、徳田典代、大槻純男、細谷健一、寺崎哲也：ヒトにおける薬物動態とその変動要因の基礎知識；薬物動態を決定する機能タンパク質、e)血液脳関門と血液脳脊髄液関門、月刊薬事、42(4)、121-136 (2000)
        2. 寺崎哲也：脳の病気を治す薬を創るために （特集）、まなびの杜、14、4-5 (2000)
        3. 寺崎哲也：分布、第3章、総合製剤学、杉山雄一、橋田充編、南山堂、東京,（2000）57-76頁
        4. 田辺修一、宍戸祐之、沢田誠吾、横倉輝男、寺崎哲也: 血液脳関門透過性改善を目指したアルギニンバソプレシンフラグメント4-9誘導体の設計、及びその脳移行性に関する研究 DDS 研究の進歩 IX (Progress in Drug Delivery System) ,静岡 DDS研究会、岡田昌二　編、 pp13-22(2000)、バイオメディカル社、東京

         

        1999年

        Original Articles

        1. K. Matsuda, M. Koguma, R. Okuyama, T. Nakazawa, Y. Matsuzaki, T. Terasaki, N. Yanai, H. Nakauchi, M. Obinata: A novel stromal cell-dependent B lymphoid stem-like cell line that induces immunoglobulin gene rearrengement. J. Biochem., 125: 602-612 (1999)
        2. S. Tanabe, Y. Shishido, Y. Nakayama, M. Furushiro, S. Hashimoto, T. Terasaki, G. Tsujimoto, T. Yokokura: Effects of arginine-vasopressin fragment 4-9 on rodent cholinergic systems. Pharmacol. Biochem. Behav., 63: 549-553 (1999).
        3. H. Sasabe, Y. Kato, T. Terasaki, T. Tsuji and Y. Sugiyama: Differences in the hepatobiliary transport of two quinolone antibiotics, grepafloxacine and lomefloxacin, in the rat. Biopharm, Drug Dispos., 20: 151-158 (1999)
        4. S. Tanabe, Y. Shimohigashi, Y. Nakayam, Y. Makino, T. Fujita, T. Nose, G. Tsujimoto, T. Yokokura, M. Naito, T. Tsuruo, T. Terasaki: In vivo and in vitro evidence of blood-brain barrier transport of a novel cationic arginine-vasopression fragment 4-9 analogue. J. Pharmacol. Exp. Ther., 290: 561-568 (1999)
        5. K. Hosoya, M. Sugawara, H. Asaba, T. Terasaki: Blood-brain barrier significantly efflux L-aspartic acid, but not D-aspartic acid: In vivo evidence by brain efflux index method. J. Neurochem. 73: 1206-1211 (1999)

        Review Articles & Book Chapters

        1. T. Terasaki and K. Hosoya: The blood-brain barrier efflux transporters as a detoxifying system for the brain. Adv. Drug Deliv. Rev., 36: 195-209 (1999)
        2. T. Terasaki, K. Hosoya: The Brain Efflux Index method (BEI). in "Brain Barrier Systems, The Alfred Benzon Symposium 45", ed. byO. Paulsen, G. M. Knudsen, T. Moos and A. Svejgaard, Munksgaard, Copenhagen, (1999) pp 114-127
        3. M. Yamato, A. Kikuchi, S. Kohsaka, T. Terasaki, H.A.von Recum, S.W.Kim, Y. Sakurai and T. Okano:Novel manipulation technology of cell sheets for tissue engineering, in “Tissue Engineering for Therapeutic Use 3” ed by Y. Ikada and T. Okano, Elsevier Science B.V., (1999) pp.99-107.

        総説・著書

        1. 寺崎哲也、細谷健一：血液脳関門研究における最近の進歩週刊・薬事新報、2050、9-15 (1999)
        2. 崎哲也： 血液脳関門：脳に対する防御と支援の二つの役割を備えたシステム Newton、21世紀を切り開くバイオメディカルエンジニアリング、第5章　薬物治療、遺伝子・組織工学の最先端、9月号（1999）120頁

         

        1998年

        Original Articles

        1. T. Kitazawa, T. Terasaki, H. Suzuki, A. Kakee and Y. Sugiyama: Efflux of taurocholic acid across the blood-brain barrier: Interaction with cyclic peptides. J. Pharmacol. Exp. Ther., 286: 890-895 (1998)
        2. S. Song, H. Suzuki, T. Terasaki, M. Lemaire and Y. Sugiyama: Modulation of the tumor disposition of vinca alkaloids by PSC 833 in vitro and in vivo. J. Pharmacol. Exp. Ther., 287: 963-968 (1998).

        Review Articles & Book Chapters

        1. T. Terasaki: Development of Brain Efflux Index (BEI) Method and Its Application to the Blood-Brain Barrier Efflux Transport Study. in "An Introduction to the Blood-Brain Barrier: Methodology and Biology" ed. by W. M. Pardridge, Cambridge Univ. Press, (1998) Chap 3, pp.24-31.

        総説・著書

        1. 寺崎哲也： 血液脳関門排出輸送機能と薬物脳内動態制御上原記念生命科学財団研究報告集、12巻、34-35、（1998）

         

        1997年

        Original Articles

        1. J. Komura, I. Tamai, M. Senmaru, T. Terasaki, Y. Sai and A. Tsuji: Brain-to-blood active transport of -alanine across the blood-brain barrier. FEBS Let., 400: 131-135-335 (1997)
        2. T. Hirohashi, T. Terasaki, M. Shigetoshi and Y. Sugiyama: In vivo and in vitro evidence for non-restricted transport of 2',7'-bis(2-carboxy-ethyl)-5(6)- carboxyfluorescein tetraacetoxymethyl ester (BCECF-AM) at the blood-brain barrier. J. Pharmacol. Exp. Ther., 280: 813-819 (1997)
        3. K. Takasawa, T. Terasaki, H. Suzuki and Y. Sugiyama: In vivo evidence for carrier-mediated efflux transport of 3'azido-3'-deoxythymidine and 2',3'-dideoxyinosine across the blood-brain barrier via a probenecid-sensitive transport system. 　 J. Pharmacol. Exp. Ther., 281: 369-375 (1997)
        4. W. Yang, T. Terasaki, K. Shiroki, S. Ohka, J. Aoki, S. Tanabe, T. Nomura, E. Terada, Y. Sugiyama and A. Nomoto: Efficient delivery of circulating poliovirus to the central nervous system independently of poliovirus receptor. Virology, 229: 421-428 (1997)
        5. T. Ooie, T. Terasaki, H. Suzuki and Y. Sugiyama: Quantitative brain microdialysis study on the mechanism of quinolones distribution in the central nervous system. Drug Metab. Dispos., 25: 784-789 (1997)
        6. H. Sasabe, T. Terasaki, A. Tsuji and Y. Sugiyama: Carrier-mediated hepatic uptake of quinolone antibiotics in the rat. J. Pharmacol. Exp. Ther., 282: 162-171 (1997)
        7. K. Takasawa, T. Terasaki, H. Suzuki, T. Ooie and Y. Sugiyama: Distributed model analysis of 3'-azido-3'-deoxythymidine and 2',3'- dideoxyinosine distribution in brain tissue and CSF. J. Pharmacol. Exp.Ther., 282: 1509-1517 (1997)
        8. T. Ooie, T. Terasaki, H. Suzuki and Y. Sugiyama: Kinetic evidence for active transport at the blood-brain barrier of quinolone antibiotics. J. Pharmacol. Exp.Ther.., 283: 293-304 (1997)
        9. Y. Mano, H. Suzuki, T. Terasaki, T. Iwahashi, K. Ono, M. Naito, T. Tsuruo and Y. Sugiyama: Kinetic analysis of the disposition of MRK 16, an anti-P-glycoprotein monoclonal antibody, in tumors: Prediction of in vivo disposition based on the in vitro kinetic parameters. J. Pharmacol. Exp.Ther., 283: 391-401 (1997)
        10. H.Kusuhara, H.Suzuki, T.Terasaki, A.Kakee, L.Lemaire and Y. Sugiyama: P-glycoprotein mediates the efflux of quinidine across the blood-brain barrier. J. Pharmacol. Exp. Ther., 283: 574-580 (1997)
        11. A. Kakee, T. Terasaki and Y. Sugiyama: Selective brain to blood efflux transport of para-aminohippuric acid across the blood-brain barrier: In vivo evidence using the brain efflux index (BEI) method. J. Pharmacol. Exp. Ther., 283: 1018-1025 (1997)
        12. T. Yamada, K. Niinuma, M. Lemaire, T. Terasaki, Y. Sugiyama: Carrier-mediated hepatic uptake of the cationic cyclopeptide, octreotide, in rats-comparison between in vivo and in vitro. Drug Metab.Dispos.,. 25(5):536-543 (1997)
        13. T. Hamada, Y. Kato, T. Terasaki, Y. Sugiyama: Cell density-dependent mitogenic effect and independent cellular handling of epidermal growth factor in primary cultured rat hepatocytes. J. Hepatology, 26(2):353-360 (1997).

        Review Articles & Book Chapters

        1. H. Suzuki, T. Terasaki and Y. Sugiyama: Role of efflux transport across the blood-brain barrier and blood-cerebrospinal fluid barrier on the disposition of xenobiotics in the central nervous system. Adv. Drug Deliv. Rev.,25: 257-285 (1997).

        総説・著書

        1. 辻 彰、寺崎哲也: 体内分布, 「わかりやすい生物薬剤学」, 第２版, 辻 彰 編, 広川書店, 東京, (1997), 第３章, pp.75-103
        2. 寺崎哲也：血液脳関門と薬物の脳内分布、　　ヒューマンサイエンス, 8(6), 18-21 (1997)

         

        1996年

        Original Articles

        1. T. Ooie, H. Suzuki, T. Terasaki and Y. Sugiyama: Characterization of the transport properties of a quinolone antibiotic, fleroxacin, in rat choroid plexus. Pharm. Res., 13: 523-527 (1996)
        2. A. Kakee, T. Terasaki and Y. Sugiyama: Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier. J. Pharmacol. Exp. Ther., 277: 1550-1559 (1996)
        3. J. Komura, I. Tamai, M. Senmaru, T. Terasaki, Y. Sai and A. Tsuji: Sodium and chloride ion-dependent transport of β-alanine across the blood-brain barrier. J. Nerochem., 67: 330-335 (1996)
        4. T. Ooie, H. Suzuki, T. Terasaki and Y. Sugiyama: Kinetics of quinolone antibiotics in rats: Efflux from cerebrospinal fluid to the circulation. Pharm. Res., 13: 1065-1068 (1996)
        5. T. Ooie, H. Suzuki, T. Terasaki and Y. Sugiyama: Comparative distribution of quinolone antibiotics in cerebrospinal fluid and brain in rats and dogs. J. Pharmacol. Exp. Ther., 278: 590-596 (1996)
        6. D. Nakai, T. Seita, T. Terasaki, S. Iwasa, Y. Shoji, Y. Mizuma and Y, Sugiyama: Cellular uptake mechanism for oligonucleotides: Involvement of endocytosis in the uptake of phosphodiester oligonucleotides by a human colorectal adenocarcinom a cell line, HCT-15. J. Pharmacol. Exp. Ther., 278: 1362-1372 (1996)
        7. T. Yamada, K. Niinuma, M. Lemaire, T. Terasaki and Y. Sugiyama: Mechanism of the tissue distribution and biliary excretion of the cyclic peptide Octreotide. J. Pharmacol. Exp. Ther., 279: 1357-1364 (1996)

        総説・著書

        1. 楠原洋之、寺崎哲也、杉山雄一：P-糖蛋白の生理機能, Current Review, 今日の癌化学療法、鶴尾隆、西條長宏編、165-171, 中外医学社、(1996)
        2. 掛江敦之、寺崎哲也、北澤健生、辻彰、杉山雄一：血液脳関門　-静的障壁からダイナミック・インターフェースへ-脳へのドラッグデリバリーの最近の進歩　その５Pharm Tech Japan, 12, 19-32 (1996)
        3. 掛江敦之、寺崎哲也、北澤健生、辻彰、杉山雄一：血液脳関門　-静的障壁からダイナミック・インターフェースへ-脳へのドラッグデリバリーの最近の進歩　その６Pharm Tech Japan, 12, 187-196 (1996)
        4. 北澤健生、寺崎哲也、掛江敦之、辻彰、杉山雄一：血液脳関門　-静的障壁からダイナミック・インターフェースへ-脳へのドラッグデリバリーの最近の進歩　その７Pharm Tech Japan, 12, 315-329 (1996)
        5. 寺崎哲也、掛江敦之：薬物相互作用のとらえ方: 排泄過程における薬物相互作用の速度論と細胞膜透過機構Progress in Medicine, 16, 26-32 (1996)